Genetic Markers for Optimizing Treatment for Schizophrenia

ABSTRACT

This document provides methods and materials related to genetic markers for predicting response to a treatment for schizophrenia (SZ). For example, methods for using such genetic markers to select optimal treatments are provided.

CLAIM OF PRIORITY

This application is a continuation of International Patent Application No. PCT/US2009/005318, filed Sep. 25, 2009, which claims priority to U.S. Provisional Application Ser. No. 61/100,176, filed on Sep. 25, 2008, which are incorporated by reference in their entirety herein.

FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

The U.S. Government has certain rights in this invention pursuant to Grant Nos. R43 MH078437, N01 MH900001, and MH074027, awarded by the National Institutes of Health.

TECHNICAL FIELD

This invention relates to genetic markers that are associated with response to treatments for schizophrenia (SZ) or schizophrenia spectrum disorders (SSDs), which includes SZ, schizotypal personality disorder (SPD), and schizoaffective disorder (SD). For example, this document provides methods for using such genetic markers to stratify patient populations in order to select optimal treatments.

BACKGROUND

The schizophrenia spectrum disorders include schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD). Schizophrenia (SZ) is considered a clinical syndrome, and is probably a constellation of several pathologies. Substantial heterogeneity is seen between cases, which is thought to reflect multiple overlapping etiologic factors, including both genetic and environmental contributions. SD is characterized by the presence of affective (depressive or manic) symptoms and schizophrenic symptoms within the same, uninterrupted episode of illness. SPD is characterized by a pervasive pattern of social and interpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationships as well as by cognitive or perceptual distortions and eccentricities of behavior, beginning by early adulthood and present in a variety of contexts.

Various genes and chromosomes have been implicated in etiology of SZ. Many studies have suggested the presence of one or more important genes relating to SZ on most or all of the autosomes (Williams et al., Hum. Mol. Genet. 8:1729-1739 (1999); Fallin et al., Am. J. Hum. Genet. 77:918-936 (2005) ; Badner et al., Mol. Psychiatry. 7:405-411 (2002); Cooper-Casey et al., Mol. Psychiatry. 10:651-656 (2005); Devlin et al., Mol. Psychiatry. 7:689-694 (2002); Fallin et al., Am. J. Hum. Genet. 73:601-611 (2003); Jablensky, Mol. Psychiatry. 11: 815-836 (2006); Kirov et al., J. Clin. Invest. 115:1440-1448 (2005); Norton et al., Curr. Opin. Psychiatry 19:158-164 (2006); Owen et al., Mol. Psychiatry. 9:14-27 (2004)). However, none of these prior studies have used high resolution genetic association methods to systematically compare genes involved in response to treatments for SSD, e.g., using anti-psychotics. Neither have any of these studies demonstrated that genetic polymorphisms in the genes defined herein are important in response to anti-psychotics.

Due to the severity of these disorders, especially the negative impact of a psychotic episode on a patient, and the diminishing recovery after each psychotic episode, there is a need to more conclusively identify individuals who will respond best to specific therapies, and/or who is likely to suffer the most severe side effects, to determine appropriate therapies based on genotypic subtype.

SUMMARY

This disclosure provides methods of identifying, selecting, and administering optimal treatments for SZ or SSDs, based on the presence of variations in genes involved in a number of pathways including: glutamate signaling and metabolism, cell adhesion, cytoskeletal architecture, vesicle formation, and trafficking, G-protein coupled receptors, carrier proteins and transporters, cell cycle modulators, neuronal development, calcium/calmodulin signaling, neuropeptide signaling, and several additional genes identified by virtue of their interaction with genes in high impact pathways and their expression in the central nervous system. This disclosure provides methods and claims relating to predicting treatment response (e.g., efficacy and likelihood of side effects) for these conditions based on their underlying genetic architecture. As described herein, methods for predicting response in order to select optimal treatments include evaluation of SNPs for genes relating to response to treatments for SZ. In some embodiments, specific exemplary SNPs are given that can be used to capture significant allelic variation in these genes. The allelic and genotypic variants thus identified can be used to stratify a patient population in order to select optimal treatments (e.g., atypical antipsychotics, typical antipsychotics, antidepressants, lithium) for patients.

In one aspect, this document features methods for predicting a human patient's likely response to a treatment for schizophrenia (SZ). Methods can include determining the identity of an allele of at least one polymorphism listed in Tables 1-20, wherein the presence of an allele associated with a known response indicates the patient's likely response to the treatment.

In another aspect, this document features methods for selecting a treatment for schizophrenia (SZ) for administration to a human patient. Methods can include determining the identity in the subject of an allele of at least one polymorphism listed in Tables 1-20; comparing the identity of the allele in the subject to a reference allele of the same polymorphism, wherein the reference allele is associated with a known response to a treatment, e.g., an allele listed in one of Tables 1-20; and selecting a treatment if the allele in the patient is the same as a reference allele that is associated with a positive response to that treatment. A treatment can be administration of an antipsychotic medication, and the at least one polymorphism can be selected from the markers listed in Tables 1-20. In some embodiments, the antipsychotic medication can be olanzapine, and the at least one polymorphism can be selected from the markers listed in Table 1 (e.g., nucleotide 31 of SEQ ID NO:2971, 2019, 684, 1109, 1336, or 2256), 6 (e.g. SEQ ID 4414, 3296, 3298, 1853, or 2390), Table 11 (e.g., nucleotide 31 of SEQ ID NO:2813, 4603, 3746, 1309, or 1588), or Table 16 (e.g., nucleotide 31 of SEQ ID NO:1197, 1717, or 248). Tables 1, 6, 11, and 16. In some embodiments, the antipsychotic medication can be risperidone, and the at least one polymorphism can be selected from the markers listed in Table 2 (e.g., nucleotide 31 of SEQ ID NO:27, 3878, 882, or 882), Table 7 (e.g., nucleotide 31 of SEQ ID NO:1439, 4213, 457, 2394, or 1571), Table 12 (e.g., nucleotide 31 of SEQ ID NO:4598, 559, 914, 4340), or Table 17 (e.g., nucleotide 31 of SEQ ID NO:1895, 22, 3078, 23, or 4573). In some embodiments, the antipsychotic medication can be quetiapine, and the at least one polymorphism can be selected from the markers listed in Table 3 (e.g., nucleotide 31 of SEQ ID NO:4571, 2383, 3737, 694, or 795), Table 8 (e.g., nucleotide 31 of SEQ ID NO:695, 2162, 574, or 4414), Table 13 (e.g., nucleotide 31 of SEQ ID NO:56, 1416, 1835, 3201, or 2445), or Table 18 (e.g., nucleotide 31 of SEQ ID NO:1292, 1291, 745, 746, or 3528). In some embodiments, the antipsychotic medication can be perphenazine, and the at least one polymorphism can be selected from the markers listed in Table 4 (e.g., nucleotide 31 of SEQ ID NO:48, 3715, 2829, 3869, or 2240), Table 9 (e.g., nucleotide 31 of SEQ ID NO:4282 or 2409), Table 14 (e.g., nucleotide 31 of SEQ ID NO:2634, 3312, 2797, 1665, or 4250), or Table 19 (e.g., nucleotide 31 of SEQ ID NO:507, 3077, 3303, 1508, or 307). In some embodiments, the antipsychotic medication can be ziprasidone, and the at least one polymorphism can be selected from the markers listed in Table 5 (e.g., nucleotide 31 of SEQ ID NO:3092, 3424, 62, 297, or 2618), Table 10 (e.g., nucleotide 31 of SEQ ID NO:1787 or 788), Table 15 (e.g., nucleotide 31 of SEQ ID NO:1711, 4425, or 2159), or Table 20 (e.g., nucleotide 31 of SEQ ID NO:3475, 1738, 2429, 2538, or 3589).

Determining the identity of an allele can include obtaining a sample comprising DNA from the subject, and determining identity of the nucleotide at the polymorphic site. Determining the identity of the nucleotide can include contacting the sample with a probe specific for a selected allele of the polymorphism, and detecting the formation of complexes between the probe and the selected allele of the polymorphism, wherein the formation of complexes between the probe and the test marker indicates the presence of the selected allele in the sample. Determining the identity of an allele can include determining the identity of a nucleotide at position 31 of one of SEQ ID NOs: 1-4617. Methods can further include selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele. Methods can further include stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects. Methods can further include administering the selected treatment to the subject.

A response can be selected from the group consisting of a change in a PANNS score; length of time until a discontinuation of therapy; likelihood of discontinuing therapy due to lack of efficacy; and likelihood of discontinuing therapy due to a serious adverse event. A positive response can be a decrease in a PANSS score relative to baseline; a long time until discontinuation of therapy; a low likelihood of discontinuing therapy due to lack of efficacy; and a low likelihood of discontinuing therapy due to a serious adverse event. Methods can further include recording the response allele in a tangible medium. A tangible medium can include a computer-readable disk, a solid state memory device, or an optical storage device.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although methods and materials similar or equivalent to those described herein can be used to practice the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.

The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.

DETAILED DESCRIPTION

Described herein are methods for predicting response to treatments for SSDs (and optionally stratifying patient populations), e.g., in order to select optimal treatments, based on evaluation of single nucleotide polymorphisms (SNPs) for genes on chromosomes 1-22. As described herein, bioinformatic and genetic analyses provided evidence of association of the disclosed SNP alleles associated with response, e.g., efficacy (positive response) or the occurrence of side effects to certain treatments for these disorders.

DEFINITIONS

As used herein, an “allele” is one of a pair or series of genetic variants of a polymorphism at a specific genomic location. A “response allele” is an allele that is associated with altered response to a treatment. Where a SNP is biallelic, both alleles will be response alleles (e.g., one will be associated with a positive response, while the other allele is associated with no or a negative response, or some variation thereof).

As used herein, “genotype” refers to the diploid combination of alleles for a given genetic polymorphism. A homozygous subject carries two copies of the same allele and a heterozygous subject carries two different alleles.

As used herein, a “haplotype” is one or a set of signature genetic changes (polymorphisms) that are normally grouped closely together on the DNA strand, and are usually inherited as a group; the polymorphisms are also referred to herein as “markers.” A “haplotype” as used herein is information regarding the presence or absence of one or more genetic markers in a given chromosomal region in a subject. A haplotype can consist of a variety of genetic markers, including indels (insertions or deletions of the DNA at particular locations on the chromosome); single nucleotide polymorphisms (SNPs) in which a particular nucleotide is changed; microsatellites; and minisatellites.

Microsatellites (sometimes referred to as a variable number of tandem repeats or VNTRs) are short segments of DNA that have a repeated sequence, usually about 2 to 5 nucleotides long (e.g., CACACA), that tend to occur in non-coding DNA. Changes in the microsatellites sometimes occur during the genetic recombination of sexual reproduction, increasing or decreasing the number of repeats found at an allele, changing the length of the allele. Microsatellite markers are stable, polymorphic, easily analyzed and occur regularly throughout the genome, making them especially suitable for genetic analysis.

“Copy number variation” (CNV), as used herein, refers to variation from the normal diploid condition for a gene or polymorphism. Individual segments of human chromosomes can be deleted or duplicated such that the subject's two chromosome carry fewer than two copies of the gene or polymorphism (a deletion or deficiency) or two or more copies (a duplication).

“Linkage disequilibrium” refers to when the observed frequencies of haplotypes in a population does not agree with haplotype frequencies predicted by multiplying together the frequency of individual genetic markers in each haplotype.

The term “chromosome” as used herein refers to a gene carrier of a cell that is derived from chromatin and comprises DNA and protein components (e.g., histones). The conventional internationally recognized individual human genome chromosome numbering identification system is employed herein. The size of an individual chromosome can vary from one type to another with a given multi-chromosomal genome and from one genome to another. In the case of the human genome, the entire DNA mass of a given chromosome is usually greater than about 100,000,000 base pairs. For example, the size of the entire human genome is about 3×10⁹ base pairs.

The term “gene” refers to a DNA sequence in a chromosome that codes for a product (either RNA or its translation product, a polypeptide). A gene contains a coding region and includes regions preceding and following the coding region (termed respectively “leader” and “trailer”). The coding region is comprised of a plurality of coding segments (“exons”) and intervening sequences (“introns”) between individual coding segments.

The term “probe” refers to an oligonucleotide. A probe can be single stranded at the time of hybridization to a target. As used herein, probes include primers, i.e., oligonucleotides that can be used to prime a reaction, e.g., a PCR reaction.

The term “label” or “label containing moiety” refers in a moiety capable of detection, such as a radioactive isotope or group containing same, and nonisotopic labels, such as enzymes, biotin, avidin, streptavidin, digoxygenin, luminescent agents, dyes, haptens, and the like. Luminescent agents, depending upon the source of exciting energy, can be classified as radioluminescent, chemiluminescent, bioluminescent, and photoluminescent (including fluorescent and phosphorescent). A probe described herein can be bound, e.g., chemically bound to label-containing moieties or can be suitable to be so bound. The probe can be directly or indirectly labeled.

The term “direct label probe” (or “directly labeled probe”) refers to a nucleic acid probe whose label after hybrid formation with a target is detectable without further reactive processing of hybrid. The term “indirect label probe” (or “indirectly labeled probe”) refers to a nucleic acid probe whose label after hybrid formation with a target is further reacted in subsequent processing with one or more reagents to associate therewith one or more moieties that finally result in a detectable entity.

The terms “target,” “DNA target,” or “DNA target region” refers to a nucleotide sequence that occurs at a specific chromosomal location. Each such sequence or portion is preferably at least partially, single stranded (e.g., denatured) at the time of hybridization. When the target nucleotide sequences are located only in a single region or fraction of a given chromosome, the term “target region” is sometimes used. Targets for hybridization can be derived from specimens which include, but are not limited to, chromosomes or regions of chromosomes in normal, diseased or malignant human cells, either interphase or at any state of meiosis or mitosis, and either extracted or derived from living or postmortem tissues, organs or fluids; germinal cells including sperm and egg cells, or cells from zygotes, fetuses, or embryos, or chorionic or amniotic cells, or cells from any other germinating body; cells grown in vitro, from either long-term or short-term culture, and either normal, immortalized or transformed; inter- or intraspecific hybrids of different types of cells or differentiation states of these cells; individual chromosomes or portions of chromosomes, or translocated, deleted or other damaged chromosomes, isolated by any of a number of means known to those with skill in the art, including libraries of such chromosomes cloned and propagated in prokaryotic or other cloning vectors, or amplified in vitro by means well known to those with skill; or any forensic material, including but not limited to blood, or other samples.

The term “hybrid” refers to the product of a hybridization procedure between a probe and a target.

The term “hybridizing conditions” has general reference to the combinations of conditions that are employable in a given hybridization procedure to produce hybrids, such conditions typically involving controlled temperature, liquid phase, and contact between a probe (or probe composition) and a target. Conveniently and preferably, at least one denaturation step precedes a step wherein a probe or probe composition is contacted with a target. Guidance for performing hybridization reactions can be found in Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (2003), 6.3.1-6.3.6. Aqueous and nonaqueous methods are described in that reference and either can be used. Hybridization conditions referred to herein are a 50% formamide, 2×SSC wash for 10 minutes at 45° C. followed by a 2×SSC wash for 10 minutes at 37° C.

Calculations of “identity” between two sequences can be performed as follows. The sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second nucleic acid sequence for optimal alignment and non-identical sequences can be disregarded for comparison purposes). The length of a sequence aligned for comparison purposes is at least 30% (e.g., at least 40%, 50%, 60%, 70%, 80%, 90% or 100%) of the length of the reference sequence. The nucleotides at corresponding nucleotide positions are then compared. When a position in the first sequence is occupied by the same nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. In some embodiments, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package, using a Blossum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

As used herein, the term “substantially identical” is used to refer to a first nucleotide sequence that contains a sufficient number of identical nucleotides to a second nucleotide sequence such that the first and second nucleotide sequences have similar activities. Nucleotide sequences that are substantially identical are at least 80% (e.g., 85%, 90%, 95%, 97% or more) identical.

The term “nonspecific binding DNA” refers to DNA which is complementary to DNA segments of a probe, which DNA occurs in at least one other position in a genome, outside of a selected chromosomal target region within that genome. An example of nonspecific binding DNA comprises a class of DNA repeated segments whose members commonly occur in more than one chromosome or chromosome region. Such common repetitive segments tend to hybridize to a greater extent than other DNA segments that are present in probe composition.

As used herein, the term “stratification” refers to the creation of a distinction between subjects on the basis of a characteristic or characteristics of the subjects. Generally, in the context of clinical trials, the distinction is used to distinguish responses or effects in different sets of patients distinguished according to the stratification parameters. In some embodiments, stratification includes distinction of subject groups based on the presence or absence of particular markers or alleles described herein. The stratification can be performed, e.g., in the course of analysis, or can be used in creation of distinct groups or in other ways.

Methods of Predicting Response and Selecting Optimal Treatment

Described herein are a variety of methods for predicting a subject's response, or selecting and optimizing (and optionally administering) a treatment for a subject having an SSD (e.g., SZ) based on the presence or absence of a response allele.

As used herein, “determining the identity of an allele” includes obtaining information regarding the identity (i.e., of a specific nucleotide), presence or absence of one or more specific alleles in a subject. Determining the identity of an allele can, but need not, include obtaining a sample comprising DNA from a subject, and/or assessing the identity, presence or absence of one or more genetic markers in the sample. The individual or organization who determines the identity of the allele need not actually carry out the physical analysis of a sample from a subject; the methods can include using information obtained by analysis of the sample by a third party. Thus the methods can include steps that occur at more than one site. For example, a sample can be obtained from a subject at a first site, such as at a health care provider, or at the subject's home in the case of a self-testing kit. The sample can be analyzed at the same or a second site, e.g., at a laboratory or other testing facility.

Determining the identity of an allele can also include or consist of reviewing a subject's medical history, where the medical history includes information regarding the identity, presence or absence of one or more response alleles in the subject, e.g., results of a genetic test.

In some embodiments, to determine the identity of an allele described herein, a biological sample that includes nucleated cells (such as blood, a cheek swab or mouthwash) is prepared and analyzed for the presence or absence of preselected markers. Such diagnoses may be performed by diagnostic laboratories, or, alternatively, diagnostic kits can be manufactured and sold to health care providers or to private individuals for self-diagnosis. Diagnostic or prognostic tests can be performed as described herein or using well known techniques, such as described in U.S. Pat. No. 5,800,998.

Results of these tests, and optionally interpretive information, can be returned to the subject, the health care provider or to a third party payor. The results can be used in a number of ways. The information can be, e.g., communicated to the tested subject, e.g., with a prognosis and optionally interpretive materials that help the subject understand the test results and prognosis. The information can be used, e.g., by a health care provider, to determine whether to administer a specific drug, or whether a subject should be assigned to a specific category, e.g., a category associated with a specific disease endophenotype, or with drug response or non-response. The information can be used, e.g., by a third party payor such as a healthcare payer (e.g., insurance company or HMO) or other agency, to determine whether or not to reimburse a health care provider for services to the subject, or whether to approve the provision of services to the subject. For example, the healthcare payer may decide to reimburse a health care provider for treatments for an SSD if the subject has a particular response allele. As another example, a drug or treatment may be indicated for individuals with a certain allele, and the insurance company would only reimburse the health care provider (or the insured individual) for prescription or purchase of the drug if the insured individual has that response allele. The presence or absence of the response allele in a patient may be ascertained by using any of the methods described herein.

Response Alleles

This document provides methods for predicting response and selecting an optimal treatment based on evaluation of one or more single nucleotide polymorphisms (SNPs) associated with specific treatment responses in subjects having SZ or SZ-spectrum disorders including SZ, SPD, or SD. Tables 1-20 and Table A list specific SNPs, variation of which is associated with altered response. One of skill in the art will appreciate that other variants can be identified and verified by Case/Control comparisons using the SNP markers presented herein. Using SNP markers that are identical to or in linkage disequilibrium with the exemplary SNPs, one can determine additional alleles of the genes, such as haplotypes, relating to response to treatment of an SSD (e.g., SZ). The allelic variants thus identified can be used, e.g., to select optimal treatments (e.g., pharmaceutical and/or psychosocial intervention) for patients.

Markers in Linkage disequilibrium (LD)

Linkage disequilibrium (LD) is a measure of the degree of association between alleles in a population. One of skill in the art will appreciate that alleles involving markers in LD with the polymorphisms described herein can also be used in a similar manner to those described herein. Methods of calculating LD are known in the art (see, e.g., Morton et al., Proc. Natl. Acad. Sci. USA 98(9):5217-21 (2001); Tapper et al., Proc. Natl. Acad. Sci. USA 102(33):11835-11839 (2005); Maniatis et al., Proc. Natl. Acad. Sci. USA 99:2228-2233 (2002)). Thus, in some cases, the methods can include analysis of polymorphisms that are in LD with a polymorphism described herein. Methods are known in the art for identifying such polymorphisms; for example, the International HapMap Project provides a public database that can be used, see hapmap.org, as well as The International HapMap Consortium, Nature 426:789-796 (2003), and The International HapMap Consortium, Nature 437:1299-1320 (2005). Generally, it will be desirable to use a HapMap constructed using data from individuals who share ethnicity with the subject. For example, a HapMap for African Americans would ideally be used to identify markers in LD with an exemplary marker described herein for use in genotyping a subject of African American descent.

Alternatively, methods described herein can include analysis of polymorphisms that show a correlation coefficient (r²) of value ≧0.5 with the markers described herein. Results can be obtained from on line public resources such as HapMap.org on the World Wide Web. The correlation coefficient is a measure of LD, and reflects the degree to which alleles at two loci (for example, two SNPs) occur together, such that an allele at one SNP position can predict the correlated allele at a second SNP position, in the case where r² is >0.5.

Identifying Additional Genetic Markers

In general, genetic markers can be identified using any of a number of methods well known in the art. For example, numerous polymorphisms in the regions described herein are known to exist and are available in public databases, which can be searched using methods and algorithms known in the art. Alternately, polymorphisms can be identified by sequencing either genomic DNA or cDNA in the region in which it is desired to find a polymorphism. According to one approach, primers are designed to amplify such a region, and DNA from a subject is obtained and amplified. The DNA is sequenced, and the sequence (referred to as a “subject sequence” or “test sequence”) is compared with a reference sequence, which can represent the “normal” or “wild type” sequence, or the “affected” sequence. In some embodiments, a reference sequence can be from, for example, the human draft genome sequence, publicly available in various databases, or a sequence deposited in a database such as GenBank. In some embodiments, the reference sequence is a composite of ethnically diverse individuals.

In general, if sequencing reveals a difference between the sequenced region and the reference sequence, a polymorphism has been identified. The fact that a difference in nucleotide sequence is identified at a particular site that determines that a polymorphism exists at that site.

In most instances, particularly in the case of SNPs, only two polymorphic variants will exist at any location. However, in the case of SNPs, up to four variants may exist since there are four naturally occurring nucleotides in DNA. Other polymorphisms, such as insertions and deletions, may have more than four alleles.

In some embodiments, the methods include determining the presence or absence of one or more other markers that are or may be associated with treatment response, e.g., in one or more genes, e.g., as described in WO 2009/092032, WO 2009/089120, WO 2009/082743, US2006/0177851, or US2009/0012371, incorporated herein in their entirety. See also, e.g., OMIM entry no. 181500 (SCZD).

Methods of Determining Identity of a Subject's Response Allele

The methods described herein include determining the identity, e.g., the specific nucleotide, presence or absence, of alleles associated with a predicted response to a treatment for an SSD, e.g., SZ. In some embodiments, a predicted response to a method of treating an SSD is determined by detecting the presence of an identical allele in both the subject and an individual with a known response to a method of treating an SSD, e.g., in an unrelated reference subject or a first or second-degree relation of the subject, and, in some cases, the absence of the allele in an reference individual having a known but opposite response. Thus the methods can include obtaining and analyzing a sample from a suitable reference individual. Samples that are suitable for use in the methods described herein contain genetic material, e.g., genomic DNA (gDNA). Genomic DNA is typically extracted from biological samples such as blood or mucosal scrapings of the lining of the mouth, but can be extracted from other biological samples including urine or expectorant. The sample itself will typically include nucleated cells (e.g., blood or buccal cells) or tissue removed from the subject. The subject can be an adult, child, fetus, or embryo. In some embodiments, the sample is obtained prenatally, either from a fetus or embryo or from the mother (e.g., from fetal or embryonic cells in the maternal circulation). Methods and reagents are known in the art for obtaining, processing, and analyzing samples. In some embodiments, the sample is obtained with the assistance of a health care provider, e.g., to draw blood. In some embodiments, the sample is obtained without the assistance of a health care provider, e.g., where the sample is obtained non-invasively, such as a sample comprising buccal cells that is obtained using a buccal swab or brush, or a mouthwash sample.

In some cases, a biological sample may be processed for DNA isolation. For example, DNA in a cell or tissue sample can be separated from other components of the sample. Cells can be harvested from a biological sample using standard techniques known in the art. For example, cells can be harvested by centrifuging a cell sample and resuspending the pelleted cells. The cells can be resuspended in a buffered solution such as phosphate-buffered saline (PBS). After centrifuging the cell suspension to obtain a cell pellet, the cells can be lysed to extract DNA, e.g., gDNA. See, e.g., Ausubel et al., 2003, supra. The sample can be concentrated and/or purified to isolate DNA. All samples obtained from a subject, including those subjected to any sort of further processing, are considered to be obtained from the subject. Routine methods can be used to extract genomic DNA from a biological sample, including, for example, phenol extraction. Alternatively, genomic DNA can be extracted with kits such as the QIAamp® Tissue Kit (Qiagen, Chatsworth, Calif.) and the Wizard® Genomic DNA purification kit (Promega). Non-limiting examples of sources of samples include urine, blood, and tissue.

The presence or absence of an allele or genotype associated with a predicted response to treatment for an SPD (e.g., SZ) as described herein can be determined using methods known in the art. For example, gel electrophoresis, capillary electrophoresis, size exclusion chromatography, sequencing, and/or arrays can be used to detect the presence or absence of specific response alleles. Amplification of nucleic acids, where desirable, can be accomplished using methods known in the art, e.g., PCR. In one example, a sample (e.g., a sample comprising genomic DNA), is obtained from a subject. The DNA in the sample is then examined to determine the identity of an allele as described herein, i.e., by determining the identity of one or more alleles associated with a selected response. The identity of an allele can be determined by any method described herein, e.g., by sequencing or by hybridization of the gene in the genomic DNA, RNA, or cDNA to a nucleic acid probe, e.g., a DNA probe (which includes cDNA and oligonucleotide probes) or an RNA probe. The nucleic acid probe can be designed to specifically or preferentially hybridize with a particular polymorphic variant.

Other methods of nucleic acid analysis can include direct manual sequencing (Church and Gilbert, Proc. Natl. Acad. Sci. USA 81:1991-1995 (1988); Sanger et al., Proc. Natl. Acad. Sci. USA 74:5463-5467 (1977); Beavis et al., U.S. Pat. No. 5,288,644); automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCP) (Schafer et al., Nat. Biotechnol. 15:33-39 (1995)); clamped denaturing gel electrophoresis (CDGE); two-dimensional gel electrophoresis (2DGE or TDGE); conformational sensitive gel electrophoresis (CSGE); denaturing gradient gel electrophoresis (DGGE) (Sheffield et al., Proc. Natl. Acad. Sci. USA 86:232-236 (1989)); denaturing high performance liquid chromatography (DHPLC, Underhill et al., Genome Res. 7:996-1005 (1997)); infrared matrix-assisted laser desorption/ionization (IR-MALDI) mass spectrometry (WO 99/57318); mobility shift analysis (Orita et al., Proc. Natl. Acad. Sci. USA 86:2766-2770 (1989)); restriction enzyme analysis (Flavell et al., Cell 15:25 (1978); Geever et al., Proc. Natl. Acad. Sci. USA 78:5081 (1981)); quantitative real-time PCR (Raca et al., Genet Test 8(4):387-94 (2004)); heteroduplex analysis; chemical mismatch cleavage (CMC) (Cotton et al., Proc. Natl. Acad. Sci. USA 85:4397-4401 (1985)); RNase protection assays (Myers et al., Science 230:1242 (1985)); use of polypeptides that recognize nucleotide mismatches, e.g., E. coli mutS protein; allele-specific PCR, and combinations of such methods. See, e.g., Gerber et al., U.S. Patent Publication No. 2004/0014095 which is incorporated herein by reference in its entirety.

Sequence analysis can also be used to detect specific polymorphic variants. For example, polymorphic variants can be detected by sequencing exons, introns, 5′ untranslated sequences, or 3′ untranslated sequences. A sample comprising DNA or RNA is obtained from the subject. PCR or other appropriate methods can be used to amplify a portion encompassing the polymorphic site, if desired. The sequence is then ascertained, using any standard method, and the presence of a polymorphic variant is determined. Real-time pyrophosphate DNA sequencing is yet another approach to detection of polymorphisms and polymorphic variants (Alderborn et al., Genome Research 10(8):1249-1258 (2000)). Additional methods include, for example, PCR amplification in combination with denaturing high performance liquid chromatography (dHPLC) (Underhill et al., Genome Research 7(10):996-1005 (1997)).

In order to detect polymorphisms and/or polymorphic variants, it may be desirable to amplify a portion of genomic DNA (gDNA) encompassing the polymorphic site. Such regions can be amplified and isolated by PCR using oligonucleotide primers designed based on genomic and/or cDNA sequences that flank the site. PCR refers to procedures in which target nucleic acid (e.g., genomic DNA) is amplified in a manner similar to that described in U.S. Pat. No. 4,683,195, and subsequent modifications of the procedure described therein. Generally, sequence information from the ends of the region of interest or beyond are used to design oligonucleotide primers that are identical or similar in sequence to opposite strands of a potential template to be amplified. See e.g., PCR Primer: A Laboratory Manual, Dieffenbach and Dveksler, (Eds.); McPherson et al., PCR Basics: From Background to Bench (Springer Verlag, 2000); Mattila et al., Nucleic Acids Res., 19:4967 (1991); Eckert et al., PCR Methods and Applications, 1:17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202. Other amplification methods that may be employed include the ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560 (1989), Landegren et al., Science 241:1077 (1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA 86:1173 (1989)), self-sustained sequence replication (Guatelli et al., Proc. Nat. Acad. Sci. USA 87:1874 (1990)), and nucleic acid based sequence amplification (NASBA). Guidelines for selecting primers for PCR amplification are well known in the art. See, e.g., McPherson et al., PCR Basics: From Background to Bench, Springer-Verlag, 2000. A variety of computer programs for designing primers are available, e.g., ‘Oligo’ (National Biosciences, Inc, Plymouth Minn.), MacVector (Kodak/IBI), and the GCG suite of sequence analysis programs (Genetics Computer Group, Madison, Wis. 53711).

In some cases, PCR conditions and primers can be developed that amplify a product only when the variant allele is present or only when the wild type allele is present (MSPCR or allele-specific PCR). For example, patient DNA and a control can be amplified separately using either a wild type primer or a primer specific for the variant allele. Each set of reactions is then examined for the presence of amplification products using standard methods to visualize the DNA. For example, the reactions can be electrophoresed through an agarose gel and the DNA visualized by staining with ethidium bromide or other DNA intercalating dye. In DNA samples from heterozygous patients, reaction products would be detected in each reaction.

Real-time quantitative PCR can also be used to determine copy number. Quantitative PCR permits both detection and quantification of specific DNA sequence in a sample as an absolute number of copies or as a relative amount when normalized to DNA input or other normalizing genes. A key feature of quantitative PCR is that the amplified DNA product is quantified in real-time as it accumulates in the reaction after each amplification cycle. Methods of quantification can include the use of fluorescent dyes that intercalate with double-stranded DNA, and modified DNA oligonucleotide probes that fluoresce when hybridized with a complementary DNA. Methods of quantification can include determining the intensity of fluorescence for fluorescently tagged molecular probes attached to a solid surface such as a microarray.

The first report of extensive copy number variation (CNV) in the human genome used intensity analysis of microarray data to document numerous examples of genes that vary in copy number (Redon et al., Nature 444(7118):444-54 (2006)). Subsequent studies have shown that certain copy number variants are associated with complex genetic diseases such as SZ (Walsh et al., Science 320(5875):539-43 (2008); and Stone et al., Nature 455(7210):237-41 (2008)).

In some embodiments, a peptide nucleic acid (PNA) probe can be used instead of a nucleic acid probe in the hybridization methods described above. PNA is a DNA mimetic with a peptide-like, inorganic backbone, e.g., N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, e.g., Nielsen et al., Bioconjugate Chemistry, The American Chemical Society, 5:1 (1994)). The PNA probe can be designed to specifically hybridize to a nucleic acid comprising a polymorphic variant.

In some cases, allele-specific oligonucleotides can also be used to detect the presence of a polymorphic variant. For example, polymorphic variants can be detected by performing allele-specific hybridization or allele-specific restriction digests. Allele specific hybridization is an example of a method that can be used to detect sequence variants, including complete genotypes of a subject (e.g., a mammal such as a human). See Stoneking et al., Am. J. Hum. Genet. 48:370-382 (1991); and Prince et al., Genome Res. 11:152-162 (2001). An “allele-specific oligonucleotide” (also referred to herein as an “allele-specific oligonucleotide probe”) is an oligonucleotide that is specific for particular a polymorphism can be prepared using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra). Allele-specific oligonucleotide probes typically can be approximately 10-50 base pairs, preferably approximately 15-30 base pairs, that specifically hybridizes to a nucleic acid region that contains a polymorphism. Hybridization conditions are selected such that a nucleic acid probe can specifically bind to the sequence of interest, e.g., the variant nucleic acid sequence. Such hybridizations typically are performed under high stringency as some sequence variants include only a single nucleotide difference. In some cases, dot-blot hybridization of amplified oligonucleotides with allele-specific oligonucleotide (ASO) probes can be performed. See, for example, Saiki et al., Nature (London) 324:163-166 (1986).

In some embodiments, allele-specific restriction digest analysis can be used to detect the existence of a polymorphic variant of a polymorphism, if alternate polymorphic variants of the polymorphism result in the creation or elimination of a restriction site. Allele-specific restriction digests can be performed in the following manner. A sample containing genomic DNA is obtained from the individual and genomic DNA is isolated for analysis. For nucleotide sequence variants that introduce a restriction site, restriction digest with the particular restriction enzyme can differentiate the alleles. In some cases, polymerase chain reaction (PCR) can be used to amplify a region comprising the polymorphic site, and restriction fragment length polymorphism analysis is conducted (see Ausubel et al., Current Protocols in Molecular Biology, supra). The digestion pattern of the relevant DNA fragment indicates the presence or absence of a particular polymorphic variant of the polymorphism and is therefore indicative of the subject's response allele. For sequence variants that do not alter a common restriction site, mutagenic primers can be designed that introduce a restriction site when the variant allele is present or when the wild type allele is present. For example, a portion of a nucleic acid can be amplified using the mutagenic primer and a wild type primer, followed by digest with the appropriate restriction endonuclease.

In some embodiments, fluorescence polarization template-directed dye-terminator incorporation (FP-TDI) is used to determine which of multiple polymorphic variants of a polymorphism is present in a subject (Chen et al., Genome Research 9(5):492-498 (1999)). Rather than involving use of allele-specific probes or primers, this method employs primers that terminate adjacent to a polymorphic site, so that extension of the primer by a single nucleotide results in incorporation of a nucleotide complementary to the polymorphic variant at the polymorphic site.

In some cases, DNA containing an amplified portion may be dot-blotted, using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra), and the blot contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the DNA is then detected. Specific hybridization of an allele-specific oligonucleotide probe (specific for a polymorphic variant indicative of a predicted response to a method of treating an SSD) to DNA from the subject is indicative of a subject's response allele.

The methods can include determining the genotype of a subject with respect to both copies of the polymorphic site present in the genome (i.e., both alleles). For example, the complete genotype may be characterized as −/−, as −/+, or as +/+, where a minus sign indicates the presence of the reference or wild type sequence at the polymorphic site, and the plus sign indicates the presence of a polymorphic variant other than the reference sequence. If multiple polymorphic variants exist at a site, this can be appropriately indicated by specifying which ones are present in the subject. Any of the detection means described herein can be used to determine the genotype of a subject with respect to one or both copies of the polymorphism present in the subject's genome.

Methods of nucleic acid analysis to detect polymorphisms and/or polymorphic variants can include, e.g., microarray analysis. Hybridization methods, such as Southern analysis, Northern analysis, or in situ hybridizations, can also be used (see Ausubel et al., Current Protocols in Molecular Biology, eds., John Wiley & Sons (2003)). To detect microdeletions, fluorescence in situ hybridization (FISH) using DNA probes that are directed to a putatively deleted region in a chromosome can be used. For example, probes that detect all or a part of a microsatellite marker can be used to detect microdeletions in the region that contains that marker.

In some embodiments, it is desirable to employ methods that can detect the presence of multiple polymorphisms (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously. Oligonucleotide arrays represent one suitable means for doing so. Other methods, including methods in which reactions (e.g., amplification, hybridization) are performed in individual vessels, e.g., within individual wells of a multi-well plate or other vessel may also be performed so as to detect the presence of multiple polymorphic variants (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously according to the methods provided herein.

Nucleic acid probes can be used to detect and/or quantify the presence of a particular target nucleic acid sequence within a sample of nucleic acid sequences, e.g., as hybridization probes, or to amplify a particular target sequence within a sample, e.g., as a primer. Probes have a complimentary nucleic acid sequence that selectively hybridizes to the target nucleic acid sequence. In order for a probe to hybridize to a target sequence, the hybridization probe must have sufficient identity with the target sequence, i.e., at least 70% (e.g., 80%, 90%, 95%, 98% or more) identity to the target sequence. The probe sequence must also be sufficiently long so that the probe exhibits selectivity for the target sequence over non-target sequences. For example, the probe will be at least 20 (e.g., 25, 30, 35, 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 or more) nucleotides in length. In some embodiments, the probes are not more than 30, 50, 100, 200, 300, 500, 750, or 1000 nucleotides in length. Probes are typically about 20 to about 1×10⁶ nucleotides in length. Probes include primers, which generally refers to a single-stranded oligonucleotide probe that can act as a point of initiation of template-directed DNA synthesis using methods such as PCR (polymerase chain reaction), LCR (ligase chain reaction), etc., for amplification of a target sequence.

The probe can be a test probe such as a probe that can be used to detect polymorphisms in a region described herein (e.g., an allele associated with treatment response as described herein). In some embodiments, the probe can bind to another marker sequence associated with SZ, SPD, or SD as described herein or known in the art.

Control probes can also be used. For example, a probe that binds a less variable sequence, e.g., repetitive DNA associated with a centromere of a chromosome, can be used as a control. Probes that hybridize with various centromeric DNA and locus-specific DNA are available commercially, for example, from Vysis, Inc. (Downers Grove, Ill.), Molecular Probes, Inc. (Eugene, Oreg.), or from Cytocell (Oxfordshire, UK). Probe sets are available commercially such from Applied Biosystems, e.g., the Assays-on-Demand SNP kits Alternatively, probes can be synthesized, e.g., chemically or in vitro, or made from chromosomal or genomic DNA through standard techniques. For example, sources of DNA that can be used include genomic DNA, cloned DNA sequences, somatic cell hybrids that contain one, or a part of one, human chromosome along with the normal chromosome complement of the host, and chromosomes purified by flow cytometry or microdissection. The region of interest can be isolated through cloning, or by site-specific amplification via the polymerase chain reaction (PCR). See, for example, Nath and Johnson, Biotechnic. Histochem. 73(1):6-22 (1998); Wheeless et al., Cytometry 17:319-326 (1994); and U.S. Pat. No. 5,491,224.

In some embodiments, the probes are labeled, e.g., by direct labeling, with a fluorophore, an organic molecule that fluoresces after absorbing light of lower wavelength/higher energy. A directly labeled fluorophore allows the probe to be visualized without a secondary detection molecule. After covalently attaching a fluorophore to a nucleotide, the nucleotide can be directly incorporated into the probe with standard techniques such as nick translation, random priming, and PCR labeling. Alternatively, deoxycytidine nucleotides within the probe can be transaminated with a linker. The fluorophore then is covalently attached to the transaminated deoxycytidine nucleotides. See, e.g., U.S. Pat. No. 5,491,224.

Fluorophores of different colors can be chosen such that each probe in a set can be distinctly visualized. For example, a combination of the following fluorophores can be used: 7-amino-4-methylcoumarin-3-acetic acid (AMCA), TEXAS RED™ (Molecular Probes, Inc., Eugene, Oreg.), 5-(and -6)-carboxy-X-rhodamine, lissamine rhodamine B, 5-(and -6)-carboxyfluorescein, fluorescein-5-isothiocyanate (FITC), 7-diethylaminocoumarin-3-carboxylic acid, tetramethylrhodamine-5-(and -6)-isothiocyanate, 5-(and -6)-carboxytetramethylrhodamine, 7-hydroxycoumarin-3-carboxylic acid, 6-[fluorescein 5-(and -6)-carboxamido]hexanoic acid, N-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a diaza-3-indacenepropionic acid, eosin-5-isothiocyanate, erythrosin-5-isothiocyanate, and CASCADE™ blue acetylazide (Molecular Probes, Inc., Eugene, Oreg.). Fluorescently labeled probes can be viewed with a fluorescence microscope and an appropriate filter for each fluorophore, or by using dual or triple band-pass filter sets to observe multiple fluorophores. See, for example, U.S. Pat. No. 5,776,688. Alternatively, techniques such as flow cytometry can be used to examine the hybridization pattern of the probes. Fluorescence-based arrays are also known in the art.

In other embodiments, the probes can be indirectly labeled with, e.g., biotin or digoxygenin, or labeled with radioactive isotopes such as ³²P and ³H. For example, a probe indirectly labeled with biotin can be detected by avidin conjugated to a detectable marker. For example, avidin can be conjugated to an enzymatic marker such as alkaline phosphatase or horseradish peroxidase. Enzymatic markers can be detected in standard colorimetric reactions using a substrate and/or a catalyst for the enzyme. Catalysts for alkaline phosphatase include 5-bromo-4-chloro-3-indolylphosphate and nitro blue tetrazolium. Diaminobenzoate can be used as a catalyst for horseradish peroxidase.

In another aspect, this document features arrays that include a substrate having a plurality of addressable areas, and methods of using them. At least one area of the plurality includes a nucleic acid probe that binds specifically to a sequence comprising a polymorphism listed in Table A, and can be used to detect the absence or presence of said polymorphism, e.g., one or more SNPs, microsatellites, minisatellites, or indels, as described herein, to determine a response allele. For example, the array can include one or more nucleic acid probes that can be used to detect a polymorphism listed in Table A. In some embodiments, the array further includes at least one area that includes a nucleic acid probe that can be used to specifically detect another marker associated with a predicted response to a method of treating an SSD (e.g., SZ), as described herein. In some embodiments, the probes are nucleic acid capture probes.

Generally, microarray hybridization is performed by hybridizing a nucleic acid of interest (e.g., a nucleic acid encompassing a polymorphic site) with the array and detecting hybridization using nucleic acid probes. In some cases, the nucleic acid of interest is amplified prior to hybridization. Hybridization and detecting are generally carried out according to standard methods. See, e.g., Published PCT Application Nos. WO 92/10092 and WO 95/11995, and U.S. Pat. No. 5,424,186. For example, the array can be scanned to determine the position on the array to which the nucleic acid hybridizes. The hybridization data obtained from the scan is typically in the form of fluorescence intensities as a function of location on the array.

Arrays can be formed on substrates fabricated with materials such as paper, glass, plastic (e.g., polypropylene, nylon, or polystyrene), polyacrylamide, nitrocellulose, silicon, optical fiber, or any other suitable solid or semisolid support, and can be configured in a planar (e.g., glass plates, silicon chips) or three dimensional (e.g., pins, fibers, beads, particles, microtiter wells, capillaries) configuration. Methods for generating arrays are known in the art and include, e.g., photolithographic methods (see, e.g., U.S. Pat. Nos. 5,143,854; 5,510,270; and 5,527,681), mechanical methods (e.g., directed-flow methods as described in U.S. Pat. No. 5,384,261), pin-based methods (e.g., as described in U.S. Pat. No. 5,288,514), and bead-based techniques (e.g., as described in PCT US/93/04145). The array typically includes oligonucleotide hybridization probes capable of specifically hybridizing to different polymorphic variants. Oligonucleotide probes that exhibit differential or selective binding to polymorphic sites may readily be designed by one of ordinary skill in the art. For example, an oligonucleotide that is perfectly complementary to a sequence that encompasses a polymorphic site (i.e., a sequence that includes the polymorphic site, within it or at one end) will generally hybridize preferentially to a nucleic acid comprising that sequence, as opposed to a nucleic acid comprising an alternate polymorphic variant.

Oligonucleotide probes forming an array may be attached to a substrate by any number of techniques, including, without limitation, (i) in situ synthesis (e.g., high-density oligonucleotide arrays) using photolithographic techniques; (ii) spotting/printing at medium to low density on glass, nylon or nitrocellulose; (iii) by masking, and (iv) by dot-blotting on a nylon or nitrocellulose hybridization membrane. Oligonucleotides can be immobilized via a linker, including by covalent, ionic, or physical linkage. Linkers for immobilizing nucleic acids and polypeptides, including reversible or cleavable linkers, are known in the art. See, for example, U.S. Pat. No. 5,451,683 and WO98/20019. Alternatively, oligonucleotides can be non-covalently immobilized on a substrate by hybridization to anchors, by means of magnetic beads, or in a fluid phase such as in microtiter wells or capillaries. Immobilized oligonucleotide probes are typically about 20 nucleotides in length, but can vary from about 10 nucleotides to about 1000 nucleotides in length.

Arrays can include multiple detection blocks (i.e., multiple groups of probes designed for detection of particular polymorphisms). Such arrays can be used to analyze multiple different polymorphisms. Detection blocks may be grouped within a single array or in multiple, separate arrays so that varying conditions (e.g., conditions optimized for particular polymorphisms) may be used during the hybridization. For example, it may be desirable to provide for the detection of those polymorphisms that fall within G-C rich stretches of a genomic sequence, separately from those falling in A-T rich segments. General descriptions of using oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. Nos. 5,858,659 and 5,837,832. In addition to oligonucleotide arrays, cDNA arrays may be used similarly in certain embodiments.

The methods described herein can include providing an array as described herein; contacting the array with a sample (e.g., all or a portion of genomic DNA that includes at least a portion of a human chromosome comprising a response allele) and/or optionally, a different portion of genomic DNA (e.g., a portion that includes a different portion of one or more human chromosomes), and detecting binding of a nucleic acid from the sample to the array. Optionally, the method includes amplifying nucleic acid from the sample, e.g., genomic DNA that includes a portion of a human chromosome described herein, and, optionally, a region that includes another region associated with a predicted response to a method of treating SZ, SD, or SPD, prior to or during contact with the array.

In some aspects, the methods described herein can include using an array that can ascertain differential expression patterns or copy numbers of one or more genes in samples from normal and affected individuals (see, e.g., Redon et al., Nature 444(7118):444-54 (2006)). For example, arrays of probes to a marker described herein can be used to measure polymorphisms between DNA from a subject having an SSD (e.g., SZ) and having a predicted response to a treatment for an SSD (e.g., SZ), and control DNA, e.g., DNA obtained from an individual that has SZ, SPD, or SD, and has a known response to a form of treatment for an SSD (e.g., SZ). Since the clones on the array contain sequence tags, their positions on the array are accurately known relative to the genomic sequence. Different hybridization patterns between DNA from an individual afflicted with an SSD (e.g., SZ) and DNA from a control individual at areas in the array corresponding to markers as described herein, and, optionally, one or more other regions associated with an SSD (e.g., SZ), are indicative of a predicted response to a treatment for an SSD (e.g., SZ). Methods for array production, hybridization, and analysis are described, e.g., in Snijders et al., Nat. Genetics 29:263-264 (2001); Klein et al., Proc. Natl. Acad. Sci. USA 96:4494-4499 (1999); Albertson et al., Breast Cancer Research and Treatment 78:289-298 (2003); and Snijders et al., “BAC microarray based comparative genomic hybridization,” in: Zhao et al. (eds), Bacterial Artificial Chromosomes: Methods and Protocols, Methods in Molecular Biology, Humana Press, 2002.

In another aspect, this document provides methods of determining the absence or presence of a response allele associated with a predicted response to treatment for an SSD (e.g., SZ) as described herein, using an array described above. The methods can include providing a two dimensional array having a plurality of addresses, each address of the plurality being positionally distinguishable from each other address of the plurality having a unique nucleic acid capture probe, contacting the array with a first sample from a test subject who is has an SSD (e.g., SZ), and comparing the binding of the first sample with one or more references, e.g., binding of a sample from a subject who is known to have an SSD (e.g., SZ), and/or binding of a sample from a subject who has an SSD (e.g., SZ) and a known response to treatment for an SSD (e.g., SZ); and comparing the binding of the first sample with the binding of the second sample. In some embodiments, the methods can include contacting the array with a third sample from a cell or subject that does not have SZ; and comparing the binding of the first sample with the binding of the third sample. In some embodiments, the second and third samples are from first or second-degree relatives of the test subject. In the case of a nucleic acid hybridization, binding with a capture probe at an address of the plurality, can be detected by any method known in the art, e.g., by detection of a signal generated from a label attached to the nucleic acid.

Schizophrenia Spectrum Disorders

The methods described herein can be used to determine an individual predicted response to a method of treating a schizophrenia spectrum disorder (SSD). The SSDs include schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). Methods for diagnosing SSDs are known in the art, see, e.g., the DSM-IV. See, e.g., WO 2009/092032, incorporated herein by reference.

Methods of Selecting and Optimizing Treatment

In some embodiments, the methods described herein include the administration of one or more treatments, e.g., antipsychotic medications, to a person identified as having or being at risk of developing an SSD (e.g., SZ). The methods can also include selecting a treatment regimen for a subject who has an SSD or is determined to be at risk for developing an SSD (e.g., SZ), based upon the absence or presence of an allele or genotype associated with response as described herein. The determination of a treatment regimen can also be based upon the absence or presence of other risk factors, e.g., as known in the art or described herein. The methods can also include administering a treatment regimen selected by a method described to a subject who has or is at risk for developing an SSD (e.g., SZ) to thereby treat, reduce risk of developing, or delay further progression of the disease. A treatment regimen can include the administration of antipsychotic medications to a subject identified as having or at risk of developing an SSD (e.g., SZ) before the onset of any psychotic episodes.

As used herein, the term “treat” or “treatment” is defined as the application or administration of a treatment regimen, e.g., a therapeutic agent or modality, to a subject, e.g., a patient. The subject can be a patient having an SSD (e.g., SZ), a symptom of an SSD (e.g., SZ), or at risk of developing (i.e., a predisposition toward) an SSD (e.g., SZ). The treatment can be to cure, heal, alleviate, relieve, alter, remedy, ameliorate, palliate, improve or affect an SSD (e.g., SZ), the symptoms of an SSD (e.g., SZ) or the predisposition toward an SSD (e.g., SZ). For example, a standard treatment regimen for schizophrenia is the administration of antipsychotic medications, which are typically antagonists acting at postsynaptic D2 dopamine receptors in the brain and can include neuroleptics and/or atypical antipsychotics. Antipsychotic medications substantially reduce the risk of relapse in the stable phase of illness. Currently accepted treatments for SZ are described in greater detail in the Practice Guideline for the Treatment of Patients With Schizophrenia American Psychiatric Association, Second Edition, American Psychiatric Association, 2004, which is incorporated herein by reference in its entirety.

The methods of determining a treatment regimen and methods of treatment or prevention of SSDs as described herein can further include the step of monitoring the subject, e.g., for a change (e.g., an increase or decrease) in one or more of the diagnostic criteria for an SSD listed herein, or any other parameter related to clinical outcome. The subject can be monitored in one or more of the following periods: prior to beginning of treatment; during the treatment; or after one or more elements of the treatment have been administered. Monitoring can be used to evaluate the need for further treatment with the same or a different therapeutic agent or modality. Generally, a decrease in one or more of the parameters described above is indicative of the improved condition of the subject, although with red blood cell and platelet levels, an increase can be associated with the improved condition of the subject.

The methods can be used, for example, to choose between alternative treatments (e.g., a particular dosage, mode of delivery, time of delivery, inclusion of adjunctive therapy, e.g., administration in combination with a second agent) based on the subject's probable drug response. In some embodiments, a treatment for a subject having an SSD (e.g., SZ) is selected based on the subject's response allele, and the treatment is administered to the subject. In some embodiments, various treatments or combinations of treatments can be administered based on the presence in a subject of a response allele as described herein. Various treatment regimens are known for treating SSDs including, for example, regimens as described herein.

With regards to both prophylactic and therapeutic methods of treatment of SSDs, according to the present methods treatment can be specifically tailored or modified, based on knowledge obtained from pharmacogenomics. “Pharmacogenomics,” as used herein, refers to the application of genomics technologies such as structural chromosomal analysis, to drugs in clinical development and on the market. See, for example, Eichelbaum et al., Clin. Exp. Pharmacol. Physiol. 23:983-985 (1996); Linder et al., Clin. Chem. 43:254-266 (1997); Wang et al. (2003) Pharmacogenetics 13:555-64; Weinshilboum and Wang (2004) Nature Rev. Drug Discovery 3:739-748; Guttmacher and Collins (2005) JAMA 294:1399-402; and Weinshilboum and Wang, Annu. Rev. Genomics Hum. Genet. 7:223-45 (2006). Specifically, as used herein, the term refers the study of how a patient's genes determine his or her response to a drug (e.g., a patient's “drug response phenotype,” or “drug response allele”). Drug response phenotypes that are influenced by inheritance and can vary from potentially life-threatening adverse reactions at one of the spectrum to lack of therapeutic efficacy at the other. The ability to determine whether and how a subject will respond to a particular drug can assist medical professionals in determining whether the drug should be administered to the subject, and at what dose. Thus, this documents provides methods for tailoring an individual's prophylactic or therapeutic treatment according to the presence of specific drug response alleles in that individual.

Standard pharmacologic therapies for SSDs include the administration of one or more antipsychotic medications, which are typically antagonists acting at postsynaptic D2 dopamine receptors in the brain. Antipsychotic medications include conventional, or first generation, antipsychotic agents, which are sometimes referred to as neuroleptics because of their neurologic side effects, and second generation antipsychotic agents, which are less likely to exhibit neuroleptic effects and have been termed atypical antipsychotics. Typical antipsychotics can include chlorpromazine, fluphenazine, haloperidol, thiothixene, trifluoperazine, perphenazine, and thioridazine; atypical antipsychotics can include aripiprazole, risperidone, clozapine, olanzapine, quetiapine, or ziprasidone.

Information generated from pharmacogenomic research using a method described herein can be used to determine appropriate dosage and treatment regimens for prophylactic or therapeutic treatment of an individual. This knowledge, when applied to dosing or drug selection, can avoid adverse reactions or therapeutic failure and thus enhance therapeutic or prophylactic efficiency when administering a therapeutic composition (e.g., a cytotoxic agent or combination of cytotoxic agents) to a patient as a means of treating or preventing progression of SSDs.

In some cases, a physician or clinician may consider applying knowledge obtained in relevant pharmacogenomics studies (e.g., using a method described herein) when determining whether to administer a pharmaceutical composition such as an antipsychotic agent or a combination of antipsychotic agents to a subject. In other cases, a physician or clinician may consider applying such knowledge when determining the dosage or frequency of treatments (e.g., administration of antipsychotic agent or combination of antipsychotic agents to a patient). As one example, a physician or clinician can determine (or have determined by, for example, a laboratory) the presence of one or more response alleles in a subject as described herein, and optionally one or more other markers associated with an SSD (e.g., SZ) or response to a treatment, of one or a group of subjects, e.g., clinical patients, or subjects who may be participating in a clinical trial, e.g., a trial designed to test the efficacy of a pharmaceutical composition (e.g., an antipsychotic or combination of antipsychotic agents); the physician or clinician can then correlate the genetic makeup of the subjects with their response to the pharmaceutical composition.

As another example, information regarding a response allele as described herein can be used to stratify or select a subject population for a clinical trial. The information can, in some embodiments, be used to stratify individuals that exhibit or are likely to exhibit a toxic response to a treatment from those that will not. In other cases, the information can be used to separate those that will be non-responders from those who will be responders. The allele s described herein can be used in pharmacogenomics-based design and manage the conduct of a clinical trial, e.g., as described in U.S. Pat. Pub. No. 2003/0108938.

As another example, information regarding a response allele as described herein, can be used to stratify or select human cells or cell lines for drug testing purposes. Human cells are useful for studying the effect of a polymorphism on physiological function, and for identifying and/or evaluating potential therapeutic agents for the treatment of SSDs, e.g., anti-psychotics. Thus the methods can include performing the present methods on genetic material from a cell line. The information can, in some embodiments, be used to separate cells that respond or are expected to respond to particular drugs from those that do not respond, e.g. which cells show altered second messenger signaling.

Also included herein are compositions and methods for the identification and treatment of subjects who have a predicted response to a treatment for an SSD (e.g., SZ), such that a theranostic approach can be taken to test such individuals to predict the effectiveness of a particular therapeutic intervention (e.g., a pharmaceutical or non-pharmaceutical intervention as described herein) and to alter the intervention to (1) reduce the risk of developing adverse outcomes and (2) enhance the effectiveness of the intervention. Thus, the methods and compositions described herein also provide a means of optimizing the treatment of a subject having such a disorder. Provided herein is a theranostic approach to treating and preventing SSDs, by integrating diagnostics and therapeutics to improve the real-time treatment of a subject. Practically, this means creating tests that can identify which patients are most suited to a particular therapy, and providing feedback on how well a drug is working to optimize treatment regimens.

Within the clinical trial setting, a theranostic method as described herein can provide key information to optimize trial design, monitor efficacy, and enhance drug safety. For instance, “trial design” theranostics can be used for patient stratification, determination of patient eligibility (inclusion/exclusion), creation of homogeneous treatment groups, and selection of patient samples that are representative of the general population. Such theranostic tests can therefore provide the means for patient efficacy enrichment, thereby minimizing the number of individuals needed for trial recruitment. “Efficacy” theranostics are useful for monitoring therapy and assessing efficacy criteria. Finally, “safety” theranostics can be used to prevent adverse drug reactions or avoid medication error.

The methods described herein can include retrospective analysis of clinical trial data as well, both at the subject level and for the entire trial, to detect correlations between an allele as described herein and any measurable or quantifiable parameter relating to the outcome of the treatment, e.g., efficacy (the results of which may be binary (i.e., yes and no) as well as along a continuum), side-effect profile (e.g., weight gain, metabolic dysfunction, lipid dysfunction, movement disorders, or extrapyramidal symptoms), treatment maintenance and discontinuation rates, return to work status, hospitalizations, suicidality, total healthcare cost, social functioning scales, response to non-pharmacological treatments, and/or dose response curves. The results of these correlations can then be used to influence decision-making, e.g., regarding treatment or therapeutic strategies, provision of services, and/or payment. For example, a correlation between a positive outcome parameter (e.g., high efficacy, low side effect profile, high treatment maintenance/low discontinuation rates, good return to work status, low hospitalizations, low suicidality, low total healthcare cost, high social function scale, favorable response to non-pharmacological treatments, and/or acceptable dose response curves) and a selected allele or genotype can influence treatment such that the treatment is recommended or selected for a subject having the selected allele or genotype.

This document also provides methods and materials to assist medical or research professionals in determining whether a particular treatment regimen is optimal. Medical professionals can be, for example, doctors, nurses, medical laboratory technologists, and pharmacists. Research professionals can be, for example, principle investigators, research technicians, postdoctoral trainees, and graduate students. A professional can be assisted by (1) determining whether specific polymorphic variants are present in a biological sample from a subject, and (2) communicating information about polymorphic variants to that professional.

Using information about specific polymorphic variants determined using a method described herein, a medical professional can take one or more actions that can affect patient care. For example, a medical professional can record information in the patient's medical record regarding the patient's likely response to a given treatment for an SSD (e.g., SZ). In some cases, a medical professional can record information regarding a treatment assessment, or otherwise transform the patient's medical record, to reflect the patient's current treatment and response allele(s). In some cases, a medical professional can review and evaluate a patient's entire medical record and assess multiple treatment strategies for clinical intervention of a patient's condition.

A medical professional can initiate or modify treatment after receiving information regarding a patient's response allele(s), for example. In some cases, a medical professional can recommend a change in therapy based on the subject's response allele(s). In some cases, a medical professional can enroll a patient in a clinical trial for, by way of example, detecting correlations between an allele or genotype as described herein and any measurable or quantifiable parameter relating to the outcome of the treatment as described above.

A medical professional can communicate information regarding a patient's expected response to a treatment to a patient or a patient's family. In some cases, a medical professional can provide a patient and/or a patient's family with information regarding SSDs and response assessment information, including treatment options, prognosis, and referrals to specialists. In some cases, a medical professional can provide a copy of a patient's medical records to a specialist.

A research professional can apply information regarding a subject's response allele(s) to advance scientific research. For example, a researcher can compile data on specific polymorphic variants. In some cases, a research professional can obtain a subject's response allele(s) as described herein to evaluate a subject's enrollment, or continued participation, in a research study or clinical trial. In some cases, a research professional can communicate information regarding a subject's response allele(s) to a medical professional. In some cases, a research professional can refer a subject to a medical professional.

Any appropriate method can be used to communicate information to another person (e.g., a professional). For example, information can be given directly or indirectly to a professional. For example, a laboratory technician can input a patient's polymorphic variant alleles as described herein into a computer-based record. In some cases, information is communicated by making a physical alteration to medical or research records. For example, a medical professional can make a permanent notation or flag a medical record for communicating the response allele determination to other medical professionals reviewing the record. In addition, any type of communication can be used to communicate allelic, genotypic, and/or treatment information. For example, mail, e-mail, telephone, and face-to-face interactions can be used. The information also can be communicated to a professional by making that information electronically available to the professional. For example, the information can be communicated to a professional by placing the information on a computer database such that the professional can access the information. In addition, the information can be communicated to a hospital, clinic, or research facility serving as an agent for the professional.

Articles of Manufacture

Also provided herein are articles of manufacture comprising a probe that hybridizes with a region of human chromosome as described herein and can be used to detect a polymorphism described herein. For example, any of the probes for detecting polymorphisms described herein can be combined with packaging material to generate articles of manufacture or kits. The kit can include one or more other elements including: instructions for use; and other reagents such as a label or an agent useful for attaching a label to the probe. Instructions for use can include instructions for diagnostic applications of the probe for predicting response to a treatment for SSDs in a method described herein. Other instructions can include instructions for attaching a label to the probe, instructions for performing in situ analysis with the probe, and/or instructions for obtaining a sample to be analyzed from a subject. In some cases, the kit can include a labeled probe that hybridizes to a region of human chromosome as described herein.

The kit can also include one or more additional reference or control probes that hybridize to the same chromosome or another chromosome or portion thereof that can have an abnormality associated with a particular response. A kit that includes additional probes can further include labels, e.g., one or more of the same or different labels for the probes. In other embodiments, the additional probe or probes provided with the kit can be a labeled probe or probes. When the kit further includes one or more additional probe or probes, the kit can further provide instructions for the use of the additional probe or probes. Kits for use in self-testing can also be provided. Such test kits can include devices and instructions that a subject can use to obtain a biological sample (e.g., buccal cells, blood) without the aid of a health care provider. For example, buccal cells can be obtained using a buccal swab or brush, or using mouthwash.

Kits as provided herein can also include a mailer (e.g., a postage paid envelope or mailing pack) that can be used to return the sample for analysis, e.g., to a laboratory. The kit can include one or more containers for the sample, or the sample can be in a standard blood collection vial. The kit can also include one or more of an informed consent form, a test requisition form, and instructions on how to use the kit in a method described herein. Methods for using such kits are also included herein. One or more of the forms (e.g., the test requisition form) and the container holding the sample can be coded, for example, with a bar code for identifying the subject who provided the sample.

Databases and Reports

Also provided herein are databases that include a list of polymorphisms as described herein, and wherein the list is largely or entirely limited to polymorphisms identified as useful for predicting a subject's response to a treatment for an SSD (e.g., SZ) as described herein. The list is stored, e.g., on a flat file or computer-readable medium. The databases can further include information regarding one or more subjects, e.g., whether a subject is affected or unaffected, clinical information such as endophenotype, age of onset of symptoms, any treatments administered and outcomes (e.g., data relevant to pharmacogenomics, diagnostics or theranostics), and other details, e.g., about the disorder in the subject, or environmental or other genetic factors. The databases can be used to detect correlations between a particular allele or genotype and the information regarding the subject.

The methods described herein can also include the generation of reports, e.g., for use by a patient, care giver, payor, or researcher, that include information regarding a subject's response allele(s), and optionally further information such as treatments administered, treatment history, medical history, predicted response, and actual response. The reports can be recorded in a tangible medium, e.g., a computer-readable disk, a solid state memory device, or an optical storage device.

Engineered Cells

Also provided herein are engineered cells that harbor one or more polymorphisms described herein, e.g., one or more response alleles. Such cells are useful for studying the effect of a polymorphism on physiological function, and for identifying and/or evaluating potential therapeutic agents such as anti-psychotics for the treatment of an SSD (e.g., SZ).

As one example, included herein are cells in which one or more of the various alleles of the genes described herein has be re-created that is associated with a response to a specific treatment. Methods are known in the art for generating cells, e.g., by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell, e.g., a cell of an animal. In some cases, the cells can be used to generate transgenic animals using methods known in the art.

The cells are preferably mammalian cells (e.g., neuronal type cells) in which an endogenous gene has been altered to include a polymorphism as described herein. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, U.S. Pat. No. 5,272,071; WO 91/06667, published in May 16, 1991.

The invention is further described in the following examples, which do not limit the scope of the invention described in the claims.

EXAMPLES Example 1 Markers Associated with Drug Response

The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), a large federally funded clinical trial designed to assess the efficacy of antipsychotics in a real world setting, is a valuable resource for determining the role of genes in drug response (Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N. Engl. J. Med. 353:1209-1223 (2005)). As part of the CATIE trial, SNP genotyping was performed for roughly half of the trial participants (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)). When combined with disease status, PANSS scores, and clinical drug response data, the genotyping data allows the identification of genetic variants (e.g., SNPs) that are statistically associated with specific responses to selected treatments.

The design of the CATIE study has been described in detail by others (see, e.g., Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N Engl. J. Med. 353:1209-1223 (2005)). Briefly, 1460 subjects were randomly assigned one of several antipsychotics and those who did not respond or chose to quit their current medication were re-randomized to another drug. Details regarding SNP genotyping and quality control have been recently published (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).

Genotype and phenotype data for the CATIE trial were made available to qualified researchers through the NIMH Center for Collaborative Genetic Studies on Mental Disorders. Data for 417 patients with schizophrenia and 419 unaffected controls self reported as having exclusively European ancestry were evaluated. This same patient population was described in a recent study by Sullivan and coworkers, which confirmed that there is no hidden stratification in the sample (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).

For the CATIE study, individual cases were diagnosed as having SZ based on DSM-III/IV criteria. All patients analyzed herein, either were taking the medication as their first antipsychotic medication or were randomly assigned at the start of the trial to a drug different from the one they were taking prior to enrollment in the CATIE Trial. This approach reflects a real world situation in which patients initiate therapy with a new drug, and eliminates the uncontrolled variable of time on the same drug prior to initiation of the study.

Treatment response for all patients was assessed using the Positive and Negative Syndrome Scale (PANSS) (Kay et al., Schizophr. Bull. 13:261-276 (1987); Kay et al., Br. J. Psychiatry Suppl 59-67 (1989); Leucht et al., Schizophr. Res. 79:231-238 (2005)). PANSS rating was performed at baseline (after a minimum 7 day drug free period) and at various time points throughout the study. The change in PANSS (delta PANSS) used here is the percent (%) change in PANSS is defined as [(PANSS_last observation−PANSS_baseline)/PANSS_basline]×100. To assess drug response, the last observation for each patient in treatment Phase 1 of the CATIE trial was used as a primary time point at which assessment of efficacy occurred.

An independent assessment of efficacy and tolerability is the time until discontinuation of drug treatment for all causes. This was the primary endpoint of the CATIE Trial (Lieberman et al., N Engl J Med 353(12):1209-23 (2005)). The longer the time to discontinuation for a given drug, the better the efficacy of the drug and its tolerability. The duration between a patient's first visit and last visit in Phase I of CATIE defined the time until discontinuation.

In addition to the quantitative time to discontinuation and delta PANSS, the CATIE consortium assigned dichotomous outcomes for patients who discontinued due to lack of efficacy due to adverse events.

Genetic analysis to document the influence of allelic variants on response to administration of olanzapine, risperidone, quetiapine, perphenazine, and ziprasidone, was performed using the PLINK 1.03 whole genome analysis toolset developed by Purcell and coworkers (Purcell et al., Am. J. Hum. Genet. 81:559-575 (2007)). For quantitative variables, PLINK calculates P values use a linear regression and an additive model for the minor allele. For dichotomous comparisons, PLINK calculates P values for the allele-specific chi-squared test and the odds ratio (OR; or relative risk) associated with the minor allele.

Confirmation of SNP Effects on DELTA PANSS for Various Drugs:

Tables 1-5 provide numerous examples of SNP-based alleles that predict altered response to olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. Tables 1-5 report the test allele, P values, and Beta weights (in % PANSS) from the linear regression for SNPs that affect DELTA PANSS for each of olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. A negative beta weight indicates that the allele is associated with a decrease in DELTA PANSS score, corresponding to greater improvement (or lowering) in symptom burden. A positive beta weight indicates that the allele is associated with an increase in DELTA PANSS score, corresponding to less improvement in symptom burden.

Confirmation of SNP Effects on Time to Discontinuation of Therapy:

Tables 6-10 provide numerous examples of SNP-based alleles that predict altered length of time until a discontinuation of various antipschotics (olanzapine, risperidone, quetiapine, perphenazine and ziprasidone). Tables 6-10 report the test allele, P values, and Beta weight from the linear regression for SNPs that affect Time to Discontinuation for each of olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. A negative beta weight indicates a quicker time to discontinuation and a positive beta weight indicates an increased time to discontinuation.

Confirmation of SNP Effects on Likelihood of Discontinuing Therapy Due to Lack of Efficacy:

Tables 11-15 provide numerous examples of SNP-based alleles that predict altered likelihood of discontinuing therapy due to lack of efficacy for olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. Tables 11-15 report the test allele, frequencies for discontinuers, P values, and ORs for SNPs that affect likelihood of discontinuing due to lack of efficacy for olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. For Tables 11-15, ORs of >1.0 indicate that the minor SNP allele reported in the table is associated with greater likelihood of discontinuing due to lack of efficacy, and ORs of <1.0 indicate that the minor SNP allele is associated with lesser likelihood of discontinuing due to lack of efficacy.

Confirmation of SNP Effects on Likelihood of Discontinuing Therapy Due to Serious Adverse Events:

Tables 16-20 provide numerous examples of SNP-based alleles that predict altered likelihood of discontinuing therapy due to serious adverse event for olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. Tables 16-20 report the test allele, frequencies for discontinuers, P values, and ORs for SNPs that affect likelihood of discontinuing due to serious adverse event for olanzapine, risperidone, quetiapine, perphenazine and ziprasidone. For Tables 16-20, ORs of >1.0 indicate that the minor SNP allele is associated with greater likelihood of discontinuing due to serious adverse event, and ORs of <1.0 indicate that the minor SNP allele is associated with lesser likelihood of discontinuing due to serious adverse event.

Other Embodiments

It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

TABLE 1 Alleles Influencing Response to Olanzapine Seq NCBI Beta Gene ID RS # Allele (PANSS) P AGBL4-C1ORF165 25 11205517 C 26.81 0.008637 AGBL4-C1ORF165 26 17373849 A 26.81 0.008637 LRP8 54 12035926 G 10.76 0.035950 PTGFRN 90 17036573 G 57.40 0.008632 PTGFRN 91 12078461 A 57.40 0.008632 SEC16B 129 869286 G 10.78 0.048400 USH2A 155 6665313 A −12.77 0.022990 USH2A 156 12403674 T −12.77 0.022990 ESRRG 181 2820879 A 15.61 0.027360 GNG4 193 508208 G −12.26 0.005302 GNG4 195 2774327 A −12.57 0.002177 FMN2 251 882869 G −10.90 0.037300 RGS7 252 1970533 C −14.29 0.007357 RGS7 254 4659581 G −16.79 0.002922 BRE 314 7558946 T 11.16 0.006172 BRE 315 6705961 T 11.05 0.008115 BRE 320 17006590 C 12.04 0.013590 HAAO 357 6738169 G 8.46 0.034550 PLEKHH2 358 12623703 G −11.12 0.049400 PLEKHH2 361 7570252 A −10.91 0.022780 PRKCE 378 1464572 T 11.40 0.031800 PRKCE 383 4953294 A −10.50 0.023400 PRKCE 384 4953297 A −10.42 0.024550 PRKCE 388 13024907 C −12.16 0.004725 EPAS1 391 17034950 A 9.49 0.035380 LRP1B 513 9283437 C −10.37 0.031560 LRP1B 516 10178963 A −9.13 0.036270 KYNU 528 351673 T −11.00 0.019100 KYNU 536 6732786 G 12.56 0.018150 KCNJ3 592 2971899 C 13.11 0.023670 PDE1A 642 16823124 A 19.39 0.001305 PDE1A 643 10497597 T 14.07 0.015900 PDE1A 648 9332425 T 16.21 0.002216 PDE1A 649 2082136 G −11.32 0.011860 PDE1A 650 2887208 C −10.20 0.018620 ERBB4 681 7563759 A −11.08 0.009072 ERBB4 682 4672666 G −8.45 0.031710 ERBB4 683 4672668 G −8.37 0.036590 ERBB4 684 4553767 G −17.12 0.000231 COL4A4 692 4423583 T 9.79 0.021630 COL4A4 695 10166736 A 9.65 0.022100 COL4A3 710 11681636 C −10.03 0.029610 ECEL1 729 12616972 C 9.24 0.025260 CNTN6 742 265799 G −10.12 0.009883 CNTN6 743 3821429 G −14.99 0.002884 CNTN4 760 1153486 T 12.01 0.003993 ITPR1 783 7432768 G −13.75 0.001128 CLASP2 817 6781846 G −9.20 0.041530 CLASP2 818 9311026 C −12.35 0.033540 FHIT 926 1470035 A −9.95 0.020820 CADPS 950 968808 T −11.00 0.014620 FOXP1 985 2597312 C 9.24 0.032610 CPNE4 1049 6792146 A 12.84 0.033130 PLD1 1109 2178532 A 27.10 0.000304 NLGN1 1111 10936764 G −10.27 0.045880 NLGN1 1116 12635897 C 12.61 0.010760 LRRC15 1149 4974536 T 11.58 0.017400 LDB2 1175 189988 T −15.99 0.025250 LDB2 1176 150260 G −15.99 0.025250 LDB2 1177 157613 G −15.99 0.025250 LDB2 1178 157611 A −13.58 0.044860 SLIT2 1188 10516357 A 10.25 0.040900 KIAA1239 1204 3910363 C 13.97 0.036390 LOC389207 1229 13142149 G 9.34 0.043370 LOC389207 1230 7656477 G −9.98 0.036830 SHROOM3 1260 9307184 G −10.00 0.032290 SCD5 1268 6852540 C 13.92 0.003715 PDLIM5 1295 2452600 T −8.37 0.042030 PDLIM5 1302 998071 C −9.77 0.025140 TSPAN5 1303 2037797 A 12.68 0.049990 COL25A1 1317 2305438 A 10.70 0.014390 COL25A1 1322 1405145 A 11.70 0.011360 COL25A1 1323 11729511 C 10.72 0.019110 COL25A1 1324 3844177 C 10.72 0.019110 COL25A1 1326 3851416 T 9.29 0.033010 COL25A1 1332 2526456 G −11.06 0.018890 COL25A1 1333 2704102 C −10.70 0.024410 COL25A1 1334 987695 G −12.86 0.005477 COL25A1 1335 7675657 A −13.36 0.003300 COL25A1 1336 4256292 G −17.74 0.000304 ANK2 1343 1989930 G −10.41 0.043040 CAMK2D 1366 7438925 G 10.60 0.022010 NDST3 1371 6534079 A 12.83 0.018010 NDST3 1375 4576085 G 18.13 0.005461 PRSS12 1378 4834679 T 27.32 0.007368 PRSS12 1379 1514657 A 27.32 0.007368 POU4F2 1425 7680105 G 17.52 0.013670 POU4F2 1429 1394279 G 15.00 0.043980 POU4F2 1430 1979903 C 22.91 0.045640 PALLD 1496 2710827 A −8.79 0.033930 PALLD 1498 4425335 G 16.65 0.000779 PALLD 1499 12511925 T 20.22 0.006582 PALLD 1501 1039385 G 11.26 0.014000 PALLD 1502 1039386 G −10.24 0.034310 DNAH5 1550 6554811 G 9.18 0.047670 CDH10 1576 983446 T 14.13 0.006220 SLC45A2 1578 10461928 G 11.86 0.048340 SLC1A3 1583 3776569 G −9.80 0.032610 EGFLAM 1594 10214135 C 10.91 0.036670 ITGA1 1601 11886 G 11.51 0.049160 ITGA1 1608 7731949 C 10.39 0.048900 ITGA1 1609 16880453 C 9.24 0.044500 ITGA1 1611 923837 T 9.03 0.046160 PDE4D 1624 12654005 G −9.77 0.034230 PDE4D 1626 2910642 C −9.77 0.034230 CMYA5 1653 259064 C 15.38 0.040600 GPR98 1689 1878878 A −8.54 0.041940 GPR98 1690 2222244 A −8.80 0.035060 SNCAIP 1751 17149141 A 15.51 0.011780 VDAC1 1770 6878448 A −9.79 0.034530 VDAC1 1771 13173424 T 10.59 0.012670 ODZ2 1787 2337017 C 18.93 0.000877 ODZ2 1789 1421989 G 18.93 0.000877 SLC22A23 1812 17136575 G −12.07 0.045960 ATXN1 1835 235147 A 11.75 0.004224 SLC17A4 1849 4712972 A −19.00 0.033590 SLC17A4 1851 1892253 T −19.00 0.033590 MSH5 1875 707937 G 12.11 0.040310 RIMS1 1901 482736 C 15.14 0.015910 RIMS1 1902 1010326 A 12.38 0.035570 RIMS1 1912 1339226 G −10.43 0.049680 STX11 1995 6935462 A 31.15 0.016300 TFB1M 2011 7775163 A 9.98 0.016750 PARK2 2017 2315321 T −8.99 0.036560 PARK2 2019 992037 T −18.66 0.000191 PARK2 2020 12055483 T −12.27 0.012430 PARK2 2021 6924602 C −11.78 0.016730 PARK2 2026 12528179 C −9.17 0.020990 PARK2 2028 11752805 A −9.16 0.025170 PARK2 2029 2155486 T −7.81 0.043870 PARK2 2030 9295173 G 8.65 0.041320 ETV1 2096 9639168 C −10.29 0.014260 STK31 2111 12532929 T −18.18 0.002355 STK31 2113 2390813 G −8.82 0.038370 CHN2 2127 245927 G −9.77 0.021040 SCRN1 2130 6976421 A 9.15 0.046930 PLEKHA8 2134 10275475 C 12.76 0.011990 SCRN1 2136 1465327 T 11.68 0.023910 VPS41 2173 2286105 A −17.06 0.004040 VPS41 2174 2074655 T −17.06 0.004040 VPS41 2175 17768153 A −17.06 0.004040 VPS41 2176 3801140 C −10.04 0.026070 VPS41 2178 4723793 G 10.82 0.028270 ABCA13 2205 10273407 C 19.32 0.002663 ABCA13 2213 10216298 G 16.64 0.015780 WBSCR17 2236 12666361 A 9.68 0.046600 HIP1 2256 17352471 A 18.55 0.000415 MAGI2 2268 3807797 T 14.32 0.015060 MAGI2 2269 3779305 A −9.96 0.041220 MAGI2 2279 848913 C −13.15 0.031560 MAGI2 2289 6971099 T −10.77 0.048300 MAGI2 2292 10280554 T 13.89 0.045990 MAGI2 2293 848934 C −15.70 0.008896 MAGI2 2300 10248584 G −13.24 0.030650 GNAI1 2302 2462131 G 9.84 0.047780 SEMA3E 2335 2713154 G −11.74 0.006444 SEMA3E 2339 2713174 C −14.11 0.000976 SEMA3E 2340 2249188 G 12.81 0.001285 SEMA3E 2341 10270844 T 10.15 0.019010 ABCB4 2350 31658 T 16.07 0.022220 ABCB4 2351 31662 A 15.43 0.022530 ADAM22 2357 2282949 C −15.09 0.000817 ADAM22 2358 6951172 T −9.25 0.034180 ADAM22 2359 9632709 C −9.25 0.034180 PON1 2366 662 G −13.91 0.004692 PPP1R9A 2370 4729174 A 10.06 0.031200 PPP1R9A 2371 7806304 C 8.99 0.049990 PPP1R9A 2375 12690919 T −9.58 0.030100 PPP1R9A 2376 854520 T −10.75 0.010670 PON1 2382 2057681 G −14.04 0.004888 PON1 2383 2299257 C −10.20 0.032230 EMID2 2402 6947185 C −11.40 0.017800 CUX1 2404 2960266 A 9.89 0.028890 KCND2 2414 7795646 G −13.25 0.037660 TBXAS1 2485 41723 G 10.56 0.041190 CNTNAP2 2499 826824 C −11.70 0.028820 CNTNAP2 2502 2022226 C −10.70 0.031970 CSMD1 2541 13272021 C −14.73 0.026830 CSMD1 2543 13260434 A −13.61 0.034730 CSMD1 2545 13254344 T 15.79 0.000870 CSMD1 2546 895696 T 15.79 0.000870 CSMD1 2547 895695 A 15.79 0.000870 CSMD1 2550 4493928 A 13.62 0.038940 MCPH1 2551 1530408 C −11.75 0.031210 MCPH1 2552 3020270 T −17.26 0.005508 MCPH1 2554 2083914 T −16.11 0.010990 MCPH1 2555 1054073 T −12.38 0.022760 MCPH1 2556 2034143 T −13.36 0.023840 MCPH1 2557 2922818 T −12.53 0.042330 MCPH1 2561 2442496 G −11.11 0.044010 ATP6V1B2 2616 13252207 A −12.69 0.017010 ATP6V1B2 2617 11204102 G −10.93 0.014960 GFRA2 2619 4506202 G 9.31 0.030150 UNC5D 2637 16884099 G −19.56 0.010900 UNC5D 2638 16884109 G −19.56 0.010900 UNC5D 2639 6989128 A −15.88 0.035710 SNTG1 2661 12545915 T 11.48 0.018550 NKAIN3 2707 16929516 T −13.15 0.031760 NKAIN3 2716 4739023 C −9.81 0.045840 NKAIN3 2723 10957263 C −18.48 0.012950 KCNB2 2736 349358 G 12.83 0.046360 KCNB2 2737 349355 T 12.83 0.046360 MMP16 2764 6994019 T 10.12 0.041750 NCALD 2782 7830291 C 10.43 0.042310 FER1L6 2840 9987271 T 14.30 0.003106 FER1L6 2845 2069078 C −13.52 0.030900 MTSS1 2854 4870913 T −13.67 0.049320 DDEF1 2859 7003309 C −10.13 0.014770 ADCY8 2889 17248206 G −9.75 0.034640 SMARCA2 2928 7872216 T −11.12 0.045320 PTPRD 2939 3858060 T −14.90 0.001771 PTPRD 2940 3843579 C −14.90 0.001771 KIAA1797 2960 7848159 G 18.05 0.019460 KIAA1797 2961 7021708 G −11.87 0.007420 KIAA1797 2962 2151002 A 14.39 0.002859 KIAA1797 2963 10511687 G −10.33 0.032580 KIAA1797 2967 6475483 T 18.99 0.000501 KIAA1797 2968 10738569 A 18.08 0.001234 KIAA1797 2969 7049134 G 18.24 0.001512 KIAA1797 2970 2383162 G 16.26 0.000090 KIAA1797 2971 4246849 A 19.56 0.000004 KIAA1797 2972 4977823 T 19.25 0.000004 KIAA1797 2973 6475490 G −9.06 0.032340 KIAA1797 2975 4579612 C −9.49 0.036220 KIAA1797 2976 4977848 A 17.87 0.000012 KIAA1797 2977 7025851 G −8.64 0.041590 KIAA1797 2981 4272463 C −9.98 0.019590 TEK 2990 1322051 A 23.07 0.014890 PIP5K1B 2999 872077 A −12.84 0.023790 TMC1 3027 6560285 T −10.98 0.022740 TMC1 3030 6560293 A 11.46 0.005511 TMC1 3035 1417614 T −10.15 0.048480 TRPM6 3045 7045338 T −10.21 0.033640 TRPM6 3046 7859201 C −9.95 0.047940 DIRAS2 3088 7028171 A 10.80 0.041780 FKTN 3111 2518128 A 9.00 0.049110 PALM2 3117 17202329 C −11.60 0.025810 PALM2 3118 736502 T −11.60 0.025810 PALM2 3119 7849027 G −11.60 0.025810 PALM2 3120 10980027 A −11.42 0.026120 SVEP1 3124 963143 A 9.53 0.026250 RALGPS1 3151 546493 G −10.21 0.049650 RALGPS1 3160 10987576 A 13.92 0.030100 SLC25A25 3161 7873492 T −15.90 0.018590 SLC25A25 3162 9695803 C −12.88 0.042060 VAV2 3187 7038256 T −17.52 0.018840 VAV2 3188 12001180 G −14.19 0.022620 OLFM1 3193 10776933 T 10.53 0.030380 OLFM1 3194 2031825 A 9.90 0.042720 PRKCQ 3229 1889001 A −9.33 0.041640 SLC16A9 3294 10128501 G −9.64 0.026350 CDH23 3304 1417207 G 11.74 0.032910 KCNMA1 3322 1907729 T −11.52 0.048920 KCNMA1 3325 10509378 T 10.47 0.032570 VTI1A 3399 7918958 G −11.04 0.017060 VTI1A 3400 7342028 T −11.33 0.019300 VTI1A 3403 11196083 T −11.18 0.022540 VTI1A 3404 7068695 C −8.61 0.045770 VTI1A 3405 4145776 G −9.41 0.043560 ATE1 3448 2420970 T 10.04 0.016610 ATE1 3449 11200251 T 11.70 0.017210 CTBP2 3455 9422765 G 10.58 0.029640 CTBP2 3456 7896555 G 10.58 0.029640 ARNTL 3492 10832020 C 10.48 0.034040 SPON1 3499 1528668 C −9.30 0.029390 SPON1 3501 11023054 A −9.41 0.030010 SPON1 3502 10832165 A −9.02 0.034340 SPON1 3503 7112850 A −9.02 0.034340 SPON1 3504 10766134 G −9.02 0.034340 ELMOD1 3559 683266 A −10.43 0.019420 TSPAN9 3594 4304861 G 10.42 0.019420 TMEM16B 3606 11063913 G −10.24 0.047260 CNOT2 3643 1595410 C 8.95 0.043750 KCNC2 3655 6582260 C −11.97 0.031940 KCNC2 3658 1526821 C −15.91 0.003126 KCNC2 3659 10785167 T −10.21 0.031070 MTIF3 3691 9805452 A −18.01 0.001309 MTIF3 3692 7334690 A −16.39 0.001186 TRPC4 3725 7336008 A 9.27 0.017370 TRPC4 3726 4943529 C 9.43 0.028090 TRPC4 3727 7319926 A −12.39 0.010750 TRPC4 3728 9532107 A −13.34 0.003121 TRPC4 3732 1538146 T 13.40 0.015790 GPC5 3777 1537027 T −10.08 0.036720 GPC5 3780 2352195 T 11.44 0.010230 GPC5 3781 2352199 C 11.68 0.009241 GPC5 3782 7321674 A 11.68 0.009241 GPC6 3804 3848066 C 12.06 0.018980 GPC6 3805 4085921 G 13.48 0.005165 GPC6 3806 1330620 A 14.43 0.002196 GPC6 3807 9589816 A 13.61 0.002511 GPC6 3810 7993501 C 12.29 0.003483 NPAS3 3873 6571605 A 13.29 0.012170 NPAS3 3874 10150948 A −11.54 0.003906 NPAS3 3876 2183276 G 10.81 0.004129 SAMD4A 3913 709939 C −8.97 0.045570 SAMD4A 3914 3813402 A −11.64 0.032790 PSMC1 3970 2236403 T −8.85 0.039710 RPS6KA5 3972 1152423 C −10.75 0.026310 BCL11B 4000 2793321 T −16.67 0.001161 BCL11B 4001 1257446 C −17.33 0.000895 BCL11B 4002 1257416 G −15.04 0.007450 BCL11B 4003 2614463 T −9.46 0.023430 C15ORF41 4042 16964046 T −28.30 0.001232 C15ORF41 4043 16964049 T −28.01 0.001237 C15ORF41 4044 1210459 T −13.82 0.018830 C15ORF41 4045 16964103 T −28.01 0.001237 C15ORF41 4046 16964104 G −28.01 0.001237 C15ORF41 4047 17508461 T −28.01 0.001237 GLDN 4057 16964316 A 41.39 0.001055 GLDN 4059 16964319 T 41.39 0.001055 GLDN 4060 10163098 G 41.39 0.001055 GLDN 4061 12443092 C 41.39 0.001055 A2BP1 4132 12922392 T −10.91 0.021710 TMC5 4139 1985395 C −9.92 0.043410 KIFC3 4149 874503 A −20.34 0.049910 CRISPLD2 4214 2934477 A 10.01 0.022330 ALOX12B 4218 9914077 G 9.66 0.040330 SDK2 4262 1846334 A 12.03 0.015780 DNAH17 4268 9302876 A 10.92 0.033350 PTPRM 4291 1893224 C 21.61 0.036710 CHST9 4317 4800797 G 12.16 0.012590 RNF24 4393 6084530 C 9.94 0.026400 FERMT1 4409 6085406 A 9.69 0.031810 PLCB1 4416 6055678 T 12.32 0.023540 MACROD2 4452 6043402 A −25.18 0.014090 KIF16B 4462 6043875 C −12.97 0.017340 MIRN155 4553 9977556 C 14.13 0.007401 ASPHD2 4573 16982107 T −22.28 0.018950 TTLL1 4591 5759120 T −22.96 0.045150 TTLL1 4594 135001 C −9.57 0.027900 TTLL1 4595 135002 C −9.57 0.027900 EFCAB6 4598 9614382 G −10.77 0.037170 EFCAB6 4600 2374773 A −11.83 0.016230 EFCAB6 4605 137794 A 22.20 0.001550 EFCAB6 4608 137821 G 13.40 0.015660 EFCAB6 4613 5764302 G 18.51 0.003064 EFCAB6 4614 5764310 C 18.29 0.002464

TABLE 2 Alleles Influencing Response to Risperidone Beta Gene Seq ID NCBI RS# Allele (PANSS) P AGBL4-C1ORF165 27 1934395 G −16.73 0.0003 AGBL4-C1ORF165 30 1934368 C −15.54 0.0012 AGBL4-C1ORF165 32 5017079 T −17.26 0.0015 AGBL4-C1ORF165 34 3121522 A −11.55 0.0067 AGBL4-C1ORF165 35 12043418 T −10.43 0.0180 AGBL4-C1ORF165 36 2355693 T −15.94 0.0016 SYT6 79 500739 T −9.31 0.0175 SLC22A15 85 7547928 T 9.84 0.0242 SLC22A15 86 2051060 C 9.84 0.0242 RALGPS2 131 4652319 T 8.61 0.0445 KCNK2 140 10779634 T 8.49 0.0478 USH2A 169 700024 G 13.89 0.0332 ESRRG 175 10495027 A −11.08 0.0345 SLC35F3 189 480993 T −8.61 0.0305 RYR2 211 651250 C −11.65 0.0071 KCNF1 287 16856887 T −10.77 0.0096 PLEKHH2 360 12621654 T 12.51 0.0072 C2ORF34 366 1067402 T −10.97 0.0289 C2ORF34 367 698792 A −10.07 0.0428 C2ORF34 375 11679997 T −17.19 0.0050 EPAS1 392 4953340 C 8.83 0.0194 CCDC85A 428 1030091 C 15.59 0.0367 CTNNA2 445 2566542 C 10.44 0.0477 CTNNA2 452 1319241 A −11.61 0.0458 CTNNA2 455 1443895 A −7.74 0.0479 CTNNA2 469 731359 C 8.22 0.0347 INPP4A 474 17032120 T 10.14 0.0148 INPP4A 475 2278206 C 8.72 0.0332 NXPH2 498 10928662 T 12.92 0.0120 LRP1B 511 1949871 C −7.89 0.0442 ARHGAP15 538 11895997 A −8.99 0.0195 ARHGAP15 541 6719609 A 12.89 0.0112 ARHGAP15 543 9677486 G 12.52 0.0140 ARHGAP15 545 7605182 C 12.36 0.0200 ARHGAP15 546 17814502 A 12.14 0.0187 KIF5C 564 6755213 A 15.31 0.0185 FMNL2 588 2272535 G −13.74 0.0376 SCN3A 615 10930148 G −9.99 0.0333 SCN3A 618 11677254 C −10.12 0.0125 PDE1A 638 2623422 G −9.80 0.0371 PDE1A 647 7601804 T −10.61 0.0400 PARD3B 664 1100393 G 10.79 0.0134 IRS1 688 2288587 C 24.29 0.0270 IRS1 689 16822570 G 24.29 0.0270 COL4A3 710 11681636 C −11.42 0.0034 SAG 731 3792096 T −11.29 0.0093 CNTN6 734 4362705 A 9.55 0.0285 CNTN6 735 6798321 C 8.70 0.0271 CNTN6 736 11925058 C 8.74 0.0412 CNTN6 752 3915436 A −12.04 0.0034 CNTN4 756 1523320 C −9.80 0.0174 CNTN4 760 1153486 T −10.35 0.0368 CNTN4 769 9823500 C 13.42 0.0087 ITPR1 774 304073 G −11.23 0.0042 ITPR1 775 304038 G −7.95 0.0479 DAZL 800 12233472 G 9.07 0.0376 DAZL 803 13064112 G 8.86 0.0446 ULK4 847 1795346 C 19.72 0.0143 GPX1 855 9814873 G 14.07 0.0013 GPX1 856 1801143 T 14.07 0.0013 GPX1 857 9827708 G 13.53 0.0022 GPX1 858 2271961 C −8.06 0.0278 GPX1 859 2352974 T −7.77 0.0396 CACNA2D3 873 17054586 C 13.91 0.0260 ERC2 881 7617962 T 13.09 0.0069 ERC2 882 1993539 T 17.98 0.0004 ERC2 883 9810436 A 9.80 0.0301 ERC2 886 7614271 G 19.29 0.0012 ERC2 887 4974168 C 15.79 0.0084 ERC2 889 2316481 A 18.68 0.0171 IL17RD 905 747089 T 12.09 0.0073 FHIT 927 9858223 A 11.91 0.0029 FHIT 928 4688167 C 11.91 0.0029 PRICKLE2 957 17069879 A −12.65 0.0047 MAGI1 972 4234687 A 11.95 0.0219 MAGI1 975 7612644 A 8.94 0.0493 GBE1 989 17019088 T 12.40 0.0161 GBE1 991 13324454 G −11.00 0.0147 GBE1 994 9871474 T −9.70 0.0394 EPHA6 1007 6439203 G 16.23 0.0104 EPHA6 1009 2317212 A 10.35 0.0420 PLCXD2 1011 6788543 C 8.27 0.0455 KALRN 1044 333354 A −8.82 0.0406 CPNE4 1048 1385969 C −10.36 0.0283 SPSB4 1082 11915229 G 16.56 0.0428 SERPINI1 1091 13090569 A −10.04 0.0277 SLC7A14 1093 6788596 G 11.57 0.0108 SLC7A14 1096 17289598 G 16.07 0.0156 TNIK 1099 4955765 G 7.70 0.0422 TNIK 1102 17217552 G −29.57 0.0346 IL1RAP 1141 3773999 C 10.31 0.0280 IL1RAP 1142 9990231 C 9.40 0.0467 SLC2A9 1156 2139243 C −9.60 0.0425 SLIT2 1185 7655084 G 9.48 0.0438 PCDH7 1199 10517215 A −13.99 0.0252 NPFFR2 1235 11936367 G −9.41 0.0401 NPFFR2 1248 9790741 G 8.50 0.0480 PAPSS1 1308 4956020 T 11.46 0.0266 PAPSS1 1309 12502059 A 11.82 0.0226 COL25A1 1321 1563004 G 14.34 0.0420 ANK2 1348 362496 G −13.64 0.0032 GPR103 1382 2013332 A −10.22 0.0382 MAML3 1392 10024138 T 8.89 0.0486 MAML3 1393 12512994 T 8.99 0.0500 FSTL5 1460 2082669 G 14.31 0.0077 TLL1 1479 3756016 C −10.74 0.0146 TLL1 1480 2292083 A −10.46 0.0167 ENPP6 1527 6830766 G 8.79 0.0263 ENPP6 1528 10020224 G 11.04 0.0089 SEMA5A 1541 11134354 A 9.74 0.0454 DNAH5 1553 7715811 T 10.04 0.0404 DNAH5 1554 1502050 G 9.91 0.0456 CDH10 1575 3822429 T −8.78 0.0313 SLC45A2 1579 35389 G 16.41 0.0135 SLC1A3 1586 6451305 C 10.80 0.0389 ITGA1 1615 1047481 G 8.75 0.0404 TNPO1 1644 2548331 A −10.68 0.0039 FCHO2 1645 478575 T 9.86 0.0094 FCHO2 1647 6895786 G 9.44 0.0173 FCHO2 1648 7727222 C 9.44 0.0173 FCHO2 1649 7709974 A 9.51 0.0184 VCAN 1669 309559 T 9.16 0.0447 VCAN 1670 160277 A −8.27 0.0453 CAST 1694 754615 C 8.91 0.0479 FBXL17 1701 288172 C −13.10 0.0099 FBXL17 1702 288144 A −13.10 0.0099 FBXL17 1712 1849012 A −13.48 0.0085 FBXL17 1713 17161232 T −12.07 0.0179 FBXL17 1714 6594298 A −12.07 0.0179 KCNN2 1729 6889371 G −14.35 0.0154 KCNN2 1730 4435855 A 9.87 0.0478 SEMA6A 1732 26591 A 8.14 0.0346 SEMA6A 1735 254231 G −8.30 0.0446 ODZ2 1799 1422421 T −11.09 0.0130 NEDD9 1815 3798729 T −15.48 0.0046 PHACTR1 1817 6458439 C 9.22 0.0253 JARID2 1827 707833 C −10.12 0.0155 PPP2R5D 1882 6901782 C 12.17 0.0380 RIMS1 1907 1015945 G 9.23 0.0430 RIMS1 1908 9351903 G −9.48 0.0287 RIMS1 1910 10498882 G −8.78 0.0330 RIMS1 1912 1339226 G −12.54 0.0079 RIMS1 1913 1546914 T −10.86 0.0165 TRDN 1935 13190807 C 10.08 0.0325 TRDN 1939 1431284 G −8.49 0.0331 TRDN 1940 17686735 G −8.91 0.0282 PDE7B 1987 6938424 T 27.27 0.0252 PLAGL1 1992 9376803 G 9.95 0.0087 PLAGL1 1993 9484836 A 12.76 0.0044 UTRN 1997 601873 A 9.86 0.0196 UTRN 2000 9390166 G 12.61 0.0018 UTRN 2001 7765923 A 11.35 0.0097 PACRG 2051 742956 G 10.81 0.0086 PACRG 2053 761625 A −9.55 0.0303 PDE10A 2057 1706123 C 9.07 0.0198 CARD11 2069 4722277 T −9.49 0.0333 SDK1 2072 11766511 G 8.33 0.0324 SDK1 2075 649186 C −11.40 0.0470 SDK1 2082 1044701 A −8.12 0.0443 ETV1 2098 4721291 C 10.36 0.0126 ETV1 2099 2237295 G −11.17 0.0181 STK31 2110 10264967 T −12.28 0.0397 CREB5 2125 4722864 A −11.11 0.0436 SCRN1 2130 6976421 A −13.32 0.0059 SCRN1 2131 6976789 T −10.14 0.0331 SCRN1 2132 4662 T −10.14 0.0331 PLEKHA8 2134 10275475 C −10.28 0.0454 PDE1C 2156 7790003 C −7.65 0.0332 BMPER 2164 6975236 T −10.77 0.0092 VPS41 2173 2286105 A 16.65 0.0095 VPS41 2176 3801140 C 10.11 0.0201 VPS41 2177 3801139 T 10.11 0.0201 VPS41 2180 12674115 G 14.84 0.0052 GRB10 2220 2074777 G 8.95 0.0190 GRB10 2221 757774 G 13.84 0.0021 GRB10 2222 6593164 C 13.84 0.0021 GRB10 2223 10281065 A 13.84 0.0021 GRB10 2225 6943901 G 13.84 0.0021 GRB10 2226 6971834 T 13.84 0.0021 WBSCR17 2241 740099 C 13.86 0.0052 WBSCR17 2243 7794574 A 14.82 0.0070 HIP1 2260 1015877 C −9.21 0.0165 HIP1 2261 2696213 T −13.55 0.0006 HIP1 2263 2253020 G −12.68 0.0013 HIP1 2264 11770686 T 11.72 0.0028 MAGI2 2275 38110 C −9.60 0.0162 MAGI2 2285 2191806 C −11.70 0.0465 CACNA2D1 2313 12531682 T 8.70 0.0412 CACNA2D1 2315 7788848 A 8.92 0.0360 CACNA2D1 2317 6952949 G −9.80 0.0201 PCLO 2319 10232216 T 10.76 0.0080 SEMA3E 2336 2713151 T −8.37 0.0470 SEMA3E 2337 2709890 A −8.37 0.0470 ADAM22 2355 1688886 G −8.72 0.0436 ADAM22 2356 2282948 C −8.42 0.0456 ADAM22 2357 2282949 C −8.42 0.0456 KCND2 2413 4727911 G −10.75 0.0226 KCND2 2414 7795646 G −10.75 0.0226 GRM8 2442 6950264 G 10.70 0.0116 GRM8 2452 1361956 A 9.55 0.0178 EXOC4 2467 10247014 T 8.60 0.0370 EXOC4 2468 10279261 G 8.90 0.0241 EXOC4 2471 4731992 A 11.91 0.0148 DGKI 2475 16874961 C 10.64 0.0245 DGKI 2476 12535157 A 9.39 0.0383 PTPRN2 2515 10263303 T 11.16 0.0202 CSMD1 2539 12541278 T −9.41 0.0194 MCPH1 2568 2959799 C −8.76 0.0245 MCPH1 2570 2454517 C −9.94 0.0121 MCPH1 2573 3020264 A −9.65 0.0221 DLC1 2576 569510 A 13.54 0.0026 DLC1 2577 2203838 C 13.22 0.0042 DLC1 2578 536147 G 11.16 0.0130 SLC7A2 2601 7002951 G 15.96 0.0059 PSD3 2606 11990818 G −8.48 0.0438 UNC5D 2644 3015796 G 9.15 0.0321 LYN 2676 17812677 T −12.56 0.0137 LYN 2677 16922508 C −12.56 0.0137 LYN 2679 6988853 A −11.16 0.0170 LYN 2681 2668003 C −9.98 0.0335 NKAIN3 2694 896489 G −10.97 0.0132 NKAIN3 2713 10504356 G −16.39 0.0144 NKAIN3 2716 4739023 C 10.11 0.0115 NKAIN3 2718 1350059 C 9.86 0.0148 DEPDC2 2725 4737868 A 9.72 0.0154 DEPDC2 2728 1434764 A −8.84 0.0352 KCNB2 2739 349350 G −9.58 0.0359 FER1L6 2839 10094533 C 14.91 0.0079 FER1L6 2842 7832499 C 15.37 0.0093 FER1L6 2843 9643188 A 15.84 0.0100 FER1L6 2844 13254498 A 14.73 0.0143 FER1L6 2846 13269044 G 14.53 0.0164 MTSS1 2856 6470298 A 16.81 0.0413 ADCY8 2897 17327900 A −13.26 0.0424 ST3GAL1 2903 2978015 T 7.73 0.0476 COL22A1 2909 7844188 G 9.41 0.0499 SMARCA2 2927 10757205 G −18.00 0.0334 SLC1A1 2937 159914 C 9.23 0.0417 KIAA1797 2966 7025868 G −10.35 0.0382 KIAA1797 2967 6475483 T −10.47 0.0443 KIAA1797 2973 6475490 G 8.73 0.0267 KIAA1797 2974 6475491 G 7.76 0.0481 KIAA1797 2977 7025851 G 9.13 0.0222 KIAA1797 2979 4977881 A −9.69 0.0307 APBA1 3004 11139084 A 8.90 0.0254 APBA1 3005 10867730 T 8.90 0.0254 MAMDC2 3008 3015182 C 19.84 0.0102 MAMDC2 3009 2975866 A 19.84 0.0102 MAMDC2 3010 3015189 G 19.84 0.0102 MAMDC2 3011 3015213 A 19.84 0.0102 TMC1 3034 2487471 T 12.41 0.0181 TMC1 3036 1663740 T 10.93 0.0398 TMC1 3037 1796991 G 10.64 0.0419 TMC1 3038 2589609 T 10.64 0.0419 PCSK5 3052 2789608 G −13.11 0.0012 ZNF169 3098 7037298 T −13.98 0.0138 GABBR2 3105 16914811 A 16.40 0.0163 GABBR2 3106 3780439 G 9.53 0.0342 CDK5RAP2 3136 3780679 G 27.19 0.0129 NTNG2 3176 3739930 A −14.54 0.0221 NTNG2 3177 3739929 G −13.48 0.0315 NPDC1 3202 4880195 C 9.93 0.0436 PITRM1 3219 3814596 G 11.27 0.0236 CACNB2 3240 10828726 G −9.12 0.0263 JMJD1C 3301 9629895 A 10.26 0.0222 CDH23 3306 7896061 C −10.49 0.0479 KCNMA1 3334 2619636 A 10.03 0.0109 KCNMA1 3335 2719986 T 8.31 0.0369 SORBS1 3368 564370 A 9.22 0.0329 ATRNL1 3413 7922670 C −7.08 0.0482 STIM1 3459 10835337 T 10.45 0.0270 STIM1 3461 7924984 A 9.80 0.0372 STIM1 3465 2959068 T 8.64 0.0443 STIM1 3466 1372805 A 8.64 0.0443 SPON1 3499 1528668 C −9.76 0.0341 SPON1 3512 3935919 C −12.74 0.0051 SPON1 3513 4757244 A −10.81 0.0129 TMEM16B 3606 11063913 G −10.79 0.0279 TMEM16B 3607 3741903 G −11.41 0.0369 LOC729025 3628 11056858 T 14.05 0.0421 LOC729025 3629 11056862 A 14.05 0.0421 PIK3C2G 3631 4764383 G −10.17 0.0186 CNOT2 3648 10506586 A 15.30 0.0359 CNOT2 3650 3817486 G 15.30 0.0359 GAS2L3 3680 35711 G −8.17 0.0381 GAS2L3 3681 35706 A −7.81 0.0441 UBL3 3696 17502901 G 9.52 0.0364 PCDH20 3737 17059750 T 25.34 0.0381 LMO7 3745 7326714 T 8.95 0.0234 LMO7 3748 2273996 T 10.31 0.0255 LMO7 3750 920701 C 10.01 0.0159 LMO7 3751 9530473 G 11.42 0.0048 LMO7 3752 7986131 T 12.23 0.0072 GPC5 3770 9652104 A 13.42 0.0357 GPC6 3804 3848066 C −9.52 0.0232 GPC6 3813 9524268 T −9.69 0.0373 NALCN 3836 9300662 G −9.36 0.0232 NALCN 3837 3916910 C 9.28 0.0411 SLC25A21 3878 2073248 C 21.08 0.0004 SLC25A21 3879 12185044 G 17.59 0.0033 LRFN5 3894 862480 T 10.55 0.0117 SAMD4A 3911 1307289 G −10.32 0.0307 SAMD4A 3912 1212968 C −10.73 0.0405 SAMD4A 3917 2057369 A 15.81 0.0011 SAMD4A 3918 17128004 A 15.81 0.0011 SAMD4A 3919 10483639 C 14.84 0.0021 PPP2R5E 3923 4899113 C −10.38 0.0337 RGS6 3953 917426 G −8.66 0.0294 RPS6KA5 3976 1286148 C −10.74 0.0234 ATP10A 4011 2930630 C 15.19 0.0036 ATP10A 4014 4906750 C 10.98 0.0198 C15ORF41 4045 16964103 T −17.91 0.0344 C15ORF41 4047 17508461 T −17.91 0.0344 MEIS2 4048 716218 A 8.24 0.0431 TBC1D2B 4094 12593545 G −11.85 0.0090 ARNT2 4105 7180510 G 9.09 0.0407 A2BP1 4113 17822719 A −11.25 0.0084 GDE1 4143 3751821 T 13.88 0.0376 MPHOSPH6 4164 8047857 C 11.70 0.0380 CRISPLD2 4215 8049317 G 9.70 0.0146 ALOX12B 4218 9914077 G 11.27 0.0096 CA10 4226 11867674 G −7.32 0.0384 CA10 4227 8076197 G 7.32 0.0384 CA10 4228 8076496 G 7.32 0.0384 CA10 4230 4794295 T −7.32 0.0384 DNAH17 4264 16971269 C 8.81 0.0441 DNAH17 4270 9907431 A −8.20 0.0466 LOXHD1 4318 11082530 T −8.69 0.0452 CCBE1 4337 12969965 A −14.12 0.0041 CCBE1 4343 1560299 T 10.34 0.0082 CCBE1 4344 4608425 A 9.12 0.0207 DOK6 4374 7243624 T 8.19 0.0338 LDLR 4384 2116897 T 14.54 0.0065 PRNT 4396 2236284 G −13.88 0.0016 PRNT 4405 968433 C −13.43 0.0019 PRNT 4406 6084875 A −10.99 0.0132 PRNT 4407 6084876 T −10.77 0.0144 FERMT1 4411 8121939 G 10.70 0.0173 MACROD2 4457 6043648 C −10.48 0.0059 KIF16B 4476 6034509 G 8.63 0.0294 KIF16B 4477 6135769 A 8.63 0.0294 KIF16B 4478 6044044 A 8.63 0.0294 KIF16B 4480 6135784 G 8.63 0.0294 KIF16B 4481 720592 T 8.63 0.0294 MAPRE1 4491 2070090 T 14.58 0.0015 PTPRT 4503 6065484 C −9.71 0.0339 PTPRT 4504 230153 T −10.49 0.0439 PTPRT 4507 6065525 A −8.79 0.0444 PTPRT 4511 2223540 T −9.31 0.0483 SNAI1 4528 6020187 G −9.54 0.0367 PDE9A 4562 2269145 T 10.22 0.0117 PDE9A 4564 12626774 C −8.69 0.0391 PDE9A 4565 2284976 A 10.74 0.0106 ARVCF 4570 887203 A 34.48 0.0147 PACSIN2 4590 2072883 G 10.39 0.0126 TTLL1 4592 1052160 T −10.20 0.0133

TABLE 3 Alleles Influencing Response to Quetiapine Gene Seq ID NCBI RS# Allele Beta (PANSS) P SCP2 39 7528867 A 28.75 0.00361 SCP2 40 11206061 C 28.75 0.00361 SCP2 41 7546714 T 14.16 0.03148 SCP2 42 6588458 A 14.87 0.03712 SCP2 44 11588200 T 20.34 0.01544 SCP2 45 2896792 T 19.99 0.01707 SCP2 46 17107767 C 19.99 0.01707 SCP2 47 12096165 G 19.99 0.01707 LRP8 50 869987 T −9.58 0.03659 LRP8 51 869988 C −9.58 0.03659 PRKACB 68 3915908 T −10.70 0.04731 PRKACB 69 3903924 G 10.57 0.04814 PRKACB 74 2642186 G 10.31 0.03302 OLFML2B 110 7537366 T 14.04 0.01786 ESRRG 183 12033378 A 12.78 0.03923 RYR2 215 4659819 T −13.39 0.00224 FMN2 251 882869 G −10.78 0.04162 KLHL29 299 9261 T 12.04 0.01064 KLHL29 300 12478701 C 11.64 0.01200 KLHL29 301 12478744 A −10.03 0.03478 DPYSL5 311 12618836 A −14.78 0.00154 DPYSL5 312 3769138 G −8.96 0.04317 CRIM1 327 4670549 T −9.16 0.04585 CDC42EP3 340 4670745 G −10.78 0.03597 CDC42EP3 341 10694 T −13.56 0.02699 SLC8A1 345 417614 A −10.33 0.02748 SLC8A1 347 11885401 C −13.70 0.03826 C2ORF34 363 1584885 C −8.90 0.04586 PRKCE 382 4953288 T −10.21 0.02069 ACYP2 415 6744662 T 16.39 0.00683 ACYP2 416 10439478 C 13.05 0.01119 CCDC85A 422 8179803 T −12.78 0.00709 CCDC85A 425 2111470 C −13.67 0.01014 CCDC85A 426 1990758 C −20.48 0.00591 CCDC85A 427 10460558 A −13.67 0.01014 OTX1 431 11125946 A 14.15 0.00223 LRP1B 516 10178963 A 9.55 0.03033 KYNU 530 7561260 G −12.92 0.04210 KYNU 532 1371516 C −15.60 0.00474 KYNU 533 6430001 A −15.14 0.00433 KYNU 534 3768844 C −16.13 0.01182 FMNL2 583 16823809 C −13.92 0.04578 PLA2R1 603 6432570 T 10.93 0.02808 PLA2R1 612 2175416 T −10.05 0.02269 PLA2R1 614 16844715 T −10.05 0.02269 CERKL 634 1967351 C 9.94 0.04738 NRP2 668 849540 T 9.96 0.04191 COL4A4 694 2276593 A 15.58 0.00053 COL4A4 695 10166736 A 14.86 0.00088 COL4A4 697 4566357 A −10.71 0.02458 DNER 712 207671 G 11.26 0.01097 DNER 713 6733289 G 12.62 0.01409 TRIP12 724 6707272 T 10.22 0.04130 TRIP12 725 6687 T −15.08 0.02818 TRIP12 726 1372086 C −12.27 0.04566 CNTN6 750 155390 G 13.19 0.00341 CNTN6 751 2291100 C 11.89 0.01478 CNTN6 752 3915436 A −11.03 0.00983 CNTN4 762 1502582 T 12.72 0.04388 SLC6A6 795 4684216 G −25.78 0.00067 ULK4 838 7627972 A −8.82 0.03737 ULK4 840 6794510 T −8.52 0.04954 ULK4 842 11129908 A −9.91 0.02216 CACNA2D3 871 2141034 A −14.13 0.02467 CACNA2D3 872 6804643 A −12.38 0.04995 FLNB 912 7632986 T −9.96 0.04182 FLNB 913 7622687 A −13.23 0.00550 PTPRG 940 9813294 A 10.41 0.01004 CADPS 942 1376917 C −21.12 0.03049 FAM19A1 982 6801913 A 10.15 0.03078 FOXP1 985 2597312 C 9.79 0.03127 FOXP1 987 1290499 T −16.99 0.01410 STX19 1000 9810986 T 29.68 0.00262 STXBP5L 1036 2169302 G 14.91 0.04740 RAB6B 1061 6765093 G 10.16 0.03627 EPHB1 1064 4955460 C −11.99 0.01041 EPHB1 1065 185257 T −10.65 0.03061 EPHB1 1066 9825380 T −10.80 0.03441 EPHB1 1067 936323 T −10.08 0.04468 EPHB1 1068 1870196 T −12.03 0.01370 TNIK 1097 6781167 A 26.27 0.00163 TNIK 1098 12486611 T 25.75 0.00178 PLD1 1106 1316415 G −10.17 0.02517 PLD1 1107 7626674 C 13.50 0.02594 PLD1 1109 2178532 A 13.50 0.02594 PCDH7 1199 10517215 A 12.34 0.04410 PCDH7 1202 2310225 A 12.78 0.01941 LIMCH1 1223 6821712 C −9.50 0.04144 NPFFR2 1249 17775309 G 9.68 0.04822 SHROOM3 1259 10022778 G 8.13 0.04828 SCD5 1263 17006038 C 13.50 0.03407 SCD5 1271 3897960 A −12.82 0.03552 HERC3 1275 3796660 A −19.26 0.03462 FAM13A1 1283 6814344 G −10.80 0.04153 FAM13A1 1284 13131633 T −10.80 0.04153 PAPSS1 1307 2672487 A −9.55 0.04604 COL25A1 1315 17039326 T 13.56 0.01265 COL25A1 1316 9996734 A 12.84 0.01446 COL25A1 1334 987695 G 10.43 0.02112 COL25A1 1335 7675657 A 9.44 0.04234 ANK2 1350 29355 G −12.76 0.03517 ANK2 1352 29319 A −12.67 0.03804 CAMK2D 1359 17046126 T 9.37 0.04666 CAMK2D 1361 1859148 C −11.78 0.02900 CAMK2D 1362 7675804 T −11.78 0.02900 CAMK2D 1363 10023113 G 19.04 0.01080 MAML3 1392 10024138 T −9.54 0.04145 POU4F2 1425 7680105 G −18.46 0.00196 POU4F2 1428 6835151 A −17.97 0.00525 POU4F2 1429 1394279 G −18.05 0.00551 FSTL5 1452 4501178 C 13.98 0.03848 FSTL5 1473 4691039 T 18.45 0.00375 CASP3 1529 2696056 G −12.54 0.04554 AHRR 1531 2721004 T −9.04 0.04234 AHRR 1532 2721012 G −10.04 0.03557 SLC1A3 1583 3776569 G −9.41 0.04957 EGFLAM 1596 2731979 C 14.60 0.03298 ITGA1 1607 2169782 T 20.56 0.00163 VCAN 1668 2287926 A 15.56 0.01299 VCAN 1671 2445874 T 12.62 0.04828 PJA2 1723 2963034 A 10.47 0.01709 KCNN2 1726 1072922 A 11.72 0.02454 KCNN2 1728 13163662 A 12.26 0.01715 ADAMTS19 1769 4835975 A 11.67 0.01495 ODZ2 1793 1529682 G −13.20 0.04506 SLC22A23 1807 3813487 A 14.38 0.01646 BRD2 1879 194677 T −26.51 0.01459 ELOVL5 1888 2562898 A 12.58 0.02447 RIMS1 1902 1010326 A −13.37 0.00906 RIMS1 1905 2496495 G −8.96 0.04892 RIMS1 1906 2250128 C −9.54 0.03816 RIMS1 1908 9351903 G 10.79 0.01570 RIMS1 1910 10498882 G 10.13 0.02668 RIMS1 1911 2807531 A 9.63 0.04062 STX11 1996 4896708 A −10.18 0.02725 PDE10A 2063 484594 C −13.01 0.03420 SDK1 2070 10265630 G 10.87 0.03561 SDK1 2071 1062213 C 10.61 0.04465 SNX13 2101 10216315 C 9.58 0.03782 STK31 2112 6957981 G 13.72 0.01342 CREB5 2119 2237361 C 9.31 0.04837 CREB5 2124 17669844 C 10.09 0.04720 SCRN1 2129 9912 T −11.55 0.02516 PDE1C 2155 6952633 G −10.82 0.03590 PDE1C 2160 4551232 A −9.19 0.04338 PDE1C 2161 10225488 A −9.19 0.04338 BMPER 2163 11978741 T 10.68 0.04675 ABCA13 2194 17132289 T 24.20 0.00500 GRB10 2216 3779072 G 13.39 0.03125 GRB10 2219 1978208 G 13.13 0.03586 GRB10 2224 12536500 T 12.05 0.04430 WBSCR17 2242 4585627 T 10.71 0.02053 GTF2IRD1 2252 2267834 G −15.82 0.00219 MAGI2 2278 1918930 C −19.68 0.00211 MAGI2 2279 848913 C −17.50 0.01199 MAGI2 2282 10259665 A 14.84 0.00299 MAGI2 2285 2191806 C 14.60 0.04286 MAGI2 2288 6466535 C 16.79 0.02393 MAGI2 2293 848934 C −19.68 0.00211 MAGI2 2301 4730829 C 12.19 0.02884 CACNA2D1 2304 17262683 C −10.61 0.04476 CACNA2D1 2305 10215394 G −10.68 0.02153 CACNA2D1 2317 6952949 G −939 0.04936 SEMA3E 2339 2713174 C 9.61 0.04165 SEMA3A 2347 1989964 T 8.01 0.04934 ABCB4 2352 31669 A −25.48 0.00291 PPP1R9A 2365 6465455 T −12.31 0.00459 PPP1R9A 2367 854738 T −14.64 0.00212 PPP1R9A 2369 961262 C −12.06 0.00394 PON1 2381 3917538 T 13.46 0.02265 PON1 2382 2057681 G 11.09 0.03250 PON1 2383 2299257 C 17.35 0.00010 EXOC4 2463 2345943 T 9.28 0.04423 EXOC4 2464 7776986 C −8.93 0.04321 EXOC4 2465 10808271 C −8.93 0.04321 PTPRN2 2535 2878355 A −11.30 0.04363 CSMD1 2544 7829968 T 14.04 0.01998 CSMD1 2548 1161518 T 11.24 0.03612 MCPH1 2571 1057090 T −11.34 0.01720 MCPH1 2572 2911968 C −13.11 0.00694 SGCZ 2594 4831307 G 10.73 0.03295 XPO7 2620 10101881 T 11.83 0.00703 XPO7 2622 2306645 T 11.83 0.00703 XPO7 2624 7013323 C 10.33 0.01964 SFRP1 2648 7833518 T 11.63 0.01928 SNTG1 2651 318861 G 33.83 0.00334 SNTG1 2652 10504093 G 26.47 0.01475 SNTG1 2657 9298278 A 9.08 0.03616 SNTG1 2659 4873135 A 8.75 0.04379 LYN 2673 1546518 C 10.00 0.02711 TOX 2685 11777927 A −13.16 0.02972 CRISPLD1 2758 13248650 G 14.91 0.00199 MMP16 2761 2616499 G 11.95 0.02270 ZFPM2 2806 7007352 G 24.36 0.00854 ZFPM2 2808 1372614 G 24.36 0.00854 SAMD12 2818 4876815 G −12.26 0.01965 FBXO32 2830 6990407 G 16.67 0.00922 FER1L6 2832 13279726 G −9.02 0.04900 COL22A1 2913 6991720 C −12.69 0.02068 COL22A1 2914 13279213 A −13.13 0.01377 COL22A1 2915 1879047 T 15.41 0.03227 COL22A1 2916 2318348 G 13.41 0.04622 SMARCA2 2923 13301640 A −17.56 0.01897 KIAA1797 2968 10738569 A −11.42 0.04514 TEK 2987 4601425 T −11.59 0.02295 TEK 2989 10511803 C −13.99 0.03164 PIP5K1B 2992 4744683 T 15.46 0.00132 PIP5K1B 2993 4534183 A −15.26 0.00152 PIP5K1B 2994 7853748 G 12.87 0.00748 TRPM3 3026 1329776 G −14.14 0.01573 NFIL3 3089 2440589 T 8.33 0.04871 GABBR2 3105 16914811 A 14.03 0.03112 SVEP1 3126 10759422 C 12.55 0.01872 RALGPS1 3160 10987576 A −13.98 0.04220 KCNT1 3195 497547 G 32.82 0.00928 PITRM1 3225 6601755 C −9.59 0.04178 CACNB2 3233 7090118 A −9.09 0.04983 ARMC3 3245 10828374 G −15.07 0.00074 ARMC3 3246 7919349 G −12.60 0.03190 ARMC3 3248 17440393 A −13.21 0.02520 ARMC3 3249 11013210 T −13.29 0.02262 ARMC3 3251 10828395 A −14.16 0.03000 JMJD1C 3303 2893922 C 12.36 0.03509 KCNMA1 3330 10509386 C 11.01 0.02073 KCNMA1 3331 11002120 T 11.01 0.02073 KCNMA1 3334 2619636 A −12.24 0.00287 KCNMA1 3335 2719986 T −11.93 0.00328 KCNMA1 3336 12780841 A −16.00 0.02220 KCNMA1 3337 1465865 C −16.00 0.02220 KCNMA1 3338 1978868 A −11.20 0.03732 NRG3 3348 7078771 A −30.75 0.02918 NRG3 3349 17107795 T −30.75 0.02918 NRG3 3351 17101125 A −30.75 0.02918 NRG3 3352 10509462 T −30.75 0.02918 SORBS1 3358 11188287 G 14.94 0.00368 SORCS3 3373 7900775 T 9.46 0.03682 SORCS3 3375 7912102 A −12.13 0.01927 SORCS3 3376 6584631 T −11.62 0.02475 SORCS3 3380 7085496 A −10.57 0.04469 SORCS3 3381 4918143 T 12.80 0.04764 ATE1 3438 10510104 G −15.97 0.01579 ATE1 3440 11598265 C −47.04 0.01634 ATE1 3441 10788208 A −47.04 0.01634 ATE1 3443 4471357 A −47.04 0.01634 ATE1 3444 10749429 T −46.22 0.01723 CTBP2 3454 769160 C 17.95 0.00445 CTBP2 3455 9422765 G 14.93 0.00756 GALNTL4 3471 7122801 T 14.69 0.00173 NELL1 3516 12799803 A −13.94 0.03618 DLG2 3538 4944461 A 18.63 0.04652 DLG2 3552 1940128 C 15.62 0.02873 DLG2 3554 582652 A 20.77 0.00323 DLG2 3555 483220 G 14.75 0.03123 OPCML 3560 10894536 A −16.26 0.02002 OPCML 3567 7119286 C −14.35 0.00460 OPCML 3568 3018406 A −10.99 0.01738 OPCML 3571 3016500 T −10.21 0.04733 OPCML 3572 6590684 G −8.83 0.04804 OPCML 3585 7936263 G 14.05 0.00248 OPCML 3587 7108670 C 13.33 0.00699 OPCML 3588 7108751 T 12.85 0.00999 LOC729025 3617 7955194 T −10.71 0.01769 LOC729025 3620 6488827 T 9.52 0.02910 LOC729025 3622 10772915 A −10.51 0.02419 LOC729025 3623 1913253 T 9.48 0.03730 LOC729025 3627 10734895 A 16.50 0.00600 ITPR2 3640 2230375 G −15.33 0.00116 NAV3 3667 7976374 A 10.13 0.03246 NAV3 3674 1731757 C −23.93 0.02158 ATXN2 3686 1544396 G −10.58 0.04357 MTIF3 3690 17085657 C −34.65 0.00588 MTIF3 3692 7334690 A −12.77 0.02160 PCDH20 3737 17059750 T −55.74 0.00040 PCDH20 3739 3812874 T −55.74 0.00040 ITGBL1 3843 7323330 A 9.34 0.02946 ITGBL1 3844 4772403 T 10.87 0.01544 ITGBL1 3851 1469855 G −18.66 0.03401 NPAS3 3865 1290203 T −10.28 0.02936 NPAS3 3867 243284 G −9.91 0.03912 SLC25A21 3880 10138134 A −21.38 0.03937 LRFN5 3893 12884090 A −10.48 0.04179 PPP2R5E 3929 7154718 G −36.65 0.01356 KCNK10 3966 12185033 T 11.24 0.02219 KCNK13 3969 769044 A −9.72 0.03184 ATP10A 4005 11853308 C −9.26 0.03688 ATP10A 4009 12442216 T −9.93 0.04477 ATP10A 4012 4906747 G 17.70 0.04997 ATP10A 4013 10873606 A −12.27 0.00657 ATP10A 4014 4906750 C 12.86 0.03028 RYR3 4021 1980102 A 9.38 0.03360 C15ORF41 4038 3784678 C 9.30 0.03009 CGNL1 4067 12595188 G 13.54 0.01546 CGNL1 4068 4774257 G 11.11 0.02124 CGNL1 4072 8034215 G −12.17 0.00844 RORA 4078 12914584 G 9.52 0.04840 KIFC3 4149 874503 A −29.26 0.03832 WWOX 4151 8061908 C 13.29 0.00239 WWOX 4152 1922620 C 12.60 0.00368 WWOX 4154 16947095 A −10.87 0.00821 WWOX 4155 7184271 C −9.30 0.03705 WWOX 4156 4887935 C 12.10 0.00692 MPHOSPH6 4165 2081257 G −21.33 0.00325 MPHOSPH6 4167 7192444 G 10.16 0.03567 MPHOSPH6 4168 11645604 A −18.83 0.00409 MPHOSPH6 4169 11647563 C −18.06 0.01012 MPHOSPH6 4171 10514533 C −14.84 0.03018 USP10 4211 8060725 A −9.05 0.04662 DNAH9 4222 11078034 C −10.61 0.02917 DNAH9 4223 9903258 G −15.15 0.00214 MSI2 4260 8065120 A 15.62 0.01491 PTPRM 4293 1866854 G 10.26 0.03005 LOXHD1 4319 986117 C 11.42 0.01869 NEDD4L 4326 9962106 T 13.10 0.01472 NEDD4L 4329 10513914 G 12.79 0.01662 NEDD4L 4330 2075405 G 13.40 0.01607 CCBE1 4342 2564495 G 10.79 0.02069 CDH7 4363 9953248 T −28.26 0.04726 TXNDC10 4373 309242 G −16.46 0.00943 DOK6 4374 7243624 T 11.80 0.01762 ZNF667 4387 10423617 T 13.70 0.01557 MACROD2 4450 708975 G 8.64 0.02963 MAPRE1 4490 410488 A 10.74 0.02545 PTPRT 4498 746413 C −9.32 0.02404 PTPRT 4502 6124439 A 15.34 0.00336 SNAI1 4524 6020157 A 21.42 0.00127 CDH4 4531 6121764 G −12.08 0.01213 CDH4 4532 1317385 C −11.06 0.02082 CDH4 4536 17811544 G 8.81 0.04843 MIRN155 4555 8134718 T 12.63 0.04551 SGSM1 4571 5760752 C −17.90 0.00009 TTLL1 4592 1052160 T 9.39 0.02651 EFCAB6 4596 7286735 T 13.61 0.01095 EFCAB6 4599 12628583 C −20.37 0.01186 EFCAB6 4612 2187887 G 11.66 0.01390 EFCAB6 4615 138102 T 9.60 0.04333

TABLE 4 Alleles Influencing Response to Perphenazine Gene Seq ID NCBI RS# Allele Beta (PANSS) P EPHB2 20 10799762 C −18.09 0.00658 EPHB2 23 309499 T 10.52 0.01061 LRP8 48 5174 A 13.42 0.00025 LRP8 52 2297660 A 12.62 0.00101 LRP8 53 2297657 A 8.84 0.02742 RALGPS2 132 6662050 A 25.81 0.00196 RALGPS2 133 3766637 C 21.70 0.00747 SLC35F3 186 7515801 G 18.89 0.00369 SLC35F3 187 479040 T 18.67 0.00518 SLC35F3 190 12118979 C −22.78 0.00162 SLC35F3 191 10495346 T −23.53 0.00174 FMN2 230 6698474 A 10.10 0.02189 FMN2 231 12123407 A 10.06 0.02354 FMN2 235 10926168 G −8.03 0.04313 FMN2 236 7520065 G −8.03 0.04313 RGS7 253 6429223 G 8.63 0.03151 PLD5 271 1548160 C −10.35 0.01789 C2ORF46 275 6747626 C −25.38 0.00733 KLHL29 295 4665612 T 18.32 0.02099 ASXL2 302 10180842 G 11.21 0.04149 BRE 317 1948922 G −10.64 0.02541 SLC8A1 349 385561 G −10.88 0.03408 PLEKHH2 362 10165660 C 11.78 0.02521 C2ORF34 374 3738980 C −13.72 0.02998 CTNNA2 448 3755095 G 13.53 0.02058 CTNNA2 449 2974169 C −8.15 0.03658 CTNNA2 455 1443895 A −7.70 0.04037 LRP1B 501 1486963 C −10.66 0.02393 LRP1B 503 1492388 T −9.32 0.01963 LRP1B 504 10469593 C −9.79 0.02421 LRP1B 505 12479163 A −9.98 0.02848 LRP1B 513 9283437 C −8.88 0.04509 LRP1B 515 4611596 C 8.49 0.04455 LRP1B 518 13418027 C −7.67 0.03880 LRP1B 521 4662370 T −10.09 0.04936 LRP1B 524 13382235 G −17.23 0.04795 KYNU 526 2043944 T −9.30 0.03330 ARHGAP15 551 11694505 C 11.08 0.01213 ARHGAP15 552 6745691 G 9.77 0.03162 ARHGAP15 553 6750323 C 9.09 0.04200 KCNJ3 593 2971904 T 17.32 0.00371 PDE1A 637 4666828 A 17.89 0.00084 NRP2 670 849526 A 10.56 0.01259 NRP2 671 849525 A 10.56 0.01259 COL4A3 708 7587228 C 13.78 0.04754 DNER 716 2052303 T −8.93 0.03447 TRIP12 727 475525 T 14.81 0.00593 CLASP2 813 4679039 C 9.32 0.03495 ULK4 838 7627972 A 9.28 0.03329 ULK4 839 7649806 A 11.03 0.01291 SEMA3F 860 2624837 T 14.68 0.03126 CACNA2D2 861 2298955 C 15.46 0.00237 CACNA2D2 863 754298 C 15.81 0.00344 IL17RD 906 6788981 T 12.41 0.04164 PTPRG 933 1320173 G −9.36 0.02371 MAGI1 976 264705 A 10.96 0.03322 PLCXD2 1017 1913495 T −10.27 0.04585 RAB6B 1061 6765093 G −10.03 0.01598 SPSB4 1084 4683550 C 11.95 0.03625 NLGN1 1121 692457 A −8.44 0.04605 NLGN1 1124 12634066 A −17.68 0.02450 NLGN1 1126 1546685 T −9.77 0.04822 NLGN1 1127 9828801 T −17.25 0.03279 IL1RAP 1143 2193877 G 9.10 0.04257 SLC2A9 1159 3733591 A 10.07 0.04856 NPFFR2 1250 2137735 A 11.74 0.01270 NPFFR2 1252 2365797 T 9.08 0.04986 SCD5 1266 7682126 G 9.52 0.03709 SCD5 1267 13106297 G 9.52 0.03709 COL25A1 1328 711865 A 8.61 0.03855 ANK2 1340 13134375 C 10.05 0.00796 ANK2 1341 13107082 G −8.30 0.02672 ANK2 1342 413019 C −7.48 0.04296 CAMK2D 1364 6853484 T 22.47 0.03898 PRSS12 1377 883686 C −8.78 0.04436 MAML3 1386 6819304 A −14.75 0.01125 MAML3 1392 10024138 T 9.42 0.02936 IL15 1403 6841939 A 9.02 0.03908 IL15 1406 4254850 C −7.95 0.04822 IL15 1407 1493015 A 8.06 0.04924 IL15 1408 6821171 G −10.89 0.01052 IL15 1409 1389098 C −10.56 0.01099 INPP4B 1411 2667108 C 42.73 0.01254 INPP4B 1414 336329 G 42.73 0.01254 INPP4B 1415 336330 T 59.30 0.01366 DCLK2 1441 12513356 G −20.95 0.02896 DCLK2 1442 6535725 A −11.73 0.00199 DCLK2 1443 4696645 A −16.65 0.00794 ODZ3 1515 6820811 G 9.79 0.03884 DNAH5 1554 1502050 G 14.21 0.00425 DNAH5 1556 7709692 C 12.80 0.01798 CDH10 1577 1835231 A −11.12 0.03042 PDE4D 1625 929820 T −10.43 0.01773 PDE4D 1626 2910642 C −8.65 0.03770 CMYA5 1651 6880680 C 18.93 0.04811 THBS4 1659 1866389 C 12.59 0.00821 VCAN 1666 11749904 C 8.13 0.04789 FBXL17 1697 12519388 T 12.44 0.02375 FBXL17 1698 12189428 G 12.44 0.02375 FBXL17 1699 17160706 C 10.03 0.04472 HSD17B4 1739 17453681 C −12.17 0.03437 SNCAIP 1748 1990879 C −10.98 0.02646 ODZ2 1791 11952245 G 8.80 0.04092 SLC22A23 1809 11967828 T 14.26 0.00461 SLC22A23 1810 17136440 T 11.88 0.01855 SLC22A23 1811 7747259 T 11.98 0.01871 ATXN1 1836 720006 A 9.92 0.01942 GABRR2 1920 6900958 T −11.49 0.02760 KLHL32 1921 6922974 A 13.21 0.03354 KLHL32 1923 998195 C −10.41 0.01262 KLHL32 1924 1997933 G 9.90 0.02072 SLC22A16 1932 7768422 C 15.08 0.04785 HS3ST5 1934 1334900 T 9.23 0.03155 TRDN 1939 1431284 G −10.87 0.01718 TRDN 1940 17686735 G −11.08 0.01349 TRDN 1942 12190077 A −11.03 0.01496 NKAIN2 1962 11753035 A 13.79 0.04159 PDE7B 1987 6938424 T 24.87 0.00239 PDE7B 1989 4475338 T 37.18 0.03146 PARK2 2037 12192200 C 8.57 0.03638 PARK2 2038 10945823 A 11.85 0.01815 PARK2 2039 10945825 A 11.00 0.02079 PARK2 2041 2105643 C 11.00 0.02079 PARK2 2042 4708961 T 8.59 0.04701 PDE10A 2060 585208 C 12.17 0.02777 PDE10A 2061 566759 G 11.62 0.03342 FERD3L 2103 10228726 G −9.79 0.04191 FERD3L 2105 11766540 C −11.46 0.01666 FERD3L 2108 6967671 T 9.66 0.04524 CREB5 2119 2237361 C −10.99 0.01522 CREB5 2123 12538892 A −10.24 0.04037 CHN2 2128 7781003 T 8.81 0.04292 BMPER 2165 7806522 C 9.75 0.04375 BMPER 2167 4140982 A 9.54 0.02586 WBSCR17 2238 6971383 A 10.51 0.01012 WBSCR17 2240 1859526 T 15.00 0.00083 WBSCR17 2242 4585627 T 11.71 0.00419 WBSCR17 2245 10279551 G 12.40 0.01521 WBSCR17 2246 7783170 C 10.80 0.02237 MAGI2 2274 758710 C −8.60 0.04552 MAGI2 2279 848913 C −18.78 0.00215 MAGI2 2297 10261439 A −16.51 0.00118 MAGI2 2300 10248584 G −18.74 0.00178 CACNA2D1 2308 258728 A 13.63 0.01824 PCLO 2316 7781142 A −9.66 0.02069 PCLO 2323 2371214 C 8.95 0.04471 PCLO 2324 2522843 A 8.57 0.04213 PCLO 2329 7799260 G −8.87 0.02973 DYNC1I1 2386 1382620 A −8.27 0.04927 DYNC1I1 2392 6968143 G −14.28 0.03029 DYNC1I1 2393 2073984 A −8.92 0.04580 ZNF3 2399 4424195 G 10.18 0.03333 DGKI 2473 834054 T 58.87 0.01393 CNTNAP2 2498 7803992 A 10.51 0.01398 CNTNAP2 2500 1525218 T 11.87 0.00588 CNTNAP2 2501 1525259 C 8.85 0.04879 CNTNAP2 2505 4726875 A 11.26 0.01023 CNTNAP2 2506 1528507 G 11.26 0.01023 CSMD1 2540 17065933 A 9.85 0.03080 CSMD1 2542 17065959 C 11.01 0.02651 MCPH1 2563 3020213 T 8.54 0.04516 MCPH1 2565 3824312 A 10.12 0.04141 XPO7 2621 1809498 C 10.91 0.00804 XPO7 2623 3816786 T 10.90 0.00819 SLC25A37 2632 10503726 C 10.65 0.02414 SLC25A37 2633 7826247 G 14.80 0.00146 NKAIN3 2704 4737609 A 15.16 0.02969 NKAIN3 2716 4739023 C −9.90 0.01595 NKAIN3 2719 4382471 T 9.45 0.04753 NKAIN3 2721 10100456 T 9.45 0.04753 KCNB2 2735 1431659 T 9.66 0.02773 KCNB2 2737 349355 T 11.11 0.04899 KCNB2 2740 7010480 G 8.56 0.03633 GRHL2 2771 17397776 T 9.02 0.03416 GRHL2 2772 17397811 A 8.91 0.03600 ZFPM2 2801 12546300 G 8.80 0.04189 ZFPM2 2807 2028553 A 11.63 0.01401 SAMD12 2827 2514602 A 18.08 0.01693 SAMD12 2829 2460983 G 24.02 0.00040 FBXO32 2831 2294089 C −14.45 0.03866 FER1L6 2834 6981430 G −8.38 0.04590 FER1L6 2837 7831422 G −17.07 0.02009 FER1L6 2838 12375254 A −16.10 0.02425 FER1L6 2841 7012186 T −12.64 0.04795 FER1L6 2847 4871463 G −10.19 0.03115 COL22A1 2907 4475485 T 14.66 0.01144 PTPRD 2940 3843579 C 9.03 0.03728 PTPRD 2941 12555585 G 10.69 0.04498 PTPRD 2949 942176 A 8.57 0.04125 PTPRD 2956 7868093 T −13.29 0.00215 TMC1 3039 10481772 C −15.33 0.01611 PCSK5 3050 7862766 T −15.54 0.01957 PCSK5 3051 2789610 C −11.58 0.02452 PCSK5 3052 2789608 G −13.59 0.00380 PCSK5 3053 4745488 C −9.53 0.04628 GNAQ 3059 1030828 A −11.43 0.00528 GNAQ 3060 11145565 C −10.32 0.01455 GNAQ 3070 6560625 C 10.71 0.03768 NTRK2 3080 1036914 C 10.00 0.02856 DAPK1 3082 6560011 C −8.82 0.03047 PTGS1 3150 7864901 G −13.40 0.01478 ABL1 3168 10901294 T 20.09 0.01102 ABL1 3169 3824400 A 12.54 0.03932 ABL1 3170 7021981 T 15.63 0.04125 ABL1 3171 11792273 G 15.63 0.04125 PNPLA7 3204 10867123 G −11.06 0.01613 CACNA1B 3210 1123190 A −11.33 0.03162 CACNB2 3241 10764566 G −9.41 0.01861 MYO3A 3281 3758447 C −10.14 0.01847 MYO3A 3283 16926660 A 16.56 0.00830 MYO3A 3286 16926667 A 12.83 0.03051 JMJD1C 3301 9629895 A 11.33 0.00735 CDH23 3309 9415039 T 9.60 0.01842 KCNMA1 3319 2288840 G −8.37 0.04573 KCNMA1 3320 7067873 C −8.67 0.04617 KCNMA1 3326 548216 C 9.26 0.02968 SORCS3 3370 752558 C 11.23 0.02285 SORCS3 3371 10884026 G 10.72 0.04684 VTI1A 3389 9971308 A −12.82 0.01260 VTI1A 3390 6585156 A −12.82 0.01260 ATE1 3450 11200257 A −15.96 0.00720 ATE1 3452 7906462 A −11.96 0.01936 CTBP2 3453 4962718 C 10.32 0.04535 IGSF22 3515 12789252 A −9.95 0.01529 KCNA4 3517 7931190 T 7.63 0.04487 C11ORF49 3522 3740691 A −9.52 0.03894 ELMOD1 3558 684901 T −11.84 0.01420 OPCML 3571 3016500 T 9.47 0.04326 OPCML 3589 4936195 G −13.29 0.03592 TMEM16B 3605 10466913 A 14.47 0.01253 STYK1 3616 10743918 C −8.54 0.03431 NAV3 3679 7137676 T 10.08 0.01847 NBEA 3715 7333195 T −14.55 0.00033 NBEA 3719 7320580 G 12.53 0.00547 NBEA 3720 7988705 A 10.21 0.03388 TRPC4 3729 1556541 C −10.31 0.01559 LMO7 3753 9573672 T 17.25 0.03651 GPC5 3790 2148226 G −8.06 0.04086 NALCN 3828 11069434 C 8.70 0.02327 NALCN 3829 9518353 C 8.09 0.03943 NOVA1 3856 178205 A −10.11 0.04524 NOVA1 3861 1955850 G −8.98 0.03229 NPAS3 3866 243291 G −8.30 0.04225 NPAS3 3869 1579702 G −13.16 0.00059 NPAS3 3871 10133530 A 12.90 0.01481 SLC25A21 3878 2073248 C 17.11 0.02495 SLC25A21 3879 12185044 G 17.49 0.04144 SLC25A21 3882 2022601 A −12.40 0.00297 SLC25A21 3883 10872897 T −12.33 0.00329 SLC25A21 3885 1367029 A −8.06 0.04998 PPP2R5E 3922 7140704 G −15.31 0.01036 RGS6 3944 2681749 C −8.81 0.03842 RGS6 3952 2238192 A −11.04 0.00721 NRXN3 3955 4020132 T 22.49 0.01259 KCNK10 3960 411627 C 9.62 0.03242 CCDC88C 3983 8015982 C −9.12 0.04057 CCDC88C 3984 10131741 G −9.12 0.04057 CCDC88C 3985 8008996 T −9.12 0.04057 CCDC88C 3986 8007791 A −9.12 0.04057 BCL11B 3999 807567 C −13.61 0.01511 ATP10A 4016 2066704 A −21.04 0.01347 RYR3 4028 16957065 G −9.77 0.03092 MEIS2 4049 1562804 T 8.07 0.02567 CGNL1 4068 4774257 G 9.24 0.03544 CGNL1 4069 4774940 C −10.55 0.01298 CGNL1 4070 7182648 T −10.00 0.02481 CLK3 4084 12441932 G 18.04 0.00243 CLK3 4085 2068982 A 15.44 0.00974 A2BP1 4114 1420058 C −8.62 0.04650 A2BP1 4120 1492382 C 11.69 0.01883 WWOX 4152 1922620 C 8.47 0.04436 MPHOSPH6 4163 8052512 T −15.17 0.00973 MPHOSPH6 4168 11645604 A −11.69 0.04876 CRISPLD2 4212 2641698 T −9.24 0.03290 CA10 4235 1501253 G −8.04 0.03701 CA10 4238 2970016 G 9.50 0.02212 CA10 4240 1503058 A −8.63 0.03181 ZFP161 4286 12604181 T 22.46 0.02818 PTPRM 4303 2509550 G −10.26 0.01680 CHST9 4317 4800797 G −10.74 0.02272 NEDD4L 4320 7243662 G −14.91 0.00869 NEDD4L 4323 292448 C −12.19 0.01301 CCBE1 4340 2851865 T 10.87 0.01560 CCBE1 4342 2564495 G 8.94 0.03843 CCBE1 4343 1560299 T 8.11 0.03784 CCBE1 4345 9954124 T 9.08 0.03681 DOK6 4378 8097743 G −7.73 0.04573 ATRN 4391 2670300 G −8.57 0.04216 FERMT1 4411 8121939 G 8.87 0.03128 PLCB1 4432 6118375 C 11.83 0.00946 MACROD2 4458 7509422 T −8.81 0.03627 PTPRT 4494 2866940 C 9.51 0.02822 PTGIS 4523 515633 A −15.94 0.03724 SNAI1 4524 6020157 A 13.30 0.02592 CDH4 4529 4347903 C 10.21 0.04356 CDH4 4530 4812313 G 8.52 0.04953 NCAM2 4549 2826852 C 8.43 0.03889 NCAM2 4550 973045 A −8.31 0.04192 NCAM2 4551 986917 A 8.13 0.04547 PCP4 4556 398802 G −7.92 0.04088 PDE9A 4562 2269145 T 13.28 0.00086 PDE9A 4564 12626774 C −13.28 0.00269

TABLE 5 Alleles Influencing Response to Ziprasidone Beta Gene Seq ID NCBI RS# Allele (PANSS) P KIF1B 3 4240911 C 9.08 0.03275 KIF1B 5 17401966 G 10.00 0.02342 KIF1B 6 12734551 G 9.47 0.02466 RP1-21O18.1 9 7539545 T −7.22 0.02811 AGBL4-C1ORF165 27 1934395 G −11.79 0.01637 LRP8 59 1416095 C 8.99 0.02855 ELTD1 61 2200810 G −14.72 0.00145 ELTD1 62 7552978 A 12.31 0.00046 ELTD1 63 12754818 C 9.47 0.00493 ELTD1 64 1352555 A 11.66 0.00104 ELTD1 66 10493622 A 12.10 0.00123 PTGFRN 92 1998922 A 10.85 0.01631 ATF6 99 1875762 T 13.32 0.04286 OLFML2B 111 12025136 C 9.46 0.03799 DPT 121 6427142 G −12.75 0.02446 RYR2 204 4376724 C 9.25 0.00789 C2ORF46 277 2562011 C 12.31 0.04666 C2ORF46 279 10210006 C −6.98 0.04505 KLHL29 297 17045574 A 39.49 0.00049 BRE 316 9309659 G −10.32 0.01956 CRIM1 333 11681392 T −8.28 0.03510 FEZ2 335 3770811 T −7.78 0.04220 FEZ2 336 1533946 G −7.68 0.04228 FEZ2 339 1179494 C 8.62 0.03384 C2ORF34 364 1067378 A 9.91 0.01158 C2ORF34 365 1067404 A 8.35 0.02429 C2ORF34 367 698792 A 8.35 0.02429 C2ORF34 373 1965789 C 8.02 0.02728 AAK1 441 12622388 G −9.39 0.02387 NAP5 477 1437909 G 8.12 0.03817 ZRANB3 490 11893424 A 19.63 0.04721 ZRANB3 491 1898524 T 19.63 0.04721 ARHGAP15 549 12478952 A −13.03 0.01912 ARHGAP15 560 10928200 T −7.07 0.03531 ARHGAP15 561 13031917 C −7.07 0.03531 FMNL2 587 1561267 C 12.60 0.03280 SCN1A 620 6432860 A 8.55 0.04669 CERKL 633 993650 G 9.92 0.02526 PDE1A 643 10497597 T −10.66 0.00616 PDE1A 645 11689230 T −9.45 0.01172 NRP2 673 13396083 C 9.55 0.01084 NRP2 674 7596827 C 8.96 0.01293 NRP2 675 6435306 A 8.36 0.02085 ERBB4 681 7563759 A 8.41 0.02528 ERBB4 683 4672668 G 7.81 0.02546 DNER 718 208791 A −14.15 0.01544 DNER 719 208784 G −14.15 0.01544 DNER 720 208785 G −14.15 0.01544 DNER 721 1323595 T −14.15 0.01544 DNER 722 208787 G −14.15 0.01544 TRIP12 723 6723005 T −14.15 0.01544 CNTN4 763 1032783 A 12.09 0.02697 ITPR1 776 3792490 A 8.08 0.04869 SLC6A6 794 1156567 C −11.62 0.03731 DAZL 799 17029179 C −10.70 0.03316 ULK4 828 4973875 C 8.31 0.02284 ULK4 831 6790569 A 10.17 0.01511 ULK4 832 9827383 C 9.98 0.00929 ULK4 833 10510719 A 9.64 0.01466 ULK4 836 9311275 C 12.05 0.00193 ULK4 837 9818955 C 12.24 0.00284 ULK4 841 6809441 C 9.93 0.00808 ULK4 842 11129908 A 7.58 0.04141 ULK4 843 7618902 G 10.22 0.00563 ULK4 848 9825741 A 13.26 0.02411 ULK4 849 17062109 T 12.68 0.02961 ULK4 850 7648578 T 12.68 0.02961 ULK4 851 3774372 C 12.68 0.02961 ULK4 852 1716685 T 12.68 0.02961 ULK4 853 2272007 A 12.68 0.02961 CACNA2D3 874 3773580 T −12.03 0.00211 CACNA2D3 875 3773569 A −10.79 0.00484 FLNB 910 12488636 C 9.12 0.00750 FLNB 911 12632456 A 8.96 0.00820 FLNB 912 7632986 T 10.69 0.00179 PRICKLE2 964 696017 A 19.24 0.01331 PRICKLE2 969 704398 G 16.10 0.02652 PRICKLE2 970 697288 T 14.55 0.03537 CDGAP 1018 7649930 G −7.50 0.03792 CDGAP 1019 1448434 C −7.50 0.03792 CDGAP 1020 6438523 A −7.50 0.03792 CDGAP 1022 6773050 C 7.89 0.04425 CPNE4 1060 2178383 G 9.24 0.00878 TNIK 1099 4955765 G 7.90 0.04965 PLD1 1104 181715 T 14.25 0.00070 LRRC15 1150 6799698 A 9.95 0.04529 SLC2A9 1162 13101772 A −16.65 0.03403 LIMCH1 1218 10026397 A −13.48 0.01236 LIMCH1 1219 4386634 G −12.75 0.01513 LIMCH1 1220 10006669 A −12.75 0.01513 LIMCH1 1221 10026359 T −11.52 0.01534 HERC3 1275 3796660 A −17.26 0.04705 HERC3 1276 2924942 T −9.92 0.02467 HERC3 1277 3017925 T −10.56 0.01611 HERC3 1278 2972021 A −9.92 0.02467 HERC3 1279 2972038 T −9.95 0.04291 FAM13A1 1285 17817631 T 13.13 0.01292 PAPSS1 1310 2522421 G −19.38 0.00665 PAPSS1 1311 2522422 A −19.38 0.00665 PAPSS1 1312 2522428 C −15.11 0.02685 PAPSS1 1313 4956136 C −14.48 0.00984 PAPSS1 1314 2158179 G −13.68 0.02076 ANK2 1351 29306 G 9.03 0.02869 GPR103 1380 17371804 T 8.54 0.03946 GPR103 1382 2013332 A −15.60 0.00293 GPR103 1385 17438900 C 8.54 0.03946 MAML3 1395 11729794 T −11.65 0.01147 MAML3 1398 1350036 T −10.40 0.01532 IL15 1402 7671019 A −7.91 0.03444 IL15 1403 6841939 A −8.22 0.03983 IL15 1404 2139383 C 7.33 0.04215 INPP4B 1418 3775655 C 14.59 0.04575 INPP4B 1419 7697702 C 23.21 0.00625 FSTL5 1461 45426 T −7.95 0.03181 SEMA5A 1535 985723 A 10.49 0.03673 SEMA5A 1545 150631 A −8.47 0.02109 DNAH5 1563 16902955 G −8.35 0.04972 DNAH5 1564 16902956 C −8.35 0.04972 DNAH5 1565 16902957 T −8.35 0.04972 DNAH5 1566 9312854 C −8.35 0.04972 SLC1A3 1586 6451305 C 7.61 0.03994 ITGA1 1615 1047481 G −9.04 0.00979 ITGA1 1616 6882655 A −11.32 0.00790 ITGA2 1617 989073 A −10.83 0.01968 TNPO1 1641 34653 T −11.03 0.03445 TNPO1 1643 266444 C −10.77 0.04440 TNPO1 1644 2548331 A 9.45 0.01692 FCHO2 1646 185435 G −10.77 0.04440 FBXL17 1707 6596770 C 8.67 0.02289 FBXL17 1709 2966805 C 8.32 0.03874 FBXL17 1715 12521975 T 8.32 0.03874 FBXL17 1716 6875297 A 8.40 0.03232 KCNN2 1724 1457762 A −9.30 0.04162 KCNN2 1725 4705504 T −8.88 0.04674 KCNN2 1731 10519388 C −12.61 0.00346 FTMT 1747 10447274 C −9.11 0.02638 TRPC7 1775 3777145 T 16.55 0.00264 TRPC7 1778 950714 G 16.55 0.00264 TRPC7 1779 2649691 A 13.42 0.01087 ODZ2 1789 1421989 G −9.39 0.03638 ODZ2 1798 3733988 T −8.71 0.01095 ODZ2 1799 1422421 T −10.86 0.00222 WWC1 1801 6893982 C 12.00 0.01232 ELOVL5 1889 1429146 T −10.60 0.00409 ELOVL5 1892 209500 T 9.45 0.00823 ELOVL5 1893 9357760 G −7.45 0.04511 ELOVL5 1894 9370196 C −7.45 0.04511 RIMS1 1917 12525154 A 9.94 0.04287 GABRR2 1919 4707535 T 8.96 0.04355 GABRR2 1920 6900958 T −8.72 0.02592 KLHL32 1921 6922974 A 9.93 0.01589 SLC22A16 1926 9400390 T 9.54 0.01475 NKAIN2 1957 173067 A −7.30 0.04805 PLAGL1 1990 9321951 T −10.19 0.02081 PLAGL1 1991 9390148 A 8.51 0.03238 SYNE1 2006 1844356 G 8.52 0.04995 PARK2 2044 7750033 T 9.93 0.01042 PARK2 2045 9364662 A −12.54 0.00244 PARK2 2046 9458610 G −12.54 0.00244 PARK2 2048 2803045 T −8.51 0.03522 PAPK2 2049 9456810 C 9.23 0.01868 SCIN 2092 2240571 G −9.01 0.00416 SCIN 2093 1034856 T 7.28 0.04436 FERD3L 2106 6963269 G −9.84 0.02537 FERD3L 2107 6967799 T −9.58 0.04433 FERD3L 2109 6461422 G −9.35 0.04636 FLJ22374 2148 10229281 A 14.63 0.02392 FLJ22374 2149 10235270 C 10.38 0.03228 PDE1C 2157 17336016 G −8.89 0.03168 EEPD1 2171 11765336 C 6.82 0.04860 ABCA13 2214 6958356 A −8.36 0.03159 HIP1 2255 1167802 C −11.66 0.00744 MAGI2 2287 1990432 A −11.65 0.01842 MAGI2 2288 6466535 C −14.03 0.00601 ABCB4 2351 31662 A −15.48 0.02305 ABCB4 2352 31669 A −17.13 0.01857 CUX1 2404 2960266 A 8.19 0.04899 CUX1 2406 10277680 A 7.91 0.04274 CUX1 2407 12537077 T 7.18 0.04337 DGKI 2477 4728414 C −7.79 0.04962 CNTNAP2 2508 1637864 T 11.76 0.01832 CNTNAP2 2509 1637840 T 11.76 0.01832 PTPRN2 2528 6459879 C −11.04 0.00677 PTPRN2 2529 1377374 T −11.04 0.00677 PTPRN2 2530 11765319 G 13.12 0.00710 PTPRN2 2531 4909222 G 13.91 0.00809 CSMD1 2549 2938236 T −15.96 0.02797 MCPH1 2559 2916741 G 13.30 0.00549 MCPH1 2560 2442497 G 14.30 0.02113 MCPH1 2561 2442496 G 14.28 0.00299 MCPH1 2562 2442492 T 14.28 0.00299 PSD3 2609 11782622 C −11.34 0.03407 GFRA2 2618 17427734 A 13.63 0.00068 PPP3CC 2625 13271367 G −7.38 0.04313 LYN 2673 1546518 C −10.47 0.00218 NKAIN3 2722 11989852 A 13.50 0.02102 NKAIN3 2724 17279355 G 11.60 0.03751 DEPDC2 2732 7007570 G 8.82 0.01437 DEPDC2 2733 13262547 G −7.34 0.03639 SAMD12 2828 16891338 G 22.53 0.02160 FBXO32 2830 6990407 G 10.85 0.02815 FER1L6 2835 7819813 A −7.58 0.04488 FER1L6 2836 11784115 A −7.58 0.04488 MTSS1 2856 6470298 A −39.87 0.01587 SMARCA2 2930 7875236 C −13.17 0.00109 SMARCA2 2931 2147263 T 7.25 0.04908 SMARCA2 2932 4741650 T −10.01 0.01459 PTPRD 2943 10124689 T 9.95 0.01535 PTPRD 2944 7036240 A −9.33 0.01486 PTPRD 2946 10977089 C 8.82 0.03318 PTPRD 2947 2031216 G 9.27 0.01691 PTPRD 2948 4742502 C −8.17 0.02984 PTPRD 2951 7027844 C −8.34 0.03640 MAMDC2 3014 1927143 T −15.03 0.00891 MAMDC2 3017 2773362 T −11.08 0.04760 TRPM3 3022 10868855 C 12.72 0.00762 TRPM3 3024 12552572 C −8.80 0.04786 GNAQ 3062 4641131 A −10.73 0.01174 GNAQ 3063 4745687 G −10.16 0.01341 GNAQ 3064 11145653 A −10.16 0.01341 GNAQ 3066 964423 T −10.16 0.01341 GNAQ 3067 4744858 A −9.59 0.02990 GNAQ 3068 10781482 T −9.59 0.02990 GNAQ 3069 7038083 G 8.74 0.01344 NFIL3 3092 7038686 A 14.05 0.00033 NFIL3 3093 4743835 A 10.03 0.01351 NFIL3 3094 4743836 T 12.65 0.00373 NFIL3 3095 4743837 A 12.65 0.00373 HIATL1 3099 9409765 A −9.40 0.01148 HIATL1 3100 9409552 G −9.40 0.01148 GABBR2 3103 3824451 G −12.63 0.02597 SVEP1 3124 963143 A 9.18 0.00632 SVEP1 3125 1571236 T −8.54 0.02390 CDK5RAP2 3137 4837771 T −10.50 0.01603 CDK5RAP2 3138 3750494 G −10.11 0.03530 CDK5RAP2 3139 10818467 C −12.93 0.04769 NPDC1 3202 4880195 C −9.44 0.03379 PITRM1 3222 6602036 A 8.85 0.04411 PRKCQ 3227 582052 G 8.68 0.01225 PRKCQ 3229 1889001 A 8.68 0.01225 CACNB2 3238 7923191 G 8.88 0.04690 ARMC3 3243 10764350 T 10.37 0.00789 ARMC3 3244 7899968 A 9.89 0.00865 ARMC3 3246 7919349 G 12.06 0.00295 ARMC3 3247 1171136 A 9.81 0.01694 ARMC3 3250 10828389 T 8.40 0.03457 MYO3A 3283 16926660 A −20.85 0.01378 SLC16A9 3294 10128501 G −7.21 0.03515 CDH23 3305 17635709 T −9.49 0.02234 KCNMA1 3319 2288840 G −8.61 0.04504 KCNMA1 3321 7069982 A −8.37 0.04942 NRG3 3339 17099789 G −9.84 0.02486 NRG3 3344 342361 G 8.89 0.02602 SORBS1 3363 11188299 C 48.52 0.00262 SORCS3 3384 10160134 A 9.25 0.02013 SORCS3 3385 697189 C 9.21 0.02224 SORCS3 3386 697190 C 8.60 0.03054 SORCS3 3387 7092104 C −8.26 0.04870 HSPA12A 3424 12777585 C −13.87 0.00037 GALNTL4 3468 4910288 A 8.82 0.01247 GALNTL4 3469 4910289 C 10.74 0.00517 ARNTL 3487 10832012 C 10.79 0.00913 ARNTL 3488 900144 G 10.54 0.00720 ARNTL 3491 10766073 A 11.30 0.00573 ARNTL 3492 10832020 C 14.35 0.00676 ARNTL 3493 9633835 A 10.92 0.00651 DLG2 3526 11233565 C 18.75 0.03009 DLG2 3527 3793946 T 7.93 0.03160 ELMOD1 3557 494957 C −10.69 0.01804 OPCML 3568 3018406 A −10.82 0.01137 LOC729025 3626 1671486 T −13.53 0.01429 LOC729025 3627 10734895 A −12.68 0.01666 CNOT2 3641 2118427 T −13.61 0.03659 CNOT2 3647 11178177 T −10.06 0.00931 CNOT2 3648 10506586 A −14.16 0.03891 CNOT2 3650 3817486 G −14.16 0.03891 CNOT2 3652 3817487 A −7.20 0.04872 NAV3 3663 11106732 G 10.46 0.01720 NAV3 3664 939458 G 9.28 0.03656 NAV3 3675 10859738 A −8.05 0.04335 NBEA 3704 2322289 C 11.51 0.02846 NBEA 3705 867503 C 17.05 0.00137 NBEA 3706 9600364 C 13.81 0.04421 NBEA 3707 2243774 C 12.69 0.00924 NBEA 3708 1160720 G 12.69 0.00924 NBEA 3712 9544444 A −7.51 0.04242 NBEA 3713 1381476 A −7.12 0.04902 FNDC3A 3734 7321178 G −9.01 0.04261 LMO7 3743 9530467 G −7.04 0.04602 GPC6 3798 995810 C 10.54 0.03120 GPC6 3799 1323974 C 10.54 0.03120 NALCN 3826 655365 A 10.44 0.03287 WDR23 3854 6573565 A −8.66 0.03293 WDR23 3855 11574503 C −8.66 0.03293 SLC25A21 3878 2073248 C −19.35 0.02491 LRFN5 3898 1241781 G −9.72 0.00583 LRFN5 3900 4143896 A −10.07 0.00549 LRFN5 3901 8020273 G −9.22 0.01337 LRFN5 3903 17112319 A −8.32 0.02770 RGS6 3930 2332699 C 8.96 0.01512 NRXN3 3955 4020132 T 15.65 0.01514 KCNK10 3965 17698533 C 8.48 0.01786 KCNK10 3966 12185033 T 8.33 0.02138 RYR3 4021 1980102 A −8.62 0.03936 RYR3 4030 1390159 T 28.21 0.01695 RYR3 4031 2132208 A 18.48 0.01782 C15ORF41 4037 4923719 G −9.69 0.04662 GLDN 4056 17524318 A 9.41 0.04870 GLDN 4063 17648140 G 10.39 0.02065 CGNL1 4074 2131730 T −12.53 0.01317 CGNL1 4075 2131731 G −12.53 0.01317 CGNL1 4077 2932209 G −12.10 0.01505 ARNT2 4104 4778836 T 9.58 0.01514 ARNT2 4105 7180510 G 8.54 0.03190 A2BP1 4135 11648047 C 12.29 0.02677 A2BP1 4136 2079753 T 10.95 0.04625 TMC5 4141 1023446 C −7.95 0.02869 MPHOSPH6 4162 7405231 C −8.41 0.01341 MPHOSPH6 4168 11645604 A 9.19 0.03174 MPHOSPH6 4170 2967355 A −8.48 0.04369 CDH13 4202 889491 T −9.24 0.02597 CRISPLD2 4217 11862286 A 12.81 0.04030 ZFP161 4282 990072 T 9.74 0.03711 PTPRM 4297 2230601 C 9.94 0.00699 PTPRM 4299 507445 T 10.76 0.00511 PTPRM 4300 630778 G 8.63 0.02079 PTPRM 4301 6506572 T 7.69 0.02980 PTPRM 4302 9949149 C 7.69 0.02980 NEDD4L 4328 4940385 C −8.10 0.02725 NEDD4L 4333 12373325 T −8.73 0.03815 CDH20 4348 1509128 T −7.19 0.03575 FERMT1 4408 6117065 A 9.07 0.02962 JAG1 4439 3748477 T 22.35 0.00872 JAG1 4440 3748478 T 21.96 0.01027 SNAI1 4524 6020157 A 9.47 0.03580 SNAI1 4526 16995010 C 11.56 0.04852 SNAI1 4528 6020187 G 12.58 0.01606 NCAM2 4542 2826349 G −11.69 0.01381 NCAM2 4543 2826351 A −11.69 0.01381 NCAM2 4551 986917 A 9.05 0.02234 PCP4 4557 2837279 C 10.32 0.04030 PCP4 4559 2837283 T 10.32 0.04030 ARVCF 4567 1110477 C 34.11 0.00323 ARVCF 4568 887200 C 25.02 0.01002 ARVCF 4570 887203 A 34.11 0.00323 HPS4 4574 5761552 T −7.93 0.02600 HPS4 4577 5761557 A −11.17 0.04242 EFCAB6 4604 6006521 G −8.28 0.03345 EFCAB6 4607 1894489 A −8.28 0.03345

TABLE 6 Alleles Influencing Time to Discontinuation for Olanzapine Gene Seq ID NCBI RS# Allele Beta (Months) P SCP2 39 7528867 A −5.09 0.03956 PRKACB 74 2642186 G −3.69 0.02840 NGF 82 7513144 C −6.44 0.00532 NGF 84 17033706 A −5.62 0.01618 ATF6 100 2089083 T 5.20 0.02796 FAM78B 114 4072242 T 3.71 0.01635 FAM78B 115 4339838 A 3.71 0.01635 FAM78B 116 6426968 T 3.46 0.02396 FAM78B 117 1002160 A 3.74 0.02369 FAM78B 118 7521995 C 3.59 0.03082 USH2A 157 11120703 C −4.96 0.03071 GNG4 192 10925976 A −3.29 0.02209 GNG4 193 508208 G 3.22 0.02748 RYR2 203 4659786 A −3.34 0.02006 RYR2 204 4376724 C 3.24 0.03034 RYR2 205 3924864 C −4.71 0.01844 ASXL2 302 10180842 G −3.88 0.03025 ASXL2 303 1076000 A −3.88 0.03025 ASXL2 304 6758088 A −3.61 0.04493 ASXL2 305 10182811 T −3.61 0.04493 BRE 323 6747817 G −3.45 0.02410 SLC8A1 350 4952404 T −3.88 0.03259 PRKCE 376 666334 T 3.33 0.04249 EPAS1 393 7589621 A 3.87 0.02990 EPAS1 394 6707241 C −3.33 0.03095 EPAS1 396 7594278 T −3.47 0.03104 CCDC85A 421 2869529 C −3.33 0.01914 CTNNA2 442 6719738 T 5.42 0.00368 CTNNA2 443 2566539 T 3.67 0.02132 CTNNA2 444 1971766 A 4.50 0.00543 CTNNA2 464 318362 C 3.50 0.02918 LRP1B 508 2171169 A 6.96 0.00601 LRP1B 511 1949871 C 3.23 0.03086 LRP1B 514 4954907 T 3.73 0.04161 KYNU 525 2278587 A 5.77 0.03983 ARHGAP15 538 11895997 A 4.21 0.00457 ARHGAP15 559 16823114 A 4.94 0.00164 ARHGAP15 560 10928200 T 5.03 0.00232 ARHGAP15 561 13031917 C 5.03 0.00232 CACNB4 573 10497094 G 5.55 0.01135 PKP4 594 4664963 G −7.01 0.03893 SCN9A 628 4447616 C 4.22 0.00360 SCN9A 629 6732627 A 4.07 0.00572 CERKL 631 10490688 T −3.69 0.02450 CERKL 632 895901 A −3.69 0.02450 CERKL 634 1967351 C 3.94 0.01038 PARD3B 657 2878473 C 3.87 0.02264 NRP2 672 849565 C 4.93 0.00871 CNTN4 761 1685456 C 3.44 0.02879 ARPP-21 819 3772395 T 4.58 0.04977 ARPP-21 822 2305234 A 4.58 0.04977 ULK4 829 6763756 T 3.89 0.00302 ULK4 832 9827383 C 4.75 0.00401 ULK4 833 10510719 A 3.83 0.01676 ULK4 834 9311270 C 4.11 0.00161 ULK4 836 9311275 C 3.61 0.00782 ULK4 842 11129908 A 2.77 0.03492 FHIT 918 7621056 A −3.75 0.02014 FHIT 919 11709440 C −3.72 0.04271 SYNPR 954 1505600 C 4.67 0.00992 SYNPR 955 4616634 G 4.67 0.00992 PRICKLE2 965 696019 A 3.12 0.04836 EPHA6 1004 2873617 G 6.10 0.03693 PLCXD2 1010 1513331 C −6.77 0.00092 CDGAP 1021 10934491 C −3.51 0.03857 CPNE4 1049 6792146 A −4.53 0.02011 CPNE4 1050 16836991 T −4.69 0.04000 SERPINI2 1089 17246389 C −4.35 0.00680 HTR3D 1128 939334 G −3.36 0.03207 LDB2 1172 10755217 G 3.92 0.02075 LDB2 1173 2135442 A 3.14 0.04385 LDB2 1181 1384606 T 4.18 0.00961 SLIT2 1189 609535 A 2.98 0.03598 SLIT2 1191 9992591 C 3.01 0.04079 PDLIM5 1301 951613 A −2.88 0.04914 COL25A1 1317 2305438 A −4.35 0.00204 COL25A1 1319 13104307 T 4.25 0.00418 COL25A1 1334 987695 G 3.78 0.01371 COL25A1 1335 7675657 A 3.79 0.01212 ANK2 1344 10488904 A −3.45 0.04253 ANK2 1351 29306 G 3.42 0.04294 ANK2 1353 29311 A 3.79 0.02417 NDST3 1369 2291416 G 4.80 0.02019 NDST3 1370 2254215 A 4.80 0.02019 NDST3 1372 2389498 T 4.80 0.02019 GPR103 1381 13110738 G −4.32 0.01034 MAML3 1387 2246759 G 2.68 0.04943 MAML3 1388 13105452 T −2.96 0.04884 DCLK2 1441 12513356 G 7.25 0.02007 FSTL5 1452 4501178 C −3.91 0.03044 FSTL5 1457 10013537 T −3.59 0.02595 FSTL5 1458 1560925 A −3.56 0.03737 FSTL5 1459 7679398 C −3.18 0.04707 PALLD 1500 13122019 A −4.08 0.00577 PALLD 1501 1039385 G −3.76 0.01217 ENPP6 1520 11132220 A −3.91 0.00434 ENPP6 1521 6829678 C −3.38 0.01190 ENPP6 1523 6831986 C −3.32 0.01562 ENPP6 1524 17679120 A −3.10 0.02310 AHRR 1530 3734145 T −4.20 0.00618 AHRR 1531 2721004 T −3.75 0.01586 SEMA5A 1536 17235037 T −5.14 0.04437 DNAH5 1548 6862469 C −3.26 0.04034 DNAH5 1549 6876673 T −3.38 0.04722 DNAH5 1554 1502050 G −4.88 0.00553 DNAH5 1555 10513155 A 3.55 0.01611 DNAH5 1563 16902955 G −3.64 0.01359 DNAH5 1564 16902956 C −3.64 0.01359 DNAH5 1566 9312854 C −3.64 0.01359 CDH10 1575 3822429 T 3.02 0.01856 ITGA1 1603 6883810 A −3.09 0.04953 ITGA1 1606 10513001 G −3.93 0.01402 GPR98 1682 168743 G 3.61 0.04407 FBXL17 1709 2966805 C −3.16 0.02699 FBXL17 1710 2922434 A −3.16 0.02699 FBXL17 1715 12521975 T −2.83 0.04529 SNCAIP 1749 7444144 G −4.03 0.02367 SNCAIP 1751 17149141 A −5.25 0.00917 ADAMTS19 1767 30651 G 4.12 0.01213 ADAMTS19 1769 4835975 A 4.28 0.01770 SLC22A23 1808 7775219 C 4.84 0.01188 SLC17A4 1847 4712969 A 6.26 0.03299 SLC17A4 1849 4712972 A 6.26 0.03299 SLC17A4 1851 1892253 T 6.26 0.03299 SLC17A1 1853 1324082 A 7.45 0.00016 SLC17A1 1855 13200784 T 5.96 0.00298 SLC17A3 1860 1165158 T 5.74 0.00507 SLC17A2 1864 13207673 T 8.13 0.03010 BTN3A1 1873 10946826 G 4.06 0.04974 BTNL2 1876 3806156 T 3.92 0.01504 BRD2 1879 194677 T 7.97 0.03348 ABCC10 1885 4714684 C −3.28 0.02282 GABRR2 1920 6900958 T 4.85 0.00568 KLHL32 1922 1766519 C 4.36 0.04226 SLC22A16 1927 9320331 A −2.98 0.03190 SLC22A16 1928 9481067 G −3.15 0.02376 TRDN 1949 2317707 T 3.44 0.04047 NKAIN2 1956 4897531 T −5.56 0.00561 PDE7B 1979 9385741 A −9.79 0.02169 PDE7B 1981 7772608 G −9.79 0.02169 SYNE1 2005 2763015 A −3.04 0.04326 PDE10A 2058 220771 T −4.31 0.03248 PDE10A 2065 9459474 C 3.29 0.04340 ETV1 2098 4721291 C −3.57 0.00685 SNX13 2100 2177652 T −3.01 0.03839 PLEKHA8 2135 10951257 G −5.03 0.01445 FLJ22374 2145 7781249 A −3.16 0.04856 BMPER 2166 2110856 C 3.31 0.03886 ABCA13 2194 17132289 T 5.86 0.04658 ABCA13 2196 17548783 C 4.09 0.00678 ABCA13 2198 17729647 G 4.10 0.02276 ABCA13 2199 7778020 A 5.30 0.03759 ABCA13 2213 10216298 G 4.48 0.04991 WBSCR17 2231 12538186 G −3.31 0.02926 WBSCR17 2232 757841 C −3.31 0.02926 WBSCR17 2234 17593300 G −3.31 0.02926 WBSCR17 2235 2190223 C −3.03 0.04859 GTF2IRD1 2252 2267834 G −3.25 0.03665 MAGI2 2266 6466021 G 3.05 0.04279 MAGI2 2281 7803949 A 3.75 0.04130 MAGI2 2299 2364920 G 3.77 0.03832 CACNA2D1 2308 258728 A 4.06 0.01520 PCLO 2310 10954689 T 4.69 0.00249 PCLO 2320 9656532 A −4.15 0.01316 PCLO 2321 2715148 A 3.39 0.01526 PCLO 2322 2522833 C 3.54 0.02043 PCLO 2324 2522843 A 3.15 0.03569 PCLO 2326 1986742 G −3.01 0.04113 SEMA3E 2344 169992 C 3.18 0.02776 ABCB4 2352 31669 A −7.80 0.00472 PON1 2366 662 G 3.57 0.02993 PON1 2382 2057681 G 3.61 0.03020 DYNC1I1 2390 4357216 C −7.82 0.00017 DYNC1I1 2391 10243540 G −4.51 0.02003 DYNC1I1 2396 42066 A −5.13 0.03555 KCND2 2414 7795646 G 4.45 0.03295 KCND2 2416 5009999 T 7.17 0.00030 CNTNAP2 2510 2717829 C −4.67 0.04813 PTPRN2 2514 11771772 A 2.76 0.04281 PTPRN2 2516 221242 A −7.62 0.00810 PTPRN2 2523 10277112 A 4.39 0.00576 CSMD1 2536 2930282 C −4.67 0.02689 CSMD1 2537 622765 A −4.67 0.02689 SGCZ 2580 2898389 C −3.13 0.03705 SGCZ 2581 7000337 T 3.79 0.01891 SGCZ 2582 10092634 C 4.52 0.00250 SGCZ 2583 1551816 G 3.71 0.02480 SGCZ 2592 17119601 G 3.63 0.02307 SGCZ 2595 7817295 A −3.49 0.01689 GFRA2 2618 17427734 A −3.28 0.02327 SNTG1 2661 12545915 T −3.21 0.04681 NKAIN3 2710 1383154 A 3.65 0.02232 CRISPLD1 2757 1455811 C 4.21 0.03212 CRISPLD1 2758 13248650 G 3.64 0.04136 CRISPLD1 2759 16939030 C −3.63 0.04272 MMP16 2768 10504845 T −3.96 0.03978 BAALC 2785 1845430 A −3.09 0.04456 ZFPM2 2792 12677825 T 2.94 0.04721 SAMD12 2819 10955887 C −3.37 0.02118 SAMD12 2820 4876841 A −3.37 0.02118 SAMD12 2821 10096317 A −3.37 0.02118 SAMD12 2822 7830423 C −3.37 0.02118 DDEF1 2860 10956511 T −3.24 0.03378 DDEF1 2862 12546206 A −3.05 0.03773 DDEF1 2877 1123205 G −3.70 0.01429 ADCY8 2889 17248206 G 4.16 0.00473 ADCY8 2891 7464362 G −3.53 0.00509 ADCY8 2892 11781997 A −3.21 0.01501 ADCY8 2893 7459573 G −2.80 0.03771 ADCY8 2894 4736722 C 3.54 0.01032 SMARCA2 2922 16937123 C −6.17 0.01464 IFT74 2985 2095405 C −4.04 0.03292 PIP5K1B 2999 872077 A 4.48 0.01597 TMC1 3030 6560293 A −2.93 0.04807 TMC1 3032 13285999 A −3.63 0.01250 TMC1 3033 10869190 A 3.29 0.02338 TMC1 3042 2501914 T −2.98 0.04993 NTRK2 3071 11140721 C −4.71 0.03889 DIRAS2 3088 7028171 A −3.45 0.04791 NFIL3 3090 7869771 C 3.78 0.01190 GABBR2 3102 10985811 C 4.14 0.01432 GABBR2 3104 13286336 C 3.72 0.02693 GABBR2 3105 16914811 A 3.68 0.03133 ZNF618 3131 1965753 T 3.40 0.02344 ZNF618 3132 10121424 T −4.06 0.01265 ZNF618 3133 1408115 G 3.40 0.02344 CDK5RAP2 3140 4837782 T 5.54 0.04600 LHX6 3149 7849627 G −3.07 0.04970 ABL1 3165 2855160 T 2.78 0.03940 EXOSC2 3166 4740366 G 4.17 0.01924 PNPLA7 3204 10867123 G 3.89 0.03144 ARHGAP21 3253 10764482 G −4.60 0.00968 ARHGAP21 3254 7070456 C −5.75 0.00076 ARHGAP21 3255 10828686 C −4.58 0.00507 ARHGAP21 3256 4415644 T −4.61 0.01621 ARHGAP21 3257 7897303 A −4.61 0.01621 MYO3A 3267 993397 A −3.33 0.02291 MYO3A 3269 17666079 C 3.13 0.01616 MYO3A 3280 1999240 C −2.89 0.04492 MYO3A 3281 3758447 C 2.96 0.02617 JMJD1C 3296 10761739 C −5.56 0.00016 JMJD1C 3297 10995505 A 3.25 0.03575 JMJD1C 3298 10740118 C −5.56 0.00016 JMJD1C 3300 12355784 A −4.21 0.00317 JMJD1C 3301 9629895 A 3.28 0.04259 JMJD1C 3302 3999089 C −4.22 0.00356 NRG3 3339 17099789 G 3.87 0.03706 NRG3 3346 512064 A −3.52 0.01230 NRG3 3347 495978 A −3.24 0.03001 NRG3 3353 17763320 A −5.32 0.04684 SORBS1 3358 11188287 G −3.73 0.04151 SORBS1 3362 11188298 C 2.87 0.04700 ATRNL1 3421 180675 A −4.33 0.01804 ATE1 3431 1693688 C −3.07 0.03457 ATE1 3435 1219505 T −2.99 0.04504 SPON1 3501 11023054 A 3.15 0.02514 SPON1 3502 10832165 A 2.89 0.03895 SPON1 3503 7112850 A 2.89 0.03895 SPON1 3504 10766134 G 2.89 0.03895 KCNA4 3517 7931190 T 3.98 0.01256 KCNA4 3518 605765 G 3.44 0.01298 LOC729025 3626 1671486 T −4.36 0.02401 ITPR2 3640 2230375 G −3.52 0.03207 CNOT2 3644 11178116 C 6.30 0.00528 CNOT2 3645 7312236 C 3.56 0.03545 CNOT2 3648 10506586 A −6.01 0.03028 CNOT2 3650 3817486 G −6.01 0.03028 CNOT2 3654 1495345 C −3.23 0.01523 NAV3 3678 1375287 C −3.04 0.04760 PLA2G1B 3687 5637 A 4.83 0.00749 N4BP2L2 3700 3742318 C −3.64 0.04574 NBEA 3722 3818423 C 4.64 0.04656 LMO7 3752 7986131 T 3.01 0.04927 SLAIN1 3756 1279445 G 6.48 0.01371 SLAIN1 3757 1279446 C 3.81 0.02101 GPC5 3771 553717 A −6.18 0.00873 GPC5 3772 342678 A −6.02 0.01104 GPC5 3773 342677 A −4.13 0.04743 GPC5 3792 17267453 C 5.64 0.01743 GPC6 3803 3899317 A −3.95 0.01952 GPC6 3809 7987964 T −3.70 0.01325 LRFN5 3895 1597045 T −3.81 0.01313 LRFN5 3897 4904776 C 3.58 0.02275 SAMD4A 3912 1212968 C −3.87 0.03653 RPS6KA5 3973 941847 T 3.22 0.04847 RPS6KA5 3975 1286060 C 3.55 0.02952 RPS6KA5 3978 1075014 C 3.50 0.01889 RPS6KA5 3980 7492628 G 3.63 0.01120 BCL11B 4000 2793321 T 4.42 0.01012 BCL11B 4001 1257446 C 5.33 0.00168 BCL11B 4002 1257416 G 4.49 0.01570 C15ORF41 4042 16964046 T 6.14 0.03662 C15ORF41 4045 16964103 T 5.94 0.04342 C15ORF41 4046 16964104 G 5.94 0.04342 C15ORF41 4047 17508461 T 5.94 0.04342 RASGRP1 4054 6492847 G 5.25 0.00540 CLK3 4086 11072496 T −4.09 0.03208 CLK3 4087 7161903 G −4.09 0.03208 ARNT2 4101 4778800 T 3.64 0.03664 A2BP1 4137 8054765 G 4.12 0.01511 CDH13 4182 1000078 C 4.19 0.00832 CDH13 4183 4783266 A 3.21 0.04507 CDH13 4184 11646849 A 2.86 0.03936 CDH13 4186 4598906 T 3.25 0.03776 ALOX12B 4218 9914077 G −4.28 0.00474 CA10 4247 4635383 C 3.15 0.04481 CA10 4250 9303606 C −3.34 0.02638 CA10 4251 12945099 C −2.91 0.03607 DLGAP1 4279 9948987 A −5.08 0.00652 ZFP161 4281 581144 T 3.23 0.04853 PTPRM 4291 1893224 C −7.33 0.03051 KIAA0802 4307 16954483 C 4.30 0.03846 NEDD4L 4334 9966665 G 4.16 0.03637 ZNF544 4388 260454 T −2.55 0.04837 ATRN 4392 2670314 A −3.66 0.01608 PRNT 4396 2236284 G 4.15 0.00569 PRNT 4397 6139537 T −4.72 0.00574 PRNT 4400 6052824 A −3.47 0.02246 PRNT 4402 6107527 G −3.95 0.00329 PRNT 4407 6084876 T 3.85 0.00683 PLCB1 4414 6055577 A −7.21 0.00012 PLCB1 4415 2235212 A −5.36 0.00098 PLCB1 4417 16994533 G −4.89 0.02509 PLCB1 4418 6077339 C 3.21 0.02841 PLCB1 4419 6055697 A 3.21 0.02841 MACROD2 4454 2236008 T 3.63 0.02258 MACROD2 4456 11697488 T 4.22 0.00955 NCAM2 4546 2826830 G −4.76 0.00790 NCAM2 4547 3787603 G −4.40 0.01385 NCAM2 4548 2826841 T −4.20 0.01788 MIRN155 4554 2828908 T 4.72 0.02933 PDE9A 4561 2269139 T −5.29 0.02419 PACSIN2 4590 2072883 G 3.22 0.04840

TABLE 7 Alleles Influencing Time to Discontinuation for Risperidone Beta Gene Seq ID NCBI RS# Allele (Months) P KIF1B 4 912962 G 2.65 0.02340000 RP1-21O18.1 7 6663699 G 3.33 0.01853000 RP1-21O18.1 8 7518989 C 3.97 0.04221000 RP1-21O18.1 15 4501834 C 2.90 0.03302000 PRKACB 74 2642186 G −4.52 0.00893200 SYT6 78 611514 A −2.76 0.03642000 NGF 80 6327 A 3.57 0.00304100 NGF 81 12145726 G −3.10 0.02638000 SEC16B 128 2862300 G −3.05 0.02147000 RYR2 212 3766884 T 5.09 0.00242100 CHRM3 227 663927 A 3.23 0.02766000 FMN2 232 10926147 G −2.63 0.03394000 PLD5 266 400904 T 2.77 0.04121000 C2ORF46 276 3102945 C 3.27 0.01632000 C2ORF46 279 10210006 C −2.96 0.03525000 KLHL29 298 7560892 A 2.44 0.04522000 SLC8A1 348 389109 T 2.98 0.03861000 OTX1 431 11125946 A −2.44 0.04789000 CTNNA2 445 2566542 C −3.25 0.04001000 CTNNA2 457 2165975 T 6.80 0.00024050 CTNNA2 460 160864 T 2.92 0.00717700 CTNNA2 463 318369 G 2.92 0.00935100 CTNNA2 465 895388 T 6.59 0.00305500 CTNNA2 466 1930 T 3.67 0.01004000 CTNNA2 467 12464777 T 2.70 0.04571000 NXPH2 499 11686876 T 3.66 0.00602200 LRP1B 502 1486958 G 2.17 0.04586000 LRP1B 503 1492388 T 2.17 0.04586000 LRP1B 507 4447563 G 2.56 0.03286000 KYNU 527 10176234 A 2.91 0.01925000 FMNL2 585 11682487 C 2.87 0.03337000 PKP4 599 2711066 C −3.38 0.03270000 SCN3A 618 11677254 C 2.99 0.01443000 PDE1A 638 2623422 G 3.22 0.02246000 PDE1A 641 6736414 T −2.90 0.02767000 ERBB4 680 1992029 G −2.89 0.04336000 COL4A3 698 6741679 A 3.61 0.00245000 COL4A3 701 6756898 C −3.20 0.03855000 CNTN6 736 11925058 C −3.10 0.01551000 CNTN6 741 1353825 T 2.59 0.04167000 CNTN6 742 265799 G −2.51 0.03496000 CNTN6 746 3772290 T −2.52 0.03244000 DAZL 801 4685357 T −2.92 0.01258000 DAZL 802 6787063 G −2.58 0.02359000 RARB 806 1286738 T −3.52 0.01698000 RARB 808 1656463 A −3.42 0.01978000 ERC2 896 885211 A 3.24 0.01495000 MAGI1 973 17073075 T 2.85 0.03110000 FOXP1 984 2196356 C 3.67 0.01155000 FOXP1 985 2597312 C 2.41 0.04753000 EPHA6 1008 6439265 T 3.21 0.03918000 EPHA6 1009 2317212 A 3.07 0.04515000 CPNE4 1053 13319291 G 2.70 0.03769000 CPNE4 1054 9812534 C −3.54 0.00697100 EPHB1 1067 936323 T 2.37 0.03698000 EPHB1 1070 4894286 A −2.48 0.04769000 CLSTN2 1079 9875409 G 3.68 0.00858000 CLSTN2 1080 347975 G 3.61 0.00676700 CLSTN2 1081 347973 A 3.66 0.00883400 NLGN1 1120 12636180 T 3.65 0.00836300 LEPREL1 1139 893054 T 3.07 0.02936000 LEPREL1 1140 573533 A 3.07 0.02936000 UBXD7 1154 7374260 C −2.34 0.03482000 SLIT2 1188 10516357 A −3.39 0.01791000 SLIT2 1190 2168802 T −3.23 0.03660000 LPHN3 1231 995447 C 6.10 0.02237000 SCD5 1268 6852540 C −2.73 0.02726000 FAM13A1 1280 7657817 T −3.41 0.03091000 COL25A1 1334 987695 G 3.06 0.01774000 COL25A1 1337 6816017 G 3.38 0.01769000 COL25A1 1338 7673867 A 3.38 0.01769000 MAML3 1392 10024138 T −2.94 0.02936000 MAML3 1394 2271391 T −2.92 0.03381000 MAML3 1396 11733737 T 2.48 0.04880000 MAML3 1397 17051001 T −2.46 0.04833000 DCLK2 1432 4405992 A 3.21 0.02212000 DCLK2 1435 12503886 A 3.20 0.02214000 DCLK2 1437 10001651 C 4.30 0.00120900 DCLK2 1438 11735949 C 3.92 0.00246700 DCLK2 1439 17503402 A 5.94 0.00000006 DCLK2 1440 11727182 G 6.09 0.00000015 DCLK2 1442 6535725 A 5.25 0.00000354 FSTL5 1455 6825091 A −3.98 0.00353700 FSTL5 1456 7442468 C −3.72 0.00854400 TLL1 1475 719753 G −4.17 0.02645000 TLL1 1481 1391334 G −2.66 0.03191000 DNAH5 1562 13154455 G 2.55 0.03762000 MYO10 1570 11750538 G 3.76 0.00464500 MYO10 1571 1560089 T 4.19 0.00092940 MYO10 1572 890910 A 4.06 0.00143400 MYO10 1573 11133860 G 3.49 0.03594000 EGFLAM 1587 4869576 T 5.29 0.04848000 ITGA2 1617 989073 A −3.08 0.01383000 PDE4D 1629 193447 T −3.44 0.01478000 VCAN 1663 28296 A −3.19 0.02343000 VCAN 1667 4558964 G −2.81 0.03877000 KCNN2 1727 3857431 T −2.53 0.04948000 LOC340069 1745 919306 C −2.90 0.03084000 LOC340069 1746 328694 A −2.67 0.03825000 ODZ2 1790 13158058 T −2.88 0.04543000 ODZ2 1797 7708354 G −3.87 0.00204100 BTNL2 1877 3763309 A −2.83 0.04171000 ELOVL5 1889 1429146 T −2.51 0.04782000 ELOVL5 1893 9357760 G −3.32 0.01840000 ELOVL5 1894 9370196 C −3.11 0.02945000 ELOVL5 1895 9474507 A −4.09 0.01209000 ELOVL5 1896 1429143 G −3.50 0.02476000 SLC22A16 1933 2428175 A 3.37 0.01885000 TRDN 1937 17737379 T −3.81 0.03039000 EYA4 1978 6929938 A 2.76 0.04420000 PARK2 2020 12055483 T 2.74 0.03047000 PARK2 2021 6924602 C 2.82 0.02018000 CREB5 2119 2237361 C 3.06 0.00892500 PLEKHA8 2139 7806238 A −3.85 0.04894000 PDE1C 2152 10224888 T 2.91 0.01164000 PDE1C 2153 3213709 G 3.98 0.01262000 ABCA13 2196 17548783 C 2.62 0.02556000 WBSCR17 2230 7808758 C −2.62 0.03618000 WBSCR17 2242 4585627 T 3.41 0.01041000 WBSCR17 2244 12699040 A 2.98 0.04337000 WBSCR17 2246 7783170 C 3.19 0.03021000 HIP1 2264 11770686 T −2.72 0.02246000 HIP1 2265 12533075 G −3.14 0.01805000 CACNA2D1 2306 17155665 T 5.33 0.00732400 SEMA3A 2347 1989964 T 2.66 0.03028000 ABCB4 2349 2097937 G 3.50 0.02621000 ADAM22 2361 10268574 T 4.89 0.00466500 PPP1R9A 2380 854542 G 2.88 0.02997000 DYNC1I1 2394 2299277 T 4.64 0.00090580 DYNC1I1 2395 12672406 T −2.95 0.02744000 CADPS2 2421 1476898 T −4.91 0.00274300 CADPS2 2422 2471194 A −4.91 0.00274300 CADPS2 2423 17144752 T −4.31 0.00489500 GRM8 2441 1008907 T −2.63 0.02952000 GRM8 2443 2299500 A −2.52 0.04283000 GRM8 2444 2299505 G 2.83 0.01773000 GRM8 2447 6951643 G 2.43 0.03151000 GRM8 2449 6975541 T 2.25 0.04225000 EXOC4 2455 7778778 G −3.22 0.04050000 EXOC4 2471 4731992 A −3.35 0.02291000 EXOC4 2472 6950383 C 2.53 0.02763000 DGKI 2474 1731951 T 3.28 0.00756500 CNTNAP2 2489 1948489 T −3.44 0.03683000 CNTNAP2 2493 1405179 C −3.56 0.00672800 CNTNAP2 2494 12535047 T −3.43 0.01179000 CNTNAP2 2510 2717829 C −4.38 0.01829000 PTPRN2 2512 221258 C −3.35 0.01476000 PTPRN2 2513 221300 C −2.85 0.03487000 SLC7A2 2600 2285295 G −8.29 0.01167000 PSD3 2604 13260536 G −2.81 0.01525000 PSD3 2605 1038606 G −2.98 0.01539000 SNTG1 2660 12548940 C −3.22 0.03371000 NKAIN3 2704 4737609 A −4.14 0.00871100 NKAIN3 2706 4739003 A −4.54 0.01948000 NKAIN3 2707 16929516 T −4.54 0.01948000 NKAIN3 2708 16929568 A −4.54 0.01948000 NKAIN3 2723 10957263 C −3.69 0.02326000 DEPDC2 2734 10808759 C 3.22 0.01531000 ZFPM2 2790 7845734 G 3.12 0.04689000 CSMD3 2815 4354335 G 3.50 0.02607000 CSMD3 2816 1513524 C 3.25 0.03740000 CSMD3 2817 2954892 G 3.20 0.03834000 SAMD12 2825 1607924 G 2.85 0.03947000 SAMD12 2826 10505340 A 3.96 0.03913000 DDEF1 2869 11774947 A 2.62 0.03014000 ADCY8 2884 3793387 T −2.74 0.02021000 ADCY8 2885 4339660 G −2.74 0.02021000 ADCY8 2886 10956553 G −2.74 0.02021000 ADCY8 2890 7016933 A −2.75 0.03555000 ST3GAL1 2904 2945779 A −2.71 0.01933000 SMARCA2 2931 2147263 T 2.36 0.04745000 SMARCA2 2932 4741650 T −2.77 0.03500000 PTPRD 2944 7036240 A −2.49 0.03516000 ADAMTSL1 2958 563805 C −3.71 0.02012000 TRPM3 3025 2993010 A −3.11 0.01876000 TRPM6 3047 1012710 C 2.72 0.03664000 SHC3 3085 9410299 G 3.81 0.00244200 SVEP1 3127 7875389 C −2.44 0.02914000 STOM 3142 2196311 G 3.53 0.03063000 NTNG2 3173 883318 G 2.92 0.00982200 NTNG2 3175 11793404 T 3.51 0.00590600 NTNG2 3176 3739930 A 4.69 0.01391000 NTNG2 3177 3739929 G 3.93 0.03744000 NTNG2 3178 7026497 A 3.30 0.00725800 VAV2 3191 2519799 G 2.40 0.03307000 VAV2 3192 2073829 G 2.48 0.01996000 NOTCH1 3200 10870085 T 3.06 0.03949000 NPDC1 3202 4880195 C −3.54 0.01601000 GRIN1 3203 7856589 A 3.98 0.00724500 CACNB2 3235 16917281 G −3.05 0.04812000 CACNB2 3236 10828679 G −5.17 0.00414500 CACNB2 3237 10764483 A −4.26 0.03404000 CDH23 3314 4747197 T −3.32 0.02496000 CDH23 3315 2070968 A −3.18 0.03747000 NRG3 3340 1937959 G 3.69 0.04772000 SORBS1 3365 17456435 C 3.83 0.02197000 VTI1A 3391 3740143 G 3.37 0.00990100 VTI1A 3392 716168 C 3.63 0.00395900 VTI1A 3393 10509963 A 3.58 0.00434700 VTI1A 3394 10885352 T 3.46 0.00581100 C11ORF49 3520 11039112 T 2.71 0.04288000 DLG2 3529 12275254 C −2.32 0.04812000 DLG2 3541 1943695 T 3.69 0.01248000 DLG2 3552 1940128 C 4.46 0.00891200 DLG2 3554 582652 A 4.10 0.02499000 OPCML 3561 882584 A −3.34 0.01873000 OPCML 3562 7120180 G −3.36 0.02284000 OPCML 3563 12284699 A −3.21 0.02482000 OPCML 3564 10791230 G −2.85 0.03642000 OPCML 3565 4937700 T −2.43 0.04986000 TSPAN9 3592 4766079 C −3.33 0.01468000 STYK1 3610 1979268 T 2.67 0.03062000 CNOT2 3642 10879096 G −4.21 0.01091000 CNOT2 3646 17107924 T −4.73 0.01533000 KCNC2 3656 4131955 T −3.44 0.01155000 KCNC2 3657 7952767 C −3.33 0.01928000 KCNC2 3658 1526821 C −3.44 0.01155000 NAV3 3665 1677923 G −4.36 0.03007000 GAS2L3 3680 35711 G 3.71 0.00138100 GAS2L3 3681 35706 A 3.34 0.00359800 NBEA 3716 1381479 C 3.95 0.02518000 GPC5 3788 7997883 G 3.22 0.01511000 GPC5 3792 17267453 C −5.90 0.00952600 GPC6 3796 9516222 G 4.40 0.00968200 GPC6 3799 1323974 C 3.69 0.01787000 NPAS3 3870 1315139 T 3.82 0.00383200 LRFN5 3902 10131436 A 3.35 0.01160000 SAMD4A 3910 11626634 A 4.01 0.03693000 RGS6 3939 1568404 T 2.76 0.01410000 RGS6 3940 847358 A −2.97 0.00824600 RGS6 3945 2681754 A −2.56 0.03572000 RGS6 3947 10136263 T −3.02 0.02383000 RGS6 3949 10149207 G −2.73 0.03271000 RGS6 3950 2239221 C −3.62 0.00400400 RGS6 3952 2238192 A −2.56 0.04299000 RASGRP1 4051 12324402 G 2.79 0.02325000 CDH13 4184 11646849 A −3.00 0.01034000 CDH13 4187 192598 A 2.59 0.03428000 CDH13 4188 7201088 G 2.74 0.02699000 CDH13 4189 9933935 T 2.55 0.04489000 CRISPLD2 4213 16974822 G 4.82 0.00014050 CRISPLD2 4214 2934477 A −2.63 0.03089000 CRISPLD2 4215 8049317 G −3.04 0.01094000 CRISPLD2 4216 2646107 C 3.85 0.00145500 CA10 4249 8069850 A 2.50 0.04822000 MSI2 4257 8066677 G 2.80 0.02093000 PTPRM 4288 535937 A 4.44 0.01262000 PTPRM 4289 524833 C 3.62 0.02496000 PTPRM 4291 1893224 C 3.98 0.02152000 PTPRM 4292 1893223 C 3.65 0.02243000 NEDD4L 4333 12373325 T 3.15 0.03253000 DOK6 4377 12967871 A −2.57 0.03545000 ZNF667 4387 10423617 T 3.65 0.02665000 MACROD2 4452 6043402 A −6.49 0.02172000 MACROD2 4459 1225890 C 2.83 0.04854000 PTPRT 4511 2223540 T 3.40 0.01583000 PTGIS 4523 515633 A −6.58 0.01351000 CDH4 4534 2427144 A −3.20 0.01535000 NCAM2 4544 9978969 T 5.05 0.00126100 PCP4 4558 16998864 A 5.20 0.01318000 PCP4 4559 2837283 T 4.41 0.03250000 ASPHD2 4573 16982107 T −6.38 0.02428000 EFCAB6 4598 9614382 G −2.97 0.02951000 EFCAB6 4606 5764214 C −2.94 0.01969000

TABLE 8 Alleles Influencing Time to Discontinuation for Quetiapine Beta Gene Seq ID NCBI RS# Allele (Months) P LRP8 57 1288519 C 2.99 0.015790 LRP8 58 1416096 A 2.49 0.041320 LRP8 60 2782497 C 2.49 0.041320 PTGFRN 87 2251406 G −6.30 0.039310 PTGFRN 88 2250457 G −6.06 0.048080 PTGFRN 89 2806864 G −6.06 0.048080 PTGFRN 94 12090536 G 3.62 0.009760 KCNN3 97 11264248 C 2.58 0.031130 FAM78B 113 10800181 G −2.51 0.036160 RYR2 208 2169902 A 4.98 0.049730 CHRM3 221 6663632 A 2.60 0.031420 RGS7 257 4659585 A −3.25 0.012550 PLD5 262 2252440 T 2.76 0.021420 PLD5 263 10926660 C 2.94 0.040370 PLD5 264 4658772 G 2.81 0.045860 PLD5 265 10926665 A 2.81 0.045860 C2ORF46 273 7577544 G 5.38 0.027520 BRE 322 10209422 T −3.26 0.035550 PRKCE 390 281473 A 4.72 0.037500 FBXO11 398 874869 C 3.48 0.003725 FBXO11 399 12463595 T 3.51 0.012290 CTNNA2 458 6547299 A 2.65 0.032160 NAP5 483 12991216 A −3.06 0.009380 NAP5 487 11695364 T 3.66 0.002984 NXPH2 499 11686876 T 2.32 0.044570 LRP1B 512 10188773 G −3.16 0.005816 ARHGAP15 540 10496944 A 3.54 0.023370 ARHGAP15 557 11693600 C −2.59 0.039310 CACNB4 565 2345160 G −6.78 0.001175 CACNB4 567 13421383 T 4.59 0.002738 CACNB4 569 12693235 C 3.79 0.009396 CACNB4 570 1806702 G 5.39 0.000368 CACNB4 572 17326195 T 5.44 0.000998 FMNL2 574 2164402 G 5.02 0.000140 FMNL2 575 6434028 C 3.42 0.003645 FMNL2 576 11684450 G 3.83 0.003748 FMNL2 577 12471183 T 4.46 0.000252 FMNL2 578 17327752 A 2.72 0.045250 FMNL2 580 2577180 G −3.10 0.040890 FMNL2 581 10497108 C 5.57 0.002176 FMNL2 582 16823807 G 5.57 0.002176 FMNL2 583 16823809 C 4.97 0.005751 FMNL2 584 10497111 A 5.42 0.005860 PLA2R1 604 949753 G −3.60 0.036320 PLA2R1 611 17241282 C 2.50 0.032790 SCN3A 617 1439807 G 2.94 0.035790 PDE1A 636 3769789 G 3.23 0.042350 ALS2 654 4675226 T 3.32 0.013680 PARD3B 666 698906 T 3.78 0.028000 PIP5K3 676 920218 A 6.52 0.022000 PIP5K3 677 10497899 T 6.52 0.022000 COL4A4 695 10166736 A −4.64 0.000053 COL4A4 696 2272202 C −3.15 0.010140 CNTN6 737 3772339 T 2.67 0.025420 CNTN6 751 2291100 C −2.61 0.042380 CNTN6 753 17038510 T 3.17 0.040590 IRAK2 785 708035 T −2.93 0.006203 IRAK2 786 11717636 C −2.92 0.007807 SLC6A6 797 2241780 C 3.33 0.038100 ARPP-21 821 4678802 C 2.75 0.020300 ERC2 884 11707255 A −2.78 0.035190 ERC2 885 11713228 C −2.62 0.047500 PTPRG 936 6785764 G −3.45 0.045750 PRICKLE2 957 17069879 A 3.56 0.030630 PRICKLE2 959 17664296 T −3.22 0.007006 PRICKLE2 961 13068250 C −3.13 0.010680 GBE1 992 3772899 G 2.37 0.048300 GBE1 995 3772891 A −2.92 0.031570 EPHA6 1009 2317212 A 3.51 0.043670 PLCXD2 1016 9288930 T 2.56 0.037560 KALRN 1045 16835902 C 2.37 0.032410 ZXDC 1047 1687462 C 2.56 0.045120 CLSTN2 1077 4683509 G −2.69 0.046860 SPSB4 1083 7651293 T 9.76 0.020290 TNIK 1102 17217552 G −7.02 0.034640 PLD1 1108 4243419 G −3.46 0.031100 PLD1 1109 2178532 A −3.39 0.032730 NLGN1 1113 16828952 A −2.57 0.019490 NLGN1 1114 9870677 C −2.57 0.030240 NLGN1 1115 993298 C −2.42 0.039420 NEGN1 1117 9874225 G −3.20 0.013690 NLGN1 1118 9878812 C −4.01 0.027250 LEPREL1 1136 17424551 G 2.67 0.046710 LEPREL1 1137 692909 T −2.78 0.048120 LEPREL1 1138 2667709 G −2.78 0.048120 LEPREL1 1140 573533 A −2.78 0.048120 LDB2 1170 9993371 T 2.66 0.019920 LDB2 1171 7690190 A 2.38 0.034790 LDB2 1174 283027 T −6.80 0.026000 PPARGC1A 1194 2290604 G −4.85 0.047300 LIMCH1 1227 17444879 T −4.57 0.009328 LIMCH1 1228 6850846 A −2.80 0.038240 SCD5 1265 6811012 T −3.95 0.023890 FAM13A1 1285 17817631 T 3.42 0.049890 PDLIM5 1290 2438142 A −3.06 0.012230 PDLIM5 1291 1353044 T −2.93 0.016380 PDLIM5 1292 2433325 A −2.93 0.016380 DKK2 1304 419764 T 3.47 0.014350 DKK2 1305 399087 C 3.29 0.039250 COL25A1 1332 2526456 G −2.96 0.025690 COL25A1 1333 2704102 C −2.85 0.032310 INPP4B 1421 17015779 C 3.04 0.046570 ENPP6 1521 6829678 C 2.84 0.008260 ENPP6 1522 7696176 C 3.00 0.005635 ENPP6 1524 17679120 A 2.77 0.012380 ENPP6 1525 4444870 T −3.02 0.007302 ENPP6 1526 11132224 C 2.90 0.012170 SEMA5A 1542 4702625 G 4.02 0.019640 SEMA5A 1543 12520210 A 2.76 0.035120 SEMA5A 1544 13174956 T 2.74 0.036440 ITGA1 1607 2169782 T −3.85 0.025750 PDE4D 1628 35274 G 2.89 0.019050 PDE4D 1629 193447 T 4.22 0.004303 PDE4D 1630 165940 T 3.12 0.021810 VCAN 1668 2287926 A −3.46 0.035700 VCAN 1671 2445874 T −3.76 0.023730 VCAN 1672 3096172 C −2.83 0.038250 CAST 1695 731827 T 2.55 0.032430 CAST 1696 17401719 C 2.40 0.044380 WWC1 1800 6555802 A −2.76 0.044570 SLC22A23 1813 9392497 T −6.80 0.040850 SLC17A1 1855 13200784 T −3.56 0.010700 SLC17A3 1858 1165162 A −3.87 0.003778 SLC17A3 1859 1165161 A −3.69 0.005748 SLC17A3 1860 1165158 T −3.64 0.009834 LRFN2 1880 1433721 G 2.82 0.032090 ELOVL5 1888 2562898 A −2.97 0.042410 RIMS1 1914 9446625 T −3.04 0.010870 RIMS1 1915 2815743 T −2.60 0.026540 RIMS1 1916 7738055 C −2.99 0.013230 SYNE1 2008 7776230 T −3.88 0.003824 PARK2 2033 4708953 C −3.17 0.018980 PARK2 2034 6930880 C −2.81 0.029210 PARK2 2040 9365421 A −2.57 0.037820 PACRG 2050 7740626 G −3.31 0.010930 PDE10A 2059 9459418 A −2.72 0.045300 CREB5 2125 4722864 A 2.94 0.049710 CRHR2 2140 975537 A −4.04 0.009416 CRHR2 2141 973002 G −3.90 0.018480 PDE1C 2158 30568 C 4.00 0.017390 PDE1C 2160 4551232 A 3.05 0.009675 PDE1C 2161 10225488 A 2.93 0.013060 PDE1C 2162 2079373 C 5.72 0.000135 VPS41 2179 2286080 G 2.66 0.032950 ABCA13 2194 17132289 T −4.82 0.034590 ABCA13 2214 6958356 A 2.68 0.023710 MAGI2 2279 848913 C 3.77 0.038580 MAGI2 2294 860246 A 3.44 0.010730 CACNA2D1 2304 17262683 C 2.93 0.034100 ABCB4 2354 2888611 C −3.65 0.038890 EMID2 2402 6947185 C 2.65 0.039810 CUX1 2410 712839 A 2.72 0.044540 DGKI 2474 1731951 T −2.34 0.044930 CREB3L2 2481 11972734 A 2.86 0.024020 CNTNAP2 2490 6963627 T 2.61 0.022370 CNTNAP2 2491 1639484 T 2.27 0.039910 CNTNAP2 2497 12703906 T −2.84 0.026380 CNTNAP2 2502 2022226 C 2.70 0.037400 PTPRN2 2517 4716882 T 2.47 0.044150 PTPRN2 2520 2335167 C 3.44 0.001937 PTPRN2 2531 4909222 G 3.33 0.004042 MCPH1 2551 1530408 C −4.05 0.031370 DLC1 2578 536147 G 3.57 0.047570 SGCZ 2587 7813614 T 2.67 0.036620 SGCZ 2592 17119601 G 3.42 0.009225 SGCZ 2593 11990657 T −2.88 0.034220 TOX 2685 11777927 A 3.34 0.035790 KCNB2 2745 2196904 C 2.81 0.043680 KCNB2 2746 2255053 A −4.29 0.028690 KCNB2 2750 2053421 G 2.80 0.028860 GRHL2 2773 4734553 G −3.15 0.015480 GRHL2 2775 13275653 C −2.64 0.044440 CSMD3 2810 17640721 C 3.26 0.029800 CSMD3 2812 11996690 A 5.85 0.030080 ADCY8 2887 12548835 T −2.65 0.040850 COL22A1 2918 1316335 A −3.79 0.008787 COL22A1 2919 9657434 T −3.78 0.009091 SMARCA2 2931 2147263 T 3.91 0.002293 SLC1A1 2938 3087879 C −2.51 0.034470 PTPRD 2939 3858060 T −2.83 0.043940 IFT74 2982 17694549 C 5.94 0.010800 IFT74 2983 3429 A 3.89 0.022060 IFT74 2985 2095405 C 4.01 0.011780 TEK 2990 1322051 A 6.03 0.014760 TRPM3 3023 718447 A 2.92 0.030650 TMC1 3028 7857300 T −2.77 0.024030 TMC1 3029 7866185 T −2.40 0.046170 NTRK2 3076 13289538 G 4.89 0.039800 NFIL3 3092 7038686 A −4.58 0.001379 NFIL3 3093 4743835 A −3.96 0.002948 NFIL3 3094 4743836 T −3.96 0.009878 NFIL3 3096 4743838 A −3.92 0.010470 ZNF169 3097 12236219 T −5.74 0.032780 RP11-35N6.1 3108 7853653 A −3.01 0.041430 FKTN 3112 885954 C −2.95 0.014930 FKTN 3113 17251166 C −2.62 0.039910 FKTN 3114 7851777 T −2.62 0.039910 CDK5RAP2 3135 4836819 A 2.34 0.033730 SLC25A25 3162 9695803 C 3.47 0.043050 ABL1 3172 10901297 A −5.46 0.033810 VAV2 3184 10993826 T −2.93 0.042390 CACNA1B 3209 7860423 A 3.28 0.039010 CACNA1B 3212 10867105 C 3.74 0.027430 PITRM1 3224 2129440 G 3.37 0.004872 PITRM1 3225 6601755 C 3.06 0.012500 MYO3A 3272 11014933 A 2.40 0.040000 MYO3A 3282 6482535 C 4.86 0.005334 MYO3A 3287 3781117 C 3.76 0.042520 SLC16A9 3293 10993988 T −2.70 0.039340 KCNMA1 3323 3781158 T −2.66 0.038640 KCNMA1 3324 2131216 T −2.64 0.039310 NRG3 3345 474496 G −2.51 0.028110 NRG3 3350 11812533 T 9.92 0.002431 NRG3 3351 17101125 A 9.70 0.007997 NRG3 3352 10509462 T 9.70 0.007997 NRG3 3353 17763320 A 5.71 0.045740 SORCS3 3372 10786808 T 3.41 0.048340 SORCS3 3378 7099674 A 3.35 0.022300 SORCS3 3383 2692331 G 3.11 0.035640 HSPA12A 3424 12777585 C 2.33 0.040560 HSPA12A 3425 1900500 A −2.71 0.018550 HSPA12A 3426 3010476 G −2.53 0.030490 HSPA12A 3428 1622217 C −2.29 0.047440 GALNTL4 3468 4910288 A −2.65 0.045940 GALNTL4 3469 4910289 C −3.20 0.027850 ARNTL 3482 7107711 C 3.16 0.049040 ARNTL 3483 7112233 T 3.16 0.049040 DLG2 3542 11234157 T −2.49 0.027170 DLG2 3544 1943696 C −2.52 0.025200 DLG2 3545 1943698 G −2.45 0.030540 DLG2 3546 11234194 C −2.41 0.030760 TSPAN9 3591 10848789 A −3.40 0.019300 TSPAN9 3593 544668 G −2.92 0.025560 TMEM16B 3604 7298357 A 2.76 0.027500 PIK3C2G 3632 7136674 G 3.28 0.016110 CHST11 3683 2141857 T 2.94 0.046000 CHST11 3684 2055861 C 2.74 0.021310 NBEA 3719 7320580 G −3.32 0.026280 NBEA 3723 17769661 T −4.29 0.019870 FNDC3A 3734 7321178 G −3.47 0.005594 LMO7 3741 502171 G −2.99 0.011840 SLAIN1 3754 9530678 A 4.05 0.009498 SLAIN1 3755 1343911 A 3.28 0.038850 SLAIN1 3757 1279446 C 2.85 0.022380 GPC5 3761 7992120 T −3.69 0.039590 NALCN 3836 9300662 G 2.35 0.042360 ITGBL1 3851 1469855 G 5.12 0.024900 ITGBL1 3852 1469853 G 3.96 0.039950 WDR23 3853 3742499 T −6.86 0.024560 GNG2 3909 12882906 G 2.64 0.026700 PPP2R5E 3925 8008684 G 4.04 0.008795 PPP2R5E 3926 2754223 G 3.45 0.009768 PPP2R5E 3928 1255741 A 2.51 0.049010 RGS6 3950 2239221 C 2.34 0.041930 NRXN3 3957 759233 G −6.25 0.005320 NRXN3 3958 8011654 C −4.84 0.027210 KCNK13 3967 3850395 C 2.63 0.032570 CCDC88C 3987 11160006 C 2.40 0.047130 RYR3 4027 937302 G 2.47 0.035410 RYR3 4028 16957065 G 2.44 0.047940 KIAA1370 4064 4776065 C 3.03 0.010740 KIAA1370 4066 1863512 G 2.93 0.013390 CGNL1 4071 4774941 G 5.44 0.006506 TBC1D2B 4088 1108478 C 3.02 0.035190 TBC1D2B 4094 12593545 G 2.92 0.044670 TBC1D2B 4095 2867985 A 3.08 0.015030 TBC1D2B 4098 12903461 T −3.20 0.031500 ARNT2 4102 4778835 G 3.49 0.023440 A2BP1 4118 1155959 C −2.43 0.044040 A2BP1 4126 1922585 T −3.14 0.009143 WWOX 4157 4129721 G 3.86 0.028820 MPHOSPH6 4172 1862820 G −2.45 0.032610 USP10 4206 1541699 G −3.07 0.018270 USP10 4207 7188512 C −3.29 0.017400 USP10 4208 964453 G −2.72 0.032580 CA10 4250 9303606 C −3.96 0.001921 CA10 4251 12945099 C −3.25 0.010160 MSI2 4260 8065120 A 3.41 0.042170 DNAH17 4267 7211232 T −5.00 0.022530 DNAH17 4269 1515022 A −2.97 0.025710 NEDD4L 4329 10513914 G −2.97 0.034390 NEDD4L 4330 2075405 G −3.56 0.014510 CCBE1 4336 17065761 C 4.89 0.006636 DOK6 4381 4438406 C −2.47 0.041000 MBP 4383 470181 G −2.87 0.020090 ZNF667 4387 10423617 T −3.23 0.029650 FERMT1 4410 10373 T −2.44 0.038370 PLCB1 4414 6055577 A 5.37 0.000740 PLCB1 4415 2235212 A 3.82 0.009620 MACROD2 4452 6043402 A 5.61 0.007932 MACROD2 4459 1225890 C 3.82 0.005841 PTPRT 4505 6065520 T −4.12 0.034490 KCNB1 4519 496511 C −3.32 0.006536 CDH4 4539 6089573 A 2.78 0.023000 NCAM2 4552 1599228 C −2.85 0.044800 EFCAB6 4614 5764310 C 4.48 0.030870

TABLE 9 Alleles Influencing Time to Discontinuation for Perphenazine Gene Seq ID NCBI RS# Allele Beta (Months) P EPHB2 19 4655108 A 5.27 0.0053 EPHB2 20 10799762 C 5.09 0.0135 EPHB2 23 309499 T −3.07 0.0122 LRP8 48 5174 A −2.95 0.0079 LRP8 49 11206127 A −2.80 0.0148 LRP8 50 869987 T −2.77 0.0219 LRP8 52 2297660 A −2.63 0.0219 LRP8 53 2297657 A −2.37 0.0440 LRP8 54 12035926 G −2.45 0.0485 NGF 81 12145726 G 2.77 0.0321 NGF 83 11102925 T 3.53 0.0167 NGF 84 17033706 A 4.94 0.0025 PTGFRN 93 4641299 G −3.48 0.0100 ATF6 98 2070150 C 4.57 0.0372 ATF6 102 12401299 G 4.24 0.0396 ATF6 106 12028953 A 4.57 0.0372 ATF6 108 12040523 T 4.57 0.0372 ESRRG 172 12757165 G −2.51 0.0409 ESRRG 173 6658528 T −2.49 0.0397 SLC35F3 191 10495346 T 5.44 0.0161 GNG4 192 10925976 A −2.92 0.0139 GNG4 193 508208 G 2.73 0.0302 GNG4 194 488618 G −2.93 0.0133 RYR2 210 1402803 G 3.55 0.0212 CHRM3 222 1431719 G 2.41 0.0430 FMN2 228 12118961 T −2.68 0.0336 RGS7 260 10737861 T 3.34 0.0252 PLD5 271 1548160 C 3.31 0.0106 PLD5 272 12128054 A 2.56 0.0403 C2ORF46 274 182971 C −2.82 0.0464 C2ORF46 277 2562011 C 3.78 0.0393 KCNK3 307 11126666 A 2.83 0.0397 CRIM1 333 11681392 T 2.93 0.0201 CRIM1 334 10189344 C 3.02 0.0207 FEZ2 337 17488036 C 3.62 0.0052 FEZ2 338 10197570 T 3.66 0.0053 CDC42EP3 342 15628 T −7.37 0.0088 SLC8A1 352 967351 A −2.41 0.0493 C2ORF34 374 3738980 C 5.69 0.0021 PRKCE 386 13003856 G 2.26 0.0393 PRKCE 387 6748375 C −2.23 0.0489 CCDC85A 419 11696109 A −2.67 0.0228 CCDC85A 420 1159916 G −3.44 0.0084 CCDC85A 424 214041 T 3.48 0.0031 CTNNA2 446 13033608 C −2.58 0.0239 CTNNA2 447 2861914 G −2.38 0.0444 CTNNA2 470 216616 G 2.87 0.0331 CTNNA2 471 216630 C 2.78 0.0216 CTNNA2 472 216657 C 2.75 0.0227 NAP5 482 13432172 G 6.27 0.0270 KYNU 533 6430001 A −3.01 0.0214 KYNU 535 3816193 A −4.57 0.0067 KCNJ3 591 2937609 C −2.78 0.0192 SCN1A 622 1461197 A 2.62 0.0354 PARD3B 658 1510765 T 3.17 0.0114 PARD3B 660 6760872 C 2.63 0.0356 PARD3B 661 4675490 G 2.55 0.0466 PARD3B 664 1100393 G 2.79 0.0410 NRP2 675 6435306 A 2.41 0.0449 ERBB4 680 1992029 G 3.43 0.0141 CNTN4 757 11129074 G 2.64 0.0455 RARB 807 17526942 T −5.76 0.0101 CLASP2 816 13098051 C 5.32 0.0041 STAC 826 3749279 T 3.88 0.0499 FHIT 916 212016 C 3.63 0.0128 PTPRG 940 9813294 A −2.60 0.0178 PRICKLE2 962 153729 A −4.68 0.0105 PRICKLE2 963 697280 G −4.01 0.0327 PRICKLE2 965 696019 A −2.59 0.0456 PRICKLE2 968 11924614 C −2.69 0.0317 GBE1 989 17019088 T 4.05 0.0034 GBE1 990 7618973 G 3.90 0.0039 GBE1 993 3821548 G 3.09 0.0169 GBE1 998 3860595 C 2.45 0.0491 CDGAP 1023 9855065 A −2.90 0.0225 CDGAP 1024 3732413 G 3.25 0.0285 CLSTN2 1079 9875409 G 3.88 0.0046 CLSTN2 1080 347975 G 3.25 0.0081 CLSTN2 1081 347973 A 2.74 0.0271 SPSB4 1084 4683550 C −4.38 0.0093 SPSB4 1086 2086180 G −3.88 0.0221 TNIK 1102 17217552 G 7.19 0.0176 NLGN1 1123 692486 G 2.58 0.0299 NLGN1 1125 11713211 C 2.58 0.0299 LDB2 1171 7690190 A 2.89 0.0202 SLIT2 1188 10516357 A −3.02 0.0155 PCDH7 1200 4611883 G 2.29 0.0357 COL25A1 1318 7666215 G 2.64 0.0383 COL25A1 1325 17596971 G 3.10 0.0355 COL25A1 1328 711865 A −3.32 0.0063 COL25A1 1329 794149 G −3.15 0.0090 COL25A1 1330 1863293 G −3.11 0.0108 COL25A1 1331 3096490 A −3.11 0.0108 ANK2 1343 1989930 G 2.77 0.0243 GPR103 1384 11732033 A 3.44 0.0256 POU4F2 1431 6839918 T 4.31 0.0428 DCLK2 1443 4696645 A 4.63 0.0132 CTSO 1446 6536124 A −3.12 0.0135 CTSO 1447 4608743 C −3.70 0.0171 CTSO 1448 17033891 C −3.56 0.0305 FSTL5 1466 13110363 G −3.94 0.0334 TLL1 1480 2292083 A 2.37 0.0457 PALLD 1483 6552873 C −3.67 0.0028 PALLD 1484 6552875 T −3.67 0.0028 PALLD 1485 6818921 C −3.67 0.0028 PALLD 1487 17054309 A 3.24 0.0301 PALLD 1488 10031058 G −3.67 0.0028 PALLD 1489 10009813 G 3.01 0.0274 PALLD 1490 6840767 C −4.05 0.0035 PALLD 1492 2712118 C −3.47 0.0063 PALLD 1493 2319900 T −3.22 0.0103 ODZ3 1517 7668885 T −3.08 0.0248 DNAH5 1556 7709692 C −3.22 0.0440 CDH10 1574 7731953 T 4.20 0.0194 SLC1A3 1581 4869676 A 3.00 0.0341 SLC1A3 1582 1645651 A −2.74 0.0254 ITGA1 1604 2860025 T 2.99 0.0223 ITGA1 1605 1820167 A −2.70 0.0308 PDE4D 1624 12654005 G 2.75 0.0365 THBS4 1660 2288395 G 3.16 0.0178 VCAN 1667 4558964 G 3.60 0.0156 GPR98 1680 666659 T −2.63 0.0226 GPR98 1681 688956 C −2.43 0.0314 GPR98 1682 168743 G 2.42 0.0441 PJA2 1720 1428931 G −4.01 0.0498 SEMA6A 1737 682684 G 2.89 0.0325 ADAMTS19 1766 1363143 C 6.33 0.0011 TRPC7 1777 3777150 A −3.15 0.0116 CTNNA1 1781 10043478 G −2.31 0.0398 PHACTR1 1818 1537340 A −3.07 0.0382 PHACTR1 1820 13219256 T −2.85 0.0451 PARC 1884 17209372 G −4.86 0.0459 RIMS1 1900 575472 G −3.10 0.0216 RIMS1 1902 1010326 A −3.32 0.0227 RIMS1 1905 2496495 G −2.71 0.0399 TRDN 1935 13190807 C −3.11 0.0268 NKAIN2 1966 1871329 C 3.76 0.0136 NKAIN2 1968 6906607 A 4.13 0.0181 NKAIN2 1969 609783 T 3.59 0.0394 EYA4 1972 533729 T 4.30 0.0065 EYA4 1973 211443 G 4.09 0.0107 EYA4 1975 6941879 G 3.47 0.0225 PARK2 2023 10945767 T −2.92 0.0091 PARK2 2024 9365311 C 2.45 0.0278 PARK2 2027 4279411 G 2.59 0.0448 PARK2 2031 6930668 T 2.85 0.0368 PAPK2 2043 9347659 G −3.36 0.0239 PARK2 2047 9365473 T −3.18 0.0319 SKAP2 2117 774256 G 2.99 0.0437 SKAP2 2118 774250 T 3.60 0.0218 CREB5 2122 1544469 G 2.84 0.0433 BMPER 2170 1420335 C −3.46 0.0063 CDC2L5 2186 3800802 T −2.98 0.0245 CDC2L5 2187 10277422 C −4.12 0.0072 ABCA13 2214 6958356 A 3.71 0.0041 GRB10 2215 2244347 C 2.91 0.0347 GRB10 2217 2244351 G 3.12 0.0218 HIP1 2256 17352471 A 3.39 0.0212 HIP1 2257 1018945 G 2.99 0.0177 HIP1 2258 757364 T −3.45 0.0049 HIP1 2259 2525467 C −2.57 0.0458 PCLO 2311 17156675 T −3.73 0.0064 PCLO 2324 2522843 A −3.12 0.0120 SEMA3E 2346 1972459 C 2.59 0.0372 ABCB4 2348 31659 C −4.54 0.0327 ABCB4 2349 2097937 G −3.25 0.0299 CUX1 2408 2694158 T 2.77 0.0311 CUX1 2409 803064 C −4.69 0.0009 TBXAS1 2482 6464451 C 9.45 0.0094 TBXAS1 2484 8192813 T 9.45 0.0094 CNTNAP2 2496 7802708 G 2.38 0.0388 PTPRN2 2532 10265417 T 3.88 0.0014 PTPRN2 2534 10266729 T 3.86 0.0015 PTPRN2 2535 2878355 A 3.10 0.0216 SGCZ 2588 6651381 A −3.01 0.0186 SLC25A37 2632 10503726 C −3.38 0.0156 SLC25A37 2633 7826247 G −4.07 0.0034 SLC25A37 2634 11778179 T −3.44 0.0171 SFRP1 2646 7843510 G −2.71 0.0223 SFRP1 2648 7833518 T −2.48 0.0353 SNTG1 2666 1542615 T −5.07 0.0370 SNTG1 2667 2623207 C −5.03 0.0388 SNTG1 2669 2623224 A −5.03 0.0388 DEPDC2 2729 16934215 A −4.41 0.0099 DEPDC2 2730 3793379 A −3.94 0.0133 DEPDC2 2731 3793381 A −3.92 0.0158 ZFPM2 2791 10464844 G 2.77 0.0428 ZFPM2 2793 16873003 C 2.88 0.0433 ZFPM2 2800 1442326 G −2.57 0.0442 CSMD3 2816 1513524 C −2.53 0.0343 CSMD3 2817 2954892 G −2.53 0.0343 MTSS1 2849 1988734 A 2.83 0.0177 MTSS1 2851 4871503 C −4.01 0.0122 FAM84B 2857 16901667 T −3.61 0.0132 SMARCA2 2924 7048496 A −4.12 0.0265 SMARCA2 2925 6475520 G −4.49 0.0214 SMARCA2 2926 6475522 A −4.61 0.0185 SMARCA2 2927 10757205 G −5.56 0.0105 PTPRD 2954 10815933 C 3.07 0.0230 PTPRD 2955 1036328 C 2.96 0.0251 PTPRD 2956 7868093 T 2.67 0.0418 KIAA1797 2962 2151002 A 2.78 0.0241 KIAA1797 2978 7030990 G −3.49 0.0127 KIAA1797 2980 4468020 T −2.72 0.0375 APBA1 3002 10867656 C −4.77 0.0119 APBA1 3003 7866199 C −4.58 0.0182 APBA1 3006 7872660 T −4.19 0.0195 TMC1 3042 2501914 T −2.41 0.0329 PCSK5 3056 10869698 A −2.65 0.0398 PCSK5 3057 10512054 C −3.57 0.0050 DIRAS2 3087 532591 C −3.61 0.0054 DIRAS2 3088 7028171 A 2.71 0.0483 GRIN3A 3110 2786716 C 3.05 0.0134 DAB2IP 3143 10985431 T 4.78 0.0496 TTLL11 3148 10985529 T 2.93 0.0247 EXOSC2 3164 4740358 C −3.92 0.0222 KCNT1 3197 11103150 A −6.26 0.0182 CACNA1B 3211 11137363 T 3.35 0.0220 PITRM1 3221 1127047 T −7.85 0.0320 CUGBP2 3232 2938015 A 2.92 0.0466 CACNB2 3236 10828679 G −3.89 0.0440 ARMC3 3252 12252340 T 3.43 0.0210 MYO3A 3262 10741104 C −2.79 0.0308 MYO3A 3264 10828912 A −2.79 0.0308 MYO3A 3268 4749090 C 3.69 0.0332 MYO3A 3280 1999240 C −2.54 0.0339 MYO3A 3285 12764197 G 3.37 0.0483 JMJD1C 3301 9629895 A −3.04 0.0157 JMJD1C 3303 2893922 C −3.79 0.0063 CDH23 3312 3802711 T −3.75 0.0039 CDH23 3315 2070968 A −2.88 0.0352 SORCS3 3374 2491377 T 2.75 0.0337 SORCS3 3382 2177744 C −3.25 0.0375 STIM1 3463 10835407 G 2.62 0.0416 STIM1 3467 725519 T 2.53 0.0438 MICAL2 3473 1159649 C 3.41 0.0069 MICAL2 3474 10765929 T 2.98 0.0178 MICAL2 3480 1493955 A 5.19 0.0169 ARNTL 3486 10766066 G 2.75 0.0358 ARNTL 3489 4414197 T 2.72 0.0378 SPON1 3505 12283632 A −2.95 0.0322 SPON1 3508 7950377 T −3.71 0.0082 SPON1 3509 7116296 T 2.86 0.0252 SPON1 3510 11023088 T 2.82 0.0301 C11ORF49 3519 11039105 T 3.25 0.0110 C11ORF49 3521 747650 A 3.18 0.0128 ELMOD1 3559 683266 A −3.00 0.0216 OPCML 3584 4937782 T −3.82 0.0085 OPCML 3585 7936263 G −3.49 0.0222 OPCML 3588 7108751 T −3.85 0.0055 N4BP2L2 3699 206336 G 2.50 0.0347 TRPC4 3731 1924378 A 2.43 0.0413 LMO7 3742 7335067 A 2.76 0.0321 GPC5 3764 7983063 G 3.01 0.0317 GPC5 3765 653774 T −2.68 0.0254 GPC5 3766 655169 T −2.63 0.0288 GPC5 3771 553717 A −5.43 0.0124 GPC5 3772 342678 A −5.43 0.0124 GPC5 3773 342677 A −4.32 0.0426 GPC5 3775 7986797 A −6.13 0.0455 GPC5 3776 9515971 G −2.89 0.0214 GPC5 3787 913005 T −2.55 0.0349 GPC6 3818 10492635 C 3.14 0.0230 NPAS3 3866 243291 G 2.62 0.0307 NPAS3 3869 1579702 G 2.43 0.0374 SLC25A21 3881 712377 C 2.69 0.0419 SLC25A21 3883 10872897 T 2.56 0.0433 SAMD4A 3913 709939 C −3.20 0.0128 SAMD4A 3915 8021957 T −3.05 0.0150 SAMD4A 3916 8021151 G −3.09 0.0166 SAMD4A 3917 2057369 A 3.17 0.0198 SAMD4A 3918 17128004 A 3.17 0.0198 SAMD4A 3919 10483639 C 3.17 0.0198 RGS6 3949 10149207 G 3.04 0.0149 RGS6 3952 2238192 A 3.31 0.0066 RGS6 3954 2803947 A 2.52 0.0484 KCNK10 3964 1950279 T 3.82 0.0017 KCNK10 3965 17698533 C 3.89 0.0020 KCNK10 3966 12185033 T 3.34 0.0074 RYR3 4019 2670947 G 3.30 0.0046 RYR3 4020 2676083 T 3.19 0.0079 RYR3 4022 2670944 G 2.61 0.0394 RYR3 4035 11072734 G −2.88 0.0293 RYR3 4036 891343 T −3.09 0.0184 CGNL1 4070 7182648 T 2.83 0.0323 RORA 4082 11071548 G −3.38 0.0061 CLK3 4084 12441932 G −3.89 0.0293 CLK3 4085 2068982 A −3.81 0.0329 HYDIN 4150 9939194 T 2.61 0.0470 WWOX 4157 4129721 G 4.71 0.0449 CDH13 4203 8049546 A −3.05 0.0406 CDH13 4204 33121 G −3.39 0.0108 DNAH17 4264 16971269 C −3.26 0.0104 DNAH17 4265 647727 C −2.96 0.0235 DNAH17 4267 7211232 T −4.14 0.0113 DLGAP1 4276 9635857 G −3.43 0.0267 DLGAP1 4278 7245298 G −3.38 0.0315 ZFP161 4281 581144 T −3.30 0.0135 ZFP161 4282 990072 T −3.87 0.0005 ZFP161 4283 11665417 T 3.81 0.0009 ZFP161 4284 9945680 A 3.81 0.0009 KIAA0802 4306 17408213 T 4.07 0.0092 OSBPL1A 4310 275857 C −5.38 0.0462 CDH7 4349 7241038 T −2.16 0.0470 DOK6 4378 8097743 G 2.79 0.0145 PLCB4 4437 13036731 G −6.85 0.0383 SEC23B 4486 1555354 C 3.49 0.0226 SEC23B 4488 2273526 G 3.63 0.0424 PTPRT 4502 6124439 A 2.99 0.0413 PTPRT 4506 6016864 A 2.49 0.0475 C21ORF37 4541 2824301 G −2.61 0.0235 PDE9A 4564 12626774 C 3.75 0.0044 ARFGAP3 4578 5758951 G −3.09 0.0101 ARFGAP3 4579 2024645 T −2.94 0.0174 ARFGAP3 4580 5758965 A −2.87 0.0186 ARFGAP3 4581 5758972 T −2.50 0.0288 ARFGAP3 4582 738536 A −2.27 0.0448 PACSIN2 4584 12166809 A −2.77 0.0222 PACSIN2 4588 7286299 A −2.58 0.0245 PACSIN2 4589 737782 G −2.47 0.0291 EFCAB6 4597 137160 G −2.60 0.0245 EFCAB6 4598 9614382 G −2.70 0.0478 EFCAB6 4600 2374773 A −2.78 0.0336

TABLE 10 Alleles Influencing Time to Discontinuation for Ziprasidone Beta Gene Seq ID NCBI RS# Allele (Months) P AGBL4-C1ORF165 27 1934395 G 4.80 0.0271 LRP8 57 1288519 C −4.06 0.0307 ESRRG 180 11117642 T 5.44 0.0114 ESRRG 184 7529655 A −5.33 0.0260 GNG4 194 488618 G −3.52 0.0290 RYR2 201 10802596 T 3.43 0.0307 FMN2 235 10926168 G −5.41 0.0044 FMN2 236 7520065 G −5.41 0.0044 FMN2 238 10926188 G −4.04 0.0337 RGS7 255 191735 A 3.32 0.0496 C2ORF46 277 2562011 C −5.56 0.0407 DDEF2 283 10593 G −6.24 0.0151 CRIM1 334 10189344 C 4.39 0.0074 FEZ2 335 3770811 T 4.59 0.0047 FEZ2 336 1533946 G 4.50 0.0056 FEZ2 338 10197570 T 4.45 0.0070 SLC8A1 347 11885401 C 6.21 0.0065 SLC8A1 353 13017237 A 9.79 0.0090 SLC8A1 354 9789739 A 9.63 0.0258 EPAS1 395 1530632 C −3.98 0.0417 EPAS1 397 7571218 A −3.93 0.0196 FBXO11 398 874869 C −3.81 0.0418 PSME4 410 1363061 T −5.57 0.0106 CCDC85A 427 10460558 A −3.89 0.0467 CTNNA2 453 17018760 T −6.17 0.0027 CTNNA2 454 1006607 G −6.68 0.0035 CTNNA2 456 2120408 C −6.68 0.0035 CTNNA2 457 2165975 T −6.68 0.0035 CTNNA2 458 6547299 A 3.53 0.0346 CTNNA2 461 17018918 G −7.13 0.0170 CTNNA2 473 3770369 C −3.46 0.0238 NAP5 483 12991216 A 4.15 0.0189 KCNJ3 590 3111017 T 3.80 0.0377 SCN3A 616 1550385 G −4.19 0.0206 CERKL 632 895901 A 3.69 0.0310 CERKL 635 4018756 A −3.55 0.0116 PDE1A 641 6736414 T −4.86 0.0300 DNER 715 17677612 T 7.75 0.0422 CHRND 730 2697800 A −4.77 0.0138 CNTN4 769 9823500 C −4.07 0.0428 ITPR1 780 3804993 G −3.82 0.0375 ATP2B2 788 1438168 G −6.00 0.0003 ATP2B2 789 4684687 T −3.58 0.0282 ATP2B2 793 34923 G −4.59 0.0037 SLC6A6 798 11713355 A −4.79 0.0330 RARB 809 6774124 C 4.25 0.0199 RARB 810 1881707 A 3.94 0.0439 GPX1 857 9827708 G 4.68 0.0220 CACNA2D3 864 11130396 T 4.97 0.0058 CACNA2D3 870 4384925 G −4.10 0.0229 ERC2 877 3796232 G 4.66 0.0023 ERC2 879 2132237 C 3.16 0.0406 FLNB 911 12632456 A −4.43 0.0025 PTPRG 932 6794009 G −4.98 0.0014 PRICKLE2 964 696017 A −9.34 0.0058 PRICKLE2 969 704398 G −8.11 0.0103 PRICKLE2 970 697288 T −6.36 0.0336 KALRN 1037 2008839 A −6.67 0.0189 KALRN 1038 2008847 T −6.19 0.0402 SERPINI2 1090 13062550 C 3.53 0.0244 TNIK 1101 9824475 G −3.43 0.0478 LEPREL1 1132 1719607 A 3.67 0.0454 LEPREL1 1136 17424551 G 3.83 0.0145 UBXD7 1151 6774540 T −3.77 0.0304 UBXD7 1152 9841810 C −3.61 0.0370 UBXD7 1153 9847223 T −3.61 0.0370 LDB2 1169 1501142 G 3.95 0.0325 LDB2 1171 7690190 A 3.03 0.0453 SLIT2 1191 9992591 C −3.09 0.0484 UBE2K 1213 2054718 T −5.34 0.0261 N4BP2 1215 4974970 A 3.25 0.0476 LIMCH1 1218 10026397 A 4.76 0.0464 LIMCH1 1222 10805090 G 4.01 0.0423 LPHN3 1232 950313 C 5.23 0.0143 LPHN3 1233 1124974 A 4.55 0.0330 FAM13A1 1283 6814344 G 3.74 0.0143 FAM13A1 1284 13131633 T 3.74 0.0143 PDLIM5 1293 2510777 C −4.41 0.0135 PDLIM5 1294 3805274 A 6.81 0.0142 PDLIM5 1298 11735212 A 4.69 0.0150 ANK2 1354 17045935 C −4.22 0.0377 ANK2 1355 2272229 T −4.22 0.0377 GPR103 1381 13110738 G 3.78 0.0275 IL15 1403 6841939 A 5.35 0.0018 IL15 1408 6821171 G −4.73 0.0174 CTSO 1449 10517625 C −5.06 0.0091 FSTL5 1461 45426 T 3.95 0.0145 TLL1 1474 6844820 G 3.85 0.0233 AHRR 1533 4956936 C 3.62 0.0435 SEMA5A 1535 985723 A −5.71 0.0138 SEMA5A 1537 2962699 T −4.97 0.0339 SEMA5A 1538 786843 G −4.42 0.0143 SEMA5A 1539 257098 G −4.34 0.0443 SEMA5A 1540 786846 C −4.34 0.0443 DNAH5 1547 1354191 G 3.62 0.0256 DNAH5 1549 6876673 T 3.21 0.0475 EGFLAM 1590 1469421 A 9.90 0.0216 EGFLAM 1596 2731979 C −5.55 0.0305 ITGA2 1619 3212527 G 3.66 0.0459 PDE4D 1632 294494 A −5.74 0.0162 PDE4D 1633 295954 G −6.72 0.0179 PDE4D 1634 295955 G −7.16 0.0182 PDE4D 1635 295963 C −6.62 0.0286 ODZ2 1787 2337017 C 9.01 0.0001 ODZ2 1789 1421989 G 5.38 0.0057 ODZ2 1795 6555784 T 6.44 0.0110 ODZ2 1797 7708354 G −3.99 0.0203 WWC1 1802 10038727 A 3.19 0.0493 JARID2 1831 4085876 T −4.30 0.0230 JARID2 1832 9476827 T −4.08 0.0325 JARID2 1833 2282821 A 3.86 0.0389 SLC17A4 1845 4712963 T 3.38 0.0369 SLC17A1 1853 1324082 A 4.13 0.0301 SLC17A1 1854 1165196 C −4.07 0.0066 SLC17A1 1856 1165177 T −3.47 0.0187 SLC17A1 1857 4712976 T 4.23 0.0349 SLC17A3 1862 1165205 A −3.47 0.0187 SLC17A2 1865 3799371 T 3.94 0.0071 SLC17A2 1866 6938233 T 3.94 0.0071 SLC17A2 1867 2071297 C 3.94 0.0071 SLC17A2 1868 442601 C −2.92 0.0380 SLC17A2 1869 9467646 G 3.94 0.0071 SLC17A2 1870 9467652 G 3.49 0.0171 BTN3A3 1874 2237236 G 3.62 0.0471 TJAP1 1886 1106841 C −4.56 0.0076 TJAP1 1887 1096699 A −4.00 0.0275 RIMS1 1909 11754022 T −3.89 0.0342 RIMS1 1910 10498882 G −3.20 0.0349 RIMS1 1911 2807531 A −3.17 0.0402 RIMS1 1912 1339226 G −5.22 0.0120 RIMS1 1913 1546914 T −5.22 0.0120 RIMS1 1917 12525154 A −4.53 0.0353 KLHL32 1925 1206149 A −4.01 0.0143 SLC22A16 1926 9400390 T −4.52 0.0082 SLC22A16 1927 9320331 A −6.63 0.0032 SLC22A16 1928 9481067 G −3.29 0.0485 UTRN 1997 601873 A 3.65 0.0261 UTRN 1998 622718 T 3.37 0.0385 UTRN 2001 7765923 A 4.18 0.0359 SYNE1 2003 2295190 T −4.67 0.0485 SLC22A3 2013 12194182 C −5.11 0.0149 SLC22A3 2014 3123636 C −4.62 0.0170 SLC22A3 2015 2048327 G −3.96 0.0307 PDE10A 2056 486002 G −3.05 0.0426 SDK1 2076 10951446 A 3.06 0.0398 SDK1 2077 4723434 A −3.39 0.0217 ETV1 2097 4721286 T −3.89 0.0465 ETV1 2099 2237295 G 3.36 0.0426 FERD3L 2107 6967799 T 4.25 0.0382 FLJ22374 2144 6956143 G 3.42 0.0350 PDE1C 2155 6952633 G 3.89 0.0259 BMPER 2164 6975236 T −4.38 0.0064 VPS41 2181 859522 G 6.61 0.0299 WBSCR17 2237 11768233 A −3.51 0.0257 CACNA2D1 2303 12535840 G 3.56 0.0387 CACNA2D1 2309 2059037 C 8.11 0.0023 CACNA2D1 2314 1468400 A −4.44 0.0254 PCLO 2318 1407640 C −3.56 0.0428 SEMA3E 2335 2713154 G −4.36 0.0077 SEMA3E 2336 2713151 T −4.07 0.0145 SEMA3E 2337 2709890 A −4.07 0.0145 SEMA3E 2339 2713174 C −4.07 0.0145 SEMA3E 2341 10270844 T 3.96 0.0349 SEMA3A 2347 1989964 T −3.31 0.0281 DYNC1I1 2384 1227517 A −2.90 0.0453 PON1 2385 13223537 C −4.34 0.0067 ZNF3 2398 7778571 G 4.12 0.0161 CNTNAP2 2496 7802708 G 4.92 0.0048 PTPRN2 2528 6459879 C 4.31 0.0174 PTPRN2 2531 4909222 G −5.59 0.0163 PTPRN2 2532 10265417 T −4.51 0.0057 PTPRN2 2534 10266729 T −4.37 0.0092 CSMD1 2538 4875250 G −4.92 0.0215 CSMD1 2541 13272021 C 4.75 0.0182 CSMD1 2543 13260434 A 4.76 0.0089 MCPH1 2571 1057090 T −3.19 0.0322 MCPH1 2572 2911968 C −4.02 0.0109 PEBP4 2630 2457426 C −3.90 0.0127 UNC5D 2642 7826624 T 5.58 0.0043 SNTG1 2670 7832799 A −4.52 0.0142 SNTG1 2671 1484128 T −5.06 0.0039 SNTG1 2672 1484129 T −5.13 0.0054 DEPDC2 2726 2053140 A 3.90 0.0168 DEPDC2 2732 7007570 G −4.38 0.0052 KCNB2 2752 13279934 G −3.76 0.0390 MMP16 2763 2139481 T 4.90 0.0059 ZFPM2 2798 9643020 A 5.63 0.0111 ZFPM2 2803 16873677 A 6.33 0.0134 ZFPM2 2808 1372614 G 7.38 0.0015 SAMD12 2824 2514588 T −3.76 0.0162 SAMD12 2825 1607924 G −3.76 0.0162 PIP5K1B 2996 17392931 C 3.56 0.0417 TMC1 3030 6560293 A 3.57 0.0306 TMC1 3032 13285999 A 4.15 0.0109 TMC1 3040 1663763 T −4.70 0.0060 TMC1 3042 2501914 T 3.32 0.0311 PCSK5 3054 1029035 C 3.30 0.0423 DAPK1 3084 3128499 G 3.41 0.0403 ZNF169 3097 12236219 T 8.59 0.0235 ZNF169 3098 7037298 T −5.08 0.0053 SVEP1 3124 963143 A −3.23 0.0363 SVEP1 3126 10759422 C −5.04 0.0091 CDK5RAP2 3135 4836819 A 3.96 0.0491 RALGPS1 3156 12551115 C 3.82 0.0205 RALGPS1 3157 12350252 A 3.20 0.0430 NTNG2 3174 10901133 C 4.14 0.0224 VAV2 3189 2810473 T −4.20 0.0474 VAV2 3190 2519109 A 3.49 0.0413 VAV2 3192 2073829 G 3.74 0.0186 NOTCH1 3200 10870085 T 5.69 0.0157 CACNA1B 3208 10867093 T 5.27 0.0472 MYO3A 3275 7097387 C 3.33 0.0364 MYO3A 3285 12764197 G 5.89 0.0029 MYO3A 3287 3781117 C 4.39 0.0263 KCNMA1 3338 1978868 A 4.83 0.0121 GALNTL4 3469 4910289 C −3.44 0.0476 ARNTL 3484 2054605 T −3.48 0.0262 SPON1 3498 1528667 G 3.58 0.0461 DLG2 3531 11233708 T −4.18 0.0137 OPCML 3569 3016388 C 3.76 0.0460 OPCML 3570 3016382 T −4.13 0.0410 STYK1 3608 2900467 G −3.66 0.0111 LOC729025 3618 10219568 A −4.68 0.0029 LOC729025 3625 3915237 C −4.68 0.0080 NAV3 3672 1012088 G −3.44 0.0335 NAV3 3678 1375287 C −5.59 0.0013 NBEA 3715 7333195 T 3.68 0.0157 GPC5 3771 553717 A 3.65 0.0358 GPC5 3774 4773644 A 6.73 0.0096 GPC5 3775 7986797 A 6.50 0.0160 NOVA1 3860 8008779 C 3.44 0.0450 NPAS3 3872 6571604 C 6.10 0.0117 NPAS3 3873 6571605 A 6.10 0.0117 SLC25A21 3882 2022601 A 3.94 0.0181 SLC25A21 3884 1154121 T 3.52 0.0409 SLC25A21 3885 1367029 A 3.22 0.0410 KCNK10 3963 4424855 T −6.33 0.0265 CCDC88C 3988 10139287 A −3.24 0.0460 BCL11B 4003 2614463 T 3.51 0.0375 ATP10A 4005 11853308 C −3.10 0.0485 C15ORF41 4042 16964046 T 10.11 0.0025 CGNL1 4070 7182648 T 5.08 0.0094 CGNL1 4072 8034215 G 4.18 0.0146 RORA 4078 12914584 G −4.14 0.0276 RORA 4080 1657792 A 3.67 0.0364 TBC1D2B 4096 3803380 G −4.30 0.0444 A2BP1 4123 7197955 C −3.54 0.0262 A2BP1 4124 7199748 C −3.51 0.0286 A2BP1 4125 11077158 C −3.51 0.0286 A2BP1 4129 1922593 T −4.92 0.0152 CDH13 4192 9926620 C 3.61 0.0222 TGIF1 4275 1662805 G 5.52 0.0101 CHST9 4311 4093026 G −4.26 0.0147 CHST9 4312 720282 G −3.86 0.0269 CHST9 4313 8084423 A −3.91 0.0304 CCBE1 4346 10503032 A 3.58 0.0278 CCBE1 4347 12454887 G 3.58 0.0278 TXNDC10 4371 1477990 A 6.75 0.0350 TXNDC10 4372 1477992 G 6.75 0.0350 ATRN 4390 151511 A −5.40 0.0111 RNF24 4394 2143235 A −7.25 0.0361 PLCB1 4415 2235212 A −3.45 0.0464 PLCB1 4435 6056252 A 4.16 0.0265 PLCB4 4436 6086690 G 4.46 0.0115 MACROD2 4451 2193028 C 5.14 0.0481 MACROD2 4460 775122 A 4.21 0.0339 MAPRE1 4491 2070090 T 5.65 0.0275 PTPRT 4497 6065432 T −3.36 0.0395 PTPRT 4508 4812631 A −4.79 0.0169 PTPRT 4509 4810366 C −4.50 0.0258 PTPRT 4510 2017914 G −4.50 0.0258 ZSWIM3 4516 6130953 A −3.92 0.0180 CDH4 4537 6121844 C 9.29 0.0321 ASPHD2 4572 8140344 A −3.39 0.0246 HPS4 4574 5761552 T 3.33 0.0341 EFCAB6 4599 12628583 C −7.08 0.0408 EFCAB6 4609 2401408 T −4.60 0.0443

TABLE 11 Alleles Influencing Discontinuation for Lack of Efficacy for Olanzapine Freq. in Discon- Odds Gene Seq ID NCBI RS# Allele tinuers P Ratio SCP2 43 13376501 C 0.167 0.017420 4.03 SCP2 46 17107767 C 0.133 0.041620 3.69 SEC16B 129 869286 G 0.367 0.028920 2.52 USH2A 161 659875 G 0.467 0.001919 3.50 USH2A 163 62906 G 0.467 0.003684 3.23 USH2A 164 386654 T 0.467 0.004272 3.17 USH2A 166 700021 A 0.567 0.023670 2.46 USH2A 168 680410 G 0.467 0.005763 3.05 ESRRG 172 12757165 G 0.200 0.023670 0.35 ESRRG 173 6658528 T 0.231 0.025770 0.34 ESRRG 175 10495027 A 0.200 0.023670 0.35 SLC35F3 188 538272 A 0.133 0.018040 0.28 SLC35F3 189 480993 T 0.133 0.029100 0.31 RYR2 196 12140458 C 0.600 0.036750 2.31 CHRM3 216 16838637 G 0.233 0.010800 0.32 CHRM3 217 1867265 A 0.233 0.025670 0.37 CHRM3 218 2355237 A 0.667 0.016160 2.69 CHRM3 224 6657343 A 0.667 0.010980 2.84 FEZ2 339 1179494 C 0.167 0.033890 0.35 SLC8A1 347 11885401 C 0.300 0.013010 3.10 PRKCE 382 4953288 T 0.200 0.037970 0.38 COMMD1 430 11125907 A 0.179 0.019890 0.31 AAK1 434 9789387 A 0.200 0.010040 0.30 AAK1 435 6546534 T 0.100 0.005196 0.20 AAK1 436 2311837 C 0.167 0.001543 0.22 AAK1 437 6712370 C 0.100 0.003597 0.19 AAK1 438 12713679 G 0.167 0.004392 0.25 AAK1 439 10779953 G 0.133 0.009626 0.25 AAK1 440 12471316 G 0.200 0.005740 0.28 CTNNA2 466 1930 T 0.667 0.010980 2.84 CTNNA2 467 12464777 T 0.667 0.016160 2.69 RAB3GAP1 489 935614 G 0.200 0.013440 3.81 ZRANB3 492 16831601 T 0.200 0.011320 3.92 ZRANB3 493 4953951 T 0.200 0.012330 3.86 ZRANB3 494 16831751 G 0.200 0.019150 3.50 ZRANB3 495 6430579 T 0.167 0.046440 3.13 LRP1B 511 1949871 C 0.133 0.021220 0.29 ARHGAP15 542 6747717 T 0.000 0.008333 0.00 ARHGAP15 544 16858944 A 0.033 0.012420 0.11 ARHGAP15 552 6745691 G 0.600 0.012320 2.75 ARHGAP15 555 10197021 T 0.600 0.014310 2.67 ARHGAP15 556 13415550 T 0.433 0.045800 2.25 FMNL2 580 2577180 G 0.300 0.023410 2.79 PLA2R1 606 2667023 C 0.033 0.043040 0.16 SCN1A 621 3812718 C 0.300 0.023380 0.39 SCN9A 627 4128577 T 0.467 0.043790 2.25 PARD3B 659 6736058 G 0.100 0.005196 0.20 PARD3B 660 6760872 C 0.100 0.005196 0.20 PARD3B 661 4675490 G 0.200 0.010040 0.30 NRP2 673 13396083 C 0.300 0.032720 0.41 NRP2 674 7596827 T 0.321 0.039530 0.41 CUL3 685 11891006 G 0.033 0.040830 0.15 CUL3 687 1542789 A 0.033 0.043040 0.16 DNER 717 6743564 C 0.567 0.012770 2.70 CNTN4 756 1523320 C 0.300 0.032770 0.41 ITPR1 774 304073 G 0.214 0.028180 0.35 ITPR1 775 304038 G 0.233 0.030860 0.38 ITPR1 777 2322830 T 0.633 0.013910 2.71 ATP2B2 792 6763274 C 0.100 0.025400 0.26 SLC6A6 794 1156567 C 0.000 0.033890 0.00 ULK4 845 1495698 C 0.533 0.045530 2.22 FLNB 913 7622687 A 0.607 0.024250 2.54 PTPRG 939 875423 T 0.667 0.038750 2.35 CADPS 947 186236 C 0.433 0.041620 2.29 PRICKLE2 958 161661 A 0.600 0.017500 2.59 FAM19A1 979 12486136 A 0.633 0.010330 2.82 FOXP1 985 2597312 C 0.567 0.006420 2.96 CDGAP 1021 10934491 C 0.433 0.008361 2.94 CDGAP 1025 16829838 T 0.267 0.036970 2.67 KALRN 1046 16835912 C 0.700 0.005012 3.22 CLSTN2 1077 4683509 G 0.067 0.036600 0.23 SPSB4 1085 7620622 A 0.100 0.032370 0.28 NLGN1 1112 16828652 A 0.000 0.029220 0.00 NLGN1 1113 16828952 A 0.200 0.027800 0.35 NLGN1 1114 9870677 C 0.167 0.045810 0.37 SLIT2 1188 10516357 A 0.567 0.009526 2.81 PPARGC1A 1192 10938963 A 0.200 0.020080 0.34 PPARGC1A 1193 8192678 A 0.167 0.039460 0.36 PCDH7 1200 4611883 G 0.233 0.004096 0.28 PCDH7 1201 6812005 G 0.233 0.015450 0.34 PCDH7 1203 12331633 C 0.767 0.000856 4.30 LIMCH1 1216 4339249 C 0.533 0.031450 2.36 LIMCH1 1222 10805090 G 0.467 0.029100 2.41 DKK2 1306 81299 T 0.000 0.045500 0.00 PAPSS1 1308 4956020 T 0.467 0.001350 3.65 PAPSS1 1309 12502059 A 0.464 0.000634 4.13 CAMK2D 1357 4834340 A 0.600 0.010420 2.79 CAMK2D 1358 11098193 T 0.433 0.045800 2.25 CAMK2D 1360 13144613 G 0.500 0.049510 2.19 DCLK2 1440 11727182 G 0.633 0.037460 2.33 CTSO 1444 11946572 G 0.500 0.028480 2.42 FSTL5 1460 2082669 G 0.367 0.026200 2.58 PALLD 1492 2712118 C 0.167 0.039460 0.36 PALLD 1494 4389538 G 0.667 0.022930 2.55 PALLD 1496 2710827 A 0.167 0.021100 0.32 ODZ3 1519 10028158 A 0.300 0.016790 2.96 SEMA5A 1543 12520210 A 0.233 0.041230 0.40 EGFLAM 1588 16903920 G 0.200 0.000669 0.21 EGFLAM 1589 2434504 A 0.300 0.032770 0.41 EGFLAM 1591 1428263 C 0.167 0.045810 0.37 EGFLAM 1593 2561111 T 0.200 0.045500 2.88 PDE4D 1626 2910642 C 0.233 0.018370 0.35 PDE4D 1627 2910641 A 0.267 0.036970 2.67 PDE4D 1632 294494 A 0.067 0.034110 0.23 ELOVL7 1636 6449505 C 0.067 0.022930 0.21 CMYA5 1650 11960229 C 0.400 0.000488 4.33 GPR98 1686 4916684 G 0.633 0.022560 2.52 FBXL17 1719 2193976 T 0.321 0.039530 0.41 KCNN2 1730 4435855 A 0.267 0.012550 3.27 LOC340069 1745 919306 C 0.233 0.027380 0.37 LOC340069 1746 328694 A 0.233 0.035330 0.39 SNCAIP 1752 10066937 A 0.367 0.016750 2.76 SNCAIP 1754 3811879 C 0.393 0.015460 2.82 SNCAIP 1755 1841972 C 0.367 0.016750 2.76 SNCAIP 1756 11241644 G 0.367 0.028920 2.52 SNCAIP 1757 2407209 A 0.567 0.041230 2.26 ADAMTS19 1767 30651 G 0.133 0.009170 0.25 ADAMTS19 1768 30645 T 0.233 0.001087 0.24 ADAMTS19 1769 4835975 A 0.107 0.003065 0.18 TRPC7 1775 3777145 T 0.267 0.005054 3.83 TRPC7 1778 950714 G 0.267 0.012550 3.27 TRPC7 1779 2649691 A 0.267 0.020420 3.00 NEDD9 1814 8180658 C 0.733 0.001341 3.90 PHACTR1 1819 9296512 G 0.600 0.011620 2.75 PHACTR1 1822 4714990 C 0.567 0.034670 2.33 PHACTR1 1825 202066 G 0.200 0.047540 0.39 ATXN1 1835 235147 A 0.700 0.002481 3.52 SLC17A1 1854 1165196 C 0.700 0.023310 2.60 SLC17A1 1856 1165177 T 0.700 0.038470 2.40 SLC17A3 1861 1165207 A 0.733 0.016160 2.82 SLC17A3 1862 1165205 T 0.733 0.019520 2.75 SLC17A2 1868 442601 C 0.533 0.008603 2.84 SLC17A2 1871 199739 T 0.500 0.022460 2.49 BTN3A1 1872 12208788 T 0.267 0.043820 2.59 KLC4 1883 3793017 C 0.033 0.002680 0.08 TRDN 1935 13190807 C 0.500 0.027710 2.41 TRDN 1945 7452290 C 0.233 0.031710 2.91 TRDN 1948 6931183 A 0.233 0.031710 2.91 TFB1M 2010 9371369 A 0.600 0.021260 2.52 SLC22A3 2013 12194182 C 0.433 0.037180 2.34 NXPH1 2089 11489426 C 0.600 0.025670 2.45 SCRN1 2133 11973169 T 0.300 0.023410 2.79 PLEKHA8 2139 7806238 A 0.300 0.010990 3.20 ABCA13 2211 10243683 T 0.167 0.043370 0.36 ABCA13 2212 3923511 G 0.133 0.045800 0.34 WBSCR17 2238 6971383 A 0.200 0.025240 0.35 WBSCR17 2247 7806531 T 0.267 0.043590 0.42 WBSCR17 2248 4717604 T 0.200 0.044160 0.39 LIMK1 2249 810532 G 0.033 0.018760 0.13 LIMK1 2250 2855726 A 0.167 0.024790 0.33 GTF2IRD1 2251 37612 C 0.533 0.037970 2.29 HIP1 2255 1167802 C 0.033 0.010560 0.11 MAGI2 2285 2191806 C 0.067 0.049510 0.25 MAGI2 2286 10255710 C 0.067 0.045500 0.24 MAGI2 2291 1528267 C 0.033 0.037030 0.15 ABCB4 2353 31671 G 0.067 0.009367 0.17 GTPBP10 2362 11972149 T 0.400 0.025630 2.53 GTPBP10 2363 17863999 A 0.400 0.023390 2.56 GTPBP10 2364 13222379 A 0.433 0.023800 2.52 CADPS2 2420 2074589 C 0.200 0.044160 0.39 SLC13A1 2426 1404836 C 0.100 0.010640 0.22 SLC13A1 2429 6963735 C 0.133 0.012940 0.27 SLC13A1 2431 10253693 T 0.567 0.004182 3.13 SLC13A1 2432 2204296 T 0.500 0.016480 2.61 EXOC4 2459 1946303 T 0.367 0.013940 2.85 EXOC4 2461 6975109 T 0.367 0.020950 2.67 PTPRN2 2519 4909289 A 0.433 0.033540 2.38 SLC7A2 2601 7002951 G 0.133 0.009654 5.62 NKAIN3 2712 10102831 A 0.233 0.000917 5.78 NKAIN3 2713 10504356 G 0.167 0.046440 3.13 NKAIN3 2714 10504358 G 0.167 0.046440 3.13 KCNB2 2744 1972888 C 0.067 0.005024 0.15 KCNB2 2745 2196904 C 0.067 0.005024 0.15 KCNB2 2747 1899077 T 0.067 0.005590 0.16 KCNB2 2748 1440355 C 0.067 0.008509 0.17 KCNB2 2749 1965805 G 0.067 0.008509 0.17 KCNB2 2750 2053421 G 0.067 0.013060 0.18 KCNB2 2753 1026869 T 0.600 0.021260 2.52 GRHL2 2774 682769 A 0.100 0.032370 0.28 ZFPM2 2803 16873677 A 0.233 0.045200 2.70 ZFPM2 2804 16873707 T 0.200 0.048840 2.83 ZFPM2 2806 7007352 G 0.233 0.048850 2.66 CSMD3 2811 10088226 G 0.133 0.000006 2.83 CSMD3 2812 11996690 A 0.133 0.000006 2.75 CSMD3 2813 7012235 C 0.133 0.000006 2.75 CSMD3 2814 10505203 A 0.100 0.008367 8.22 FER1L6 2834 6981430 G 0.533 0.024230 2.46 KIAA1797 2960 7848159 G 0.267 0.008146 3.53 KIAA1797 2962 2151002 A 0.567 0.031480 2.36 KIAA1797 2964 2039390 A 0.267 0.003735 4.06 KIAA1797 2965 7858506 G 0.267 0.018600 3.05 PIP5K1B 2995 963707 G 0.167 0.039460 0.36 TMC1 3041 13298704 C 0.300 0.038290 2.55 GNAQ 3061 7048811 G 0.400 0.032850 2.43 DIRAS2 3086 690232 A 0.071 0.037160 0.23 DIRAS2 3087 532591 C 0.100 0.031340 0.27 HIATL1 3099 9409765 A 0.333 0.038170 0.42 HIATL1 3100 9409552 G 0.333 0.045500 0.44 TTLL11 3144 13299260 C 0.300 0.038470 0.42 TSC1 3179 1073123 G 0.367 0.028920 2.52 TSC1 3180 7858160 T 0.367 0.032120 2.48 TSC1 3182 7035308 A 0.500 0.035810 2.32 VAV2 3186 7023551 G 0.367 0.046930 2.32 CACNA1B 3213 10867107 C 0.400 0.037670 2.36 CACNB2 3239 729245 A 0.067 0.045500 0.24 JMJD1C 3297 10995505 A 0.067 0.019550 0.20 JMJD1C 3299 10761747 G 0.067 0.021170 0.20 JMJD1C 3301 9629895 A 0.067 0.039190 0.23 JMJD1C 3303 2893922 C 0.033 0.043040 0.16 SORCS3 3388 7072425 T 0.000 0.032590 0.00 VTI1A 3398 7097587 A 0.067 0.019510 0.20 ATRNL1 3411 10885719 T 0.200 0.040790 0.38 ATRNL1 3412 4364974 G 0.067 0.005590 0.16 ATRNL1 3414 2804207 C 0.357 0.022000 0.38 ATRNL1 3416 10787584 C 0.367 0.025060 0.40 ATRNL1 3417 2420098 G 0.367 0.027030 0.41 ATRNL1 3421 180675 A 0.036 0.030580 0.14 ATRNL1 3422 180635 T 0.100 0.043730 0.30 ATE1 3438 10510104 G 0.000 0.039290 0.00 ATE1 3445 4752611 A 0.533 0.024230 2.46 ATE1 3449 11200251 T 0.500 0.007236 2.94 CTBP2 3455 9422765 G 0.400 0.010300 2.91 CTBP2 3456 7896555 G 0.400 0.010300 2.91 STIM1 3457 7952083 C 0.233 0.004090 0.28 STIM1 3458 10835249 G 0.233 0.025670 0.37 SPON1 3496 1876427 G 0.100 0.037670 0.29 SPON1 3497 2049723 C 0.067 0.022930 0.21 81.99 mb 3525 1939631 G 0.567 0.028670 2.39 DLG2 3553 624493 G 0.300 0.009859 3.25 DLG2 3554 582652 A 0.286 0.014700 3.20 DLG2 3555 483220 G 0.300 0.023410 2.79 TSPAN9 3595 10774140 C 0.500 0.033890 2.33 TMEM16B 3597 4930809 T 0.433 0.021070 2.56 ITPR2 3638 7955049 G 0.033 0.017100 0.12 KCNC2 3660 10879888 G 0.133 0.045800 0.34 NAV3 3675 10859738 A 0.667 0.019110 2.63 N4BP2L2 3701 1081796 A 0.400 0.001406 3.82 N4BP2L2 3702 208431 G 0.393 0.011630 2.95 NBEA 3705 867503 C 0.000 0.045500 0.00 NBEA 3709 669933 A 0.033 0.017100 0.12 NBEA 3710 2105174 T 0.033 0.017100 0.12 NBEA 3711 9530540 C 0.167 0.029030 0.34 NBEA 3717 1536634 T 0.267 0.016160 0.35 NBEA 3718 2798337 A 0.167 0.045810 0.37 LMO7 3741 502171 G 0.267 0.031820 0.39 LMO7 3742 7335067 A 0.433 0.033540 2.38 LMO7 3744 7321748 C 0.100 0.001027 0.16 LMO7 3745 7326714 T 0.100 0.001107 0.16 LMO7 3746 9318373 A 0.633 0.000265 4.30 LMO7 3749 11617789 G 0.000 0.006411 0.00 LMO7 3751 9530473 G 0.133 0.012940 0.27 SLAIN1 3758 9318496 T 0.033 0.023440 0.13 SLAIN1 3759 1146920 C 0.033 0.002680 0.08 SLAIN1 3760 10507874 G 0.000 0.021650 0.00 GPC5 3767 9560813 T 0.533 0.000872 3.76 GPC5 3768 9560814 C 0.533 0.001213 3.62 GPC5 3784 10507993 G 0.367 0.045470 2.34 GPC5 3786 1933197 C 0.333 0.022930 0.39 GPC6 3793 2209880 A 0.400 0.018060 2.67 GPC6 3813 9524268 T 0.567 0.000671 3.85 GPC6 3820 9524371 C 0.100 0.018410 0.25 GPC6 3821 7337873 C 0.133 0.039470 0.33 NALCN 3827 588083 C 0.300 0.045020 0.43 NPAS3 3870 1315139 T 0.214 0.015640 0.32 SLC25A21 3890 1950367 G 0.067 0.019110 10.64 LRFN5 3891 7148640 G 0.467 0.018600 2.58 RGS6 3932 11158926 T 0.633 0.001891 3.49 RGS6 3933 7156200 C 0.433 0.029870 2.42 RGS6 3934 11623548 T 0.333 0.045500 0.44 RGS6 3943 2214965 T 0.233 0.047940 0.41 RGS6 3950 2239221 C 0.233 0.035330 0.39 ATP10A 4005 11853308 C 0.233 0.007423 0.30 ATP10A 4006 7179423 G 0.600 0.030800 2.38 ATP10A 4007 2066707 G 0.167 0.004267 0.25 ATP10A 4008 7178018 A 0.533 0.037970 2.29 MEIS2 4050 6495883 G 0.167 0.045810 0.37 CGNL1 4071 4774941 G 0.200 0.012330 3.86 CGNL1 4073 16977507 A 0.167 0.049540 3.09 CGNL1 4076 16977597 T 0.033 0.024940 3.86 RORA 4078 12914584 G 0.067 0.011070 0.18 RORA 4079 4774370 C 0.067 0.028920 0.22 RORA 4082 11071548 G 0.667 0.004725 3.17 TBC1D2B 4096 3803380 G 0.033 0.014590 0.12 SH3GL3 4108 2244838 C 0.367 0.005772 3.26 A2BP1 4113 17822719 A 0.214 0.018470 0.33 A2BP1 4115 11077043 G 0.321 0.028620 0.39 A2BP1 4128 9934782 G 0.300 0.005930 0.32 WWOX 4158 3764342 C 0.300 0.002226 4.10 WWOX 4160 12051258 T 0.167 0.049540 3.09 MPHOSPH6 4162 7405231 C 0.667 0.027720 2.48 MPHOSPH6 4175 2967339 T 0.300 0.034910 2.59 MPHOSPH6 4178 1011433 C 0.300 0.020520 2.87 MPHOSPH6 4181 2932812 A 0.300 0.031820 2.63 CDH13 4205 11862993 A 0.167 0.028590 3.55 CA10 4239 9893317 A 0.633 0.030830 2.41 CA10 4240 1503058 A 0.300 0.016270 0.36 MSI2 4255 1007462 C 0.233 0.002145 0.26 PTPRM 4294 11081352 T 0.500 0.014360 2.66 PTPRM 4295 649598 T 0.467 0.035860 2.33 PTPRM 4296 623258 T 0.467 0.043790 2.25 PTPRM 4298 619379 C 0.467 0.049190 2.21 OSBPL1A 4310 275857 C 0.100 0.025860 5.44 CCBE1 4338 4558500 C 0.200 0.024430 0.35 CCBE1 4339 1557406 G 0.200 0.037970 0.38 CDH7 4353 10871590 A 0.143 0.015220 0.27 CDH7 4354 10460125 T 0.133 0.033930 0.32 CDH7 4355 7237421 T 0.133 0.039470 0.33 CDH7 4356 8092259 G 0.133 0.044400 0.33 CDH7 4358 1484725 T 0.133 0.045800 0.34 DOK6 4382 9962570 T 0.533 0.003976 3.14 LDLR 4384 2116897 T 0.400 0.023390 2.56 PLCB1 4420 2294259 C 0.133 0.039470 0.33 PLCB1 4435 6056252 A 0.533 0.015830 2.62 PLCB4 4436 6086690 G 0.533 0.015830 2.62 MACROD2 4445 11908639 G 0.667 0.004725 3.17 MACROD2 4446 1743471 A 0.667 0.005888 3.09 MACROD2 4448 459322 G 0.643 0.011440 2.87 MACROD2 4449 459874 C 0.633 0.012670 2.74 MACROD2 4453 175805 T 0.400 0.041920 2.32 MACROD2 4455 6043616 C 0.267 0.047700 2.55 KIF16B 4484 6080359 C 0.067 0.045500 0.24 PTPRT 4497 6065432 T 0.467 0.003684 3.23 PTPRT 4498 746413 C 0.633 0.007999 2.92 PTPRT 4499 1126101 G 0.233 0.042280 0.40 PTPRT 4500 6065434 T 0.500 0.008152 2.89 PTPRT 4501 6016688 T 0.433 0.002313 3.48 CDH4 4538 6142884 A 0.333 0.038750 0.43 NCAM2 4543 2826351 A 0.567 0.006420 2.96 NCAM2 4545 232518 C 0.133 0.015300 0.27 EFCAB6 4599 12628583 C 0.233 0.029220 2.96 EFCAB6 4602 470083 C 0.367 0.008227 3.10 EFCAB6 4603 137733 T 0.167 0.000139 0.16 EFCAB6 4606 5764214 C 0.200 0.001341 0.23 EFCAB6 4609 2401408 T 0.367 0.011470 2.94 EFCAB6 4612 2187887 G 0.133 0.004437 0.22 EFCAB6 4613 5764302 G 0.200 0.020750 3.45 EFCAB6 4614 5764310 C 0.200 0.011320 3.92

TABLE 12 Alleles Influencing Discontinuation for Lack of Efficacy for Risperidone Freq. in Discon- Odds Gene Seq ID NCBI RS# Allele tinuers P Ratio RP1-21O18.1 14 1000313 G 0.18 0.0402 0.46 RP1-21O18.1 17 4661575 T 0.30 0.0461 0.52 LRP8 55 17108202 G 0.50 0.0262 2.00 DPT 121 6427142 G 0.21 0.0378 2.39 DPT 125 1018453 C 0.39 0.0311 0.51 SEC16B 126 1889981 T 0.33 0.0087 2.58 SEC16B 128 2862300 G 0.40 0.0023 2.76 SEC16B 129 869286 G 0.37 0.0017 2.95 SEC16B 130 1934650 C 0.26 0.0105 2.71 PLA2G4A 135 12128551 A 0.12 0.0353 0.39 PLA2G4A 137 12720662 T 0.16 0.0449 0.46 KCNK2 150 11120527 T 0.37 0.0169 2.25 USH2A 161 659875 G 0.37 0.0065 2.56 USH2A 163 62906 G 0.37 0.0093 2.40 USH2A 165 10864235 A 0.48 0.0212 2.08 USH2A 168 680410 G 0.37 0.0096 2.43 ESRRG 179 12023399 G 0.37 0.0265 2.10 ESRRG 182 12037068 C 0.07 0.0247 0.30 ESRRG 184 7529655 A 0.08 0.0301 0.34 RYR2 196 12140458 C 0.32 0.0423 0.52 RYR2 215 4659819 T 0.58 0.0419 1.88 FMN2 234 11801848 C 0.47 0.0073 2.34 FMN2 236 7520065 G 0.55 0.0078 2.29 FMN2 237 897662 T 0.56 0.0041 2.45 FMN2 239 1542400 G 0.32 0.0051 0.41 FMN2 240 4659569 T 0.15 0.0237 0.40 FMN2 241 10754696 T 0.15 0.0386 0.43 FMN2 242 10754697 A 0.15 0.0390 0.44 FMN2 243 16832176 C 0.13 0.0427 0.43 DDEF2 283 10593 G 0.27 0.0199 2.39 BRE 325 1546029 C 0.16 0.0500 0.47 PLEKHH2 359 4952676 G 0.35 0.0465 0.53 PLEKHH2 360 12621654 T 0.40 0.0232 2.15 CCDC85A 421 2869529 C 0.45 0.0431 1.89 COMMD1 429 7569442 C 0.19 0.0075 0.38 COMMD1 430 11125907 A 0.23 0.0096 0.41 CTNNA2 463 318369 G 0.29 0.0061 0.41 CTNNA2 464 318362 C 0.19 0.0168 0.42 NAP5 482 13432172 G 0.00 0.0261 0.00 KYNU 525 2278587 A 0.00 0.0142 0.00 KYNU 529 16858404 T 0.05 0.0164 0.24 ARHGAP15 559 16823114 A 0.53 0.0004 3.03 ARHGAP15 561 13031917 C 0.53 0.0007 2.92 PKP4 596 1990815 C 0.31 0.0333 0.50 PKP4 597 10933492 A 0.27 0.0490 2.09 PKP4 600 2528582 G 0.29 0.0231 0.48 CERKL 635 4018756 A 0.59 0.0461 1.90 PDE1A 639 11895090 A 0.40 0.0307 2.03 PDE1A 641 6736414 T 0.39 0.0085 2.41 PARD3B 662 7559302 T 0.42 0.0125 2.26 COL4A3 699 6758076 C 0.05 0.0164 0.24 CNTN4 770 12497768 T 0.60 0.0391 1.91 ERC2 883 9810436 A 0.37 0.0265 2.10 ERC2 897 1878270 C 0.27 0.0141 0.44 ERC2 899 9881216 T 0.27 0.0167 0.45 ERC2 900 7633140 A 0.29 0.0180 0.46 ERC2 901 7627759 C 0.31 0.0316 0.50 IL17RD 903 2035654 C 0.08 0.0175 0.31 IL17RD 905 747089 T 0.27 0.0109 2.64 FHIT 914 2253211 C 0.68 0.0007 2.94 PTPRG 931 7427981 A 0.47 0.0044 2.52 PTPRG 934 1713531 C 0.40 0.0493 0.54 CADPS 943 9843019 T 0.10 0.0281 0.36 CADPS 949 11925708 A 0.28 0.0409 0.50 MAGI1 972 4234687 A 0.15 0.0387 0.43 MAGI1 973 17073075 T 0.19 0.0279 0.45 EPHA6 1006 6438925 G 0.03 0.0303 0.22 CPNE4 1059 2178385 A 0.44 0.0422 1.91 CPNE4 1060 2178383 G 0.26 0.0402 0.50 CLSTN2 1074 7632885 G 0.31 0.0048 0.40 CLSTN2 1075 4683499 G 0.42 0.0149 0.47 CLSTN2 1076 6439927 C 0.26 0.0325 0.49 HTR3D 1128 939334 G 0.18 0.0247 0.43 LEPREL1 1133 9835230 A 0.31 0.0301 2.17 PCDH7 1199 10517215 A 0.05 0.0260 0.26 PCDH7 1202 2310225 A 0.16 0.0500 0.47 LIMCH1 1223 6821712 C 0.40 0.0224 2.11 LIMCH1 1224 11734372 T 0.34 0.0352 0.51 LPHN3 1231 995447 C 0.02 0.0271 0.14 PDLIM5 1296 2452601 G 0.29 0.0296 0.49 PDLIM5 1299 7690296 G 0.29 0.0376 0.51 PDLIM5 1301 951613 A 0.29 0.0390 0.51 NDST3 1371 6534079 A 0.08 0.0072 0.27 NDST3 1374 6820851 T 0.23 0.0346 0.48 NDST3 1376 6534084 C 0.23 0.0437 0.49 MAML3 1397 17051001 T 0.47 0.0307 1.98 POU4F2 1427 1104532 A 0.05 0.0414 0.29 FSTL5 1454 4352428 G 0.42 0.0358 1.98 FSTL5 1468 7699959 A 0.40 0.0487 0.54 FSTL5 1471 1994770 A 0.60 0.0060 2.35 TLL1 1477 9637646 T 0.24 0.0181 0.45 PALLD 1491 2319901 G 0.58 0.0139 2.17 ODZ3 1514 2675532 C 0.23 0.0242 0.46 MYO10 1569 388887 T 0.53 0.0255 2.02 MYO10 1570 11750538 G 0.24 0.0477 0.51 MYO10 1572 890910 A 0.22 0.0083 0.39 CDH10 1575 3822429 T 0.34 0.0166 0.47 C1QTNF3 1580 6898170 G 0.30 0.0096 0.43 EGFLAM 1591 1428263 C 0.14 0.0476 0.43 EGFLAM 1595 16903966 C 0.22 0.0410 2.33 ELOVL7 1637 4700394 T 0.68 0.0207 2.10 VCAN 1669 309559 T 0.56 0.0189 2.07 MEF2C 1674 652660 G 0.13 0.0427 0.43 GPR98 1688 2366926 G 0.19 0.0168 0.42 GPR98 1689 1878878 A 0.44 0.0321 1.98 GPR98 1691 2438359 T 0.29 0.0024 0.37 SEMA6A 1735 254231 G 0.42 0.0328 0.52 SNX24 1761 10066638 G 0.63 0.0301 1.97 TRPC7 1775 3777145 T 0.02 0.0063 0.10 TRPC7 1776 11748766 C 0.35 0.0082 2.48 TRPC7 1778 950714 G 0.02 0.0079 0.10 TRPC7 1779 2649691 A 0.05 0.0219 0.25 ODZ2 1792 1529681 A 0.40 0.0165 2.23 ODZ2 1795 6555784 T 0.13 0.0153 0.37 ODZ2 1797 7708354 G 0.42 0.0103 2.31 RNF144B 1841 494248 C 0.26 0.0326 2.27 LRFN2 1881 846505 T 0.31 0.0266 0.49 SLC22A16 1929 723685 C 0.11 0.0431 3.23 SLC22A16 1930 7740547 C 0.30 0.0487 2.03 STX11 1995 6935462 A 0.00 0.0460 0.00 PARK2 2019 992037 T 0.18 0.0316 0.45 PARK2 2033 4708953 C 0.68 0.0262 2.04 PARK2 2038 10945823 A 0.32 0.0334 2.10 PARK2 2039 10945825 A 0.32 0.0404 2.04 PARK2 2041 2105643 C 0.34 0.0435 1.99 PDE10A 2062 7752880 G 0.13 0.0226 0.39 SDK1 2081 4723505 T 0.52 0.0118 2.21 SDK1 2082 1044701 A 0.24 0.0013 0.34 NXPH1 2084 6970999 G 0.13 0.0088 0.34 NXPH1 2085 2189464 T 0.11 0.0093 0.33 SCIN 2093 1034856 T 0.55 0.0078 2.29 SNX13 2102 4470902 T 0.48 0.0441 1.88 NPY 2114 16129 T 0.35 0.0370 0.52 NPY 2115 16124 A 0.37 0.0381 0.52 PDE1C 2153 3213709 G 0.08 0.0036 0.25 EEPD1 2172 196618 A 0.24 0.0324 2.31 ABCA13 2190 17132163 T 0.02 0.0158 0.12 ABCA13 2191 12113721 A 0.02 0.0158 0.12 GRB10 2215 2244347 C 0.21 0.0010 0.32 GRB10 2217 2244351 G 0.33 0.0112 0.44 GRB10 2218 2237477 T 0.24 0.0233 0.46 HIP1 2264 11770686 T 0.55 0.0085 2.29 MAGI2 2272 1860538 G 0.35 0.0368 0.52 MAGI2 2273 2075013 C 0.35 0.0368 0.52 MAGI2 2277 12531031 T 0.10 0.0199 0.34 MAGI2 2296 10953851 T 0.06 0.0229 0.30 MAGI2 2298 10269174 G 0.29 0.0105 0.43 SEMA3E 2346 1972459 C 0.42 0.0274 2.04 PPP1R9A 2372 7806202 G 0.53 0.0063 2.37 PPP1R9A 2373 1918482 A 0.29 0.0025 0.37 PPP1R9A 2374 6465460 G 0.31 0.0090 0.42 PPP1R9A 2376 854520 T 0.55 0.0262 1.99 PPP1R9A 2377 854532 T 0.52 0.0200 2.06 PPP1R9A 2378 854535 C 0.56 0.0335 1.93 EXOC4 2458 10488165 C 0.26 0.0118 0.43 EXOC4 2471 4731992 A 0.29 0.0471 2.05 DGKI 2474 1731951 T 0.40 0.0409 0.53 CNTNAP2 2508 1637864 T 0.27 0.0130 2.56 CNTNAP2 2509 1637840 T 0.27 0.0130 2.56 SGCZ 2596 2898413 A 0.21 0.0420 2.35 PSD3 2607 7837572 T 0.24 0.0408 2.23 PSD3 2610 11781914 G 0.55 0.0012 2.77 PSD3 2611 1492289 C 0.58 0.0032 2.50 UNC5D 2636 2589344 T 0.10 0.0130 0.32 UNC5D 2643 6468338 T 0.05 0.0383 0.28 NKAIN3 2686 4297032 T 0.19 0.0268 2.64 NKAIN3 2687 16928845 A 0.19 0.0268 2.64 NKAIN3 2688 16928883 C 0.20 0.0378 2.46 NKAIN3 2689 16928902 C 0.19 0.0429 2.40 NKAIN3 2703 16929381 T 0.23 0.0269 2.46 NKAIN3 2704 4737609 A 0.24 0.0324 2.31 NKAIN3 2710 1383154 A 0.29 0.0231 2.29 NKAIN3 2724 17279355 G 0.16 0.0458 2.59 MMP16 2762 2248057 G 0.56 0.0113 2.20 GRHL2 2775 13275653 C 0.27 0.0366 0.50 GRHL2 2777 4734573 C 0.18 0.0271 0.44 NCALD 2780 2387620 G 0.18 0.0113 0.39 ZFPM2 2790 7845734 G 0.06 0.0395 0.33 ZFPM2 2802 6469014 T 0.08 0.0175 0.31 ZFPM2 2805 11986654 G 0.02 0.0366 0.15 FER1L6 2845 2069078 C 0.22 0.0013 4.33 FER1L6 2846 13269044 G 0.21 0.0081 3.18 DDEF1 2875 2791349 C 0.37 0.0362 2.01 DDEF1 2883 4504679 A 0.45 0.0097 2.28 ST3GAL1 2902 2978014 A 0.43 0.0241 2.10 ST3GAL1 2903 2978015 T 0.44 0.0321 1.98 ST3GAL1 2904 2945779 A 0.46 0.0406 1.96 SMARCA2 2933 10116703 A 0.37 0.0301 0.51 PTPRD 2955 1036328 C 0.21 0.0397 0.48 PIP5K1B 2998 1541082 A 0.13 0.0359 3.11 TMC1 3043 348478 G 0.15 0.0497 0.45 PCSK5 3052 2789608 G 0.26 0.0068 0.40 ZNF169 3097 12236219 T 0.11 0.0463 3.18 FKTN 3111 2518128 A 0.53 0.0264 1.99 ABL1 3165 2855160 T 0.48 0.0441 1.88 CUGBP2 3232 2938015 A 0.15 0.0031 0.31 CACNB2 3242 10828879 A 0.32 0.0290 2.14 SORBS1 3354 2296966 A 0.11 0.0096 5.30 SORBS1 3361 10882584 G 0.12 0.0166 4.26 VTI1A 3391 3740143 G 0.23 0.0242 0.46 VTI1A 3393 10509963 A 0.23 0.0126 0.42 VTI1A 3394 10885352 T 0.23 0.0187 0.44 GRK5 3429 10510055 C 0.32 0.0091 0.43 MICAL2 3481 2270511 G 0.19 0.0429 2.40 SPON1 3511 11023098 T 0.27 0.0460 0.51 DLG2 3528 2060147 G 0.32 0.0109 2.47 DLG2 3529 12275254 C 0.48 0.0060 2.40 DLG2 3530 983590 T 0.29 0.0334 2.16 DLG2 3531 11233708 T 0.45 0.0248 2.04 TSPAN9 3592 4766079 C 0.55 0.0056 2.37 STYK1 3613 6488316 T 0.37 0.0214 0.48 STYK1 3614 7350597 A 0.39 0.0498 0.54 LOC729025 3619 1624759 G 0.43 0.0165 2.20 LOC729025 3625 3915237 C 0.15 0.0020 0.30 PIK3C2G 3633 11043979 C 0.30 0.0447 0.52 NAV3 3668 10859620 G 0.37 0.0484 0.54 NAV3 3670 11107419 T 0.19 0.0056 0.37 NAV3 3673 1677893 A 0.56 0.0113 2.20 NAV3 3675 10859738 A 0.55 0.0249 2.01 ATXN2 3685 616559 G 0.27 0.0481 2.08 TRPC4 3730 1855253 A 0.60 0.0487 1.86 NPAS3 3864 11851667 C 0.15 0.0183 0.39 NPAS3 3875 7144144 C 0.58 0.0112 2.20 NPAS3 3877 11156807 T 0.35 0.0465 0.53 LRFN5 3892 10149327 T 0.48 0.0340 1.94 LRFN5 3900 4143896 A 0.37 0.0138 0.46 LRFN5 3902 10131436 A 0.21 0.0121 0.41 LRFN5 3903 17112319 A 0.31 0.0205 0.47 SAMD4A 3911 1307289 G 0.12 0.0272 0.38 SAMD4A 3912 1212968 C 0.11 0.0412 0.41 PPP2R5E 3922 7140704 G 0.24 0.0477 2.16 RPS6KA5 3977 7156252 T 0.40 0.0259 2.07 CCDC88C 3981 1970911 A 0.19 0.0045 3.72 CCDC88C 3988 10139287 A 0.22 0.0390 0.48 GLDN 4055 17647970 T 0.29 0.0390 0.51 GLDN 4058 2470172 C 0.37 0.0447 0.53 RORA 4081 12594561 T 0.53 0.0342 1.93 RORA 4083 12595483 G 0.60 0.0243 2.02 TBC1D2B 4093 11634607 T 0.50 0.0198 2.07 ARNT2 4103 11072931 T 0.15 0.0390 0.44 A2BP1 4118 1155959 C 0.29 0.0473 0.52 CDH13 4192 9926620 C 0.26 0.0325 0.49 CDH13 4199 10514574 G 0.06 0.0098 0.26 MSI2 4257 8066677 G 0.18 0.0092 0.38 SDK2 4263 7219778 A 0.31 0.0148 0.46 HRNBP3 4272 7212305 A 0.19 0.0429 2.40 PTPRM 4289 524833 C 0.06 0.0395 0.33 CHST9 4314 17703962 G 0.26 0.0376 2.20 CCBE1 4340 2851865 T 0.50 0.0007 2.94 CCBE1 4343 1560299 T 0.65 0.0041 2.47 CCBE1 4344 4608425 A 0.58 0.0011 2.77 CDH7 4359 7244664 G 0.11 0.0204 4.07 CDH7 4360 8089669 A 0.48 0.0314 1.96 CDH7 4369 2587427 A 0.44 0.0240 2.06 DOK6 4375 1550597 C 0.62 0.0014 2.75 DOK6 4376 1550598 A 0.61 0.0023 2.60 DOK6 4377 12967871 A 0.55 0.0044 2.43 MBP 4383 470181 G 0.24 0.0317 0.48 ZNF667 4386 7251105 G 0.48 0.0441 1.88 ZNF544 4389 12462307 T 0.48 0.0106 2.24 KIF16B 4461 4814465 T 0.61 0.0238 2.03 KIF16B 4464 2144883 T 0.52 0.0264 1.99 KIF16B 4465 2328019 C 0.52 0.0264 1.99 KIF16B 4472 6034464 A 0.55 0.0339 1.93 KIF16B 4473 2876428 C 0.53 0.0264 1.99 KCNB1 4517 2057077 C 0.48 0.0237 2.04 SNAI1 4528 6020187 G 0.08 0.0175 0.31 CDH4 4538 6142884 A 0.37 0.0447 0.53 C21ORF37 4540 12483129 C 0.28 0.0066 0.41 NCAM2 4550 973045 A 0.61 0.0059 2.36 NCAM2 4551 986917 A 0.34 0.0352 0.51 PDE9A 4564 12626774 C 0.18 0.0071 0.37 PDE9A 4566 11702778 A 0.60 0.0023 2.59 ASPHD2 4573 16982107 T 0.10 0.0239 4.54 PACSIN2 4587 1071960 C 0.19 0.0356 0.46 EFCAB6 4598 9614382 G 0.44 0.0003 3.30 EFCAB6 4600 2374773 A 0.48 0.0038 2.50 EFCAB6 4606 5764214 C 0.55 0.0339 1.93

TABLE 13 Alleles Influencing Discontinuation for Lack of Efficacy for Quetiapine Freq. in Discon- Odds Gene Seq ID NCBI RS# Allele tinuers P Ratio RP1-21O18.1 16 2221926 T 0.19 0.04706 2.46 EPHB2 21 7536195 T 0.19 0.04706 2.46 LRP8 53 2297657 A 0.24 0.00457 0.36 LRP8 54 12035926 G 0.27 0.02170 0.44 LRP8 55 17108202 G 0.25 0.00468 0.36 LRP8 56 11206139 G 0.73 0.00009 3.88 PRKACB 70 648856 G 0.13 0.02387 0.37 PRKACB 71 599686 T 0.13 0.02995 0.39 PRKACB 72 6701486 A 0.13 0.02995 0.39 PRKACB 74 2642186 G 0.13 0.03741 0.40 PTGFRN 90 17036573 G 0.08 0.00800 11.25 PTGFRN 91 12078461 A 0.08 0.00800 11.25 ATF6 103 16856629 C 0.02 0.00704 0.10 ATF6 105 10918104 A 0.02 0.01105 0.11 ATF6 107 2880056 A 0.02 0.01281 0.11 ATF6 108 12040523 T 0.02 0.03532 0.15 ATF6 109 2499856 T 0.23 0.00880 3.10 FAM78B 113 10800181 G 0.40 0.04051 2.04 SEC16B 129 869286 G 0.29 0.02588 2.35 SEC16B 130 1934650 C 0.18 0.00622 3.98 MR1 134 3845422 A 0.10 0.02526 0.33 KCNK2 145 7547655 A 0.38 0.00990 2.48 KCNK2 149 1112101 G 0.40 0.01024 2.48 KCNK2 150 11120527 T 0.33 0.04745 2.06 USH2A 152 4655413 T 0.46 0.00426 2.62 USH2A 153 17025030 C 0.46 0.00696 2.47 ESRRG 176 1984137 C 0.58 0.02649 2.07 ESRRG 177 10218694 A 0.23 0.02617 0.44 ESRRG 178 12088947 A 0.23 0.02912 0.45 RYR2 213 2685297 G 0.40 0.03807 2.03 PLD5 268 12063701 G 0.15 0.03267 0.39 DDEF2 282 10204214 T 0.21 0.00189 4.29 DDEF2 283 10593 G 0.21 0.00383 3.79 KLHL29 296 6544949 G 0.13 0.00720 4.98 CRIM1 326 6757374 T 0.17 0.01455 3.35 CRIM1 330 3770876 C 0.56 0.01400 2.24 CRIM1 331 2160367 C 0.58 0.01239 2.27 CRIM1 332 1017154 T 0.50 0.04593 1.93 SLC8A1 351 12611602 C 0.58 0.00890 2.37 PRKCE 380 6732900 T 0.29 0.00898 0.41 PRKCE 381 4953270 G 0.31 0.02235 0.46 AAK1 440 12471316 G 0.54 0.04224 1.94 NAP5 483 12991216 A 0.50 0.00267 2.72 NAP5 487 11695364 T 0.18 0.02907 0.42 LRP1B 523 1900936 T 0.25 0.04561 0.48 LRP1B 524 13382235 G 0.14 0.01726 3.94 ARHGAP15 554 4334442 C 0.25 0.04842 2.25 KIF5C 563 4130558 A 0.19 0.04706 2.46 FMNL2 578 17327752 A 0.15 0.04849 0.44 FMNL2 581 10497108 C 0.00 0.00447 0.00 FMNL2 582 16823807 G 0.00 0.00447 0.00 FMNL2 583 16823809 C 0.00 0.00447 0.00 FMNL2 584 10497111 A 0.02 0.01655 0.12 SCN1A 619 4667862 A 0.42 0.04132 2.00 SCN1A 620 6432860 A 0.42 0.04594 1.96 SCN9A 623 4303728 A 0.15 0.03987 2.86 SCN7A 630 3791251 G 0.15 0.01036 3.94 PARD3B 663 919936 C 0.27 0.03201 0.47 TRIP12 724 6707272 T 0.42 0.03547 2.04 SAG 732 3828307 T 0.12 0.00222 8.74 CNTN6 740 17271519 G 0.44 0.04244 1.97 CNTN6 747 3772284 A 0.31 0.02855 0.47 CNTN6 748 1479530 G 0.25 0.01613 0.42 CNTN6 749 155900 T 0.65 0.00160 2.87 CNTN6 750 155390 G 0.54 0.00161 2.84 CNTN6 754 17038701 G 0.00 0.01986 0.00 CNTN4 755 10510226 G 0.58 0.02551 2.08 CNTN4 764 6785626 A 0.58 0.00711 2.42 CNTN4 769 9823500 C 0.33 0.04745 2.06 ITPR1 778 3804992 A 0.29 0.00983 0.40 ITPR1 779 7637793 T 0.31 0.01401 0.43 ITPR1 781 9880562 T 0.25 0.03955 0.48 ITPR1 782 3792512 C 0.27 0.03678 2.27 DAZL 800 12233472 G 0.37 0.04928 2.00 RARB 806 1286738 T 0.06 0.00514 0.20 RARB 808 1656463 A 0.06 0.02341 0.26 STAC 824 17035045 T 0.31 0.03607 2.18 STAC 825 4678878 C 0.48 0.02767 2.07 ULK4 828 4973875 C 0.54 0.03348 2.01 ULK4 830 9311268 A 0.54 0.02627 2.07 ULK4 839 7649806 A 0.52 0.02926 2.05 ULK4 844 1495696 C 0.56 0.02230 2.12 ULK4 846 9834824 G 0.56 0.02988 2.04 PTPRG 937 1388612 A 0.25 0.02461 2.50 PTPRG 939 875423 T 0.35 0.01178 0.43 PTPRG 940 9813294 A 0.58 0.01594 2.23 PTPRG 941 2242352 G 0.44 0.02509 2.12 CADPS 946 9830865 A 0.12 0.04366 0.39 CADPS 949 11925708 A 0.29 0.04142 0.49 FAM19A1 982 6801913 A 0.42 0.00550 2.59 GBE1 996 4411908 G 0.24 0.04031 0.47 GBE1 998 3860595 C 0.25 0.04872 0.49 CDGAP 1021 10934491 C 0.42 0.00171 2.96 CPNE4 1058 6806898 T 0.17 0.04662 2.60 EPHB1 1071 4894251 A 0.65 0.00909 2.39 EPHB1 1072 750543 A 0.65 0.01178 2.32 SERPINI2 1087 4955673 C 0.37 0.02729 0.48 SERPINI1 1092 1492022 C 0.28 0.02449 0.45 TNIK 1099 4955765 G 0.54 0.04224 1.94 TNIK 1103 9861012 G 0.46 0.03900 1.99 PLD1 1106 1316415 G 0.31 0.02235 0.46 NLGN1 1111 10936764 G 0.40 0.01864 2.25 NLGN1 1119 4894645 T 0.24 0.01686 2.75 NLGN1 1120 12636180 T 0.38 0.03547 2.08 IL1RAP 1143 2193877 G 0.10 0.01230 0.30 LDB2 1169 1501142 G 0.12 0.04366 0.39 LDB2 1171 7690190 A 0.27 0.03088 0.47 SLIT2 1187 621806 C 0.21 0.01399 0.40 SLIT2 1189 609535 A 0.21 0.02111 0.42 SLIT2 1191 9992591 C 0.21 0.04085 0.46 CCKAR 1197 2040342 C 0.08 0.02797 0.31 KIAA1239 1206 17575883 A 0.23 0.04319 2.34 PDLIM5 1293 2510777 C 0.60 0.04428 1.96 PAPSS1 1307 2672487 A 0.25 0.03955 0.48 PAPSS1 1313 4956136 C 0.17 0.04662 2.60 CAMK2D 1364 6853484 T 0.21 0.00215 4.23 CAMK2D 1365 10488959 C 0.17 0.02586 2.95 CAMK2D 1367 7680434 T 0.17 0.02586 2.95 MAML3 1387 2246759 G 0.60 0.00827 2.39 MAML3 1390 6831959 A 0.38 0.04067 0.51 INPP4B 1416 17015544 T 0.31 0.00038 4.23 INPP4B 1417 3775654 G 0.21 0.00215 4.23 POU4F2 1426 10010958 T 0.02 0.00412 0.09 POU4F2 1430 1979903 C 0.02 0.04533 0.16 FSTL5 1450 17041096 C 0.13 0.02590 0.38 FSTL5 1451 7657675 A 0.13 0.02942 0.38 FSTL5 1467 13117227 T 0.25 0.00608 3.15 FSTL5 1472 13101933 T 0.25 0.01610 2.69 ODZ3 1516 6841520 G 0.10 0.00833 7.13 ODZ3 1518 9312304 A 0.37 0.03183 2.14 DNAH5 1549 6876673 T 0.56 0.03635 2.01 DNAH5 1557 895321 C 0.44 0.02509 2.12 DNAH5 1558 895317 T 0.44 0.02509 2.12 DNAH5 1559 895316 G 0.44 0.02509 2.12 DNAH5 1568 339428 T 0.37 0.02245 0.47 EGFLAM 1590 1469421 A 0.06 0.04830 0.30 ITGA1 1613 1421927 C 0.46 0.02134 2.19 ITGA1 1614 10940281 A 0.44 0.04406 1.99 ITGA2 1618 1421937 C 0.38 0.04744 2.05 ELOVL7 1637 4700394 T 0.42 0.04081 0.51 VCAN 1663 28296 A 0.42 0.02028 2.20 FBXL17 1700 10463584 G 0.25 0.01012 2.91 PJA2 1721 11738695 C 0.56 0.01318 2.26 PJA2 1722 1045706 A 0.56 0.01628 2.21 SEMA6A 1733 17139820 T 0.29 0.04179 2.22 LOC340069 1744 2561513 A 0.62 0.02586 2.09 LOC340069 1746 328694 A 0.60 0.03713 1.99 TRPC7 1773 3734125 G 0.42 0.01815 2.26 ATXN1 1835 235147 A 0.63 0.00049 3.18 SLC17A4 1852 1165157 C 0.15 0.03146 0.41 TRDN 1945 7452290 C 0.10 0.04044 0.36 NKAIN2 1954 342623 T 0.06 0.03778 0.29 NKAIN2 1956 4897531 T 0.06 0.03778 0.29 NKAIN2 1970 781487 C 0.17 0.04280 2.64 PDE7B 1979 9385741 A 0.08 0.00800 11.25 PDE7B 1980 6570049 T 0.10 0.00833 7.13 PDE7B 1981 7772608 G 0.08 0.03174 5.50 PDE7B 1982 4382284 T 0.21 0.00112 0.29 PDE7B 1983 6570055 C 0.29 0.00693 0.39 PDE7B 1984 2327665 G 0.52 0.01748 2.18 PDE7B 1985 2018448 G 0.52 0.01748 2.18 PDE7B 1986 11154835 A 0.52 0.02118 2.14 SYNE1 2004 718527 A 0.50 0.01101 2.32 TFB1M 2011 7775163 A 0.23 0.00614 0.37 PARK2 2036 1555011 G 0.37 0.02007 2.28 PARK2 2049 9456810 C 0.29 0.04545 0.50 PDE10A 2061 566759 G 0.06 0.02341 0.26 FERD3L 2107 6967799 T 0.14 0.01716 0.35 FERD3L 2109 6461422 G 0.13 0.01893 0.36 CRHR2 2142 2190242 C 0.37 0.01228 2.44 CRHR2 2143 4723003 T 0.21 0.00721 3.38 PDE1C 2162 2079373 C 0.04 0.01102 0.18 CDC2L5 2182 3735135 C 0.00 0.02684 0.00 CDC2L5 2183 12531761 G 0.00 0.02684 0.00 CDC2L5 2185 12536726 G 0.00 0.02863 0.00 ABCA13 2206 4072503 G 0.00 0.02684 0.00 ABCA13 2207 1317162 C 0.00 0.02684 0.00 ABCA13 2208 12113920 T 0.00 0.02684 0.00 ABCA13 2210 1918602 T 0.00 0.03652 0.00 WBSCR17 2228 10950221 A 0.25 0.01269 0.41 WBSCR17 2234 17593300 G 0.35 0.01932 0.46 WBSCR17 2236 12666361 A 0.35 0.02424 0.47 PCLO 2333 4129230 T 0.23 0.01020 0.39 PCLO 2334 10240976 T 0.33 0.01650 0.44 SEMA3E 2338 2722963 G 0.42 0.01335 2.35 SEMA3E 2339 2713174 C 0.50 0.04125 1.96 SEMA3E 2340 2249188 G 0.38 0.04895 0.52 SEMA3E 2342 17504676 G 0.31 0.01401 0.43 PON1 2381 3917538 T 0.33 0.01804 2.39 PON1 2382 2057681 G 0.40 0.03807 2.03 DYNC1I1 2389 2171555 A 0.23 0.03512 2.42 ZNF3 2398 7778571 G 0.37 0.01729 2.32 EMID2 2402 6947185 C 0.25 0.01964 0.42 CUX1 2407 12537077 T 0.52 0.01748 2.18 CUX1 2408 2694158 T 0.46 0.01228 2.33 GRM8 2433 1419508 A 0.65 0.00083 3.05 GRM8 2434 17627206 T 0.63 0.00136 2.90 GRM8 2435 954661 T 0.63 0.00136 2.90 GRM8 2436 2157752 T 0.19 0.00623 0.35 GRM8 2437 10954112 C 0.29 0.04545 0.50 GRM8 2438 2283079 G 0.62 0.00542 2.51 GRM8 2443 2299500 A 0.25 0.00346 0.35 GRM8 2445 13222700 T 0.65 0.00056 3.17 GRM8 2446 11763603 C 0.65 0.00079 3.07 GRM8 2449 6975541 T 0.62 0.00542 2.51 CNTNAP2 2495 6464776 C 0.46 0.02746 2.09 CNTNAP2 2511 2530309 G 0.27 0.00696 2.97 CSMD1 2549 2938236 T 0.12 0.00734 5.78 DLC1 2575 17788913 T 0.56 0.04725 1.92 DLC1 2578 536147 G 0.06 0.00596 0.20 SLC7A2 2599 2248010 G 0.48 0.02122 2.15 UNC5D 2636 2589344 T 0.31 0.03607 2.18 TOX 2683 4738731 C 0.60 0.00624 2.46 TOX 2684 12115074 C 0.60 0.00749 2.42 NKAIN3 2690 4604422 C 0.63 0.00333 2.65 NKAIN3 2692 1993125 C 0.27 0.00753 0.39 NKAIN3 2693 7835901 C 0.60 0.01415 2.24 NKAIN3 2696 827683 C 0.27 0.02869 2.37 NKAIN3 2699 1480194 C 0.27 0.03678 2.27 NKAIN3 2700 16929287 G 0.29 0.00878 2.79 NKAIN3 2701 936616 T 0.29 0.01777 2.50 NKAIN3 2708 16929568 A 0.17 0.04280 2.64 NKAIN3 2716 4739023 C 0.38 0.04353 0.50 NKAIN3 2722 11989852 A 0.14 0.02493 3.47 NKAIN3 2724 17279355 G 0.13 0.02869 3.37 KCNB2 2754 2981104 C 0.23 0.03512 2.42 BAALC 2785 1845430 A 0.27 0.02098 0.44 BAALC 2786 3956319 T 0.00 0.04448 0.00 ADCY8 2894 4736722 C 0.58 0.01611 2.20 ADCY8 2896 7461448 A 0.04 0.04502 0.24 COL22A1 2912 2318340 T 0.35 0.01777 2.35 COL22A1 2916 2318348 G 0.27 0.02869 2.37 ZC3H3 2920 7464822 A 0.40 0.03075 2.13 SMARCA2 2928 7872216 T 0.27 0.01266 2.72 TEK 2988 664461 C 0.27 0.01966 0.44 PIP5K1B 2997 4745375 T 0.08 0.02797 0.31 TRPM3 3020 1932701 C 0.04 0.01421 0.19 TRPM6 3046 7859201 C 0.52 0.00672 2.45 TRPM6 3048 4300062 C 0.35 0.02477 2.24 TRPM6 3049 7024831 A 0.35 0.02477 2.24 PCSK5 3055 1029034 G 0.48 0.00086 3.14 NFIL3 3091 6479339 T 0.23 0.00993 3.05 SVEP1 3124 963143 A 0.26 0.01788 0.41 TTLL11 3146 10120546 C 0.50 0.03239 2.02 TTLL11 3147 12551572 G 0.46 0.03023 2.06 ABCA2 3201 12337910 G 0.25 0.00053 4.63 ARMC3 3250 10828389 T 0.38 0.04099 2.04 ARHGAP21 3256 4415644 T 0.37 0.04307 2.03 ARHGAP21 3257 7897303 A 0.37 0.04928 2.00 ARHGAP21 3258 11593521 C 0.35 0.01247 2.47 MYO3A 3261 10828909 A 0.38 0.04067 0.51 MYO3A 3263 11014853 T 0.38 0.04067 0.51 MYO3A 3267 993397 A 0.46 0.02746 2.09 MYO3A 3280 1999240 C 0.50 0.04892 1.91 JMJD1C 3297 10995505 A 0.15 0.03454 0.41 KCNMA1 3317 10762731 G 0.60 0.01762 2.19 KCNMA1 3318 10762732 T 0.60 0.01762 2.19 KCNMA1 3333 2673436 A 0.33 0.00587 0.40 NRG3 3342 2644208 T 0.25 0.04263 0.47 SORCS3 3372 10786808 T 0.04 0.00852 0.17 ATRNL1 3406 11197045 G 0.15 0.02514 0.39 ATRNL1 3407 11197046 G 0.15 0.02514 0.39 ATRNL1 3408 2420071 C 0.17 0.03243 0.42 ATE1 3446 10732824 A 0.00 0.00915 0.00 ATE1 3447 3750835 A 0.00 0.01186 0.00 ATE1 3451 11200260 T 0.04 0.02999 0.22 ATE1 3452 7906462 A 0.04 0.03826 0.23 STIM1 3462 10835406 G 0.50 0.03012 2.05 STIM1 3463 10835407 G 0.50 0.04125 1.96 STIM1 3464 10767767 T 0.50 0.04301 1.96 MICAL2 3481 2270511 G 0.27 0.01113 2.76 DLG2 3537 10898192 G 0.02 0.04533 0.16 DLG2 3540 11233954 A 0.02 0.02001 0.13 DLG2 3551 7101454 C 0.58 0.02649 2.07 ELMOD1 3556 6588969 A 0.62 0.03256 2.03 OPCML 3575 7107264 C 0.21 0.04981 2.34 OPCML 3576 1941219 G 0.23 0.03512 2.42 OPCML 3578 6590699 T 0.30 0.02929 2.31 OPCML 3579 6590700 C 0.33 0.00553 2.82 OPCML 3580 6590701 G 0.37 0.01729 2.32 OPCML 3581 7935298 A 0.31 0.03607 2.18 TMEM16B 3596 9645764 C 0.10 0.00498 0.26 TMEM16B 3597 4930809 T 0.10 0.01395 0.30 TMEM16B 3599 11610348 A 0.10 0.00195 14.36 TMEM16B 3600 3782638 G 0.10 0.00195 14.36 TMEM16B 3601 1860961 G 0.10 0.00195 14.36 TMEM16B 3602 12578500 A 0.10 0.00833 7.13 ITPR2 3635 1049376 G 0.13 0.01493 0.35 ITPR2 3636 2570 C 0.21 0.03297 0.45 CNOT2 3646 17107924 T 0.19 0.04706 2.46 CNOT2 3651 17108018 G 0.19 0.04706 2.46 LMO7 3740 9573627 G 0.46 0.04582 1.94 LMO7 3743 9530467 G 0.42 0.04202 0.51 LMO7 3749 11617789 G 0.21 0.03308 2.54 GPC6 3805 4085921 G 0.23 0.03640 0.46 GPC6 3808 4394948 C 0.25 0.01318 0.41 GPC6 3811 885192 G 0.16 0.03428 0.41 GPC6 3813 9524268 T 0.17 0.03524 0.43 GPC6 3815 9524290 G 0.06 0.02341 0.26 GPC6 3816 9524298 A 0.06 0.02512 0.26 GPC6 3817 9516323 T 0.06 0.02740 0.27 ITGBL1 3839 1335589 T 0.12 0.03133 0.37 ITGBL1 3847 1436261 C 0.12 0.03498 0.38 LRFN5 3904 1033877 G 0.19 0.04082 0.45 NRXN3 3959 8022988 T 0.27 0.03678 2.27 MAGEL2 4004 6576608 A 0.29 0.01477 0.43 RYR3 4025 2077268 T 0.04 0.02999 0.22 RYR3 4032 8036377 A 0.42 0.04594 1.96 RYR3 4033 2043054 G 0.38 0.04062 2.03 C15ORF41 4039 6495868 G 0.27 0.01966 0.44 TBC1D2B 4088 1108478 C 0.10 0.02526 0.33 TBC1D2B 4092 8030999 G 0.23 0.03895 2.38 A2BP1 4122 8055711 T 0.17 0.01639 0.38 WWOX 4153 11641213 G 0.63 0.00580 2.51 WWOX 4154 16947095 A 0.62 0.00946 2.36 CDH13 4200 13337699 A 0.35 0.03829 0.50 USP10 4210 744839 T 0.54 0.02481 2.09 DNAH9 4221 12601236 A 0.21 0.00624 0.36 RAB11FIP4 4225 315431 T 0.17 0.01292 0.37 CA10 4251 12945099 C 0.58 0.01047 2.36 CACNG4 4261 9303513 G 0.52 0.01329 2.26 DNAH17 4268 9302876 A 0.40 0.00851 2.54 DLGAP1 4277 3915772 G 0.08 0.04077 0.33 KIAA0802 4304 10502383 A 0.15 0.02191 0.38 KIAA0802 4305 17407982 C 0.15 0.02191 0.38 KIAA0802 4306 17408213 T 0.16 0.03428 0.41 CHST9 4315 9949654 C 0.13 0.03741 0.40 CHST9 4316 1426879 C 0.21 0.02111 0.42 CHST9 4317 4800797 G 0.21 0.02244 0.42 RNF24 4394 2143235 A 0.12 0.03993 3.42 PRNT 4401 7269641 C 0.13 0.03741 0.40 PRNT 4402 6107527 G 0.48 0.01356 2.30 PRNT 4403 6037950 T 0.13 0.03741 0.40 PLCB1 4412 6055513 G 0.25 0.00057 0.30 PLCB1 4432 6118375 C 0.44 0.00111 3.06 PLCB1 4433 4295085 A 0.38 0.02536 0.48 PLCB4 4438 6056653 G 0.21 0.03653 2.50 JAG1 4439 3748477 T 0.00 0.03317 0.00 PTPRT 4492 6029924 A 0.40 0.03807 2.03 PTPRT 4493 6016664 C 0.42 0.04594 1.96 PTPRT 4495 4812571 C 0.46 0.04972 1.92 PTPRT 4496 7263976 C 0.50 0.00816 2.40 PTPRT 4498 746413 C 0.35 0.01178 0.43 PTPRT 4499 1126101 G 0.60 0.00181 2.80 PTPRT 4501 6016688 T 0.13 0.00325 0.29 SLC37A1 4560 401396 C 0.23 0.04041 0.47 RIBC2 4616 5765398 A 0.28 0.02449 0.45 RIBC2 4617 2092101 G 0.29 0.04017 0.49

TABLE 14 Alleles Influencing Discontinuation for Lack of Efficacy for Perphenazine Gene Seq ID NCBI RS# Allele Freq. in Discontinuers P Odds Ratio EPHB2 20 10799762 C 0.02 0.0049860 0.09 SCP2 41 7546714 T 0.21 0.0474200 2.52 LRP8 52 2297660 A 0.57 0.0165700 2.28 LRP8 54 12035926 G 0.53 0.0389800 2.00 PRKACB 73 10493750 C 0.36 0.0414600 0.50 PRKACB 74 2642186 G 0.44 0.0210700 2.27 PRKACB 75 11163905 G 0.63 0.0085300 2.48 PRKACB 76 2134648 C 0.59 0.0217800 2.16 PRKACB 77 2134646 T 0.59 0.0302300 2.07 OLFML2B 110 7537366 T 0.09 0.0464400 0.36 SLC35F3 191 10495346 T 0.02 0.0227000 0.13 FMN2 240 4659569 T 0.36 0.0098790 2.64 FMN2 241 10754696 T 0.36 0.0098790 2.64 FMN2 242 10754697 A 0.32 0.0414500 2.20 PLD5 269 12061610 C 0.29 0.0422200 0.49 C2ORF46 280 2914424 T 0.18 0.0276700 3.19 DDEF2 283 10593 G 0.26 0.0207800 2.70 SLC8A1 346 417591 G 0.09 0.0333800 0.34 SLC8A1 349 385561 G 0.11 0.0391000 0.37 C2ORF34 368 11888605 A 0.26 0.0066990 0.38 C2ORF34 369 3862996 C 0.26 0.0066990 0.38 C2ORF34 370 10445928 C 0.19 0.0077750 0.36 C2ORF34 371 734016 A 0.19 0.0077750 0.36 C2ORF34 372 6544767 A 0.19 0.0077750 0.36 C2ORF34 374 3738980 C 0.05 0.0297800 0.26 PRKCE 379 10865208 C 0.52 0.0087580 2.49 PSME4 400 805438 A 0.59 0.0154300 2.26 PSME4 401 805391 T 0.43 0.0453100 0.50 CCDC85A 420 1159916 G 0.36 0.0364900 2.16 CCDC85A 428 1030091 C 0.00 0.0353000 0.00 CTNNA2 466 1930 T 0.59 0.0217800 2.16 NAP5 477 1437909 G 0.28 0.0244500 0.45 NAP5 480 2217747 T 0.57 0.0266600 2.11 RAB3GAP1 488 10174944 T 0.23 0.0386700 2.54 NXPH2 500 12470031 G 0.38 0.0209800 2.32 KYNU 532 1371516 C 0.28 0.0307700 2.43 KYNU 533 6430001 A 0.38 00313900 2.18 PKP4 598 3771645 C 0.17 0.0244400 0.40 PKP4 601 2528593 A 0.15 0.0300900 0.39 PARD3B 665 849221 T 0.13 0.0245200 4.43 COL4A3 698 6741679 A 0.41 0.0477000 2.01 CNTN4 766 12496950 G 0.48 0.0048920 2.65 ATP2B2 792 6763274 C 0.33 0.0054240 3.04 CACNA2D3 876 10865992 G 0.19 0.0402600 0.45 ERC2 878 815453 G 0.31 0.0239400 2.43 ERC2 880 11130482 C 0.29 0.0270100 2.49 IL17RD 903 2035654 C 0.19 0.0327500 2.91 STX19 1000 9810986 T 0.07 0.0098710 0.36 PLCXD2 1017 1913495 T 0.07 0.0069750 0.24 STXBP5L 1026 471031 G 0.59 0.0207900 2.18 STXBP5L 1027 657578 G 0.59 0.0302300 2.07 STXBP5L 1028 603635 T 0.36 0.0198100 2.41 STXBP5L 1030 1191296 A 0.34 0.0221100 2.38 STXBP5L 1032 1108170 T 0.57 0.0462000 1.99 STXBP5L 1034 6787048 T 0.33 0.0324900 2.26 STXBP5L 1035 12186062 C 0.41 0.0329200 2.15 RAB6B 1062 1880663 C 0.09 0.0464400 0.36 HTR3D 1128 939334 G 0.41 0.0038100 2.86 HTR3D 1129 6779545 A 0.54 0.0371400 2.04 HTR3D 1130 1000952 C 0.24 0.0101100 0.39 SLIT2 1188 10516357 A 0.41 0.0079380 2.61 SLIT2 1190 2168802 T 0.31 0.0239400 2.43 PCDH7 1202 2310225 A 0.38 0.0310500 2.22 SHROOM3 1257 344141 C 0.28 0.0333300 0.47 SCD5 1273 17354301 T 0.14 0.0397400 0.41 CAMK2D 1364 6853484 T 0.05 0.0244300 0.39 CAMK2D 1365 10488959 C 0.05 0.0244300 2.85 CAMK2D 1366 7438925 G 0.21 0.0474200 2.52 MAML3 1391 11734419 G 0.16 0.0404600 0.42 IL15 1403 6841939 A 0.55 0.0078430 2.48 IL15 1404 2139383 T 0.34 0.0060710 0.39 IL15 1406 4254850 C 0.31 0.0023750 0.35 IL15 1407 1493015 A 0.41 0.0477000 2.01 IL15 1408 6821171 G 0.19 0.0402600 0.45 INPP4B 1410 2667101 G 0.39 0.0458500 2.05 INPP4B 1412 336378 T 0.05 0.0234000 2.49 INPP4B 1413 1353603 A 0.05 0.0275500 2.05 INPP4B 1419 7697702 C 0.07 0.0419200 7.31 DCLK2 1443 4696645 A 0.05 0.0419800 0.28 CTSO 1446 6536124 A 0.38 0.0381700 2.12 FSTL5 1450 17041096 C 0.05 0.0102200 0.22 FSTL5 1451 7657675 A 0.05 0.0162900 0.23 FSTL5 1455 6825091 A 0.38 0.0106300 2.58 FSTL5 1456 7442468 C 0.40 0.0145300 2.43 FSTL5 1463 1023957 C 0.32 0.0171800 2.56 FSTL5 1464 17459954 T 0.33 0.0115500 2.71 FSTL5 1465 6814301 T 0.36 0.0243900 2.30 TLL1 1476 2322443 T 0.34 0.0463700 0.50 PALLD 1487 17054309 A 0.12 0.0453800 0.40 SEMA5A 1541 11134354 A 0.29 0.0088690 3.12 SEMA5A 1542 4702625 G 0.26 0.0346000 2.44 CDH10 1574 7731953 T 0.04 0.0229400 0.20 PDE4D 1623 2936193 G 0.07 0.0443900 0.32 PDE4D 1635 295963 C 0.07 0.0370100 0.31 TNPO1 1639 6452685 T 0.05 0.0022400 0.17 TNPO1 1640 6884453 G 0.07 0.0061530 0.23 TNPO1 1642 12187110 T 0.09 0.0117600 0.28 TNPO1 1644 2548331 A 0.59 0.0217800 2.16 FCHO2 1645 478575 C 0.31 0.0051750 0.37 FCHO2 1647 6895786 G 0.17 0.0008214 0.27 FCHO2 1648 7727222 C 0.17 0.0017100 0.29 FCHO2 1649 7709974 A 0.17 0.0017100 0.29 VCAN 1665 11741157 T 0.57 0.0006516 3.21 VCAN 1666 11749904 C 0.55 0.0011520 3.05 VCAN 1667 4558964 G 0.12 0.0277900 0.37 GPR98 1681 688956 C 0.59 0.0032750 2.71 GPR98 1682 168743 G 0.19 0.0330500 0.43 GPR98 1683 16868901 C 0.09 0.0408800 0.35 GPR98 1689 1878878 A 0.50 0.0290000 2.10 FBXL17 1700 10463584 G 0.26 0.0062720 3.37 ODZ2 1791 11952245 G 0.40 0.0391900 2.09 ODZ2 1792 1529681 A 0.23 0.0367500 0.45 ODZ2 1796 1560654 T 0.14 0.0149000 0.35 GABRP 1804 732157 C 0.60 0.0459700 1.96 SLC22A23 1809 11967828 T 0.26 0.0117900 3.00 SLC22A23 1810 17136440 T 0.26 0.0207800 2.70 SLC22A23 1811 7747259 T 0.26 0.0243200 2.63 JARID2 1826 9396578 T 0.14 0.0172900 0.36 RIMS1 1902 1010326 A 0.36 0.0098790 2.64 SLC22A16 1926 9400390 T 0.21 0.0397600 0.45 TRDN 1951 7453704 C 0.40 0.0145300 2.43 TRDN 1952 2169092 T 0.53 0.0199600 2.19 PDE7B 1987 6938424 T 0.10 0.0072410 10.96 PDE7B 1988 17065190 A 0.07 0.0470000 7.04 PARK2 2024 9365311 C 0.40 0.0459700 0.51 PDE10A 2064 7761766 G 0.41 0.0152800 2.37 SDK1 2074 663466 A 0.09 0.0464400 0.36 SKAP2 2118 774250 T 0.09 0.0295100 0.33 CREB5 2122 1544469 G 0.16 0.0296000 0.40 PDE1C 2154 2191876 T 0.07 0.0113200 0.25 PDE1C 2157 17336016 G 0.19 0.0077750 0.36 BMPER 2167 4140982 A 0.40 0.0268900 2.21 WBSCR17 2240 1859526 T 0.33 0.0130000 2.63 WBSCR17 2244 12699040 A 0.21 0.0394900 0.45 LIMK1 2249 810532 G 0.05 0.0249400 0.25 MAGI2 2277 12531031 T 0.21 0.0474200 2.52 MAGI2 2279 848913 C 0.04 0.0142100 0.18 MAGI2 2286 10255710 C 0.21 0.0243700 2.93 MAGI2 2300 10248584 G 0.05 0.0249400 0.25 MAGI2 2301 4730829 C 0.31 0.0147600 2.64 PCLO 2330 976714 T 0.47 0.0202300 2.23 SEMA3E 2342 17504676 G 0.48 0.0278100 2.13 ABCB4 2349 2097937 G 0.29 0.0428000 2.29 PON1 2383 2299257 C 0.26 0.0332100 0.46 DYNC1I1 2390 4357216 C 0.19 0.0289000 2.98 GRM8 2448 17684592 A 0.36 0.0439300 2.10 EXOC4 2454 1345938 C 0.17 0.0298100 0.42 EXOC4 2456 7783217 C 0.17 0.0216500 0.40 EXOC4 2457 6961517 T 0.16 0.0153600 0.37 EXOC4 2458 10488165 C 0.48 0.0064380 2.58 EXOC4 2460 972420 C 0.69 0.0108100 2.42 DGKI 2476 12535157 A 0.18 0.0019130 0.29 DGKI 2477 4728414 C 0.24 0.0197800 0.43 DGKI 2478 1528103 C 0.24 0.0197800 0.43 DGKI 2479 10268638 A 0.22 0.0205800 0.42 TBXAS1 2483 2270163 G 0.30 0.0340200 0.47 CNTNAP2 2495 6464776 C 0.12 0.0453800 0.40 PTPRN2 2522 4716883 G 0.03 0.0282100 0.21 PTPRN2 2532 10265417 T 0.41 0.0413100 0.50 PTPRN2 2535 2878355 A 0.16 0.0296000 0.40 MCPH1 2563 3020213 T 0.50 0.0404600 2.00 PSD3 2615 1506894 C 0.02 0.0289900 0.14 GFRA2 2618 17427734 A 0.26 0.0095710 0.40 PEBP4 2630 2457426 C 0.43 0.0498900 0.52 ENTPD4 2631 9644075 G 0.24 0.0386800 2.46 SLC25A37 2632 10503726 C 0.41 0.0000072 6.07 SLC25A37 2633 7826247 G 0.43 0.0001645 4.09 SLC25A37 2634 11778179 T 0.36 0.0000056 7.95 SFRP1 2649 10106678 C 0.57 0.0351300 2.03 SNTG1 2667 2623207 C 0.12 0.0319900 4.16 NKAIN3 2715 10957255 G 0.41 0.0099140 2.52 NKAIN3 2716 4739023 C 0.41 0.0279200 0.47 NKAIN3 2719 4382471 T 0.38 0.0313900 2.18 NKAIN3 2720 7835051 G 0.43 0.0266600 0.48 NKAIN3 2721 10100456 T 0.38 0.0313900 2.18 DEPDC2 2727 10097733 T 0.14 0.0373800 0.40 CRISPLD1 2756 1455795 T 0.03 0.0406700 0.23 CRISPLD1 2758 13248650 G 0.38 0.0065000 2.77 GRHL2 2770 13263539 G 0.64 0.0112200 2.36 GRHL2 2771 17397776 T 0.53 0.0183100 2.23 GRHL2 2772 17397811 A 0.53 0.0199600 2.19 NCALD 2784 7813132 C 0.33 0.0077350 2.85 ZFPM2 2797 7003445 C 0.59 0.0002598 3.61 ZFPM2 2799 3779776 G 0.22 0.0250600 2.79 ZFPM2 2800 1442326 G 0.45 0.0002781 3.78 ZFPM2 2801 12546300 G 0.47 0.0025700 2.96 ZFPM2 2807 2028553 A 0.31 0.0087100 2.87 SAMD12 2823 11774993 G 0.38 0.0275800 0.48 SAMD12 2824 2514588 T 0.41 0.0229200 2.24 SAMD12 2825 1607924 G 0.41 0.0229200 2.24 SAMD12 2826 10505340 A 0.17 0.0146800 3.79 FER1L6 2836 11784115 A 0.22 0.0383600 0.46 FER1L6 2842 7832499 C 0.05 0.0355900 0.27 FER1L6 2844 13254498 A 0.05 0.0355900 0.27 MTSS1 2855 1978661 A 0.40 0.0179500 2.35 COL22A1 2908 13271565 T 0.40 0.0268900 2.21 COL22A1 2915 1879047 T 0.07 0.0039890 0.22 SMARCA2 2922 16937123 C 0.19 0.0146900 3.51 PTPRD 2942 1500326 T 0.26 0.0473300 0.49 PTPRD 2953 4742533 C 0.18 0.0444300 0.44 TRPM6 3044 2274923 C 0.20 0.0014970 5.88 GNAQ 3065 11145659 T 0.31 0.0087100 2.87 GNAQ 3068 10781482 T 0.31 0.0105500 2.80 GNAQ 3070 6560625 C 0.33 0.0324900 2.26 DAPK1 3083 1927973 C 0.57 0.0442700 1.98 RP11-35N6.1 3109 10989207 T 0.48 0.0346100 2.05 SVEP1 3123 7043896 A 0.21 0.0394900 0.45 SVEP1 3125 1571236 T 0.21 0.0435800 0.46 STOM 3142 2196311 G 0.07 0.0416700 0.32 ABL1 3169 3824400 A 0.19 0.0327500 2.91 TSC1 3180 7858160 T 0.26 0.0117900 3.00 PNPLA7 3204 10867123 G 0.12 0.0278700 0.37 PITRM1 3214 7094698 A 0.22 0.0148200 0.40 PITRM1 3215 3740607 G 0.41 0.0107600 0.42 PITRM1 3216 2388557 A 0.21 0.0435800 0.46 CUGBP2 3231 658469 C 0.38 0.0275800 0.48 CACNB2 3234 7898858 A 0.62 0.0136900 2.31 CDH23 3310 9415998 G 0.59 0.0049580 2.58 CDH23 3311 9415047 C 0.39 0.0322000 0.48 CDH23 3312 3802711 T 0.34 0.0001127 5.09 CDH23 3314 4747197 T 0.38 0.0051710 2.84 CDH23 3315 2070968 A 0.31 0.0026060 3.48 KCNMA1 3327 7897566 C 0.50 0.0150500 2.31 SORBS1 3359 7079293 T 0.26 0.0188200 0.43 SORBS1 3360 4918918 T 0.25 0.0235300 0.43 SORBS1 3363 11188299 C 0.12 0.0104800 6.45 SORBS1 3367 540746 T 0.31 0.0298900 0.47 SORCS3 3372 10786808 T 0.31 0.0026060 3.48 SORCS3 3382 2177744 C 0.24 0.0386800 2.46 VTI1A 3403 11196083 T 0.17 0.0298100 0.42 ATRNL1 3420 10885833 C 0.21 0.0068830 3.91 ARNTL 3483 7112233 T 0.10 0.0075890 0.29 ARNTL 3489 4414197 T 0.14 0.0105300 0.34 ARNTL 3490 11022753 C 0.14 0.0149000 0.35 ARNTL 3491 10766073 A 0.16 0.0267100 0.39 SPON1 3497 2049723 C 0.33 0.0209500 2.44 SPON1 3514 4756787 C 0.21 0.0270900 2.87 NELL1 3516 12799803 A 0.29 0.0366100 2.34 KCNA4 3518 605765 G 0.56 0.0079790 2.50 81.99 mb 3524 1939640 A 0.21 0.0290900 0.43 ELMOD1 3559 683266 A 0.38 0.0085320 2.65 OPCML 3575 7107264 C 0.21 0.0474200 2.52 OPCML 3580 6590701 G 0.33 0.0387300 2.21 TSPAN9 3594 4304861 G 0.60 0.0124100 2.32 CNOT2 3652 3817487 A 0.47 0.0410600 2.01 NBEA 3703 17081356 G 0.05 0.0244300 2.21 TRPC4 3729 1556541 C 0.19 0.0019590 0.29 LMO7 3741 502171 G 0.52 0.0466300 1.95 LMO7 3742 7335067 A 0.18 0.0096220 0.35 LMO7 3743 9530467 G 0.33 0.0365100 0.49 GPC5 3766 655169 T 0.47 0.0076730 2.54 GPC5 3768 9560814 C 0.38 0.0377100 2.14 GPC5 3769 7987869 C 0.57 0.0133300 2.30 GPC5 3788 7997883 G 0.31 0.0406600 0.49 GPC5 3790 2148226 G 0.22 0.0282600 0.44 ITGBL1 3838 7998372 T 0.55 0.0443400 1.96 ITGBL1 3848 9300690 C 0.60 0.0442200 1.98 NOVA1 3862 2144335 A 0.11 0.0240600 0.34 NOVA1 3863 1950420 G 0.12 0.0199300 0.35 NPAS3 3864 11851667 C 0.21 0.0435300 0.46 NPAS3 3868 1579701 C 0.28 0.0044010 0.37 NPAS3 3869 1579702 G 0.28 0.0062430 0.38 NPAS3 3871 10133530 A 0.22 0.0136200 3.18 GNG2 3906 8017705 A 0.30 0.0404500 0.48 PPP2R5E 3925 8008684 G 0.09 0.0464400 0.36 RGS6 3949 10149207 G 0.23 0.0154200 0.41 CCDC88C 3982 4904764 G 0.22 0.0282600 0.44 RYR3 4035 11072734 G 0.36 0.0439300 2.10 RYR3 4036 891343 T 0.38 0.0456700 2.06 MEIS2 4049 1562804 T 0.53 0.0094870 2.41 RASGRP1 4052 17574546 C 0.09 0.0042040 0.24 RASGRP1 4053 16967120 T 0.07 0.0026770 0.20 CGNL1 4068 4774257 G 0.43 0.0284600 2.15 RORA 4082 11071548 G 0.59 0.0104800 2.39 TBC1D2B 4097 4473152 G 0.43 0.0163500 2.34 TBC1D2B 4098 12903461 T 0.43 0.0194300 2.27 SH3GL3 4106 11633764 A 0.13 0.0418200 0.39 PCSK6 4110 11247300 A 0.21 0.0143000 3.32 A2BP1 4130 2346943 G 0.59 0.0292500 2.10 CRISPLD2 4215 8049317 G 0.53 0.0281400 2.09 GAS7 4219 10491088 C 0.14 0.0051100 0.31 DNAH9 4220 4141189 A 0.33 0.0268400 0.47 CA10 4250 9303606 C 0.64 0.0009870 3.07 CA10 4251 12945099 C 0.66 0.0018140 2.90 DLGAP1 4278 7245298 G 0.37 0.0454100 2.12 ZFP161 4282 990072 T 0.54 0.0033140 2.78 ZFP161 4283 11665417 T 0.34 0.0452600 0.50 ZFP161 4284 9945680 A 0.34 0.0452600 0.50 PTPRM 4293 1866854 G 0.45 0.0383900 2.06 NEDD4L 4328 4940385 C 0.53 0.0094870 2.41 NEDD4L 4329 10513914 G 0.38 0.0313900 2.18 NEDD4L 4330 2075405 G 0.34 0.0422200 2.13 DOK6 4381 4438406 C 0.55 0.0011520 3.05 DOK6 4382 9962570 T 0.36 0.0364900 2.16 MACROD2 4441 994567 C 0.38 0.0456700 2.06 MACROD2 4442 6135115 G 0.29 0.0272100 2.43 MACROD2 4443 204606 G 0.38 0.0456700 2.06 MACROD2 4444 6079395 G 0.62 0.0275800 2.10 SEC23B 4489 963435 G 0.47 0.0410600 2.01 KCNB1 4518 13042686 G 0.02 0.0225300 0.13 CDH4 4531 6121764 G 0.52 0.0311800 2.08 CDH4 4532 1317385 C 0.52 0.0338600 2.05 CDH4 4533 6089669 A 0.40 0.0330100 2.15 CDH4 4536 17811544 G 0.33 0.0365100 0.49 CDH4 4537 6121844 C 0.17 0.0071560 4.69 PDE9A 4564 12626774 C 0.19 0.0017080 0.30

TABLE 15 Alleles Influencing Discontinuation for Lack of Efficacy for Ziprasidone Gene Seq ID NCBI RS# Allele Freq. in Discontinuers P Odds Ratio PIK3CD 1 10779729 A 0.17 0.03768 0.33 RP1-21O18.1 7 6663699 G 0.43 0.04776 2.49 RP1-21O18.1 13 10803343 G 0.07 0.03146 3.67 AGBL4-C1ORF165 28 11205538 C 0.18 0.00368 0.22 AGBL4-C1ORF165 33 4285747 C 0.21 0.00472 0.24 AGBL4-C1ORF165 34 3121522 A 0.20 0.00239 0.22 AGBL4-C1ORF165 35 12043418 T 0.23 0.00649 0.27 AGBL4-C1ORF165 36 2355693 T 0.17 0.00620 0.24 AGBL4-C1ORF165 37 3122291 T 0.30 0.00854 0.30 KCNN3 96 6664817 G 0.07 0.03146 4.58 ATF6 99 1875762 T 0.21 0.00932 5.91 ATF6 101 10918029 A 0.13 0.04796 5.08 RYR2 198 637520 T 0.60 0.04589 2.42 RYR2 199 604735 A 0.60 0.01027 3.14 RYR2 214 2249847 C 0.57 0.00892 3.24 FMN2 244 3795677 A 0.46 0.01047 3.40 FMN2 245 10157105 G 0.43 0.02019 2.95 FMN2 246 12122068 C 0.33 0.03497 2.90 FMN2 247 10926223 C 0.33 0.03497 2.90 RGS7 255 191735 A 0.23 0.00948 0.29 RGS7 257 4659585 A 0.23 0.00187 0.23 RGS7 258 10802917 G 0.73 0.00136 4.44 RGS7 259 670659 T 0.50 0.02311 2.78 C2ORF46 274 182971 C 0.30 0.01499 3.74 NTSR2 288 4669767 C 0.27 0.02258 0.34 KLHL29 289 747345 A 0.20 0.01128 0.28 KLHL29 294 10172684 G 0.17 0.01797 0.29 KCNK3 306 1275982 C 0.57 0.02803 2.68 KCNK3 307 11126666 A 0.43 0.03939 2.65 BRE 324 12468596 A 0.33 0.04203 2.80 CRIM1 329 3770919 G 0.13 0.01918 0.26 SLC8A1 344 2110922 T 0.53 0.02358 2.74 PRKCE 387 6748375 C 0.57 0.01031 3.14 PSME4 402 805399 A 0.43 0.02019 2.95 PSME4 403 805404 C 0.43 0.03166 2.70 PSME4 404 805415 C 0.43 0.03166 2.70 PSME4 405 805319 G 0.43 0.03166 2.70 PSME4 406 805360 T 0.53 0.03460 2.56 PSME4 407 3731967 A 0.57 0.01031 3.14 PSME4 408 10183655 T 0.57 0.01576 2.93 PSME4 409 17045488 G 0.40 0.04485 2.57 PSME4 410 1363061 T 0.30 0.01499 3.74 ACYP2 411 17039547 C 0.40 0.04485 2.57 ACYP2 412 918357 G 0.30 0.00854 0.30 CTNNA2 444 1971766 A 0.60 0.01027 3.14 CTNNA2 445 2566542 C 0.29 0.01526 4.00 NAP5 478 1437904 T 0.13 0.01918 0.26 NAP5 479 10176860 C 0.07 0.02497 0.20 NAP5 481 1434227 A 0.07 0.00408 0.14 NAP5 484 1975218 A 0.03 0.03959 0.15 NXPH2 499 11686876 T 0.23 0.00948 0.29 LRP1B 509 10201482 C 0.07 0.04085 0.22 LRP1B 522 11691595 G 0.50 0.04995 2.40 LRP1B 523 1900936 T 0.63 0.03077 2.62 CACNB4 571 13429172 C 0.13 0.01369 0.25 FMNL2 576 11684450 G 0.57 0.04807 2.40 FMNL2 587 1561267 C 0.23 0.01379 4.72 FMNL2 588 2272535 G 0.20 0.03335 4.00 FMNL2 589 3817620 G 0.20 0.03335 4.00 PDE1A 642 16823124 A 0.13 0.04935 0.32 PDE1A 650 2887208 C 0.57 0.03096 2.62 ALS2 651 3219171 T 0.17 0.00447 13.00 ALS2 652 10469756 T 0.20 0.00448 8.25 ALS2 653 12470229 C 0.13 0.04796 5.08 NRP2 672 849565 C 0.30 0.00729 4.43 COL4A3 700 2178631 C 0.63 0.02157 2.79 COL4A3 702 4263106 T 0.27 0.03801 3.17 COL4A3 703 6750210 C 0.33 0.02476 3.17 COL4A3 704 12468691 C 0.30 0.01499 3.74 COL4A3 705 6436674 T 0.20 0.03335 4.00 COL4A3 708 7587228 C 0.20 0.03335 4.00 COL4A3 709 10188531 G 0.20 0.03335 4.00 TRIP12 728 17324331 G 0.20 0.02246 0.32 ECEL1 729 12616972 C 0.23 0.02700 0.34 CNTN6 737 3772339 T 0.57 0.03396 2.56 CNTN6 745 2055738 C 0.63 0.01481 2.97 CNTN6 746 3772290 T 0.63 0.01481 2.97 CNTN4 759 11915265 T 0.53 0.02359 2.79 CNTN4 760 1153486 T 0.53 0.03460 2.56 CNTN4 761 1685456 C 0.63 0.00912 3.23 CNTN4 762 1502582 T 0.30 0.04823 2.81 CNTN4 765 9876071 T 0.27 0.00756 0.29 CNTN4 766 12496950 G 0.17 0.00895 0.25 CNTN4 767 12494838 G 0.13 0.02656 0.28 FBXL2 811 4234254 C 0.03 0.00374 0.08 FBXL2 812 6783644 G 0.03 0.00636 0.09 CLASP2 815 4629282 G 0.03 0.00758 0.10 ULK4 827 11707955 C 0.67 0.02840 2.69 CACNA2D3 868 13082611 G 0.20 0.01128 0.28 CACNA2D3 869 17140 T 0.13 0.01918 0.26 ERC2 877 3796232 G 0.17 0.00189 0.20 ERC2 893 17825409 C 0.13 0.04935 0.32 IL17RD 904 747088 A 0.03 0.02878 0.13 PTPRG 935 4447755 C 0.33 0.04203 2.80 PRICKLE2 966 4994608 A 0.20 0.02389 0.32 FAM19A1 982 6801913 A 0.40 0.03564 2.72 FOXP1 986 2166780 T 0.50 0.04995 2.40 HTR1F 999 1027689 T 0.23 0.01166 4.87 PLCXD2 1012 13074817 G 0.64 0.01277 3.15 PLCXD2 1013 13079085 C 0.63 0.02157 2.79 PLCXD2 1014 6768713 A 0.63 0.02157 2.79 PLCXD2 1015 12490166 A 0.63 0.02936 2.66 STXBP5L 1033 2331921 A 0.57 0.02343 2.73 STXBP5L 1035 12186062 C 0.57 0.02102 2.80 KALRN 1040 634265 A 0.57 0.04088 2.50 CPNE4 1055 9289393 T 0.57 0.04445 2.45 CPNE4 1056 9289395 G 0.50 0.01500 3.00 CPNE4 1057 876519 G 0.63 0.04302 2.47 CLSTN2 1076 6439927 C 0.47 0.01391 3.09 TNIK 1101 9824475 G 0.43 0.04776 2.49 SLC2A9 1159 3733591 A 0.07 0.04693 0.23 LDB2 1184 13110882 G 0.23 0.00948 0.29 SLIT2 1188 10516357 A 0.47 0.03353 2.63 LPHN3 1232 950313 C 0.07 0.03405 0.21 LPHN3 1233 1124974 A 0.07 0.03436 0.21 SCD5 1265 6811012 T 0.07 0.04693 0.23 FAM13A1 1286 1398938 T 0.10 0.04921 7.44 COL25A1 1317 2305438 A 0.23 0.01934 0.32 ANK2 1345 967099 T 0.57 0.01031 3.14 ANK2 1348 362496 G 0.47 0.00490 3.70 ANK2 1351 29306 G 0.40 0.01771 3.11 ANK2 1353 29311 A 0.40 0.01771 3.11 MAML3 1395 11729794 T 0.37 0.04302 0.41 MAML3 1397 17051001 T 0.53 0.02358 2.74 DCLK2 1437 10001651 C 0.17 0.04589 0.34 DCLK2 1438 11735949 C 0.23 0.01934 0.32 FSTL5 1461 45426 T 0.20 0.00239 0.22 TLL1 1478 17505781 T 0.13 0.03639 0.30 PALLD 1503 17614715 T 0.53 0.01774 2.92 PALLD 1504 13116423 T 0.53 0.02056 2.83 PALLD 1505 924511 T 0.53 0.02358 2.74 ODZ3 1515 6820811 G 0.50 0.00940 3.25 AHRR 1534 2251843 C 0.30 0.04890 0.40 SEMA5A 1535 985723 A 0.27 0.02372 3.64 DNAH5 1550 6554811 G 0.63 0.01481 2.97 DNAH5 1551 2401810 G 0.57 0.02803 2.68 DNAH5 1552 2401809 A 0.57 0.03096 2.62 DNAH5 1561 1530498 G 0.17 0.03768 0.33 ITGA1 1606 10513001 G 0.13 0.03639 0.30 ITGA1 1611 923837 T 0.70 0.03581 2.63 PDE4D 1627 2910641 A 0.40 0.04485 2.57 GPR98 1685 4916681 T 0.67 0.00934 3.23 GPR98 1687 16868980 C 0.60 0.00359 3.71 GPR98 1688 2366926 G 0.60 0.00418 3.60 GPR98 1691 2438359 T 0.63 0.04302 2.47 GPR98 1693 2950852 A 0.17 0.01503 6.60 FBXL17 1702 288144 A 0.37 0.04060 2.70 FBXL17 1703 289227 C 0.37 0.04060 2.70 FBXL17 1711 7706429 A 0.03 0.00027 0.05 SNX2 1758 4343835 C 0.60 0.01547 2.94 ODZ2 1787 2337017 C 0.03 0.03959 0.15 PHACTR1 1822 4714990 C 0.53 0.04006 2.51 ATXN1 1838 3812206 T 0.47 0.03353 2.63 RNF144B 1842 9477749 C 0.53 0.04468 2.45 RNF144B 1843 531481 T 0.10 0.03664 0.27 SLC17A1 1857 4712976 T 0.30 0.04823 2.81 BTNL2 1878 2076530 G 0.27 0.03146 0.36 RIMS1 1903 9446563 G 0.60 0.02274 2.75 GABRR2 1918 282128 A 0.33 0.01999 0.35 SLC22A16 1929 723685 C 0.00 0.03653 0.00 NKAIN2 1957 173067 A 0.17 0.01277 0.27 NKAIN2 1958 163284 A 0.20 0.02389 0.32 NKAIN2 1959 12195023 T 0.10 0.01931 0.23 NKAIN2 1960 163295 A 0.23 0.04101 0.37 NKAIN2 1971 11154271 C 0.37 0.00515 4.20 SYNE1 2007 4472361 G 0.40 0.04485 2.57 SYNE1 2008 7776230 T 0.40 0.04485 2.57 CARD11 2069 4722277 T 0.63 0.03077 2.62 FERD3L 2103 10228726 G 0.23 0.02613 3.84 FERD3L 2104 7780145 G 0.37 0.01461 3.36 CREB5 2121 6977628 T 0.50 0.02002 3.00 CREB5 2126 886750 A 0.43 0.04776 2.49 PDE1C 2155 6952633 G 0.23 0.03717 0.36 PDE1C 2158 30568 C 0.33 0.01104 3.75 PDE1C 2159 30589 G 0.37 0.00079 5.98 CDC2L5 2186 3800802 T 0.50 0.02977 2.67 ABCA13 2193 17661898 A 0.00 0.04995 0.00 ABCA13 2196 17548783 C 0.29 0.02100 0.33 WBSCR17 2229 7777301 C 0.67 0.00253 3.91 WBSCR17 2230 7808758 C 0.67 0.00401 3.67 WBSCR17 2233 10950240 A 0.70 0.01192 3.20 PCLO 2330 976714 T 0.20 0.02246 0.32 ABCB4 2351 31662 A 0.00 0.04995 0.00 ADAM22 2360 2299199 G 0.30 0.04943 0.40 ZNF3 2398 7778571 G 0.17 0.04663 0.34 SLC13A1 2429 6963735 C 0.17 0.00895 0.25 SLC13A1 2430 2140516 C 0.43 0.01233 3.24 GRM8 2451 2106183 T 0.13 0.04935 0.32 CNTNAP2 2507 6958824 A 0.33 0.00550 4.36 CNTNAP2 2508 1637864 T 0.30 0.01499 3.74 CNTNAP2 2509 1637840 T 0.30 0.01499 3.74 PTPRN2 2519 4909289 A 0.13 0.02396 0.27 PTPRN2 2526 2335836 C 0.18 0.03901 0.33 CSMD1 2543 13260434 A 0.07 0.04693 0.23 SGCZ 2580 2898389 C 0.57 0.02343 2.73 SGCZ 2583 1551816 G 0.27 0.02258 0.34 SGCZ 2584 4428672 T 0.27 0.03146 0.36 SGCZ 2585 12545852 C 0.27 0.03146 0.36 SGCZ 2586 728845 A 0.30 0.03569 0.38 SGCZ 2589 1903597 G 0.27 0.03146 0.36 SGCZ 2591 1461868 A 0.13 0.04935 0.32 SGCZ 2592 17119601 G 0.13 0.04935 0.32 SLC7A2 2597 2588233 C 0.23 0.01488 0.30 SLC25A37 2635 10092233 G 0.13 0.04796 5.08 UNC5D 2642 7826624 T 0.07 0.03436 0.21 SNTG1 2665 2467203 A 0.40 0.04485 2.57 SNTG1 2668 2625758 G 0.40 0.04485 2.57 PLAG1 2682 13273123 G 0.32 0.01744 3.55 DEPDC2 2732 7007570 G 0.54 0.02220 2.85 BAALC 2788 11785583 G 0.07 0.00914 0.16 BAALC 2789 4734695 C 0.17 0.01797 0.29 CSMD3 2815 4354335 G 0.53 0.00617 3.59 MTSS1 2848 17371123 G 0.67 0.00934 3.23 DDEF1 2862 12546206 A 0.53 0.03460 2.56 DDEF1 2865 12675390 C 0.43 0.00396 3.96 DDEF1 2866 1469286 T 0.39 0.00810 3.75 DDEF1 2868 16904231 C 0.37 0.01461 3.36 DDEF1 2870 16904239 A 0.37 0.01461 3.36 DDEF1 2871 16904241 G 0.37 0.01461 3.36 DDEF1 2872 4733783 T 0.37 0.01461 3.36 DDEF1 2873 4733788 G 0.37 0.01461 3.36 DDEF1 2875 2791349 C 0.10 0.01382 0.22 DDEF1 2876 6470814 A 0.37 0.01461 3.36 DDEF1 2877 1123205 G 0.53 0.02358 2.74 DDEF1 2878 11786705 G 0.37 0.01461 3.36 DDEF1 2879 4574884 G 0.10 0.01575 0.22 DDEF1 2880 17287702 T 0.10 0.02672 0.25 DDEF1 2881 16904260 C 0.10 0.02672 0.25 DDEF1 2882 10086454 C 0.13 0.03639 0.30 ST3GAL1 2905 17722401 A 0.67 0.01855 2.92 ST3GAL1 2906 10112722 G 0.67 0.01999 2.86 COL22A1 2910 4909444 T 0.17 0.04150 0.33 COL22A1 2911 12674962 C 0.23 0.00649 0.27 COL22A1 2918 1316335 A 0.10 0.04978 0.29 COL22A1 2919 9657434 T 0.10 0.04978 0.29 SMARCA2 2928 7872216 T 0.27 0.03801 3.17 TEK 2987 4601425 T 0.50 0.02311 2.78 TEK 2989 10511803 C 0.37 0.00799 3.80 MAMDC2 3012 943537 T 0.13 0.00466 0.21 MAMDC2 3013 4531114 A 0.07 0.03436 0.21 MAMDC2 3015 11142029 T 0.13 0.00675 0.22 MAMDC2 3016 1927098 C 0.07 0.03436 0.21 MAMDC2 3017 2773362 T 0.07 0.03522 0.21 MAMDC2 3018 3858107 T 0.13 0.03639 0.30 MAMDC2 3019 1180079 T 0.07 0.04085 0.22 TRPM3 3020 1932701 C 0.00 0.04995 0.00 TMC1 3040 1663763 T 0.42 0.04056 2.72 TRPM6 3044 2274923 C 0.18 0.03027 4.71 PCSK5 3053 4745488 C 0.47 0.02199 2.84 RP11-35N6.1 3109 10989207 T 0.50 0.04995 2.40 FKTN 3115 635712 C 0.50 0.01500 3.00 PALM2 3116 17202273 C 0.10 0.03664 0.27 PALM2 3117 17202329 C 0.10 0.03664 0.27 PALM2 3119 7849027 G 0.10 0.03664 0.27 PALM2 3121 7032940 A 0.07 0.00516 0.14 PALM2 3122 7036157 G 0.07 0.00643 0.15 SVEP1 3128 4978939 C 0.63 0.03077 2.62 ZNF618 3129 4978561 T 0.10 0.02672 0.25 ZNF618 3130 4979326 A 0.10 0.03664 0.27 DAB2IP 3143 10985431 T 0.00 0.00727 0.00 RALGPS1 3152 2025955 T 0.47 0.01391 3.09 RALGPS1 3153 10760473 G 0.47 0.01391 3.09 RALGPS1 3155 13298677 G 0.33 0.02037 3.28 RALGPS1 3157 12350252 A 0.25 0.00393 0.25 RALGPS1 3158 1028866 G 0.30 0.00569 0.28 RALGPS1 3159 1028865 T 0.27 0.00756 0.29 ABL1 3170 7021981 T 0.23 0.02613 3.84 ABL1 3171 11792273 G 0.23 0.02613 3.84 NOTCH1 3200 10870085 T 0.10 0.04978 0.29 ABCA2 3201 12337910 G 0.00 0.01981 0.00 PITRM1 3217 4242746 T 0.47 0.03567 2.63 CACNB2 3240 10828726 G 0.53 0.04946 2.39 MYO3A 3262 10741104 C 0.70 0.02563 2.79 MYO3A 3264 10828912 A 0.70 0.02563 2.79 MYO3A 3285 12764197 G 0.07 0.03005 0.21 MYO3A 3287 3781117 C 0.07 0.01800 0.18 CDH23 3308 1227051 C 0.38 0.03748 2.90 KCNMA1 3322 1907729 T 0.03 0.03959 0.15 KCNMA1 3328 10824519 T 0.30 0.02563 0.36 KCNMA1 3329 10824520 T 0.30 0.03569 0.38 KCNMA1 3332 11002137 C 0.30 0.03569 0.38 NRG3 3339 17099789 G 0.07 0.04593 0.23 NRG3 3340 1937959 G 0.07 0.01065 0.16 NRG3 3341 7902584 G 0.07 0.01800 0.18 HSPA12A 3426 3010476 G 0.57 0.01576 2.93 GRK5 3430 10787948 C 0.57 0.02343 2.73 ATE1 3431 1693688 C 0.20 0.01128 0.28 ATE1 3435 1219505 T 0.30 0.04890 0.40 ARNTL 3485 4372426 C 0.60 0.02093 2.80 ARNTL 3488 900144 G 0.61 0.04410 2.50 SPON1 3514 4756787 C 0.03 0.03959 0.15 OPCML 3577 7110672 C 0.07 0.01288 0.17 OPCML 3579 6590700 C 0.10 0.03664 0.27 OPCML 3583 12419575 A 0.07 0.02497 0.20 OPCML 3585 7936263 G 0.17 0.03768 0.33 OPCML 3588 7108751 T 0.13 0.04096 0.31 OPCML 3589 4936195 G 0.03 0.02534 0.13 TSPAN9 3592 4766079 C 0.07 0.01800 0.18 STYK1 3615 10845198 T 0.47 0.04942 2.43 ITPR2 3639 7955200 C 0.13 0.04935 0.32 SLC46A3 3693 1617234 C 0.30 0.04890 0.40 SLC46A3 3694 715704 G 0.53 0.04946 2.39 NBEA 3704 2322289 C 0.04 0.03687 0.14 NBEA 3714 4500591 A 0.10 0.00775 0.19 NBEA 3721 7327540 A 0.33 0.02840 0.37 NBEA 3722 3818423 C 0.13 0.01918 0.26 NBEA 3724 3794388 C 0.07 0.03436 0.21 GPC5 3762 9523312 G 0.17 0.00620 0.24 GPC5 3763 9523313 G 0.17 0.01797 0.29 GPC5 3779 1972350 T 0.47 0.02199 2.84 GPC6 3812 9301916 C 0.47 0.03353 2.63 GPC6 3813 9524268 T 0.47 0.03353 2.63 GPC6 3819 4468463 G 0.03 0.03959 0.15 ITGBL1 3839 1335589 T 0.20 0.04238 0.36 NOVA1 3863 1950420 G 0.43 0.03166 2.70 SLC25A21 3881 712377 C 0.27 0.02292 0.34 SLC25A21 3885 1367029 T 0.37 0.02034 0.35 GNG2 3908 10138800 A 0.27 0.02258 0.34 SAMD4A 3918 17128004 A 0.37 0.03069 2.90 SAMD4A 3919 10483639 C 0.37 0.04060 2.70 RGS6 3953 917426 G 0.57 0.03396 2.56 KCNK10 3961 1956541 T 0.30 0.04823 2.81 KCNK10 3965 17698533 C 0.47 0.04942 2.43 KCNK13 3968 12892344 A 0.30 0.03581 0.38 ATXN3 3989 10140469 G 0.40 0.01304 3.33 ATXN3 3990 12588287 C 0.40 0.01771 3.11 ATXN3 3991 10146087 G 0.40 0.01771 3.11 ATXN3 3992 11850101 A 0.40 0.01771 3.11 ATXN3 3993 10146249 A 0.40 0.01771 3.11 ATXN3 3994 1048755 A 0.40 0.01771 3.11 ATXN3 3995 8020781 C 0.40 0.01771 3.11 ATXN3 3996 1072958 G 0.40 0.01771 3.11 ATXN3 3997 1072957 C 0.40 0.01771 3.11 ATP10A 4017 4906654 T 0.23 0.04150 3.47 RYR3 4024 8043532 C 0.53 0.03460 2.56 RYR3 4031 2132208 A 0.20 0.00448 8.25 CGNL1 4069 4774940 C 0.10 0.01931 0.23 CGNL1 4070 7182648 T 0.07 0.04693 0.23 TBC1D2B 4096 3803380 G 0.30 0.02800 3.21 ARNT2 4105 7180510 G 0.50 0.02977 2.67 A2BP1 4117 8059039 T 0.27 0.02372 3.64 A2BP1 4118 1155959 C 0.40 0.04485 2.57 A2BP1 4133 7498500 C 0.17 0.00895 0.25 A2BP1 4138 7191615 A 0.13 0.04796 5.08 EEF2K 4148 4275840 T 0.37 0.00515 4.20 PLCG2 4161 8043845 C 0.10 0.01382 0.22 MPHOSPH6 4163 8052512 T 0.07 0.04085 0.22 CDH13 4193 1424189 T 0.13 0.00967 0.23 CDH13 4195 723920 A 0.20 0.03105 0.34 CDH13 4197 11864731 A 0.20 0.00783 0.27 CDH13 4198 10514577 G 0.23 0.02700 0.34 RAB11FIP4 4224 757378 T 0.53 0.04006 2.51 CA10 4227 8076197 A 0.30 0.02563 0.36 CA10 4228 8076496 A 0.30 0.02563 0.36 CA10 4231 203010 T 0.73 0.00507 3.70 CA10 4233 203042 A 0.27 0.01595 0.32 CA10 4234 4794315 G 0.67 0.01999 2.86 CA10 4236 9896168 G 0.63 0.02793 2.70 CA10 4240 1503058 A 0.70 0.02535 2.82 CA10 4241 11652641 G 0.37 0.02505 3.00 CA10 4242 12150128 C 0.29 0.04460 3.00 DNAH17 4266 11649879 T 0.13 0.04796 5.08 OSBPL1A 4309 6508259 A 0.07 0.01250 0.17 NEDD4L 4335 11152073 A 0.07 0.00309 0.13 CDH7 4351 976882 A 0.33 0.01781 0.34 CDH7 4352 12970791 T 0.33 0.01999 0.35 CDH7 4353 10871590 A 0.53 0.04946 2.39 CDH7 4359 7244664 G 0.10 0.00808 0.23 CDH7 4362 9950064 A 0.10 0.00808 2.70 CDH7 4364 9945997 A 0.10 0.00808 2.49 CDH7 4366 1976073 C 0.07 0.03146 0.29 CDH7 4367 2587438 C 0.07 0.03146 3.36 CDH7 4368 205084 C 0.07 0.03146 0.29 PLCB1 4413 8123568 A 0.37 0.04060 2.70 PLCB1 4415 2235212 A 0.37 0.02505 3.00 PLCB1 4425 718711 A 0.07 0.00063 0.10 PLCB1 4426 6133621 C 0.07 0.00096 0.11 KIF16B 4464 2144883 T 0.27 0.01108 0.30 KIF16B 4465 2328019 C 0.27 0.01108 0.30 KIF16B 4466 2144886 T 0.33 0.02615 0.36 KIF16B 4467 2180443 A 0.33 0.02840 0.37 KIF16B 4468 2144891 A 0.33 0.02840 0.37 KIF16B 4469 6111075 T 0.33 0.02840 0.37 KIF16B 4470 6111076 C 0.33 0.02840 0.37 KIF16B 4471 1884598 G 0.33 0.02840 0.37 KIF16B 4472 6034464 A 0.33 0.02840 0.37 KIF16B 4475 7263619 T 0.39 0.04638 2.64 PTPRT 4501 6016688 T 0.33 0.04203 2.80 PTPRT 4502 6124439 A 0.40 0.03564 2.72 ARVCF 4567 1110477 C 0.07 0.03146 0.22 ARVCF 4568 887200 C 0.10 0.00808 2.39 ARVCF 4570 887203 A 0.07 0.03146 2.63

TABLE 16 Alleles Influencing Discontinuation from Adverse Events for Olanzapine Gene Seq ID NCBI RS # Allele Freq. in Discontinuers P Odds Ratio RP1-21O18.1 10 6693853 T 0.58 0.037160 1.99 RP1-21O18.1 11 6665012 G 0.58 0.037160 1.99 AGBL4-C1orf165 38 3121518 A 0.27 0.037710 0.47 SEC16B 126 1889981 T 0.37 0.042350 2.06 SEC16B 127 1415085 A 0.12 0.045540 0.39 USH2A 154 7548730 C 0.40 0.030090 2.12 GNG4 192 10925976 A 0.58 0.022620 2.13 RYR2 204 4376724 C 0.29 0.041420 0.49 RYR2 205 3924864 C 0.27 0.001269 3.92 CHRM3 226 479933 A 0.32 0.030190 2.27 CHRM3 227 663927 A 0.33 0.031270 2.22 FMN2 248 11799544 T 0.21 0.000617 5.46 FMN2 249 10926257 T 0.21 0.000617 5.46 BRE 321 6732163 G 0.31 0.042990 2.14 CRIM1 328 3770939 T 0.42 0.029140 2.11 PRKCE 377 556650 T 0.27 0.018600 2.58 PRKCE 387 6748375 C 0.38 0.038590 0.50 EPAS1 391 17034950 A 0.44 0.011130 2.38 ACYP2 412 918357 G 0.63 0.015920 2.25 ACYP2 413 10186140 C 0.04 0.037230 0.23 CCDC85A 421 2869529 C 0.48 0.042890 1.97 CCDC85A 423 214047 C 0.04 0.028760 0.22 CCDC85A 424 214041 T 0.58 0.003955 2.60 CCDC85A 426 1990758 C 0.25 0.016630 2.71 CTNNA2 449 2974169 C 0.33 0.016640 0.44 CTNNA2 450 2916519 T 0.33 0.021340 0.46 NAP5 487 11695364 T 0.38 0.011400 2.45 LRP1B 517 11681928 A 0.42 0.029140 2.11 LRP1B 522 11691595 G 0.44 0.036940 2.03 ARHGAP15 537 354714 T 0.31 0.030730 0.47 ARHGAP15 548 2381466 A 0.26 0.022920 0.44 ARHGAP15 559 16823114 A 0.19 0.006185 0.35 ARHGAP15 560 10928200 T 0.19 0.008093 0.36 ARHGAP15 561 13031917 C 0.19 0.008668 0.36 CACNB4 566 6736449 C 0.60 0.012000 2.30 CACNB4 568 7582231 C 0.60 0.026450 2.09 KCNJ3 591 2937609 C 0.23 0.024360 0.42 CERKL 632 895901 A 0.48 0.009179 2.41 NRP2 668 849540 T 0.60 0.020530 2.16 NRP2 669 849538 T 0.58 0.022620 2.13 NRP2 670 849526 A 0.37 0.043550 0.51 NRP2 671 849525 A 0.36 0.049730 0.51 ERBB4 678 12998535 T 0.40 0.016090 2.31 ERBB4 679 3828242 G 0.40 0.019260 2.27 ERBB4 680 1992029 G 0.42 0.029140 2.11 DNER 714 10170426 T 0.00 0.032350 0.00 CNTN6 739 3732517 C 0.19 0.044470 0.45 CNTN4 758 17029515 G 0.31 0.003594 0.37 CNTN4 759 11915265 T 0.29 0.004547 0.36 CNTN4 760 1153486 T 0.33 0.021340 0.46 CNTN4 761 1685456 C 0.36 0.025010 0.47 ITPR1 774 304073 G 0.52 0.043680 2.00 IRAK2 786 11717636 C 0.42 0.036420 0.50 ATP2B2 787 241508 A 0.56 0.049230 1.95 ATP2B2 791 11719939 G 0.40 0.005456 2.66 ATP2B2 792 6763274 C 0.40 0.006565 2.61 ULK4 833 10510719 A 0.15 0.032150 0.41 FLNB 907 9834312 A 0.18 0.039760 0.43 FHIT 920 9311767 G 0.56 0.001187 2.97 FHIT 930 12638466 G 0.42 0.029140 2.11 PRICKLE2 967 696027 T 0.37 0.016110 2.37 PLCXD2 1010 1513331 C 0.21 0.049150 2.37 STXBP5L 1029 2331538 T 0.35 0.024240 0.47 STXBP5L 1031 17249426 A 0.33 0.031120 2.27 STXBP5L 1032 1108170 T 0.35 0.032280 0.47 STXBP5L 1036 2169302 G 0.21 0.049150 2.37 KALRN 1039 9880957 G 0.35 0.014620 0.44 KALRN 1042 661798 C 0.62 0.018480 2.19 CPNE4 1049 6792146 A 0.21 0.022010 2.81 CPNE4 1051 6808429 C 0.23 0.004598 3.54 CPNE4 1052 6802747 G 0.13 0.039290 3.16 CPNE4 1058 6806898 T 0.27 0.013610 2.73 RAB6B 1061 6765093 G 0.50 0.040170 1.98 SERPINI2 1088 9841174 C 0.54 0.044170 1.94 SERPINI2 1089 17246389 C 0.44 0.003797 2.71 TNIK 1099 4955765 G 0.65 0.008359 2.44 PLD1 1105 4894760 T 0.40 0.016090 2.31 NLGN1 1118 9878812 C 0.04 0.031720 0.22 HTR3C 1131 6443938 A 0.50 0.001657 2.94 IL1RAP 1144 6788050 G 0.10 0.026700 4.63 SLC2A9 1157 1568318 C 0.13 0.028860 0.38 SLC2A9 1158 938563 G 0.14 0.030440 0.39 SLC2A9 1160 4529048 C 0.12 0.004553 0.28 SLC2A9 1163 7669607 T 0.12 0.013260 0.32 SLC2A9 1164 10023068 A 0.06 0.003129 0.18 SLC2A9 1165 9291640 C 0.06 0.003129 0.18 SLC2A9 1166 9291642 C 0.06 0.027060 0.27 SLC2A9 1167 12509955 T 0.13 0.028860 0.38 PPARGC1A 1193 8192678 A 0.44 0.036940 2.03 CCKAR 1197 2040342 C 0.33 0.000003 7.29 CCKAR 1198 2130250 A 0.44 0.005535 2.59 KIAA1239 1210 11727634 C 0.28 0.017050 2.63 LIMCH1 1226 4861131 T 0.20 0.049210 0.46 NPFFR2 1235 11936367 G 0.48 0.001589 2.98 CXCL9 1253 2869460 A 0.08 0.027240 0.30 FAM13A1 1288 1996139 A 0.13 0.019840 3.83 FAM13A1 1289 1513811 T 0.13 0.039290 3.16 COL25A1 1319 13104307 T 0.23 0.004186 0.35 COL25A1 1335 7675657 A 0.19 0.035530 0.44 ANK2 1339 313941 G 0.04 0.025670 2.98 ANK2 1346 11942005 G 0.27 0.018600 2.58 ANK2 1351 29306 G 0.13 0.013790 0.34 ANK2 1353 29311 A 0.12 0.008824 0.30 NDST3 1372 2389498 T 0.06 0.027060 0.27 NDST3 1373 4558930 C 0.06 0.044670 0.30 MAML3 1399 7698089 T 0.25 0.003842 0.35 MAML3 1400 7656823 A 0.25 0.003842 0.35 MAML3 1401 4863720 C 0.25 0.007220 0.38 IL15 1405 10519613 A 0.21 0.049150 2.37 FSTL5 1452 4501178 C 0.35 0.015790 2.42 FSTL5 1462 17459658 C 0.04 0.014570 0.19 FSTL5 1466 13110363 G 0.21 0.011500 3.17 FSTL5 1469 7375994 A 0.31 0.005990 2.90 FSTL5 1470 13113862 A 0.27 0.022870 2.55 FSTL5 1473 4691039 T 0.31 0.041440 2.19 AHRR 1530 3734145 T 0.42 0.025630 2.15 DNAH5 1548 6862469 C 0.60 0.011470 2.32 DNAH5 1549 6876673 T 0.58 0.017380 2.20 MYO10 1569 388887 T 0.30 0.026150 0.46 CDH10 1575 3822429 T 0.29 0.012420 0.42 SLC1A3 1585 6878201 T 0.31 0.042990 2.14 ITGA1 1599 13189973 T 0.08 0.002099 0.21 ITGA1 1600 4865747 T 0.04 0.004332 0.15 ITGA1 1602 17209947 A 0.04 0.005148 0.15 PDE4D 1622 10461657 G 0.04 0.026570 0.21 PDE4D 1631 294492 T 0.17 0.005492 4.26 PDE4D 1632 294494 A 0.33 0.013880 2.53 PDE4D 1634 295955 G 0.17 0.021490 3.14 PDE4D 1635 295963 C 0.17 0.023690 3.09 GPR98 1682 168743 G 0.17 0.045620 0.44 FBXL17 1705 12515105 C 0.32 0.023730 0.46 FBXL17 1716 6875297 C 0.67 0.038610 2.06 FBXL17 1717 4957554 C 0.16 0.000345 0.23 FBXL17 1718 2024528 A 0.65 0.012500 2.41 FBXL17 1719 2193976 T 0.63 0.021020 2.17 SEMA6A 1734 34971 G 0.44 0.039310 2.02 SNCAIP 1750 17149128 G 0.23 0.044370 2.36 ODZ2 1794 10055910 T 0.35 0.015790 2.42 GABRP 1803 11134650 C 0.19 0.008509 3.57 ATXN1 1835 235147 A 0.32 0.030020 0.47 RNF144B 1839 1408267 G 0.10 0.033690 0.35 BTN3A3 1874 2237236 G 0.23 0.009517 0.39 BTNL2 1876 3806156 T 0.23 0.012340 0.40 KLC4 1883 3793017 C 0.37 0.022690 2.26 SLC22A16 1931 17071722 T 0.22 0.026790 2.68 SLC22A16 1932 7768422 C 0.21 0.031910 2.59 TRDN 1949 2317707 T 0.27 0.028460 0.46 NKAIN2 1954 342623 T 0.25 0.021300 2.62 NKAIN2 1965 9388339 A 0.33 0.035850 2.18 PLAGL1 1990 9321951 T 0.27 0.037250 0.48 SYNE1 2005 2763015 A 0.62 0.038590 1.99 CARD11 2068 3735131 C 0.10 0.032970 4.41 CREB5 2120 7791555 G 0.16 0.043170 0.42 ABCA13 2194 17132289 T 0.02 0.044780 0.16 ABCA13 2195 7802110 G 0.16 0.021480 0.38 ABCA13 2197 6966506 A 0.13 0.022690 0.37 ABCA13 2199 7778020 A 0.04 0.037230 0.23 LIMK1 2249 810532 G 0.10 0.049050 0.37 MAGI2 2271 10238177 A 0.25 0.024210 0.44 MAGI2 2295 848942 C 0.52 0.044370 1.97 PCLO 2321 2715148 C 0.40 0.032390 0.49 PCLO 2325 2888019 T 0.60 0.030960 2.09 PCLO 2326 1986742 G 0.60 0.033770 2.02 CUX1 2400 940482 T 0.06 0.012400 0.23 KCND2 2412 802372 C 0.04 0.048060 0.24 GRM8 2439 2283061 G 0.56 0.014440 2.25 EXOC4 2453 7786489 A 0.12 0.044870 0.39 PTPRN2 2516 221242 A 0.16 0.040950 2.86 PTPRN2 2523 10277112 A 0.17 0.007146 0.32 PTPRN2 2534 10266729 C 0.62 0.047940 1.94 MCPH1 2560 2442497 G 0.21 0.019710 2.85 SGCZ 2579 9325685 C 0.30 0.007190 0.39 PSD3 2613 3758141 C 0.27 0.007317 3.00 LYN 2674 2719268 G 0.35 0.021410 2.33 NKAIN3 2705 975688 T 0.23 0.040790 0.47 DEPDC2 2728 1434764 A 0.25 0.019020 0.43 CSMD3 2815 4354335 G 0.40 0.021160 2.29 CSMD3 2816 1513524 C 0.35 0.042990 2.08 CSMD3 2817 2954892 G 0.35 0.042990 2.08 FBXO32 2830 6990407 G 0.04 0.048060 0.24 MTSS1 2853 9771920 A 0.21 0.012920 3.11 MTSS1 2854 4870913 T 0.21 0.035420 2.55 DDEF1 2861 6984815 A 0.21 0.027150 0.43 DDEF1 2862 12546206 A 0.46 0.045530 1.96 DDEF1 2877 1123205 G 0.50 0.013310 2.41 ADCY8 2891 7464362 G 0.48 0.020830 2.18 ADCY8 2892 11781997 A 0.65 0.003414 2.69 ADCY8 2893 7459573 G 0.54 0.034640 2.01 ADCY8 2894 4736722 C 0.33 0.034380 0.49 PTPRD 2953 4742533 C 0.38 0.020570 2.29 PTPRD 2954 10815933 C 0.37 0.031300 2.15 KIAA1797 2959 12336110 A 0.35 0.018390 2.37 KIAA1797 2960 7848159 G 0.04 0.028760 0.22 PIP5K1B 2995 963707 G 0.44 0.036940 2.03 PIP5K1B 2998 1541082 A 0.02 0.018550 0.12 TMC1 3032 13285999 A 0.62 0.014200 2.26 NTRK2 3071 11140721 C 0.15 0.029140 3.14 ZNF618 3134 2269454 G 0.40 0.005456 2.66 LHX6 3149 7849627 G 0.50 0.040170 1.98 ABL1 3165 2855160 T 0.27 0.046630 0.49 EXOSC2 3166 4740366 G 0.10 0.033690 0.35 ABL1 3172 10901297 A 0.13 0.045020 3.34 MYO3A 3267 993397 A 0.56 0.005913 2.49 MYO3A 3277 2096176 T 0.29 0.026170 0.46 MYO3A 3280 1999240 C 0.56 0.031870 2.03 MYO3A 3281 3758447 C 0.29 0.045580 0.49 MYO3A 3289 2050440 A 0.35 0.030820 0.48 SLC16A9 3291 1171648 A 0.12 0.017090 0.33 SLC16A9 3292 1171643 G 0.12 0.021930 0.35 JMJD1C 3298 10740118 C 0.50 0.013410 2.28 JMJD1C 3301 9629895 A 0.10 0.020610 0.32 JMJD1C 3302 3999089 C 0.54 0.032810 2.03 CDH23 3314 4747197 T 0.46 0.004661 2.63 CDH23 3315 2070968 A 0.31 0.019160 2.46 NRG3 3339 17099789 G 0.06 0.019680 0.25 NRG3 3341 7902584 G 0.02 0.015140 0.12 NRG3 3345 474496 G 0.46 0.013080 2.32 NRG3 3347 495978 A 0.42 0.045280 1.98 ATRNL1 3420 10885833 C 0.17 0.040800 2.72 ATRNL1 3421 180675 A 0.28 0.029530 2.38 ATRNL1 3422 180635 T 0.35 0.042990 2.08 ATE1 3431 1693688 C 0.54 0.011740 2.31 ATE1 3433 7086628 C 0.62 0.013770 2.28 ATE1 3434 2132902 T 0.54 0.015650 2.23 ATE1 3435 1219505 T 0.58 0.017380 2.20 MICAL2 3472 2015963 T 0.58 0.037160 1.99 81.99 mb 3523 2186693 T 0.17 0.015130 0.38 DLG2 3533 10898148 A 0.32 0.016760 2.49 DLG2 3534 7950988 T 0.31 0.039880 2.18 DLG2 3549 11234225 T 0.58 0.011850 2.31 DLG2 3550 6592211 A 0.60 0.008591 2.40 DLG2 3551 7101454 C 0.56 0.030440 2.05 OPCML 3573 11223425 A 0.27 0.028460 0.46 OPCML 3574 4937764 T 0.67 0.034380 2.06 OPCML 3575 7107264 C 0.21 0.019710 2.85 OPCML 3576 1941219 G 0.23 0.023090 2.65 TMEM16B 3598 16933813 A 0.18 0.016520 3.29 TMEM16B 3602 12578500 A 0.17 0.021490 3.14 STYK1 3609 1078437 G 0.56 0.031990 2.05 STYK1 3613 6488316 T 0.62 0.007691 2.46 STYK1 3614 7350597 A 0.60 0.008762 2.42 STYK1 3615 10845198 T 0.54 0.025310 2.10 STYK1 3616 10743918 C 0.22 0.010240 0.38 CNOT2 3641 2118427 T 0.19 0.043910 2.53 CNOT2 3648 10506586 A 0.15 0.007767 4.40 CNOT2 3649 2870879 G 0.15 0.016660 3.64 CNOT2 3650 3817486 G 0.15 0.029140 3.14 NAV3 3676 392085 G 0.08 0.030900 0.31 SLC46A3 3695 952648 G 0.31 0.047380 0.50 NBEA 3722 3818423 C 0.06 0.034830 0.28 FNDC3A 3733 9535073 C 0.30 0.030100 2.31 FNDC3A 3734 7321178 G 0.37 0.048800 2.02 PCDH20 3738 3812872 C 0.38 0.016200 2.34 GPC5 3771 553717 A 0.21 0.006283 3.55 GPC5 3772 342678 A 0.21 0.007109 3.49 NALCN 3834 499685 T 0.56 0.031870 2.03 ITGBL1 3847 1436261 C 0.10 0.042770 0.36 ITGBL1 3851 1469855 G 0.27 0.045860 2.21 ITGBL1 3852 1469853 G 0.27 0.045860 2.21 NPAS3 3870 1315139 T 0.56 0.017950 2.19 LRFN5 3895 1597045 T 0.40 0.009054 2.57 LRFN5 3896 8015480 C 0.42 0.006701 2.57 GNG2 3907 4898721 C 0.29 0.015270 2.60 RGS6 3941 2238199 T 0.56 0.047580 1.95 RGS6 3943 2214965 T 0.52 0.029010 2.06 RGS6 3951 2239219 C 0.60 0.041800 1.97 RGS6 3952 2238192 A 0.54 0.020630 2.15 PSMC1 3971 6575121 C 0.13 0.039290 3.16 RPS6KA5 3973 941847 T 0.14 0.005797 0.30 RPS6KA5 3978 1075014 C 0.23 0.020310 0.42 RPS6KA5 3979 11159988 C 0.23 0.020310 0.42 BCL11B 3998 807450 C 0.19 0.044470 0.45 RYR3 4028 16957065 G 0.52 0.025210 2.11 PCSK6 4109 755867 A 0.10 0.026420 0.33 A2BP1 4117 8059039 T 0.30 0.016110 2.60 A2BP1 4134 7191740 C 0.08 0.014440 0.27 A2BP1 4137 8054765 G 0.15 0.025300 0.39 MPHOSPH6 4173 2967391 G 0.06 0.005492 0.20 MPHOSPH6 4174 2967340 C 0.06 0.007233 0.21 MPHOSPH6 4176 902542 A 0.06 0.008486 0.21 MPHOSPH6 4177 2967337 C 0.06 0.020940 0.25 MPHOSPH6 4179 2967333 G 0.08 0.021700 0.29 MPHOSPH6 4180 2967328 C 0.08 0.024080 0.30 CDH13 4186 4598906 T 0.23 0.040790 0.47 CDH13 4193 1424189 T 0.58 0.005441 2.52 CDH13 4195 723920 A 0.58 0.028050 2.07 CDH13 4196 10514579 C 0.43 0.043520 2.04 CDH13 4198 10514577 G 0.58 0.035950 2.01 DNAH17 4266 11649879 T 0.02 0.036340 0.15 KIAA0802 4305 17407982 C 0.10 0.033790 0.35 CHST9 4316 1426879 C 0.18 0.010190 0.36 CHST9 4317 4800797 G 0.19 0.017440 0.40 CDH7 4350 4455070 T 0.58 0.003955 2.60 CDH7 4351 976882 A 0.58 0.003955 2.60 CDH7 4352 12970791 T 0.58 0.003955 2.60 PRNT 4398 2065704 A 0.27 0.017580 0.43 PRNT 4402 6107527 G 0.60 0.003612 2.63 PRNT 4404 6052833 C 0.27 0.017580 0.43 PRNT 4407 6084876 T 0.28 0.034420 0.47 PLCB1 4422 6039249 G 0.38 0.041780 2.05 JAG1 4439 3748477 T 0.08 0.032450 5.48 JAG1 4440 3748478 T 0.08 0.036660 5.30 MACROD2 4448 459322 G 0.29 0.027170 0.45 MACROD2 4449 459874 C 0.31 0.037940 0.49 MACROD2 4453 175805 T 0.14 0.030440 0.39 MACROD2 4454 2236008 T 0.15 0.022950 0.39 KIF16B 4482 7352372 G 0.35 0.015790 2.42 KIF16B 4483 6075069 T 0.29 0.029600 2.33 PTPRT 4497 6065432 T 0.15 0.046150 0.43 PTPRT 4500 6065434 T 0.19 0.047650 0.45 PTPRT 4501 6016688 T 0.12 0.027980 0.36 SNAI1 4524 6020157 A 0.04 0.006507 0.16 SNAI1 4525 4647957 T 0.04 0.044900 0.24 SNAI1 4527 1543442 A 0.46 0.045210 1.97 CDH4 4530 4812313 G 0.17 0.045620 0.44 NCAM2 4551 986917 A 0.27 0.022450 0.44 TTLL1 4593 5996268 C 0.10 0.031900 4.43

TABLE 17 Alleles Influencing Discontinuation from Adverse Events for Risperidone Gene Name Seq ID NCBI RS# Allele Freq. in Discontinuers P Odds Ratio EPHB2 22 309500 T 0.77 0.00038 4.64 EPHB2 23 309499 T 0.73 0.00064 4.19 AGBL4-C1orf165 24 319965 A 0.63 0.01910 2.57 SCP2 39 7528867 A 0.17 0.00230 6.20 KCNK2 141 2123331 G 0.23 0.01638 0.34 KCNK2 142 12038094 T 0.20 0.01409 0.32 KCNK2 144 4655272 A 0.43 0.02761 0.42 KCNK2 146 12039875 A 0.23 0.02608 0.37 KCNK2 147 2363564 C 0.23 0.01638 0.34 KCNK2 148 10779647 T 0.23 0.02241 0.36 USH2A 158 301760 C 0.20 0.04605 0.39 ESRRG 177 10218694 A 0.53 0.02252 2.47 ESRRG 178 12088947 A 0.53 0.02705 2.39 RYR2 200 2275287 A 0.50 0.04452 2.22 RGS7 261 12038803 A 0.07 0.00676 0.16 PLD5 267 924775 A 0.07 0.03049 0.22 C2orf46 278 10168400 A 0.20 0.02607 0.35 DDEF2 281 2666218 G 0.46 0.04821 2.38 KCNK3 306 1275982 C 0.17 0.02448 0.33 PRKCE 382 4953288 T 0.20 0.04436 0.39 PRKCE 385 2595222 A 0.50 0.04981 2.18 PRKCE 389 1020445 C 0.13 0.02699 0.30 ACYP2 417 17045754 C 0.23 0.04732 2.63 CTNNA2 444 1971766 A 0.46 0.03393 2.39 NAP5 486 7559239 T 0.23 0.03500 0.39 LRP1B 506 825429 C 0.70 0.02783 2.51 KYNU 531 6429997 C 0.20 0.04605 0.39 FMNL2 579 2346182 G 0.17 0.02911 0.34 FMNL2 580 2577180 G 0.07 0.03477 0.23 PKP4 595 4664966 A 0.23 0.04641 0.41 PLA2R1 602 3828323 C 0.73 0.01120 2.96 PLA2R1 605 3828324 C 0.27 0.01331 0.35 PLA2R1 607 2715921 G 0.27 0.04121 2.58 PLA2R1 608 2667011 G 0.37 0.00620 3.17 PLA2R1 609 2667012 C 0.70 0.00320 3.38 PLA2R1 610 2715936 G 0.50 0.00093 3.85 PLA2R1 613 4665145 T 0.40 0.01053 2.86 PLA2R1 614 16844715 T 0.17 0.01169 0.29 SCN9A 625 6746030 A 0.30 0.01662 2.92 SCN9A 626 2226711 C 0.30 0.01662 2.92 COL4A3 706 4619602 C 0.27 0.03951 0.41 COL4A3 707 2070735 A 0.20 0.01791 3.48 COL4A3 708 7587228 C 0.17 0.03155 3.40 COL4A3 710 11681636 C 0.27 0.04554 0.42 CNTN6 733 11919853 C 0.47 0.04077 2.27 CNTN6 736 11925058 C 0.63 0.00087 3.76 CNTN4 772 1039255 C 0.67 0.03408 2.39 ATP2B2 790 11710165 C 0.10 0.01529 0.24 ATP2B2 793 34923 G 0.07 0.00416 0.15 RARB 804 1286654 T 0.50 0.04190 2.24 RARB 807 17526942 T 0.20 0.02770 3.17 ZNF445 854 6766334 C 0.17 0.00844 0.28 CACNA2D3 866 9825455 A 0.07 0.01258 0.18 FHIT 915 2630167 G 0.20 0.04080 2.90 FHIT 916 212016 C 0.33 0.04923 2.33 CADPS 944 9311842 T 0.37 0.04663 2.30 CADPS 945 1148827 A 0.17 0.03827 3.27 CADPS 948 17357618 C 0.40 0.03887 2.33 SYNPR 954 1505600 C 0.33 0.04270 2.39 SYNPR 955 4616634 G 0.33 0.04923 2.33 FAM19A1 983 9310118 G 0.50 0.03501 2.31 GBE1 988 11922101 T 0.13 0.00579 6.15 GBE1 997 3755713 C 0.11 0.02588 0.26 EPHA6 1005 4621347 A 0.10 0.04537 4.33 CDGAP 1023 9855065 A 0.30 0.01662 2.92 KALRN 1041 17289013 T 0.57 0.01923 2.52 KALRN 1042 661798 C 0.70 0.02783 2.51 KALRN 1043 3772756 G 0.21 0.01221 3.74 RAB6B 1061 6765093 G 0.27 0.03951 0.41 NLGN1 1122 10936780 G 0.23 0.03707 2.78 NLGN1 1127 9828801 T 0.20 0.04080 2.90 PPARGC1A 1193 8192678 A 0.13 0.01734 0.28 CCKAR 1198 2130250 A 0.13 0.01090 0.26 KIAA1239 1206 17575883 A 0.30 0.04286 2.46 KIAA1239 1208 2928297 A 0.77 0.00182 3.91 KIAA1239 1209 2973226 C 0.70 0.01451 2.77 KIAA1239 1211 1382979 A 0.50 0.00546 3.00 NPFFR2 1247 4694116 A 0.10 0.00095 17.89 NPFFR2 1251 1513895 T 0.10 0.00526 9.00 SHROOM3 1260 9307184 G 0.57 0.01387 2.72 HERC3 1274 4312724 C 0.40 0.04325 2.29 CAMK2D 1365 10488959 C 0.00 0.04342 0.00 CAMK2D 1367 7680434 T 0.00 0.04342 0.00 GPR103 1383 7688947 C 0.43 0.01320 2.72 GPR103 1384 11732033 A 0.43 0.01320 2.72 GPR103 1385 17438900 C 0.43 0.01320 2.72 MAML3 1394 2271391 T 0.57 0.00646 2.93 MAML3 1399 7698089 T 0.30 0.03766 0.42 MAML3 1400 7656823 A 0.30 0.03777 0.42 MAML3 1401 4863720 C 0.30 0.03799 0.42 INPP4B 1422 2130685 T 0.30 0.01930 2.87 POU4F2 1428 6835151 A 0.23 0.03442 2.82 DCLK2 1437 10001651 C 0.00 0.00193 0.00 DCLK2 1438 11735949 C 0.13 0.03114 0.31 DCLK2 1439 17503402 A 0.13 0.00133 0.19 DCLK2 1440 11727182 G 0.13 0.00281 0.21 DCLK2 1442 6535725 A 0.20 0.01445 0.32 TLL1 1481 1391334 G 0.54 0.02492 2.49 TLL1 1482 1497947 T 0.63 0.04990 2.21 DNAH5 1546 1971860 A 0.33 0.03466 0.42 DNAH5 1567 168131 G 0.20 0.04011 0.38 SLC1A3 1584 2032892 C 0.03 0.01907 2.39 TNPO1 1644 2548331 A 0.27 0.02529 0.38 CMYA5 1652 1129770 A 0.30 0.01191 3.09 VCAN 1664 33612 C 0.17 0.03863 0.36 FBXL17 1705 12515105 C 0.60 0.02317 2.47 FBXL17 1706 4957550 G 0.40 0.03712 0.44 SNX2 1759 12109789 G 0.17 0.04433 0.37 SNX24 1764 6595416 T 0.13 0.04980 0.34 TRPC7 1774 17170027 C 0.20 0.04605 0.39 SLC17A3 1863 629444 T 0.20 0.04080 2.90 ELOVL5 1890 974323 T 0.43 0.01484 2.68 ELOVL5 1893 9357760 G 0.43 0.01677 2.63 ELOVL5 1894 9370196 C 0.43 0.02108 2.54 ELOVL5 1895 9474507 A 0.40 0.00003 5.77 ELOVL5 1897 9367529 G 0.43 0.01027 2.82 SLC22A16 1927 9320331 A 0.17 0.03655 0.35 SLC22A16 1928 9481067 G 0.30 0.02783 0.40 SLC22A16 1930 7740547 C 0.07 0.04709 0.25 TRDN 1938 1367674 T 0.03 0.04564 0.16 TRDN 1950 6915835 C 0.12 0.04099 0.29 NKAIN2 1960 163295 A 0.60 0.00945 2.81 NKAIN2 1963 7751055 A 0.23 0.03500 0.39 EYA4 1974 17301622 G 0.71 0.02285 2.69 EYA4 1976 7454561 G 0.70 0.02379 2.57 SYNE1 2006 1844356 G 0.63 0.02268 2.50 TFB1M 2009 3822964 C 0.27 0.03951 0.41 TFB1M 2012 162978 A 0.54 0.04178 2.29 PARK2 2025 9355924 A 0.57 0.04551 2.21 PARK2 2030 9295173 G 0.30 0.03243 0.41 CARD11 2067 3735124 C 0.30 0.03944 2.50 NPY 2114 16129 T 0.25 0.01422 0.33 NPY 2115 16124 A 0.29 0.02665 0.38 CREB5 2119 2237361 C 0.30 0.03810 0.42 CHN2 2128 7781003 T 0.17 0.03863 0.36 SCRN1 2136 1465327 T 0.43 0.01822 2.67 PLEKHA8 2137 10488086 A 0.30 0.00832 3.27 PLEKHA8 2138 17158623 G 0.07 0.00089 3.48 PLEKHA8 2139 7806238 A 0.27 0.03062 2.74 FLJ22374 2150 17159526 G 0.25 0.04469 2.67 FLJ22374 2151 10253781 T 0.32 0.00290 3.84 BMPER 2169 969363 C 0.54 0.02311 2.59 IGFBP3 2189 10282088 A 0.33 0.04664 2.36 ABCA13 2190 17132163 T 0.20 0.01791 3.48 ABCA13 2191 12113721 A 0.20 0.01791 3.48 WBSCR17 2238 6971383 A 0.18 0.02082 0.32 PPP1R9A 2377 854532 T 0.23 0.04641 0.41 DYNC1I1 2397 12666041 A 0.37 0.00854 3.03 CADPS2 2424 2501443 C 0.30 0.03777 0.42 EXOC4 2462 6966403 A 0.20 0.03113 0.36 EXOC4 2466 2346442 A 0.23 0.01663 0.34 EXOC4 2469 10224683 A 0.20 0.03484 0.37 EXOC4 2470 7792546 A 0.20 0.03484 0.37 DGKI 2474 1731951 T 0.30 0.01220 0.35 DGKI 2480 12707359 T 0.67 0.00496 3.13 CNTNAP2 2503 3915305 C 0.43 0.03940 2.29 CNTNAP2 2504 10952682 G 0.43 0.03940 2.29 CNTNAP2 2505 4726875 A 0.57 0.04551 2.21 CNTNAP2 2506 1528507 G 0.57 0.04551 2.21 MCPH1 2551 1530408 C 0.33 0.03909 2.43 SGCZ 2579 9325685 C 0.27 0.03499 0.40 PSD3 2603 13275817 A 0.43 0.04370 2.26 PEBP4 2629 17757261 G 0.37 0.03754 2.39 UNC5D 2640 2579898 G 0.50 0.03736 2.28 SNTG1 2652 10504093 G 0.13 0.04839 3.45 LYN 2675 868541 A 0.65 0.02167 2.69 LYN 2680 2668005 G 0.43 0.00771 2.94 LYN 2681 2668003 C 0.40 0.01375 2.75 NKAIN3 2688 16928883 C 0.30 0.00181 4.14 NKAIN3 2689 16928902 C 0.27 0.00970 3.36 NKAIN3 2695 1901409 C 0.60 0.02660 2.42 NKAIN3 2703 16929381 T 0.27 0.03810 2.62 NKAIN3 2706 4739003 A 0.23 0.03707 2.78 NKAIN3 2709 1156385 A 0.53 0.00769 2.87 NKAIN3 2710 1383154 A 0.33 0.03909 2.43 NKAIN3 2711 10504354 A 0.50 0.01120 2.73 KCNB2 2738 12541900 G 0.63 0.02155 2.52 KCNB2 2741 2249770 C 0.30 0.02264 2.77 CRISPLD1 2755 2383928 T 0.20 0.04362 2.87 CRISPLD1 2760 10100216 T 0.13 0.00797 0.25 GRHL2 2775 13275653 C 0.57 0.02411 2.50 GRHL2 2777 4734573 C 0.43 0.04370 2.26 GRHL2 2778 11994917 T 0.50 0.02393 2.45 NCALD 2780 2387620 G 0.47 0.02910 2.39 NCALD 2781 2226401 C 0.37 0.02985 2.48 BAALC 2786 3956319 T 0.00 0.02195 0.00 ZFPM2 2804 16873707 T 0.17 0.02020 3.80 ZFPM2 2808 1372614 G 0.20 0.04080 2.90 DDEF1 2862 12546206 A 0.23 0.04641 0.41 DDEF1 2877 1123205 G 0.23 0.04553 0.41 ADCY8 2888 2860416 T 0.27 0.02630 2.83 ADCY8 2895 6986982 A 0.03 0.01092 0.11 ADCY8 2896 7461448 A 0.03 0.01268 0.11 ADCY8 2897 17327900 A 0.00 0.02195 0.00 ADCY8 2898 11991124 T 0.03 0.01377 0.12 ADCY8 2899 10505569 G 0.00 0.03313 0.00 KCNQ3 2900 977939 A 0.27 0.03951 0.41 SMARCA2 2933 10116703 A 0.67 0.02993 2.43 PTPRD 2951 7027844 C 0.67 0.02137 2.56 PTPRD 2952 6477333 A 0.60 0.01340 2.67 ADAMTSL1 2957 574090 T 0.20 0.01092 3.85 ADAMTSL1 2958 563805 C 0.23 0.01647 3.26 IFT74 2983 3429 A 0.00 0.02520 0.00 IFT74 2984 17694631 C 0.00 0.02421 0.00 TEK 2986 10967731 A 0.17 0.04607 0.37 APBA1 3000 1761287 G 0.73 0.00082 4.08 APBA1 3001 2781542 G 0.50 0.00322 3.21 APBA1 3004 11139084 A 0.57 0.01590 2.59 APBA1 3005 10867730 T 0.57 0.01590 2.59 APBA1 3006 7872660 T 0.37 0.00620 3.17 APBA1 3007 7033141 G 0.33 0.03058 2.54 TRPM3 3021 10780950 T 0.33 0.02355 2.65 NTRK2 3072 1212171 C 0.67 0.00739 2.97 NTRK2 3073 1187329 A 0.60 0.03818 2.29 NTRK2 3074 7867174 G 0.50 0.00422 3.10 NTRK2 3075 7038866 A 0.43 0.01677 2.63 NTRK2 3076 13289538 G 0.10 0.01746 5.96 NTRK2 3077 2799482 C 0.57 0.00050 3.92 NTRK2 3078 2799483 C 0.57 0.00050 3.92 NTRK2 3079 1899641 G 0.40 0.03136 2.42 DAPK1 3081 11141876 T 0.21 0.04177 2.88 SHC3 3085 9410299 C 0.30 0.00082 0.25 GABBR2 3101 10985765 C 0.27 0.02822 2.78 FKTN 3113 17251166 C 0.13 0.04715 0.34 FKTN 3114 7851777 T 0.13 0.04715 0.34 SVEP1 3127 7875389 C 0.73 0.00439 3.36 TTLL11 3145 10985483 T 0.20 0.03113 0.36 TTLL11 3146 10120546 C 0.20 0.04605 0.39 RALGPS1 3154 10987552 T 0.53 0.03236 2.33 VAV2 3183 7865299 G 0.30 0.02264 2.77 ABCA2 3201 12337910 G 0.21 0.02903 3.13 MYO3A 3259 7896978 C 0.30 0.02476 2.73 MYO3A 3279 3737316 T 0.33 0.00478 3.41 MYO3A 3285 12764197 G 0.36 0.00480 3.47 NRG3 3343 17744778 C 0.40 0.03887 2.33 NRG3 3347 495978 A 0.14 0.01097 0.26 SORCS3 3379 7099585 T 0.43 0.02281 2.57 ATRNL1 3410 10787571 G 0.11 0.03701 0.29 ATRNL1 3415 1590733 A 0.29 0.04766 0.42 ATE1 3436 1874664 C 0.30 0.01662 2.92 ATE1 3437 3763753 T 0.30 0.01824 2.88 GALNTL4 3470 11021734 C 0.37 0.03487 2.43 ARNTL 3491 10766073 A 0.13 0.04343 0.33 ARNTL 3492 10832020 C 0.03 0.00807 0.10 ARNTL 3494 1044432 T 0.33 0.00688 3.23 ARNTL 3495 1044431 A 0.32 0.01280 3.06 DLG2 3535 10898155 T 0.33 0.03494 0.42 DLG2 3536 1400313 A 0.37 0.04233 0.44 STYK1 3616 10743918 C 0.54 0.02196 2.54 PIK3C2G 3634 10743268 G 0.60 0.01279 2.69 KCNC2 3656 4131955 T 0.50 0.02118 2.49 KCNC2 3657 7952767 C 0.50 0.01359 2.73 KCNC2 3658 1526821 C 0.50 0.02118 2.49 KCNC2 3659 10785167 T 0.50 0.02578 2.42 NAV3 3666 1677914 G 0.18 0.03894 3.22 NAV3 3669 1479027 G 0.20 0.04362 2.87 NAV3 3671 1731743 G 0.20 0.04362 2.87 GAS2L3 3682 17030333 T 0.13 0.01380 4.89 N4BP2L2 3699 206336 G 0.64 0.02909 2.48 LMO7 3747 9593132 T 0.13 0.04839 3.45 GPC5 3785 17188557 G 0.10 0.00821 0.21 GPC5 3787 913005 T 0.70 0.00078 3.97 GPC5 3789 6492630 A 0.70 0.00707 3.06 GPC5 3790 2148226 G 0.13 0.00281 0.21 GPC5 3791 9523825 G 0.27 0.01569 0.35 GPC6 3795 16948547 G 0.43 0.01320 2.72 GPC6 3800 1323975 A 0.13 0.04715 0.34 GPC6 3803 3899317 A 0.27 0.01846 0.36 ITGBL1 3845 7338172 G 0.03 0.03464 0.15 ITGBL1 3846 3783215 C 0.03 0.03464 0.15 LRFN5 3892 10149327 T 0.17 0.00995 0.28 PPP2R5E 3920 6573508 C 0.07 0.01965 0.20 PPP2R5E 3921 10137202 C 0.00 0.00811 0.00 PPP2R5E 3929 7154718 G 0.10 0.02065 5.74 RGS6 3950 2239221 C 0.60 0.04465 2.23 ATP10A 4010 7175557 C 0.14 0.03709 3.69 RYR3 4026 16973353 A 0.30 0.04357 0.43 RASGRP1 4051 12324402 G 0.10 0.02382 0.26 GLDN 4063 17648140 G 0.17 0.01940 0.31 CGNL1 4067 12595188 G 0.30 0.01662 2.92 CGNL1 4070 7182648 T 0.03 0.00749 0.10 CGNL1 4072 8034215 G 0.07 0.00754 0.17 TBC1D2B 4090 16969397 T 0.23 0.02425 3.02 ARNT2 4101 4778800 T 0.37 0.02342 2.59 ARNT2 4104 4778836 T 0.17 0.04433 0.37 PCSK6 4111 12595154 G 0.60 0.04353 2.24 A2BP1 4131 1507031 A 0.23 0.04036 0.40 TMC5 4140 8059797 A 0.50 0.04981 2.18 MPHOSPH6 4178 1011433 C 0.27 0.02037 2.95 MPHOSPH6 4180 2967328 C 0.27 0.03810 2.62 USP10 4207 7188512 C 0.50 0.01120 2.73 USP10 4208 964453 G 0.37 0.02342 2.59 USP10 4210 744839 T 0.47 0.00756 2.90 CA10 4232 12603762 C 0.63 0.00320 3.24 CA10 4235 1501253 G 0.53 0.01613 2.59 CA10 4237 1393735 G 0.63 0.00399 3.16 CA10 4238 2970016 G 0.33 0.02168 0.39 MSI2 4256 792402 A 0.03 0.02702 0.14 MSI2 4257 8066677 G 0.13 0.02117 0.29 HRNBP3 4272 7212305 A 0.00 0.02520 0.00 HRNBP3 4273 907898 C 0.00 0.02782 0.00 DLGAP1 4278 7245298 G 0.03 0.02018 0.13 CDH7 4357 8093720 A 0.20 0.04011 0.38 CDH7 4358 1484725 T 0.20 0.04145 0.38 CDH7 4361 2046407 G 0.43 0.02108 2.54 CDH7 4365 2628210 G 0.37 0.02342 2.59 ATRN 4390 151511 A 0.57 0.04551 2.21 PLCB1 4421 2662990 T 0.03 0.03012 0.14 PLCB1 4424 6086591 A 0.43 0.04766 2.22 MACROD2 4451 2193028 C 0.27 0.01064 3.32 MACROD2 4455 6043616 C 0.23 0.03311 2.86 MAPRE1 4491 2070090 T 0.43 0.00448 3.15 CDH4 4534 2427144 A 0.67 0.04706 2.26 NCAM2 4548 2826841 T 0.37 0.04663 2.30 ASPHD2 4573 16982107 T 0.17 0.00073 7.90 HPS4 4574 5761552 T 0.67 0.02553 2.49 HPS4 4575 739291 C 0.30 0.00564 3.48 HPS4 4576 3747134 G 0.30 0.00564 3.48 HPS4 4577 5761557 A 0.25 0.03046 2.88 TTLL1 4593 5996268 C 0.17 0.04629 3.08

TABLE 18 Alleles Influencing Discontinuation from Adverse Events for Quetiapine Freq. in Seq Discon- Odds Gene Name ID NCBI RS# Allele tinuers P Ratio KIF1B 2 4846198 A 0.30 0.0258 0.44 RP1-21O18.1 18 10803354 A 0.60 0.0111 2.45 LRP8 56 11206139 G 0.36 0.0387 0.48 ELTD1 64 1352555 A 0.45 0.0407 2.05 ELTD1 65 4650627 A 0.11 0.0229 0.33 NGF 80 6327 A 0.57 0.0436 2.01 MR1 134 3845422 A 0.32 0.0285 2.33 KCNK2 138 10864143 A 0.48 0.0140 2.40 USH2A 151 1339411 T 0.32 0.0481 2.15 ESRRG 183 12033378 A 0.27 0.0380 2.35 RYR2 206 2010045 G 0.62 0.0307 2.16 RYR2 207 2618687 T 0.52 0.0452 2.00 CHRM3 226 479933 A 0.11 0.0209 0.32 CHRM3 227 663927 A 0.11 0.0255 0.33 FMN2 228 12118961 T 0.61 0.0326 2.11 FMN2 229 12145060 A 0.55 0.0142 2.37 FMN2 231 12123407 A 0.57 0.0288 2.13 FMN2 248 11799544 T 0.00 0.0478 0.00 FMN2 249 10926257 T 0.00 0.0478 0.00 FMN2 250 4659973 T 0.25 0.0477 0.47 RGS7 258 10802917 G 0.36 0.0317 0.47 DDEF2 284 10929580 C 0.59 0.0083 2.50 KLHL29 289 747345 A 0.61 0.0022 2.90 KLHL29 290 737565 A 0.64 0.0048 2.69 KLHL29 291 747344 G 0.64 0.0050 2.67 KLHL29 292 6727901 G 0.64 0.0065 2.60 KLHL29 293 7570872 G 0.50 0.0365 2.06 KLHL29 294 10172684 G 0.45 0.0321 2.13 BRE 322 10209422 T 0.29 0.0034 3.49 BRE 323 6747817 G 0.27 0.0387 2.33 CCDC85A 418 4672096 G 0.00 0.0316 0.00 CCDC85A 424 214041 T 0.48 0.0225 2.22 CTNNA2 457 2165975 T 0.23 0.0317 2.61 CTNNA2 458 6547299 A 0.18 0.0023 0.29 CTNNA2 462 17018919 C 0.18 0.0266 2.98 CTNNA2 464 318362 C 0.25 0.0338 0.44 ARHGAP15 539 13032052 C 0.07 0.0416 0.29 ARHGAP15 544 16858944 A 0.09 0.0435 0.34 ARHGAP15 545 7605182 C 0.07 0.0498 0.30 ARHGAP15 546 17814502 A 0.09 0.0067 0.24 KIF5C 562 7355478 T 0.02 0.0262 0.14 FMNL2 580 2577180 G 0.32 0.0207 2.46 FMNL2 585 11682487 C 0.41 0.0412 2.08 FMNL2 586 6434113 C 0.34 0.0325 2.24 PLA2R1 604 949753 G 0.34 0.0080 2.77 ALS2 654 4675226 T 0.11 0.0311 0.35 CUL3 686 16866061 G 0.48 0.0361 2.08 IRS1 690 10205233 T 0.11 0.0412 3.56 IRS1 691 1560251 T 0.18 0.0423 2.69 COL4A4 693 10933165 C 0.55 0.0113 2.40 COL4A4 695 10166736 A 0.57 0.0114 2.40 DNER 712 207671 G 0.57 0.0231 2.19 CNTN6 742 265799 G 0.70 0.0137 2.45 CNTN6 744 265767 A 0.67 0.0054 2.73 CNTN6 745 2055738 C 0.71 0.0002 3.89 CNTN6 746 3772290 T 0.68 0.0003 3.57 CNTN6 754 17038701 G 0.14 0.0351 3.26 CNTN4 770 12497768 T 0.57 0.0436 2.01 IRAK2 784 6804954 A 0.34 0.0443 0.49 IRAK2 785 708035 T 0.50 0.0165 2.30 IRAK2 786 11717636 C 0.57 0.0407 2.03 RARB 805 17525900 C 0.18 0.0266 2.98 CACNA2D2 861 2298955 C 0.20 0.0158 3.11 CACNA2D2 862 743757 C 0.18 0.0423 2.69 CACNA2D3 867 4928040 A 0.20 0.0314 0.42 FLNB 907 9834312 A 0.25 0.0218 0.42 FLNB 911 12632456 A 0.23 0.0493 0.46 FHIT 921 11919495 A 0.50 0.0024 2.89 FHIT 922 9871875 C 0.50 0.0024 2.89 FHIT 923 9834182 A 0.50 0.0107 2.43 FHIT 929 815718 C 0.08 0.0413 0.29 PTPRG 938 1388613 C 0.07 0.0053 0.20 CADPS 944 9311842 T 0.07 0.0216 0.26 MAGI1 974 9840574 T 0.43 0.0339 2.12 FAM19A1 981 11707519 G 0.25 0.0445 2.33 GBE1 992 3772899 G 0.34 0.0101 0.40 HTR1F 999 1027689 T 0.16 0.0445 2.84 PLCXD2 1016 9288930 T 0.30 0.0462 0.48 ZXDC 1047 1687462 C 0.30 0.0461 0.47 CLSTN2 1078 6775380 A 0.45 0.0254 2.22 CLSTN2 1080 347975 G 0.45 0.0166 2.33 CLSTN2 1081 347973 A 0.43 0.0359 2.18 TNIK 1100 9870583 C 0.36 0.0230 0.44 NLGN1 1111 10936764 G 0.16 0.0416 0.41 HTR3D 1129 6779545 A 0.55 0.0409 2.03 LEPREL1 1139 893054 T 0.36 0.0232 2.33 LEPREL1 1140 573533 A 0.36 0.0273 2.27 SLC2A9 1164 10023068 A 0.36 0.0149 2.48 SLC2A9 1166 9291642 C 0.27 0.0084 3.00 SLC2A9 1168 6820230 T 0.18 0.0401 0.42 LDB2 1182 1990280 G 0.55 0.0080 2.50 LDB2 1184 13110882 G 0.52 0.0111 2.41 KIAA1239 1206 17575883 A 0.02 0.0104 0.11 KIAA1239 1207 17575897 T 0.05 0.0147 0.19 TBC1D1 1212 13110318 A 0.18 0.0105 3.67 LIMCH1 1225 7674006 C 0.09 0.0317 4.70 CXCL9 1254 10518143 C 0.14 0.0030 0.26 SCD5 1262 7684732 C 0.34 0.0429 2.14 SCD5 1265 6811012 T 0.30 0.0333 2.33 SCD5 1269 6848340 T 0.25 0.0142 2.87 FAM13A1 1280 7657817 T 0.30 0.0240 2.46 FAM13A1 1287 1708673 T 0.02 0.0212 0.13 FAMI3A1 1288 1996139 A 0.02 0.0262 0.14 PDLIM5 1291 1353044 T 0.48 0.0002 3.78 PDLIM5 1292 2433325 A 0.48 0.0002 3.78 PDLIM5 1293 2510777 C 0.30 0.0054 0.36 PDLIM5 1295 2452600 T 0.41 0.0141 2.42 PDLIM5 1297 7662466 A 0.32 0.0185 0.43 PDLIM5 1299 7690296 G 0.32 0.0499 0.49 PDLIM5 1300 17021918 T 0.41 0.0217 2.29 DKK2 1304 419764 T 0.23 0.0280 0.42 COL25A1 1320 11942576 C 0.50 0.0180 2.27 COL25A1 1336 4256292 G 0.41 0.0412 2.08 ANK2 1347 10019154 A 0.25 0.0071 0.36 ANK2 1348 362496 G 0.48 0.0029 2.84 ANK2 1349 29329 T 0.59 0.0226 2.21 MAML3 1387 2246759 G 0.25 0.0035 0.33 MAML3 1389 4863683 C 0.36 0.0467 2.08 MAML3 1390 6831959 A 0.68 0.0075 2.60 MAML3 1391 11734419 G 0.48 0.0090 2.50 INPP4B 1416 17015544 T 0.05 0.0221 0.21 INPP4B 1420 336391 T 0.18 0.0311 0.41 INPP4B 1422 2130685 T 0.09 0.0334 0.32 FSTL5 1450 17041096 C 0.43 0.0032 3.01 FSTL5 1451 7657675 A 0.40 0.0060 2.77 FSTL5 1452 4501178 C 0.25 0.0314 2.49 PALLD 1483 6552873 C 0.18 0.0171 0.37 PALLD 1486 9312333 C 0.18 0.0209 0.38 PALLD 1488 10031058 G 0.18 0.0209 0.38 PALLD 1489 10009813 G 0.50 0.0230 2.20 PALLD 1490 6840767 C 0.14 0.0387 0.38 PALLD 1493 2319900 T 0.23 0.0496 0.46 PALLD 1506 4364224 T 0.55 0.0229 2.23 ODZ3 1513 2675534 T 0.09 0.0358 0.32 ENPP6 1525 4444870 T 0.57 0.0145 2.33 AHRR 1531 2721004 T 0.45 0.0193 2.28 AHRR 1532 2721012 G 0.45 0.0039 2.84 DNAH5 1546 1971860 A 0.34 0.0048 0.37 EGFLAM 1592 9292705 A 0.14 0.0447 3.09 EGFLAM 1596 2731979 C 0.25 0.0017 4.03 EGFLAM 1597 2731968 C 0.18 0.0043 4.35 EGFLAM 1598 16903982 A 0.14 0.0065 5.29 ITGA1 1604 2860025 T 0.11 0.0458 0.37 ITGA1 1610 2279587 T 0.00 0.0137 0.00 ITGA1 1612 12520591 G 0.00 0.0169 0.00 ITGA2 1620 3212576 G 0.07 0.0175 0.25 ITGA2 1621 7719848 A 0.17 0.0428 0.41 PDE4D 1635 295963 C 0.20 0.0233 2.92 TNPO1 1639 6452685 T 0.26 0.0347 2.44 VCAN 1667 4558964 G 0.14 0.0125 0.32 ODZ2 1788 11134468 G 0.02 0.0397 0.15 SLC22A23 1812 17136575 G 0.05 0.0182 0.20 ATXN1 1837 3812192 T 0.26 0.0050 0.35 SLC17A3 1859 1165161 A 0.39 0.0300 2.20 RIMS1 1904 2463702 G 0.34 0.0300 0.46 RIMS1 1915 2815743 T 0.62 0.0382 2.09 NKAIN2 1954 342623 T 0.25 0.0215 2.67 NKAIN2 1967 1031881 C 0.34 0.0016 3.40 NKAIN2 1968 6906607 A 0.32 0.0078 2.85 NKAIN2 1969 609783 T 0.32 0.0207 2.46 PDE7B 1982 4382284 T 0.57 0.0122 2.39 STX11 1996 4896708 A 0.18 0.0011 0.26 SYNE1 2006 1844356 G 0.52 0.0184 2.26 SYNE1 2008 7776230 T 0.39 0.0441 2.08 PDE10A 2059 9459418 A 0.36 0.0360 2.17 NXPH1 2083 10238726 G 0.59 0.0009 3.18 NXPH1 2086 7777974 A 0.50 0.0273 2.16 NXPH1 2087 10257265 C 0.45 0.0070 2.60 NXPH1 2088 970526 G 0.48 0.0079 2.58 PDE1C 2160 4551232 A 0.25 0.0212 0.42 PDE1C 2161 10225488 A 0.25 0.0212 0.42 BMPER 2168 12672492 A 0.09 0.0358 0.32 BMPER 2169 969363 C 0.45 0.0169 2.38 CDC2L5 2184 10272641 G 0.55 0.0233 2.19 CDC2L5 2185 12536726 G 0.14 0.0284 3.53 ABCA13 2192 6974064 A 0.20 0.0391 2.59 ABCA13 2210 1918602 T 0.12 0.0430 3.54 WBSCR17 2239 1012127 T 0.43 0.0135 2.41 WBSCR17 2242 4585627 T 0.48 0.0451 2.01 HIP1 2258 757364 T 0.33 0.0323 0.46 MAGI2 2267 2428920 C 0.11 0.0209 0.32 MAGI2 2280 1121066 A 0.61 0.0218 2.22 MAGI2 2290 6954793 C 0.23 0.0152 2.96 PCLO 2334 10240976 T 0.66 0.0036 2.80 SEMA3E 2342 17504676 G 0.60 0.0335 2.12 SEMA3E 2346 1972459 C 0.50 0.0453 2.00 DYNC1I1 2396 42066 A 0.05 0.0204 0.20 CADPS2 2425 2428769 G 0.25 0.0259 0.43 GRM8 2433 1419508 A 0.27 0.0050 0.35 GRM8 2434 17627206 T 0.27 0.0080 0.38 GRM8 2435 954661 T 0.27 0.0080 0.38 GRM8 2438 2283079 G 0.30 0.0170 0.42 GRM8 2440 10234189 T 0.59 0.0030 2.80 GRM8 2441 1008907 T 0.59 0.0039 2.72 GRM8 2447 6951643 G 0.27 0.0050 0.35 GRM8 2449 6975541 T 0.30 0.0170 0.42 GRM8 2450 1419442 T 0.20 0.0244 0.40 GRM8 2451 2106183 T 0.41 0.0322 2.16 CNTNAP2 2488 1639471 G 0.20 0.0244 0.40 CNTNAP2 2492 6978796 A 0.20 0.0258 0.41 CSMD1 2537 622765 A 0.27 0.0387 2.33 MCPH1 2551 1530408 C 0.27 0.0192 2.63 MCPH1 2553 2440416 G 0.29 0.0296 2.44 MCPH1 2558 2920660 A 0.25 0.0347 2.45 MCPH1 2566 4841224 T 0.50 0.0213 2.23 MCPH1 2567 3739391 A 0.14 0.0421 0.39 PEBP4 2626 4872539 C 0.14 0.0047 0.28 PEBP4 2627 7829416 G 0.14 0.0059 0.29 PEBP4 2628 6558183 T 0.11 0.0378 0.36 SNTG1 2653 10957739 G 0.36 0.0399 2.15 SNTG1 2671 1484128 T 0.16 0.0132 0.34 SNTG1 2672 1484129 T 0.20 0.0487 0.45 NKAIN3 2705 975688 T 0.45 0.0166 2.33 NKAIN3 2709 1156385 A 0.45 0.0216 2.24 NKAIN3 2711 10504354 A 0.45 0.0166 2.33 KCNB2 2743 2256675 A 0.14 0.0245 3.63 KCNB2 2746 2255053 A 0.14 0.0245 3.63 MMP16 2765 1915023 T 0.02 0.0138 0.12 MMP16 2766 7821897 C 0.02 0.0161 0.12 GRHL2 2773 4734553 G 0.52 0.0406 2.03 CSMD3 2809 6981814 A 0.41 0.0412 2.08 MTSS1 2852 4871506 T 0.39 0.0218 0.45 SMARCA2 2931 2147263 T 0.30 0.0042 0.35 SLC1A1 2935 9886720 T 0.36 0.0460 2.10 SLC1A1 2936 4742008 A 0.39 0.0498 2.04 RP11-35N6.1 3108 7853653 A 0.48 0.0329 2.12 VAV2 3185 10993832 A 0.36 0.0467 2.08 VAV2 3189 2810473 T 0.39 0.0498 2.04 KCNT1 3195 497547 G 0.09 0.0110 7.10 KCNT1 3196 11103147 G 0.02 0.0442 0.16 KCNT1 3197 11103150 A 0.02 0.0489 0.16 KCNT1 3198 10858158 G 0.02 0.0489 0.16 KCNT1 3199 11103157 C 0.02 0.0489 0.16 ABCA2 3201 12337910 G 0.02 0.0247 0.13 CACNA1B 3205 7391010 C 0.07 0.0175 0.25 VTI1A 3391 3740143 G 0.18 0.0454 0.43 HSPA12A 3427 10787720 C 0.20 0.0174 3.06 ATE1 3446 10732824 A 0.19 0.0061 4.00 ATE1 3447 3750835 A 0.17 0.0200 3.40 SPON1 3500 10832163 T 0.25 0.0381 0.45 SPON1 3506 10832170 T 0.36 0.0317 0.47 SPON1 3507 1406356 A 0.36 0.0258 0.46 SPON1 3510 11023088 T 0.64 0.0154 2.38 DLG2 3528 2060147 G 0.36 0.0005 3.89 DLG2 3530 983590 T 0.34 0.0007 3.80 DLG2 3532 12225388 A 0.30 0.0030 3.36 DLG2 3533 10898148 A 0.31 0.0054 3.09 DLG2 3534 7950988 T 0.29 0.0084 2.99 DLG2 3543 4451754 A 0.45 0.0443 2.02 ELMOD1 3556 6588969 A 0.32 0.0094 0.39 OPCML 3566 4936168 C 0.45 0.0216 2.24 OPCML 3579 6590700 C 0.09 0.0435 0.34 OPCML 3582 4937780 G 0.09 0.0400 0.33 TSPAN9 3593 544668 G 0.52 0.0233 2.19 KCNC2 3662 2471664 C 0.09 0.0358 0.32 PCDH17 3735 7324697 A 0.14 0.0167 0.33 LMO7 3746 9318373 A 0.39 0.0407 0.49 GPC6 3808 4394948 C 0.52 0.0429 2.02 GPC6 3822 9561551 C 0.34 0.0482 2.11 ITGBL1 3849 17686597 C 0.02 0.0305 0.14 ITGBL1 3850 2281991 G 0.02 0.0377 0.15 ITGBL1 3852 1469853 G 0.02 0.0323 0.14 SLC25A21 3888 7153409 A 0.14 0.0245 3.63 SLC25A21 3889 4900678 C 0.14 0.0284 3.53 LRFN5 3902 10131436 A 0.18 0.0310 0.40 LRFN5 3904 1033877 G 0.45 0.0126 2.41 GNG2 3905 8018469 T 0.57 0.0436 2.01 RGS6 3950 2239221 C 0.34 0.0365 0.48 CCDC88C 3987 11160006 C 0.26 0.0287 0.43 BCL11B 4001 1257446 C 0.16 0.0215 0.37 BCL11B 4002 1257416 G 0.20 0.0298 0.42 KIAA1370 4064 4776065 C 0.18 0.0311 0.41 TBC1D2B 4089 10519181 C 0.16 0.0318 0.39 TBC1D2B 4091 2241885 C 0.30 0.0210 0.43 TBC1D2B 4093 11634607 T 0.20 0.0089 0.35 TBC1D2B 4095 2867985 A 0.18 0.0112 0.35 A2BP1 4114 1420058 C 0.69 0.0127 2.49 A2BP1 4116 8047133 C 0.66 0.0300 2.16 A2BP1 4118 1155959 C 0.61 0.0218 2.22 A2BP1 4119 12926215 G 0.39 0.0087 2.64 A2BP1 4121 4289011 C 0.60 0.0067 2.60 A2BP1 4122 8055711 T 0.50 0.0012 3.11 WWOX 4153 11641213 G 0.32 0.0185 0.43 WWOX 4156 4887935 C 0.48 0.0186 2.28 CDH13 4185 7196979 G 0.64 0.0283 2.20 RAB11FIP4 4225 315431 T 0.43 0.0430 2.05 CA10 4232 12603762 C 0.30 0.0462 0.48 CA10 4234 4794315 G 0.30 0.0462 0.48 CA10 4241 11652641 G 0.09 0.0435 0.34 CA10 4243 16951177 C 0.02 0.0053 0.09 MSI2 4255 1007462 C 0.64 0.0164 2.32 HRNBP3 4272 7212305 A 0.25 0.0445 2.33 PTPRM 4287 503716 T 0.00 0.0478 0.00 NEDD4L 4325 11663936 T 0.32 0.0028 3.27 NEDD4L 4327 12457509 A 0.43 0.0044 2.77 NEDD4L 4329 10513914 G 0.43 0.0085 2.56 NEDD4L 4330 2075405 G 0.36 0.0107 2.59 NEDD4L 4331 4940679 G 0.61 0.0051 2.65 NEDD4L 4332 7242486 G 0.61 0.0055 2.65 CCBE1 4336 17065761 C 0.02 0.0262 0.14 CCBE1 4337 12969965 A 0.32 0.0320 2.29 ZNF667 4387 10423617 T 0.33 0.0092 2.77 RNF24 4393 6084530 C 0.16 0.0234 0.37 PLCB1 4412 6055513 G 0.61 0.0139 2.36 PLCB1 4414 6055577 A 0.07 0.0325 0.28 PLCB1 4433 4295085 A 0.66 0.0299 2.16 PLCB4 4434 6086686 A 0.66 0.0300 2.16 MACROD2 4447 1657969 T 0.23 0.0430 0.45 KIF16B 4462 6043875 C 0.52 0.0345 2.08 PTPRT 4498 746413 C 0.66 0.0127 2.42 PTPRT 4501 6016688 T 0.43 0.0203 2.28 KCNB1 4519 496511 C 0.60 0.0273 2.18 MIRN155 4554 2828908 T 0.11 0.0281 0.34

TABLE 19 Alleles Influencing Discontinuation from Adverse Events for Perphenazine Freq. in Seq NCBI Dis- Odds Gene Name ID RS# Allele continuers P Ratio EPHB2 23 309499 T 0.63 0.0425 2.31 ELTD1 67 4625238 T 0.33 0.0444 2.45 PRKACB 74 2642186 G 0.11 0.0060 0.20 NGF 83 11102925 T 0.07 0.0337 0.22 KCNK2 139 2841598 G 0.37 0.0315 0.41 USH2A 170 12030122 C 0.23 0.0051 4.41 ESRRG 180 11117642 T 0.23 0.0269 3.13 RYR2 213 2685297 G 0.07 0.0072 0.16 RYR2 214 2249847 C 0.18 0.0255 0.32 FMN2 234 11801848 C 0.53 0.0116 2.79 FMN2 235 10926168 G 0.67 0.0148 2.77 FMN2 236 7520065 G 0.67 0.0148 2.77 RGS7 256 10802916 T 0.20 0.0315 0.36 PLD5 270 6673239 T 0.20 0.0315 0.36 HPCAL1 285 16856020 T 0.23 0.0297 3.07 KCNK3 306 1275982 C 0.23 0.0316 0.37 KCNK3 307 11126666 A 0.03 0.0009 0.07 KCNK3 308 7584568 G 0.33 0.0185 0.37 KCNK3 309 1627854 G 0.37 0.0425 0.43 BRE 321 6732163 G 0.07 0.0281 0.21 BRE 323 6747817 G 0.10 0.0451 0.29 CDC42EP3 343 7607934 G 0.10 0.0248 0.26 SLC8A1 355 17026039 G 0.30 0.0227 2.89 PRKCE 376 666334 T 0.50 0.0053 3.13 ACYP2 414 2090182 T 0.03 0.0414 0.19 CTNNA2 468 1444539 C 0.20 0.0225 3.56 NAP5 485 13392755 T 0.57 0.0130 2.75 LRP1B 504 10469593 C 0.10 0.0106 0.22 LRP1B 505 12479163 A 0.10 0.0451 0.29 LRP1B 507 4447563 G 0.10 0.0005 0.14 KYNU 534 3768844 C 0.30 0.0227 2.89 ARHGAP15 550 6732131 A 0.17 0.0082 0.27 ARHGAP15 553 6750323 C 0.17 0.0082 0.27 ARHGAP15 554 4334442 C 0.10 0.0248 0.26 ARHGAP15 555 10197021 T 0.23 0.0422 0.39 ARHGAP15 557 11693600 C 0.57 0.0333 2.38 FMNL2 579 2346182 G 0.50 0.0286 2.44 FMNL2 586 6434113 C 0.07 0.0171 0.19 SCN9A 624 7589835 A 0.27 0.0228 3.05 CERKL 632 895901 A 0.50 0.0453 2.26 PDE1A 648 9332425 T 0.23 0.0351 0.38 PARD3B 655 1861763 C 0.33 0.0328 2.60 PARD3B 656 1019357 G 0.33 0.0328 2.60 PARD3B 667 1079943 G 0.17 0.0066 0.26 COL4A3 698 6741679 A 0.50 0.0172 2.65 TRIP12 728 17324331 G 0.47 0.0411 2.32 CNTN6 746 3772290 T 0.57 0.0412 2.30 CNTN4 768 13077493 T 0.07 0.0404 0.23 CNTN4 773 11920374 A 0.50 0.0332 2.39 ATP2B2 791 11719939 G 0.07 0.0281 0.21 ATP2B2 792 6763274 C 0.07 0.0310 0.22 ARPP-21 820 1963934 C 0.40 0.0257 2.59 ARPP-21 821 4678802 C 0.67 0.0334 2.45 CACNA2D3 865 4928009 A 0.40 0.0165 2.78 CACNA2D3 866 9825455 A 0.33 0.0444 2.45 ERC2 888 1485672 T 0.10 0.0045 0.19 ERC2 890 9873480 C 0.11 0.0025 0.17 ERC2 891 11708280 A 0.10 0.0053 0.20 ERC2 892 6765986 C 0.10 0.0061 0.20 ERC2 894 4974206 G 0.17 0.0153 0.30 ERC2 895 13064525 C 0.13 0.0154 0.27 FLNB 908 2259091 C 0.50 0.0202 2.59 PRICKLE2 960 17664984 T 0.04 0.0296 0.14 PRICKLE2 962 153729 A 0.32 0.0193 2.98 MAGI1 971 7649739 G 0.18 0.0334 0.34 MAGI1 977 6445525 C 0.33 0.0345 0.41 MAGI1 978 4688632 G 0.33 0.0409 0.42 FAM19A1 980 6548986 T 0.53 0.0313 2.40 RAB6B 1061 6765093 G 0.60 0.0140 2.73 EPHB1 1069 13314927 G 0.40 0.0294 2.53 LEPREL1 1134 1666486 A 0.37 0.0318 2.54 LEPREL1 1135 1447935 T 0.33 0.0496 2.41 LRRC15 1148 4974514 A 0.53 0.0313 2.40 SLC2A9 1155 1401438 T 0.30 0.0454 2.52 PPARGC1A 1195 6448226 G 0.27 0.0458 0.41 SOD3 1196 17622933 T 0.47 0.0093 2.94 NPFFR2 1239 4574375 G 0.07 0.0044 2.61 NPFFR2 1248 9790741 G 0.17 0.0498 0.37 SHROOM3 1255 3943037 G 0.43 0.0021 3.83 SHROOM3 1256 13138237 G 0.43 0.0058 3.19 SHROOM3 1258 4276307 A 0.23 0.0422 0.39 FAM13A1 1286 1398938 T 0.20 0.0225 3.56 FAM13A1 1287 1708673 T 0.20 0.0347 3.19 FAM13A1 1288 1996139 A 0.20 0.0347 3.19 COL25A1 1320 11942576 C 0.20 0.0261 0.35 COL25A1 1329 794149 G 0.50 0.0453 2.26 CAMK2D 1368 17532826 A 0.33 0.0328 2.60 GPR103 1383 7688947 C 0.07 0.0483 0.24 MAML3 1401 4863720 C 0.63 0.0208 2.61 IL15 1406 4254850 C 0.67 0.0148 2.77 INPP4B 1423 2627802 T 0.33 0.0278 0.40 DCLK2 1434 10002404 A 0.60 0.0380 2.35 TLL1 1479 3756016 C 0.20 0.0473 0.39 PALLD 1500 13122019 A 0.64 0.0298 2.54 PALLD 1507 1071738 C 0.57 0.0081 3.02 PALLD 1508 13116548 T 0.50 0.0008 4.00 PALLD 1509 11733251 A 0.50 0.0022 3.52 PALLD 1510 10518037 T 0.50 0.0027 3.43 PALLD 1511 6843588 G 0.57 0.0167 2.65 PALLD 1512 2331450 A 0.50 0.0027 3.43 ITGA1 1606 10513001 G 0.03 0.0469 0.16 THBS4 1654 385771 C 0.03 0.0071 0.10 THBS4 1655 366471 G 0.03 0.0071 0.10 THBS4 1656 256447 C 0.03 0.0087 0.10 THBS4 1657 256444 C 0.07 0.0233 0.21 THBS4 1661 7736549 A 0.04 0.0160 0.12 MEF2C 1676 700592 G 0.63 0.0054 3.14 MEF2C 1677 304151 C 0.50 0.0022 3.52 MEF2C 1678 4518438 T 0.65 0.0271 2.66 MEF2C 1679 3850651 C 0.57 0.0333 2.38 FBXL17 1717 4957554 C 0.20 0.0261 0.35 HSD17B4 1742 246965 G 0.27 0.0089 0.32 LOC340069 1746 328694 A 0.30 0.0334 0.40 TRPC7 1774 17170027 C 0.17 0.0394 0.35 ODZ2 1790 13158058 T 0.17 0.0026 0.23 PHACTR1 1821 12526453 C 0.17 0.0498 0.37 ATXN1 1835 235147 A 0.20 0.0144 0.31 SLC17A4 1846 9348694 T 0.40 0.0218 2.67 SLC17A4 1848 1892248 T 0.40 0.0300 2.51 SLC17A2 1865 3799371 T 0.53 0.0087 2.91 SLC17A2 1866 6938233 T 0.53 0.0087 2.91 SLC17A2 1867 2071297 C 0.53 0.0087 2.91 SLC17A2 1868 442601 C 0.13 0.0274 0.30 SLC17A2 1869 9467646 G 0.53 0.0104 2.84 SLC17A2 1870 9467652 G 0.53 0.0116 2.79 SLC17A2 1871 199739 T 0.13 0.0330 0.31 BTNL2 1876 3806156 T 0.23 0.0291 0.37 RIMS1 1898 530028 G 0.64 0.0390 2.41 RIMS1 1899 511211 C 0.63 0.0425 2.31 TRDN 1936 2873479 A 0.20 0.0205 3.63 TRDN 1943 12178740 G 0.00 0.0450 0.00 TRDN 1944 4509144 T 0.00 0.0450 0.00 TRDN 1946 6902416 G 0.00 0.0450 0.00 TRDN 1947 9490794 T 0.00 0.0450 0.00 NKAIN2 1955 9490937 C 0.07 0.0391 8.64 EYA4 1977 9385647 C 0.20 0.0379 0.37 PARK2 2016 2064419 G 0.33 0.0278 0.40 PARK2 2018 3765474 C 0.27 0.0320 0.39 PARK2 2019 992037 T 0.17 0.0124 0.29 PARK2 2022 6455738 A 0.17 0.0186 0.31 PARK2 2034 6930880 C 0.18 0.0334 0.34 PARK2 2035 2023079 C 0.17 0.0394 0.35 PARK2 2047 9365473 T 0.33 0.0368 2.55 PDE10A 2055 484842 G 0.03 0.0469 0.16 CARD11 2066 2679258 A 0.70 0.0486 2.33 SDK1 2073 663486 T 0.30 0.0326 2.70 SDK1 2074 663466 A 0.30 0.0227 2.89 NXPH1 2090 6962955 A 0.25 0.0134 0.32 SCIN 2094 849760 C 0.20 0.0379 0.37 CREB5 2121 6977628 T 0.07 0.0247 0.21 CREB5 2126 886750 A 0.10 0.0451 0.29 SCRN1 2129 9912 T 0.40 0.0119 2.93 FLJ22374 2145 7781249 A 0.23 0.0042 0.28 FLJ22374 2147 10258097 A 0.63 0.0230 2.56 CDC2L5 2186 3800802 T 0.46 0.0309 2.49 CDC2L5 2187 10277422 C 0.37 0.0168 2.84 GTF2IRD1 2253 6964833 C 0.43 0.0360 2.40 HIP1 2257 1018945 G 0.30 0.0182 0.36 MAGI2 2282 10259665 A 0.10 0.0106 0.22 CACNA2D1 2303 12535840 G 0.30 0.0490 0.43 PCLO 2311 17156675 T 0.47 0.0290 2.46 ABCB4 2348 31659 C 0.23 0.0051 4.41 ABCB4 2351 31662 A 0.23 0.0096 3.89 DYNC1I1 2389 2171555 A 0.17 0.0467 3.29 DYNC1I1 2394 2299277 T 0.37 0.0118 3.01 KCND2 2411 10276880 G 0.10 0.0045 13.67 KCND2 2417 12154976 T 0.37 0.0234 2.68 KCND2 2418 2189974 C 0.37 0.0458 2.39 SLC13A1 2426 1404836 C 0.07 0.0310 0.22 DGKI 2477 4728414 C 0.57 0.0076 2.96 DGKI 2478 1528103 C 0.57 0.0076 2.96 DGKI 2479 10268638 A 0.50 0.0361 2.35 CNTNAP2 2487 1639481 G 0.64 0.0383 2.42 CNTNAP2 2496 7802708 G 0.17 0.0153 0.30 MCPH1 2574 7844367 C 0.17 0.0467 3.29 KCNB2 2754 2981104 C 0.23 0.0413 2.84 NCALD 2780 2387620 G 0.50 0.0453 2.26 FER1L6 2833 4242352 C 0.43 0.0461 2.29 MTSS1 2852 4871506 T 0.33 0.0341 0.41 KCNQ3 2901 2597363 G 0.17 0.0261 3.87 NTRK2 3074 7867174 G 0.10 0.0027 0.18 NTRK2 3075 7038866 A 0.07 0.0025 0.13 NTRK2 3077 2799482 C 0.04 0.0005 0.06 NTRK2 3078 2799483 C 0.07 0.0012 0.12 NTRK2 3079 1899641 G 0.07 0.0020 0.13 STOM 3142 2196311 G 0.27 0.0308 2.86 RALGPS1 3160 10987576 A 0.03 0.0469 0.16 ABL1 3167 2855190 C 0.03 0.0469 0.16 ABCA2 3201 12337910 G 0.20 0.0205 3.63 PRKCQ 3226 806399 A 0.40 0.0447 2.35 PRKCQ 3228 2236380 T 0.47 0.0472 2.27 PRKCQ 3230 4748667 A 0.23 0.0164 0.34 CACNB2 3239 729245 A 0.47 0.0411 2.32 MYO3A 3267 993397 A 0.53 0.0178 2.63 MYO3A 3288 3006844 G 0.25 0.0295 0.37 JMJD1C 3299 10761747 G 0.40 0.0300 2.51 JMJD1C 3301 9629895 A 0.37 0.0318 2.54 JMJD1C 3303 2893922 C 0.37 0.0007 4.55 CDH23 3313 4747195 T 0.40 0.0342 2.46 CDH23 3314 4747197 T 0.40 0.0394 2.40 VTI1A 3401 17585548 G 0.37 0.0359 2.49 ATE1 3439 7075881 T 0.03 0.0414 0.20 ATE1 3444 10749429 T 0.03 0.0414 2.37 CTBP2 3454 769160 C 0.00 0.0173 0.00 GALNTL4 3468 4910288 A 0.53 0.0484 2.23 MICAL2 3473 1159649 C 0.07 0.0016 0.13 STYK1 3609 1078437 G 0.53 0.0313 2.40 STYK1 3611 3759259 A 0.53 0.0342 2.37 STYK1 3612 10845187 C 0.53 0.0428 2.29 STYK1 3615 10845198 T 0.60 0.0140 2.73 LOC729025 3630 11056890 C 0.07 0.0193 0.20 MTIF3 3689 1885990 A 0.30 0.0454 2.52 UBL3 3698 9578147 G 0.23 0.0053 0.29 PCDH17 3736 4884285 T 0.37 0.0234 2.68 GPC5 3778 1330469 T 0.60 0.0109 2.83 GPC6 3794 1008993 T 0.03 0.0106 0.11 GPC6 3795 16948547 G 0.07 0.0192 0.20 NALCN 3824 625331 C 0.03 0.0327 0.14 NALCN 3825 676602 A 0.00 0.0220 0.00 NALCN 3837 3916910 C 0.10 0.0262 0.26 ITGBL1 3840 875116 C 0.10 0.0148 0.23 ITGBL1 3841 915343 T 0.07 0.0373 0.23 ITGBL1 3842 1296174 A 0.07 0.0447 0.24 ITGBL1 3846 3783215 C 0.07 0.0281 0.21 ITGBL1 3847 1436261 C 0.07 0.0483 0.24 NOVA1 3862 2144335 A 0.36 0.0240 2.78 SLC25A21 3882 2022601 A 0.36 0.0313 0.40 SLC25A21 3885 1367029 T 0.36 0.0248 0.38 SLC25A21 3886 10140136 A 0.13 0.0164 0.27 SLC25A21 3887 9806037 G 0.17 0.0250 0.32 SAMD4A 3910 11626634 A 0.23 0.0028 5.00 PPP2R5E 3922 7140704 G 0.30 0.0099 3.37 PPP2R5E 3924 10152067 G 0.29 0.0442 2.65 GLDN 4062 17648128 A 0.57 0.0315 2.40 GLDN 4063 17648140 G 0.57 0.0333 2.38 A2BP1 4118 1155959 C 0.53 0.0313 2.40 A2BP1 4119 12926215 G 0.07 0.0131 0.18 A2BP1 4120 1492382 C 0.07 0.0175 0.19 A2BP1 4121 4289011 C 0.20 0.0453 0.38 TMC5 4142 2353696 T 0.47 0.0472 2.27 EEF2K 4144 8059561 C 0.10 0.0217 0.25 EEF2K 4145 10521118 A 0.20 0.0205 3.63 CDH13 4191 1862832 T 0.27 0.0458 0.41 CDH13 4201 1833965 A 0.17 0.0186 0.31 CRISPLD2 4214 2934477 A 0.27 0.0458 0.41 CA10 4226 11867674 G 0.27 0.0056 0.30 CA10 4229 985758 G 0.13 0.0154 0.27 CA10 4230 4794295 T 0.27 0.0056 0.30 SDK2 4263 7219778 A 0.27 0.0173 0.35 HRNBP3 4274 4313839 C 0.20 0.0453 0.38 OSBPL1A 4308 2077984 C 0.03 0.0414 0.14 NEDD4L 4321 1008899 A 0.03 0.0273 0.14 NEDD4L 4322 292456 G 0.13 0.0395 0.32 NEDD4L 4324 4941375 C 0.03 0.0306 0.14 CDH7 4355 7237421 T 0.53 0.0248 2.49 CDH7 4356 8092259 G 0.50 0.0405 2.37 PRNT 4399 2065705 C 0.21 0.0485 0.38 PLCB1 4412 6055513 G 0.67 0.0282 2.51 PLCB1 4417 16994533 G 0.30 0.0451 2.55 KIF16B 4463 4814474 A 0.60 0.0224 2.54 KIF16B 4465 2328019 C 0.23 0.0240 0.36 KIF16B 4474 12624938 A 0.32 0.0275 2.79 SEC23B 4485 1022681 A 0.03 0.0079 0.10 SEC23B 4486 1555354 C 0.07 0.0212 0.20 PTPRT 4502 6124439 A 0.10 0.0377 0.28 CDH4 4539 6089573 A 0.73 0.0096 3.30 PDE9A 4563 2245730 C 0.70 0.0093 3.03 PDE9A 4564 12626774 C 0.17 0.0226 0.32 ARVCF 4569 2073746 A 0.43 0.0080 3.06 ARFGAP3 4579 2024645 T 0.63 0.0050 3.17 ARFGAP3 4580 5758965 A 0.63 0.0116 2.83 ARFGAP3 4583 4822208 T 0.63 0.0276 2.49 PACSIN2 4584 12166809 A 0.64 0.0031 3.51 PACSIN2 4585 5759013 A 0.63 0.0041 3.25 PACSIN2 4586 4820494 C 0.63 0.0041 3.25 PACSIN2 4587 1071960 C 0.43 0.0210 2.62 PACSIN2 4588 7286299 A 0.60 0.0469 2.27

TABLE 20 Alleles Influencing Discontinuation from Adverse Events for Ziprasidone Freq. in Gene Seq Discon- Odds Name ID NCBI # Correct tinuers P Ratio RP1-21O18.1 12 2175771 C 0.09 0.0354 0.22 AGBL4-C1orf165 28 11205538 C 0.59 0.0415 2.72 SCP2 42 6588458 A 0.14 0.0427 5.68 FAM78B 112 6662013 T 0.14 0.0239 0.24 FAM78B 117 1002160 A 0.41 0.0067 4.09 FAM78B 118 7521995 C 0.40 0.0177 3.56 FAM78B 119 715421 A 0.45 0.0071 3.91 FAM78B 120 10800198 C 0.45 0.0181 3.28 DPT 121 6427142 G 0.00 0.0466 0.00 PLA2G4A 137 12720662 T 0.41 0.0019 5.15 USH2A 159 1805049 G 0.59 0.0042 4.04 USH2A 160 2274117 G 0.59 0.0042 4.04 USH2A 162 773498 G 0.59 0.0042 4.04 USH2A 167 773042 T 0.50 0.0074 3.80 ESRRG 171 1833036 A 0.68 0.0127 3.47 ESRRG 172 12757165 G 0.59 0.0035 4.18 ESRRG 173 6658528 T 0.64 0.0448 2.68 ESRRG 174 11117612 G 0.59 0.0042 4.04 RYR2 197 1806641 C 0.27 0.0463 0.36 RYR2 202 12048201 G 0.00 0.0236 0.00 RYR2 209 3766871 A 0.14 0.0427 5.68 CHRM3 219 7513746 G 0.23 0.0303 0.31 CHRM3 220 6429154 G 0.23 0.0391 0.33 CHRM3 222 1431719 G 0.23 0.0391 0.33 CHRM3 225 10802801 A 0.23 0.0391 0.33 FMN2 228 12118961 T 0.73 0.0273 3.14 FMN2 230 6698474 A 0.68 0.0311 2.95 FMN2 231 12123407 A 0.68 0.0408 2.79 FMN2 233 11591010 C 0.00 0.0378 0.00 PLD5 271 1548160 C 0.14 0.0424 0.27 PLD5 272 12128054 A 0.14 0.0308 0.26 DDEF2 283 10593 G 0.18 0.0224 5.41 BRE 313 7572644 C 0.00 0.0373 0.00 PLEKHH2 360 12621654 T 0.14 0.0498 0.29 PRKCE 378 1464572 T 0.68 0.0120 3.52 PRKCE 386 13003856 G 0.59 0.0477 2.62 PRKCE 387 6748375 C 0.18 0.0315 0.29 EPAS1 393 7589621 A 0.41 0.0115 3.69 CCDC85A 424 214041 T 0.18 0.0404 0.31 CTNNA2 451 53915 G 0.50 0.0173 3.22 CTNNA2 454 1006607 G 0.27 0.0068 5.33 CTNNA2 456 2120408 C 0.27 0.0068 5.33 CTNNA2 457 2165975 T 0.27 0.0068 5.33 NAP5 476 13414473 C 0.59 0.0135 3.33 UBXD2 496 6430585 A 0.09 0.0448 0.23 UBXD2 497 1042712 C 0.05 0.0174 0.12 PLA2R1 610 2715936 G 0.00 0.0373 0.00 PDE1A 640 833119 C 0.27 0.0481 3.19 PARD3B 657 2878473 C 0.32 0.0418 3.08 ERBB4 683 4672668 G 0.27 0.0358 0.34 DNER 711 2396644 A 0.45 0.0224 3.13 CNTN6 735 6798321 C 0.36 0.0339 0.35 CNTN6 736 11925058 C 0.25 0.0064 0.23 CNTN6 737 3772339 T 0.18 0.0142 0.25 CNTN6 738 4286413 T 0.17 0.0079 0.19 CNTN4 767 12494838 G 0.45 0.0465 2.69 CNTN4 771 11129386 A 0.23 0.0391 0.33 SLC6A6 798 11713355 A 0.32 0.0146 3.97 STAC 823 4678874 G 0.36 0.0350 3.05 ULK4 839 7649806 A 0.27 0.0463 0.36 ERC2 902 17216615 C 0.14 0.0427 5.68 FHIT 917 802778 A 0.00 0.0297 0.00 FHIT 929 815718 C 0.32 0.0418 3.08 CADPS 949 11925708 A 0.64 0.0448 2.68 CADPS 950 968808 T 0.65 0.0235 3.18 CADPS 952 9825965 C 0.64 0.0448 2.68 SYNPR 953 1812207 A 0.68 0.0226 3.14 SYNPR 956 7618831 T 0.60 0.0359 2.89 CPNE4 1059 2178385 A 0.59 0.0264 2.95 RAB6B 1061 6765093 G 0.14 0.0185 0.23 EPHB1 1063 7650345 G 0.14 0.0393 0.27 EPHB1 1068 1870196 T 0.09 0.0448 0.23 CLSTN2 1073 6439926 A 0.23 0.0500 0.34 SPSB4 1084 4683550 C 0.14 0.0143 10.89 SPSB4 1086 2086180 G 0.14 0.0427 5.68 NLGN1 1121 692457 A 0.64 0.0186 3.18 NLGN1 1122 10936780 G 0.20 0.0050 9.00 NLGN1 1123 692486 G 0.64 0.0186 3.18 NLGN1 1124 12634066 A 0.18 0.0074 8.22 NLGN1 1125 11713211 C 0.59 0.0477 2.62 NLGN1 1127 9828801 T 0.14 0.0389 5.84 HTR3C 1131 6443938 A 0.64 0.0305 2.92 LDB2 1177 157613 G 0.14 0.0389 5.84 LDB2 1179 158278 G 0.14 0.0389 5.84 LDB2 1180 150261 C 0.14 0.0101 11.84 SLIT2 1191 9992591 C 0.64 0.0095 3.57 SOD3 1196 17622933 T 0.10 0.0427 0.23 KIAA1239 1205 1435378 G 0.09 0.0497 0.24 UBE2K 1214 1003212 T 0.23 0.0313 4.06 NPFFR2 1234 1520503 T 0.18 0.0187 0.26 CXCL9 1254 10518143 C 0.05 0.0080 0.10 SCD5 1261 4693474 C 0.55 0.0263 2.95 SCD5 1264 993380 A 0.55 0.0263 2.95 FAM13A1 1281 4544678 C 0.32 0.0311 0.34 FAM13A1 1282 7691186 G 0.32 0.0311 0.34 FAM13A1 1283 6814344 G 0.36 0.0448 0.37 FAM13A1 1284 13131633 T 0.36 0.0448 0.37 COL25A1 1317 2305438 A 0.59 0.0477 2.62 COL25A1 1327 3096507 C 0.15 0.0403 0.27 ANK2 1345 967099 T 0.18 0.0315 0.29 ANK2 1348 362496 G 0.09 0.0278 0.20 GPR103 1381 13110738 G 0.00 0.0047 0.00 GPR103 1382 2013332 A 0.05 0.0361 0.14 IL15 1405 10519613 A 0.00 0.0466 0.00 INPP4B 1416 17015544 T 0.23 0.0356 3.94 INPP4B 1424 1391099 G 0.00 0.0345 0.00 DCLK2 1433 10014161 C 0.80 0.0026 5.50 DCLK2 1436 7665011 A 0.77 0.0052 4.43 DCLK2 1438 11735949 C 0.64 0.0134 3.37 DCLK2 1442 6535725 A 0.68 0.0311 2.95 CTSO 1449 10517625 C 0.32 0.0418 3.08 FSTL5 1471 1994770 A 0.23 0.0303 0.31 ENPP6 1522 7696176 C 0.23 0.0097 0.25 ENPP6 1523 6831986 C 0.23 0.0176 0.28 ENPP6 1524 17679120 A 0.32 0.0408 0.36 DNAH5 1560 1445823 C 0.59 0.0120 3.41 CDH10 1574 7731953 T 0.00 0.0378 0.00 CDH10 1576 983446 T 0.05 0.0058 0.09 EGFLAM 1589 2434504 A 0.64 0.0339 2.84 EGFLAM 1591 1428263 C 0.55 0.0396 2.82 ITGA1 1599 13189973 T 0.41 0.0420 2.82 ITGA1 1606 10513001 G 0.45 0.0328 2.89 VCAN 1672 3096172 C 0.05 0.0455 0.15 GPR98 1684 10062714 T 0.27 0.0358 0.34 GPR98 1687 16868980 C 0.10 0.0032 0.13 GPR98 1688 2366926 G 0.14 0.0060 0.19 FBXL17 1708 286769 T 0.10 0.0341 0.21 HSD17B4 1738 2636968 G 0.77 0.0003 6.66 HSD17B4 1740 32662 T 0.23 0.0071 0.24 HSD17B4 1741 463098 A 0.77 0.0005 6.28 HSD17B4 1742 246965 G 0.77 0.0005 6.17 HSD17B4 1743 246968 A 0.68 0.0008 5.26 LOC340069 1746 328694 A 0.68 0.0234 3.11 SNCAIP 1753 304379 C 0.27 0.0114 0.27 SNCAIP 1755 1841972 C 0.36 0.0350 3.05 SNCAIP 1756 11241644 G 0.36 0.0350 3.05 SNX2 1758 4343835 C 0.23 0.0391 0.33 SNX2 1760 2407403 G 0.59 0.0191 3.13 SNX24 1762 246286 T 0.64 0.0059 3.88 SNX24 1763 246266 C 0.64 0.0062 3.92 CTNNA1 1780 1828187 G 0.50 0.0213 3.11 CTNNA1 1782 176382 G 0.50 0.0251 3.00 CTNNA1 1783 10038162 A 0.50 0.0251 3.00 CTNNA1 1784 9327829 T 0.50 0.0251 3.00 CTNNA1 1785 3763016 G 0.50 0.0251 3.00 CTNNA1 1786 10045605 C 0.50 0.0251 3.00 GABRP 1805 3792811 G 0.59 0.0191 3.13 SERPINB6 1806 1358869 C 0.23 0.0391 0.33 PHACTR1 1823 12527257 C 0.05 0.0104 0.10 PHACTR1 1824 9367368 C 0.05 0.0111 0.10 RNF144B 1840 6927687 C 0.05 0.0365 0.14 RNF144B 1843 531481 T 0.41 0.0284 3.07 RNF144B 1844 527984 T 0.40 0.0411 2.95 TJAP1 1887 1096699 A 0.50 0.0307 2.90 GABRR2 1918 282128 A 0.73 0.0207 3.29 GABRR2 1920 6900958 T 0.14 0.0308 0.26 KLHL32 1925 1206149 A 0.59 0.0446 2.67 NKAIN2 1958 163284 A 0.59 0.0120 3.41 NKAIN2 1959 12195023 T 0.50 0.0028 4.43 NKAIN2 1961 163291 A 0.59 0.0304 2.89 EYA4 1977 9385647 C 0.64 0.0066 3.79 UTRN 1997 601873 A 0.23 0.0401 0.33 UTRN 1999 760855 T 0.09 0.0098 0.16 UTRN 2001 7765923 A 0.09 0.0183 0.18 UTRN 2002 6906465 G 0.45 0.0101 3.84 SLC22A3 2015 2048327 G 0.50 0.0251 3.00 PARK2 2032 6455807 G 0.14 0.0239 0.24 PARK2 2034 6930880 C 0.18 0.0404 0.31 CARD11 2066 2679258 A 0.27 0.0463 0.36 CARD11 2069 4722277 T 0.23 0.0098 0.25 SDK1 2076 10951446 A 0.27 0.0469 0.35 SDK1 2080 651245 A 0.55 0.0491 2.60 NXPH1 2086 7777974 A 0.64 0.0012 4.90 NXPH1 2087 10257265 C 0.50 0.0143 3.35 NXPH1 2088 970526 G 0.50 0.0212 3.22 SCIN 2092 2240571 G 0.64 0.0448 2.68 NPY 2114 16129 T 0.27 0.0274 0.32 NPY 2115 16124 A 0.27 0.0358 0.34 BMPER 2163 11978741 T 0.09 0.0448 0.23 BMPER 2164 6975236 T 0.59 0.0063 3.78 GRB10 2215 2244347 C 0.14 0.0141 0.22 WBSCR17 2233 10950240 A 0.30 0.0337 0.33 WBSCR17 2237 11768233 A 0.55 0.0363 2.77 MAGI2 2266 6466021 G 0.36 0.0482 2.86 MAGI2 2283 7789445 A 0.23 0.0276 4.18 CACNA2D1 2312 2368020 A 0.45 0.0057 4.04 CACNA2D1 2314 1468400 A 0.45 0.0042 4.31 CACNA2D1 2315 7788848 A 0.45 0.0094 3.69 PCLO 2327 17282763 C 0.18 0.0404 0.31 PCLO 2328 12539066 T 0.55 0.0037 4.20 PCLO 2330 976714 T 0.64 0.0030 4.30 PCLO 2331 7778238 C 0.77 0.0071 4.22 PCLO 2332 2190045 C 0.18 0.0030 0.19 SEMA3E 2340 2249188 G 0.68 0.0408 2.79 SEMA3E 2343 215274 C 0.23 0.0176 0.28 SEMA3E 2345 3801562 C 0.23 0.0232 0.29 PPP1R9A 2365 6465455 T 0.27 0.0207 0.30 PPP1R9A 2369 961262 C 0.27 0.0155 0.29 DYNC1I1 2379 1478984 G 0.09 0.0261 0.20 PON1 2385 13223537 C 0.41 0.0420 2.82 DYNC1I1 2386 1382620 A 0.09 0.0216 0.19 DYNC1I1 2387 983350 T 0.09 0.0216 0.19 DYNC1I1 2388 983352 T 0.09 0.0261 0.20 CUX1 2403 425964 T 0.27 0.0068 5.33 CUX1 2405 427039 T 0.27 0.0278 3.70 SLC13A1 2427 2222510 A 0.14 0.0048 0.18 SLC13A1 2428 2462152 G 0.14 0.0060 0.19 SLC13A1 2429 6963735 C 0.68 0.0003 6.00 PTPRN2 2518 6943534 T 0.50 0.0488 2.62 PTPRN2 2519 4909289 A 0.45 0.0475 2.70 PTPRN2 2524 6960916 A 0.50 0.0488 2.62 PTPRN2 2525 6966663 G 0.50 0.0488 2.62 PTPRN2 2532 10265417 T 0.64 0.0429 2.72 PTPRN2 2533 10081235 A 0.64 0.0448 2.68 CSMD1 2538 4875250 G 0.41 0.0004 6.82 PSD3 2608 6992325 C 0.41 0.0115 3.69 PSD3 2611 1492289 C 0.64 0.0095 3.57 PSD3 2612 4921968 A 0.55 0.0263 2.95 PSD3 2614 11778310 G 0.45 0.0328 2.89 PEBP4 2626 4872539 C 0.50 0.0074 3.75 PEBP4 2627 7829416 G 0.50 0.0093 3.63 PEBP4 2628 6558183 T 0.45 0.0009 5.50 UNC5D 2641 1439158 G 0.14 0.0498 0.29 PRKDC 2650 4873770 T 0.09 0.0079 3.19 SNTG1 2654 6999728 A 0.32 0.0036 5.44 SNTG1 2655 2106156 A 0.05 0.0130 0.11 SNTG1 2656 1000638 T 0.05 0.0174 0.12 SNTG1 2660 12548940 C 0.05 0.0284 0.13 SNTG1 2670 7832799 A 0.41 0.0497 2.72 NKAIN3 2691 2084799 C 0.27 0.0359 0.34 NKAIN3 2693 7835901 C 0.64 0.0186 3.18 GRHL2 2776 4734037 C 0.27 0.0481 3.19 GRHL2 2778 11994917 T 0.55 0.0233 3.03 GRHL2 2779 1131862 G 0.36 0.0222 3.38 NCALD 2780 2387620 G 0.45 0.0328 2.89 NCALD 2781 2226401 C 0.36 0.0075 4.25 BAALC 2787 13279226 A 0.32 0.0418 3.08 SAMD12 2829 2460983 G 0.32 0.0418 3.08 DDEF1 2858 3871 C 0.45 0.0465 2.69 DDEF1 2863 7838372 T 0.27 0.0170 4.25 DDEF1 2864 6991714 A 0.05 0.0361 0.14 DDEF1 2867 2670886 C 0.30 0.0281 3.64 DDEF1 2874 2670882 G 0.27 0.0481 3.19 COL22A1 2907 4475485 T 0.18 0.0224 5.41 COL22A1 2914 13279213 A 0.41 0.0420 2.82 SMARCA2 2929 7048976 G 0.36 0.0448 0.37 PTPRD 2941 12555585 G 0.32 0.0256 3.47 PTPRD 2943 10124689 T 0.14 0.0498 0.29 TRPM6 3045 7045338 T 0.18 0.0315 0.29 TRPM6 3049 7024831 A 0.09 0.0129 0.17 PCSK5 3058 10124834 T 0.05 0.0455 0.15 NTRX2 3079 1899641 G 0.09 0.0448 0.23 DAPK1 3082 6560011 C 0.18 0.0142 0.25 SVEP1 3124 963143 A 0.59 0.0446 2.67 SVEP1 3126 10759422 C 0.36 0.0411 2.95 DAB2IP 3143 10985431 T 0.32 0.0076 4.60 TSC1 3181 11243940 G 0.50 0.0354 2.80 TSC1 3182 7035308 A 0.50 0.0354 2.80 KCNT1 3195 497547 G 0.18 0.0224 5.41 ABCA2 3201 12337910 G 0.25 0.0217 4.47 PITRM1 3215 3740607 G 0.32 0.0311 0.34 PITRM1 3217 4242746 T 0.09 0.0087 0.16 PITRM1 3220 3829918 G 0.14 0.0239 0.24 MYO3A 3259 7896978 C 0.09 0.0354 0.22 MYO3A 3260 11014839 A 0.09 0.0354 0.22 MYO3A 3265 6482521 C 0.14 0.0101 11.84 MYO3A 3266 872754 G 0.14 0.0101 11.84 MYO3A 3270 1339814 T 0.36 0.0411 2.95 MYO3A 3271 11014917 A 0.05 0.0174 0.12 MYO3A 3273 5012431 C 0.41 0.0358 0.36 MYO3A 3274 12773856 C 0.41 0.0358 0.36 MYO3A 3276 2139795 G 0.41 0.0358 0.36 MYO3A 3278 3758449 C 0.41 0.0358 0.36 MYO3A 3287 3781117 C 0.05 0.0284 0.13 CDH23 3307 10999947 A 0.45 0.0328 2.89 VTI1A 3395 2044366 C 0.00 0.0070 0.00 VT11A 3396 11196051 G 0.05 0.0104 0.10 VTI1A 3397 10885371 A 0.05 0.0321 0.14 ATRNL1 3418 2068463 C 0.27 0.0207 0.30 ATE1 3431 1693688 C 0.68 0.0013 4.94 ATE1 3432 2935718 C 0.64 0.0186 3.18 ATE1 3433 7086628 C 0.64 0.0448 2.68 ATE1 3435 1219505 T 0.68 0.0127 3.47 MICAL2 3475 2010463 A 0.64 0.0002 6.07 MICAL2 3476 10831750 T 0.50 0.0115 3.47 MICAL2 3477 7117171 G 0.50 0.0074 3.75 MICAL2 3478 17477949 T 0.25 0.0120 0.26 MICAL2 3479 954428 G 0.64 0.0030 4.30 DLG2 3540 11233954 A 0.00 0.0186 0.00 DLG2 3547 11234221 A 0.59 0.0191 3.13 DLG2 3548 11234222 A 0.59 0.0191 3.13 OPCML 3578 6590699 T 0.41 0.0185 3.36 OPCML 3581 7935298 A 0.41 0.0185 3.36 OPCML 3582 4937780 G 0.41 0.0185 3.36 OPCML 3586 12792779 T 0.35 0.0228 3.55 OPCML 3587 7108670 C 0.41 0.0185 3.36 OPCML 3589 4936195 G 0.40 0.0007 6.57 TSPAN9 3595 10774140 C 0.09 0.0354 0.22 LOC729025 3618 10219568 A 0.64 0.0448 2.68 PIK3C2G 3633 11043979 C 0.60 0.0474 2.72 ITPR2 3637 16930669 C 0.20 0.0380 4.38 ITPR2 3639 7955200 C 0.45 0.0224 3.13 CNOT2 3642 10879096 G 0.05 0.0455 0.15 KCNC2 3661 10735985 G 0.64 0.0134 3.37 MTIF3 3688 3759433 T 0.32 0.0256 3.47 SLC46A3 3693 1617234 C 0.64 0.0448 2.68 UBL3 3697 9551767 C 0.14 0.0081 0.20 UBL3 3698 9578147 G 0.14 0.0081 0.20 NBEA 3719 7320580 G 0.50 0.0143 3.35 NBEA 3720 7988705 A 0.50 0.0173 3.22 NBEA 3722 3818423 C 0.50 0.0173 3.22 NBEA 3723 17769661 T 0.36 0.0411 2.95 TRPC4 3732 1538146 T 0.23 0.0232 0.29 GPC5 3792 17267453 C 0.14 0.0427 5.68 GPC6 3812 9301916 C 0.09 0.0098 0.16 GPC6 3813 9524268 T 0.09 0.0098 0.16 NALCN 3823 16958230 G 0.23 0.0046 7.16 NALCN 3824 625331 C 0.27 0.0278 3.70 NALCN 3830 2390576 G 0.41 0.0477 0.38 NALCN 3832 1538240 C 0.80 0.0215 3.79 NALCN 3833 518212 G 0.18 0.0244 0.27 ITGBL1 3838 7998372 T 0.82 0.0079 4.50 NOVA1 3857 1473722 G 0.05 0.0284 0.13 NOVA1 3858 17111388 C 0.05 0.0321 0.14 NOVA1 3859 3794485 C 0.05 0.0284 0.13 NPAS3 3867 243284 G 0.59 0.0477 2.62 NPAS3 3871 10133530 A 0.27 0.0278 3.70 GNG2 3907 4898721 C 0.05 0.0361 0.14 GNG2 3908 10138800 A 0.64 0.0339 2.84 RGS6 3931 36340 A 0.25 0.0460 0.33 RGS6 3935 11623588 T 0.73 0.0111 3.70 RGS6 3936 10151019 A 0.09 0.0448 0.23 RGS6 3938 1076317 C 0.77 0.0132 3.78 RGS6 3939 1568404 T 0.77 0.0176 3.58 RGS6 3942 1520332 T 0.18 0.0244 0.27 RGS6 3946 1099968 G 0.14 0.0424 0.27 RGS6 3948 2190508 C 0.14 0.0498 0.29 KCNK10 3962 12587003 C 0.36 0.0311 3.17 CCDC88C 3987 11160006 C 0.23 0.0391 0.33 CCDC88C 3988 10139287 A 0.61 0.0048 4.40 ATP10A 4015 4906620 C 0.05 0.0135 0.11 RYR3 4018 2251107 G 0.59 0.0191 3.13 RYR3 4029 4780144 C 0.09 0.0079 0.38 GLDN 4057 16964316 A 0.14 0.0389 5.84 GLDN 4059 16964319 T 0.14 0.0389 5.84 GLDN 4060 10163098 G 0.14 0.0389 5.84 GLDN 4061 12443092 C 0.14 0.0389 5.84 CGNL1 4068 4774257 G 0.05 0.0135 0.11 RORA 4078 12914584 G 0.59 0.0027 4.33 RORA 4080 1657792 A 0.32 0.0311 0.34 SH3GL3 4107 17158811 A 0.14 0.0011 2.89 EEF2K 4148 4275840 T 0.05 0.0409 0.15 USP10 4209 3829554 G 0.18 0.0315 0.29 CA10 4231 203010 T 0.32 0.0311 0.34 CA10 4233 203042 A 0.64 0.0448 2.68 CA10 4240 1503058 A 0.30 0.0192 0.29 ZFP161 4285 12605370 C 0.18 0.0224 5.41 ZFP161 4286 12604181 T 0.23 0.0276 4.18 CCBE1 4337 12969965 A 0.36 0.0222 3.38 CDH7 4349 7241038 T 0.73 0.0152 3.50 CDH7 4351 976882 A 0.73 0.0199 3.36 CDH7 4352 12970791 T 0.73 0.0207 3.29 DOK6 4379 11662555 G 0.27 0.0358 0.34 DOK6 4380 12959721 A 0.27 0.0463 0.36 MACROD2 4451 2193028 C 0.00 0.0466 0.00 SEC23B 4487 2273525 T 0.14 0.0389 5.84 PTPRT 4505 6065520 T 0.05 0.0104 0.10 PTPRT 4512 6072869 G 0.32 0.0418 3.08 SNAI1 4524 6020157 A 0.32 0.0418 3.08 SNAI1 4527 1543442 A 0.23 0.0500 0.34 SLC37A1 4560 401396 C 0.45 0.0224 3.13 EFCAB6 4601 4823125 A 0.45 0.0181 3.28 EFCAB6 4603 137733 T 0.32 0.0311 0.34 EFCAB6 4606 5764214 C 0.27 0.0358 0.34 EFCAB6 4611 8141695 A 0.45 0.0465 2.69

TABLE A Summary of SNPs (NCBI Human Genome Reference Assembly Build 36.3) Seq ID Gene Chr Position (BP) Seq ID Gene Chr Position (BP) 1 PIK3CD 1 9,713,582 2 KIF1B 1 10,204,773 3 KIF1B 1 10,230,040 4 KIF1B 1 10,271,299 5 KIF1B 1 10,308,058 6 KIF1B 1 10,314,123 7 RP1-21O18.1 1 15,160,805 8 RP1-21O18.1 1 15,178,638 9 RP1-21O18.1 1 15,204,190 10 RP1-21O18.1 1 15,225,545 11 RP1-21O18.1 1 15,227,828 12 RP1-21O18.1 1 15,230,092 13 RP1-21O18.1 1 15,265,882 14 RP1-21O18.1 1 15,278,076 15 RP1-21O18.1 1 15,281,743 16 RP1-21O18.1 1 15,285,942 17 RP1-21O18.1 1 15,287,000 18 RP1-21O18.1 1 15,311,577 19 EPHB2 1 22,976,971 20 EPHB2 1 22,984,956 21 EPHB2 1 23,015,083 22 EPHB2 1 23,106,187 23 EPHB2 1 23,107,533 24 AGBL4-C1ORF165 1 48,833,568 25 AGBL4-C1ORF165 1 48,864,626 26 AGBL4-C1ORF165 1 48,885,834 27 AGBL4-C1ORF165 1 49,006,963 28 AGBL4-C1ORF165 1 49,010,181 29 AGBL4-C1ORF165 1 49,012,555 30 AGBL4-C1ORF165 1 49,046,634 31 AGBL4-C1ORF165 1 49,108,184 32 AGBL4-C1ORF165 1 49,109,043 33 AGBL4-C1ORF165 1 49,124,764 34 AGBL4-C1ORF165 1 49,132,460 35 AGBL4-C1ORF165 1 49,133,207 36 AGBL4-C1ORF165 1 49,150,727 37 AGBL4-C1ORF165 1 49,214,610 38 AGBL4-C1ORF165 1 49,243,353 39 SCP2 1 53,226,518 40 SCP2 1 53,228,487 41 SCP2 1 53,261,152 42 SCP2 1 53,283,563 43 SCP2 1 53,284,873 44 SCP2 1 53,285,107 45 SCP2 1 53,286,570 46 SCP2 1 53,290,585 47 SCP2 1 53,290,637 48 LRP8 1 53,485,315 49 LRP8 1 53,486,137 50 LRP8 1 53,495,778 51 LRP8 1 53,495,937 52 LRP8 1 53,504,903 53 LRP8 1 53,519,183 54 LRP8 1 53,524,722 55 LRP8 1 53,527,479 56 LRP8 1 53,535,369 57 LRP8 1 53,558,737 58 LRP8 1 53,581,246 59 LRP8 1 53,581,281 60 LRP8 1 53,581,618 61 ELTD1 1 79,151,010 62 ELTD1 1 79,153,054 63 ELTD1 1 79,165,344 64 ELTD1 1 79,175,923 65 ELTD1 1 79,246,223 66 ELTD1 1 79,256,985 67 ELTD1 1 79,272,148 68 PRKACB 1 84,299,506 69 PRKACB 1 84,301,022 70 PRKACB 1 84,306,260 71 PRKACB 1 84,306,347 72 PRKACB 1 84,323,437 73 PRKACB 1 84,334,853 74 PRKACB 1 84,343,593 75 PRKACB 1 84,366,987 76 PRKACB 1 84,435,529 77 PRKACB 1 84,450,848 78 SYT6 1 114,452,599 79 SYT6 1 114,478,552 80 NGF 1 115,631,509 81 NGF 1 115,658,774 82 NGF 1 115,664,140 83 NGF 1 115,672,877 84 NGF 1 115,679,147 85 SLC22A15 1 116,329,613 86 SLC22A15 1 116,353,502 87 PTGFRN 1 117,246,888 88 PTGFRN 1 117,267,288 89 PTGFRN 1 117,271,304 90 PTGFRN 1 117,272,017 91 PTGFRN 1 117,273,572 92 PTGFRN 1 117,277,238 93 PTGFRN 1 117,284,884 94 PTGFRN 1 117,316,638 95 CGN 1 149,743,817 96 KCNN3 1 152,950,730 97 KCNN3 1 152,954,821 98 ATF6 1 160,027,900 99 ATF6 1 160,052,935 100 ATF6 1 160,062,017 101 ATF6 1 160,062,520 102 ATF6 1 160,101,079 103 ATF6 1 160,102,111 104 ATF6 1 160,107,168 105 ATF6 1 160,108,831 106 ATF6 1 160,118,977 107 ATF6 1 160,143,072 108 ATF6 1 160,147,921 109 ATF6 1 160,193,261 110 OLFML2B 1 160,222,129 111 OLFML2B 1 160,247,126 112 FAM78B 1 164,309,282 113 FAM78B 1 164,314,302 114 FAM78B 1 164,348,193 115 FAM78B 1 164,348,737 116 FAM78B 1 164,350,112 117 FAM78B 1 164,364,382 118 FAM78B 1 164,365,940 119 FAM78B 1 164,388,390 120 FAM78B 1 164,392,047 121 DPT 1 166,937,301 122 DPT 1 166,944,971 123 DPT 1 166,954,638 124 DPT 1 166,961,651 125 DPT 1 166,964,218 126 SEC16B 1 176,201,673 127 SEC16B 1 176,201,898 128 SEC16B 1 176,210,214 129 SEC16B 1 176,210,435 130 SEC16B 1 176,215,337 131 RALGPS2 1 176,976,589 132 RALGPS2 1 177,012,234 133 RALGPS2 1 177,114,846 134 MR1 1 179,279,594 135 PLA2G4A 1 185,173,669 136 PLA2G4A 1 185,178,610 137 PLA2G4A 1 185,200,715 138 KCNK2 1 213,266,926 139 KCNK2 1 213,267,433 140 KCNK2 1 213,269,771 141 KCNK2 1 213,286,968 142 KCNK2 1 213,302,819 143 KCNK2 1 213,304,166 144 KCNK2 1 213,312,765 145 KCNK2 1 213,332,299 146 KCNK2 1 213,336,427 147 KCNK2 1 213,347,737 148 KCNK2 1 213,393,108 149 KCNK2 1 213,426,881 150 KCNK2 1 213,474,680 151 USH2A 1 213,537,370 152 USH2A 1 213,895,122 153 USH2A 1 213,896,517 154 USH2A 1 213,911,770 155 USH2A 1 213,954,742 156 USH2A 1 213,955,280 157 USH2A 1 214,209,606 158 USH2A 1 214,404,156 159 USH2A 1 214,415,387 160 USH2A 1 214,429,760 161 USH2A 1 214,464,725 162 USH2A 1 214,466,781 163 USH2A 1 214,476,504 164 USH2A 1 214,498,585 165 USH2A 1 214,498,863 166 USH2A 1 214,498,944 167 USH2A 1 214,506,295 168 USH2A 1 214,506,786 169 USH2A 1 214,509,837 170 USH2A 1 214,572,091 171 ESRRG 1 214,773,635 172 ESRRG 1 214,783,160 173 ESRRG 1 214,788,713 174 ESRRG 1 214,788,951 175 ESRRG 1 214,789,245 176 ESRRG 1 214,811,868 177 ESRRG 1 214,827,730 178 ESRRG 1 214,836,783 179 ESRRG 1 214,886,050 180 ESRRG 1 214,891,848 181 ESRRG 1 214,950,266 182 ESRRG 1 214,951,990 183 ESRRG 1 214,952,115 184 ESRRG 1 214,962,423 185 SLC35F3 1 232,371,799 186 SLC35F3 1 232,375,209 187 SLC35F3 1 232,397,501 188 SLC35F3 1 232,500,781 189 SLC35F3 1 232,515,592 190 SLC35F3 1 232,524,008 191 SLC35F3 1 232,525,097 192 GNG4 1 233,780,076 193 GNG4 1 233,794,439 194 GNG4 1 233,795,519 195 GNG4 1 233,825,193 196 RYR2 1 235,343,646 197 RYR2 1 235,413,480 198 RYR2 1 235,435,907 199 RYR2 1 235,441,114 200 RYR2 1 235,500,248 201 RYR2 1 235,513,475 202 RYR2 1 235,568,481 203 RYR2 1 235,614,223 204 RYR2 1 235,616,144 205 RYR2 1 235,661,657 206 RYR2 1 235,725,107 207 RYR2 1 235,743,969 208 RYR2 1 235,793,994 209 RYR2 1 235,844,707 210 RYR2 1 235,887,079 211 RYR2 1 235,891,567 212 RYR2 1 235,942,911 213 RYR2 1 235,964,467 214 RYR2 1 235,999,612 215 RYR2 1 236,061,906 216 CHRM3 1 237,894,973 217 CHRM3 1 237,906,730 218 CHRM3 1 237,924,147 219 CHRM3 1 237,929,034 220 CHRM3 1 237,943,889 221 CHRM3 1 237,944,344 222 CHRM3 1 237,947,826 223 CHRM3 1 237,952,433 224 CHRM3 1 237,958,134 225 CHRM3 1 237,969,464 226 CHRM3 1 237,996,528 227 CHRM3 1 238,001,974 228 FMN2 1 238,340,274 229 FMN2 1 238,349,704 230 FMN2 1 238,361,987 231 FMN2 1 238,362,705 232 FMN2 1 238,386,530 233 FMN2 1 238,407,239 234 FMN2 1 238,426,833 235 FMN2 1 238,443,154 236 FMN2 1 238,455,099 237 FMN2 1 238,486,712 238 FMN2 1 238,494,888 239 FMN2 1 238,512,719 240 FMN2 1 238,516,765 241 FMN2 1 238,519,250 242 FMN2 1 238,520,251 243 FMN2 1 238,525,003 244 FMN2 1 238,559,357 245 FMN2 1 238,559,913 246 FMN2 1 238,564,221 247 FMN2 1 238,564,870 248 FMN2 1 238,669,725 249 FMN2 1 238,670,023 250 FMN2 1 238,703,639 251 FMN2 1 238,704,194 252 RGS7 1 239,024,094 253 RGS7 1 239,026,696 254 RGS7 1 239,049,800 255 RGS7 1 239,145,433 256 RGS7 1 239,198,639 257 RGS7 1 239,202,133 258 RGS7 1 239,215,583 259 RGS7 1 239,228,398 260 RGS7 1 239,576,418 261 RGS7 1 239,588,948 262 PLD5 1 240,358,903 263 PLD5 1 240,452,068 264 PLD5 1 240,454,472 265 PLD5 1 240,454,888 266 PLD5 1 240,458,406 267 PLD5 1 240,632,975 268 PLD5 1 240,640,372 269 PLD5 1 240,643,721 270 PLD5 1 240,694,244 271 PLD5 1 240,708,546 272 PLD5 1 240,723,055 273 C2ORF46 2 8,262,682 274 C2ORF46 2 8,321,006 275 C2ORF46 2 8,342,299 276 C2ORF46 2 8,354,700 277 C2ORF46 2 8,355,126 278 C2ORF46 2 8,357,838 279 C2ORF46 2 8,383,937 280 C2ORF46 2 8,384,366 281 DDEF2 2 9,320,439 282 DDEF2 2 9,458,300 283 DDEF2 2 9,463,481 284 DDEF2 2 9,464,814 285 HPCAL1 2 10,301,740 286 KCNF1 2 10,952,881 287 KCNF1 2 10,982,079 288 NTSR2 2 11,726,315 289 KLHL29 2 23,504,556 290 KLHL29 2 23,504,709 291 KLHL29 2 23,504,805 292 KLHL29 2 23,507,416 293 KLHL29 2 23,519,201 294 KLHL29 2 23,533,545 295 KLHL29 2 23,634,723 296 KLHL29 2 23,641,228 297 KLHL29 2 23,648,425 298 KLHL29 2 23,782,141 299 KLHL29 2 23,784,540 300 KLHL29 2 23,794,852 301 KLHL29 2 23,801,093 302 ASXL2 2 25,824,008 303 ASXL2 2 25,830,860 304 ASXL2 2 25,889,540 305 ASXL2 2 25,909,377 306 KCNK3 2 26,772,593 307 KCNK3 2 26,782,315 308 KCNK3 2 26,798,797 309 KCNK3 2 26,807,044 310 DPYSL5 2 6,936,993 311 DPYSL5 2 26,991,120 312 DPYSL5 2 27,023,044 313 BRE 2 28,173,537 314 BRE 2 28,173,685 315 BRE 2 28,178,705 316 BRE 2 28,179,762 317 BRE 2 28,195,657 318 BRE 2 28,212,255 319 BRE 2 28,212,485 320 BRE 2 28,243,350 321 BRE 2 28,281,970 322 BRE 2 28,284,035 323 BRE 2 28,285,741 324 BRE 2 28,357,445 325 BRE 2 28,396,438 326 CRIM1 2 36,443,527 327 CRIM1 2 36,467,658 328 CRIM1 2 36,471,032 329 CRIM1 2 36,485,964 330 CRIM1 2 36,532,532 331 CRIM1 2 36,535,123 332 CRIM1 2 36,537,212 333 CRIM1 2 36,611,604 334 CRIM1 2 36,632,391 335 FEZ2 2 36,634,284 336 FEZ2 2 36,634,905 337 FEZ2 2 36,645,798 338 FEZ2 2 36,657,394 339 FEZ2 2 36,663,000 340 CDC42EP3 2 37,717,087 341 CDC42EP3 2 37,725,643 342 CDC42EP3 2 37,726,375 343 CDC42EP3 2 37,741,421 344 SLC8A1 2 40,217,148 345 SLC8A1 2 40,230,588 346 SLC8A1 2 40,253,816 347 SLC8A1 2 40,267,644 348 SLC8A1 2 40,270,423 349 SLC8A1 2 40,279,466 350 SLC8A1 2 40,414,134 351 SLC8A1 2 40,430,629 352 SLC8A1 2 40,461,774 353 SLC8A1 2 40,492,801 354 SLC8A1 2 40,494,296 355 SLC8A1 2 40,524,198 356 HAAO 2 42,872,648 357 HAAO 2 42,918,059 358 PLEKHH2 2 43,780,963 359 PLEKHH2 2 43,783,487 360 PLEKHH2 2 43,785,627 361 PLEKHH2 2 43,839,444 362 PLEKHH2 2 43,846,952 363 C2ORF34 2 44,500,542 364 C2ORF34 2 44,501,551 365 C2ORF34 2 44,529,327 366 C2ORF34 2 44,529,730 367 C2ORF34 2 44,536,723 368 C2ORF34 2 44,593,376 369 C2ORF34 2 44,599,767 370 C2ORF34 2 44,686,360 371 C2ORF34 2 44,722,640 372 C2ORF34 2 44,726,913 373 C2ORF34 2 44,739,819 374 C2ORF34 2 44,834,623 375 C2ORF34 2 44,846,991 376 PRKCE 2 45,737,717 377 PRKCE 2 45,755,958 378 PRKCE 2 45,807,414 379 PRKCE 2 45,910,006 380 PRKCE 2 45,919,740 381 PRKCE 2 45,927,156 382 PRKCE 2 45,979,475 383 PRKCE 2 46,065,162 384 PRKCE 2 46,085,029 385 PRKCE 2 46,085,876 386 PRKCE 2 46,108,254 387 PRKCE 2 46,130,026 388 PRKCE 2 46,139,028 389 PRKCE 2 46,226,779 390 PRKCE 2 46,257,075 391 EPAS1 2 46,392,298 392 EPAS1 2 46,401,568 393 EPAS1 2 46,435,886 394 EPAS1 2 46,438,356 395 EPAS1 2 46,443,888 396 EPAS1 2 46,458,097 397 EPAS1 2 46,459,163 398 FBXO11 2 47,947,841 399 FBXO11 2 47,952,212 400 PSME4 2 53,909,692 401 PSME4 2 53,957,822 402 PSME4 2 53,968,471 403 PSME4 2 53,970,304 404 PSME4 2 53,978,295 405 PSME4 2 53,988,933 406 PSME4 2 54,018,352 407 PSME4 2 54,055,952 408 PSME4 2 54,064,285 409 PSME4 2 54,136,333 410 PSME4 2 54,137,945 411 ACYP2 2 54,187,233 412 ACYP2 2 54,189,467 413 ACYP2 2 54,216,479 414 ACYP2 2 54,245,303 415 ACYP2 2 54,247,074 416 ACYP2 2 54,312,954 417 ACYP2 2 54,350,261 418 CCDC85A 2 56,266,849 419 CCDC85A 2 56,271,283 420 CCDC85A 2 56,312,732 421 CCDC85A 2 56,325,663 422 CCDC85A 2 56,325,994 423 CCDC85A 2 56,344,184 424 CCDC85A 2 56,356,533 425 CCDC85A 2 56,416,774 426 CCDC85A 2 56,424,062 427 CCDC85A 2 56,425,867 428 CCDC85A 2 56,493,023 429 COMMD1 2 62,036,964 430 COMMD1 2 62,193,184 431 OTX1 2 63,151,654 432 AAK1 2 69,546,510 433 AAK1 2 69,569,349 434 AAK1 2 69,639,692 435 AAK1 2 69,650,512 436 AAK1 2 69,673,078 437 AAK1 2 69,708,598 438 AAK1 2 69,716,927 439 AAK1 2 69,740,261 440 AAK1 2 69,768,980 441 AAK1 2 69,834,530 442 CTNNA2 2 79,613,746 443 CTNNA2 2 79,635,253 444 CTNNA2 2 79,644,485 445 CTNNA2 2 79,648,869 446 CTNNA2 2 79,827,051 447 CTNNA2 2 79,934,690 448 CTNNA2 2 79,950,787 449 CTNNA2 2 79,998,204 450 CTNNA2 2 79,998,431 451 CTNNA2 2 80,091,949 452 CTNNA2 2 80,246,403 453 CTNNA2 2 80,252,218 454 CTNNA2 2 80,302,393 455 CTNNA2 2 80,303,744 456 CTNNA2 2 80,303,795 457 CTNNA2 2 80,305,615 458 CTNNA2 2 80,305,672 459 CTNNA2 2 80,323,975 460 CTNNA2 2 80,331,785 461 CTNNA2 2 80,341,439 462 CTNNA2 2 80,341,671 463 CTNNA2 2 80,342,285 464 CTNNA2 2 80,346,411 465 CTNNA2 2 80,348,223 466 CTNNA2 2 80,368,183 467 CTNNA2 2 80,377,795 468 CTNNA2 2 80,498,999 469 CTNNA2 2 80,598,484 470 CTNNA2 2 80,657,667 471 CTNNA2 2 80,670,274 472 CTNNA2 2 80,682,874 473 CTNNA2 2 80,703,322 474 INPP4A 2 98,449,370 475 INPP4A 2 98,538,676 476 NAP5 2 133,368,245 477 NAP5 2 133,513,639 478 NAP5 2 133,547,260 479 NAP5 2 133,558,451 480 NAP5 2 133,567,502 481 NAP5 2 133,613,763 482 NAP5 2 133,619,788 483 NAP5 2 133,620,453 484 NAP5 2 133,628,562 485 NAP5 2 133,692,413 486 NAP5 2 133,970,443 487 NAP5 2 134,029,768 488 RAB3GAP1 2 135,514,217 489 RAB3GAP1 2 135,649,190 490 ZRANB3 2 135,701,191 491 ZRANB3 2 135,867,882 492 ZRANB3 2 135,868,244 493 ZRANB3 2 135,903,815 494 ZRANB3 2 135,981,101 495 ZRANB3 2 136,029,379 496 UBXD2 2 136,223,397 497 UBXD2 2 136,262,314 498 NXPH2 2 139,205,858 499 NXPH2 2 139,218,623 500 NXPH2 2 139,301,576 501 LRP1B 2 140,708,533 502 LRP1B 2 140,710,220 503 LRP1B 2 140,711,565 504 LRP1B 2 140,740,113 505 LRP1B 2 140,749,675 506 LRP1B 2 140,836,079 507 LRP1B 2 140,917,629 508 LRP1B 2 141,253,166 509 LRP1B 2 141,446,369 510 LRP1B 2 141,470,624 511 LRP1B 2 141,472,804 512 LRP1B 2 141,702,891 513 LRP1B 2 141,715,030 514 LRP1B 2 141,896,198 515 LRP1B 2 142,007,651 516 LRP1B 2 142,065,965 517 LRP1B 2 142,066,600 518 LRP1B 2 142,371,205 519 LRP1B 2 142,371,483 520 LRP1B 2 142,395,682 521 LRP1B 2 142,529,079 522 LRP1B 2 142,573,134 523 LRP1B 2 142,591,970 524 LRP1B 2 142,598,638 525 KYNU 2 143,355,132 526 KYNU 2 143,368,826 527 KYNU 2 143,405,309 528 KYNU 2 143,430,832 529 KYNU 2 143,434,516 530 KYNU 2 143,439,309 531 KYNU 2 143,455,211 532 KYNU 2 143,465,263 533 KYNU 2 143,504,218 534 KYNU 2 143,513,164 535 KYNU 2 143,516,377 536 KYNU 2 143,598,044 537 ARHGAP15 2 143,606,219 538 ARHGAP15 2 143,685,981 539 ARHGAP15 2 143,692,950 540 ARHGAP15 2 143,698,840 541 ARHGAP15 2 143,729,953 542 ARHGAP15 2 143,729,996 543 ARHGAP15 2 143,738,248 544 ARHGAP15 2 143,739,424 545 ARHGAP15 2 143,757,220 546 ARHGAP15 2 143,769,771 547 ARHGAP15 2 143,848,173 548 ARHGAP15 2 143,849,979 549 ARHGAP15 2 143,943,051 550 ARHGAP15 2 143,999,263 551 ARHGAP15 2 144,018,166 552 ARHGAP15 2 144,025,496 553 ARHGAP15 2 144,034,639 554 ARHGAP15 2 144,040,124 555 ARHGAP15 2 144,064,434 556 ARHGAP15 2 144,068,893 557 ARHGAP15 2 144,097,012 558 ARHGAP15 2 144,273,491 559 ARHGAP15 2 144,283,468 560 ARHGAP15 2 144,294,622 561 ARHGAP15 2 144,295,364 562 KIF5C 2 149,333,649 563 KIF5C 2 149,521,137 564 KIF5C 2 149,539,190 565 CACNB4 2 152,527,508 566 CACNB4 2 152,578,170 567 CACNB4 2 152,587,594 568 CACNB4 2 152,607,303 569 CACNB4 2 152,632,727 570 CACNB4 2 152,638,370 571 CACNB4 2 152,655,949 572 CACNB4 2 152,659,379 573 CACNB4 2 152,684,248 574 FMNL2 2 152,981,465 575 FMNL2 2 152,996,148 576 FMNL2 2 153,007,734 577 FMNL2 2 153,075,073 578 FMNL2 2 153,096,733 579 FMNL2 2 153,097,194 580 FMNL2 2 153,102,193 581 FMNL2 2 153,146,684 582 FMNL2 2 153,146,906 583 FMNL2 2 153,147,303 584 FMNL2 2 153,147,664 585 FMNL2 2 153,159,182 586 FMNL2 2 153,166,996 587 FMNL2 2 153,201,156 588 FMNL2 2 153,201,532 589 FMNL2 2 153,207,856 590 KCNJ3 2 155,289,884 591 KCNJ3 2 155,329,292 592 KCNJ3 2 155,397,929 593 KCNJ3 2 155,403,085 594 PKP4 2 159,035,950 595 PKP4 2 159,058,381 596 PKP4 2 159,099,329 597 PKP4 2 159,132,118 598 PKP4 2 159,175,274 599 PKP4 2 159,214,299 600 PKP4 2 159,219,409 601 PKP4 2 159,240,155 602 PLA2R1 2 160,516,321 603 PLA2R1 2 160,516,560 604 PLA2R1 2 160,519,430 605 PLA2R1 2 160,543,237 606 PLA2R1 2 160,543,645 607 PLA2R1 2 160,550,074 608 PLA2R1 2 160,575,305 609 PLA2R1 2 160,575,799 610 PLA2R1 2 160,584,453 611 PLA2R1 2 160,599,255 612 PLA2R1 2 160,612,267 613 PLA2R1 2 160,616,115 614 PLA2R1 2 160,623,352 615 SCN3A 2 165,671,518 616 SCN3A 2 165,685,811 617 SCN3A 2 165,708,114 618 SCN3A 2 165,732,374 619 SCN1A 2 166,596,685 620 SCN1A 2 166,606,110 621 SCN1A 2 166,617,790 622 SCN1A 2 166,632,718 623 SCN9A 2 166,764,674 624 SCN9A 2 166,781,097 625 SCN9A 2 166,807,404 626 SCN9A 2 166,817,960 627 SCN9A 2 166,857,449 628 SCN9A 2 166,871,909 629 SCN9A 2 166,874,107 630 SCN7A 2 166,970,599 631 CERKL 2 182,130,703 632 CERKL 2 182,145,339 633 CERKL 2 182,164,093 634 CERKL 2 182,228,354 635 CERKL 2 182,239,099 636 PDE1A 2 182,767,445 637 PDE1A 2 182,821,396 638 PDE1A 2 182,826,618 639 PDE1A 2 182,840,603 640 PDE1A 2 182,886,451 641 PDE1A 2 182,918,516 642 PDE1A 2 182,932,372 643 PDE1A 2 182,971,998 644 PDE1A 2 183,013,022 645 PDE1A 2 183,013,344 646 PDE1A 2 183,050,970 647 PDE1A 2 183,061,827 648 PDE1A 2 183,067,065 649 PDE1A 2 183,086,558 650 PDE1A 2 183,088,998 651 ALS2 2 202,278,237 652 ALS2 2 202,288,513 653 ALS2 2 202,305,680 654 ALS2 2 202,341,183 655 PARD3B 2 205,237,235 656 PARD3B 2 205,244,163 657 PARD3B 2 205,347,353 658 PARD3B 2 205,620,648 659 PARD3B 2 205,625,989 660 PARD3B 2 205,639,010 661 PARD3B 2 205,650,805 662 PARD3B 2 205,659,848 663 PARD3B 2 205,705,702 664 PARD3B 2 205,725,077 665 PARD3B 2 205,907,031 666 PARD3B 2 205,967,382 667 PARD3B 2 206,172,710 668 NRP2 2 206,294,712 669 NRP2 2 206,296,221 670 NRP2 2 206,300,940 671 NRP2 2 206,301,486 672 NRP2 2 206,318,296 673 NRP2 2 206,441,948 674 NRP2 2 206,442,661 675 NRP2 2 206,443,765 676 PIP5K3 2 208,955,629 677 PIP5K3 2 208,956,492 678 ERBB4 2 211,975,964 679 ERBB4 2 211,983,182 680 ERBB4 2 212,022,377 681 ERBB4 2 213,497,122 682 ERBB4 2 213,505,758 683 ERBB4 2 213,507,896 684 ERBB4 2 213,508,611 685 CUL3 2 225,109,321 686 CUL3 2 225,148,088 687 CUL3 2 225,149,052 688 IRS1 2 227,304,756 689 IRS1 2 227,307,777 690 IRS1 2 227,322,249 691 IRS1 2 227,362,192 692 COL4A4 2 227,583,201 693 COL4A4 2 227,591,892 694 COL4A4 2 227,606,678 695 COL4A4 2 227,608,663 696 COL4A4 2 227,622,869 697 COL4A4 2 227,630,259 698 COL4A3 2 227,768,751 699 COL4A3 2 227,795,487 700 COL4A3 2 227,795,722 701 COL4A3 2 227,800,650 702 COL4A3 2 227,801,143 703 COL4A3 2 227,818,028 704 COL4A3 2 227,848,813 705 COL4A3 2 227,864,848 706 COL4A3 2 227,875,258 707 COL4A3 2 227,885,145 708 COL4A3 2 227,885,723 709 COL4A3 2 227,886,069 710 COL4A3 2 227,889,666 711 DNER 2 229,942,770 712 DNER 2 229,964,830 713 DNER 2 229,972,935 714 DNER 2 230,110,447 715 DNER 2 230,162,171 716 DNER 2 230,170,094 717 DNER 2 230,176,862 718 DNER 2 230,262,864 719 DNER 2 230,270,658 720 DNER 2 230,270,700 721 DNER 2 230,271,362 722 DNER 2 230,271,569 723 TRIP12 2 230,296,640 724 TRIP12 2 230,317,393 725 TRIP12 2 230,340,512 726 TRIP12 2 230,422,269 727 TRIP12 2 230,442,325 728 TRIP12 2 230,447,453 729 ECEL1 2 233,048,959 730 CHRND 2 233,091,660 731 SAG 2 233,903,639 732 SAG 2 233,909,134 733 CNTN6 3 1,222,723 734 CNTN6 3 1,231,380 735 CNTN6 3 1,247,244 736 CNTN6 3 1,251,092 737 CNTN6 3 1,268,504 738 CNTN6 3 1,292,727 739 CNTN6 3 1,295,271 740 CNTN6 3 1,311,397 741 CNTN6 3 1,313,259 742 CNTN6 3 1,336,323 743 CNTN6 3 1,341,846 744 CNTN6 3 1,350,581 745 CNTN6 3 1,357,151 746 CNTN6 3 1,357,358 747 CNTN6 3 1,372,414 748 CNTN6 3 1,375,419 749 CNTN6 3 1,378,076 750 CNTN6 3 1,396,673 751 CNTN6 3 1,399,850 752 CNTN6 3 1,400,997 753 CNTN6 3 1,403,635 754 CNTN6 3 1,414,974 755 CNTN4 3 2,072,897 756 CNTN4 3 2,267,019 757 CNTN4 3 2,285,875 758 CNTN4 3 2,287,398 759 CNTN4 3 2,287,451 760 CNTN4 3 2,298,242 761 CNTN4 3 2,321,860 762 CNTN4 3 2,326,831 763 CNTN4 3 2,336,802 764 CNTN4 3 2,375,967 765 CNTN4 3 2,384,532 766 CNTN4 3 2,386,061 767 CNTN4 3 2,734,283 768 CNTN4 3 2,736,667 769 CNTN4 3 2,758,344 770 CNTN4 3 3,046,742 771 CNTN4 3 3,047,912 772 CNTN4 3 3,048,509 773 CNTN4 3 3,067,546 774 ITPR1 3 4,511,386 775 ITPR1 3 4,527,175 776 ITPR1 3 4,688,162 777 ITPR1 3 4,720,230 778 ITPR1 3 4,725,489 779 ITPR1 3 4,725,558 780 ITPR1 3 4,725,674 781 ITPR1 3 4,729,125 782 ITPR1 3 4,841,416 783 ITPR1 3 4,846,598 784 IRAK2 3 10,234,114 785 IRAK2 3 10,251,163 786 IRAK2 3 10,252,129 787 ATP2B2 3 10,358,996 788 ATP2B2 3 10,412,280 789 ATP2B2 3 10,416,147 790 ATP2B2 3 10,418,090 791 ATP2B2 3 10,432,572 792 ATP2B2 3 10,432,857 793 ATP2B2 3 10,439,753 794 SLC6A6 3 14,421,894 795 SLC6A6 3 14,422,977 796 SLC6A6 3 14,464,931 797 SLC6A6 3 14,495,168 798 SLC6A6 3 14,503,422 799 DAZL 3 16,599,020 800 DAZL 3 16,602,617 801 DAZL 3 16,611,406 802 DAZL 3 16,611,469 803 DAZL 3 16,627,901 804 RARB 3 25,506,269 805 RARB 3 25,544,885 806 RARB 3 25,589,536 807 RARB 3 25,592,407 808 RARB 3 25,593,163 809 RARB 3 25,620,267 810 RARB 3 25,620,425 811 FBXL2 3 33,317,991 812 FBXL2 3 33,400,034 813 CLASP2 3 33,516,308 814 CLASP2 3 33,516,362 815 CLASP2 3 33,592,794 816 CLASP2 3 33,752,897 817 CLASP2 3 33,761,745 818 CLASP2 3 33,780,565 819 ARPP-21 3 35,697,969 820 ARPP-21 3 35,742,792 821 ARPP-21 3 35,750,253 822 ARPP-21 3 35,760,612 823 STAC 3 36,432,376 824 STAC 3 36,433,107 825 STAC 3 36,445,311 826 STAC 3 36,459,827 827 ULK4 3 41,283,352 828 ULK4 3 41,329,536 829 ULK4 3 41,344,053 830 ULK4 3 41,348,228 831 ULK4 3 41,350,671 832 ULK4 3 41,363,412 833 ULK4 3 41,365,143 834 ULK4 3 41,369,174 835 ULK4 3 41,395,796 836 ULK4 3 41,421,630 837 ULK4 3 41,438,204 838 ULK4 3 41,455,051 839 ULK4 3 41,468,595 840 ULK4 3 41,469,435 841 ULK4 3 41,469,609 842 ULK4 3 41,476,741 843 ULK4 3 41,482,456 844 ULK4 3 41,507,368 845 ULK4 3 41,507,554 846 ULK4 3 41,508,106 847 ULK4 3 41,584,470 848 ULK4 3 41,736,832 849 ULK4 3 41,785,368 850 ULK4 3 41,833,735 851 ULK4 3 41,852,418 852 ULK4 3 41,900,305 853 ULK4 3 41,971,140 854 ZNF445 3 44,542,069 855 GPX1 3 49,429,116 856 GPX1 3 49,545,204 857 GPX1 3 49,624,993 858 GPX1 3 49,853,117 859 GPX1 3 49,865,617 860 SEMA3F 3 50,180,966 861 CACNA2D2 3 50,406,198 862 CACNA2D2 3 50,451,382 863 CACNA2D2 3 50,523,899 864 CACNA2D3 3 54,127,859 865 CACNA2D3 3 54,216,922 866 CACNA2D3 3 54,217,081 867 CACNA2D3 3 54,331,793 868 CACNA2D3 3 54,494,308 869 CACNA2D3 3 54,540,948 870 CACNA2D3 3 54,774,489 871 CACNA2D3 3 54,918,069 872 CACNA2D3 3 54,953,081 873 CACNA2D3 3 54,955,060 874 CACNA2D3 3 54,996,262 875 CACNA2D3 3 55,019,916 876 CACNA2D3 3 55,094,024 877 ERC2 3 55,519,913 878 ERC2 3 55,743,028 879 ERC2 3 55,757,809 880 ERC2 3 55,760,546 881 ERC2 3 55,858,272 882 ERC2 3 55,877,492 883 ERC2 3 55,902,605 884 ERC2 3 55,954,550 885 ERC2 3 55,985,742 886 ERC2 3 56,002,843 887 ERC2 3 56,119,301 888 ERC2 3 56,164,173 889 ERC2 3 56,175,003 890 ERC2 3 56,245,378 891 ERC2 3 56,304,151 892 ERC2 3 56,337,250 893 ERC2 3 56,347,766 894 ERC2 3 56,368,109 895 ERC2 3 56,393,831 896 ERC2 3 56,422,909 897 ERC2 3 56,462,620 898 ERC2 3 56,464,816 899 ERC2 3 56,491,685 900 ERC2 3 56,496,204 901 ERC2 3 56,496,259 902 ERC2 3 56,510,277 903 IL17RD 3 57,115,148 904 IL17RD 3 57,128,722 905 IL17RD 3 57,128,909 906 IL17RD 3 57,143,381 907 FLNB 3 58,057,749 908 FLNB 3 58,069,197 909 FLNB 3 58,075,809 910 FLNB 3 58,083,555 911 FLNB 3 58,093,595 912 FLNB 3 58,139,576 913 FLNB 3 58,143,446 914 FHIT 3 59,824,587 915 FHIT 3 59,949,555 916 FHIT 3 59,956,565 917 FHIT 3 59,966,929 918 FHIT 3 60,339,716 919 FHIT 3 60,367,407 920 FHIT 3 60,478,148 921 FHIT 3 61,027,539 922 FHIT 3 61,027,560 923 FHIT 3 61,027,682 924 FHIT 3 61,135,266 925 FHIT 3 61,137,444 926 FHIT 3 61,159,361 927 FHIT 3 61,213,258 928 FHIT 3 61,214,250 929 FHIT 3 61,228,928 930 FHIT 3 61,234,576 931 PTPRG 3 61,484,177 932 PTPRG 3 61,488,535 933 PTPRG 3 61,493,156 934 PTPRG 3 61,723,402 935 PTPRG 3 62,142,228 936 PTPRG 3 62,196,081 937 PTPRG 3 62,219,484 938 PTPRG 3 62,219,610 939 PTPRG 3 62,221,462 940 PTPRG 3 62,245,596 941 PTPRG 3 62,256,476 942 CADPS 3 62,473,418 943 CADPS 3 62,487,886 944 CADPS 3 62,498,262 945 CADPS 3 62,548,478 946 CADPS 3 62,720,200 947 CADPS 3 62,748,989 948 CADPS 3 62,789,812 949 CADPS 3 62,801,974 950 CADPS 3 62,836,232 951 CADPS 3 62,846,542 952 CADPS 3 62,855,968 953 SYNPR 3 63,451,187 954 SYNPR 3 63,493,882 955 SYNPR 3 63,500,043 956 SYNPR 3 63,531,349 957 PRICKLE2 3 64,058,457 958 PRICKLE2 3 64,091,416 959 PRICKLE2 3 64,123,328 960 PRICKLE2 3 64,136,626 961 PRICKLE2 3 64,140,665 962 PRICKLE2 3 64,153,423 963 PRICKLE2 3 64,153,968 964 PRICKLE2 3 64,159,437 965 PRICKLE2 3 64,160,166 966 PRICKLE2 3 64,176,516 967 PRICKLE2 3 64,178,866 968 PRICKLE2 3 64,181,567 969 PRICKLE2 3 64,184,717 970 PRICKLE2 3 64,186,645 971 MAGI1 3 65,373,938 972 MAGI1 3 65,407,523 973 MAGI1 3 65,496,864 974 MAGI1 3 65,505,289 975 MAGI1 3 65,576,735 976 MAGI1 3 65,839,896 977 MAGI1 3 65,968,144 978 MAGI1 3 65,975,330 979 FAM19A1 3 68,196,007 980 FAM19A1 3 68,232,575 981 FAM19A1 3 68,409,920 982 FAM19A1 3 68,614,345 983 FAM19A1 3 68,673,127 984 FOXP1 3 70,972,978 985 FOXP1 3 71,021,299 986 FOXP1 3 71,295,488 987 FOXP1 3 71,476,030 988 GBE1 3 81,687,469 989 GBE1 3 81,694,225 990 GBE1 3 81,702,278 991 GBE1 3 81,727,601 992 GBE1 3 81,816,787 993 GBE1 3 81,841,418 994 GBE1 3 81,848,716 995 GBE1 3 81,859,450 996 GBE1 3 81,885,108 997 GBE1 3 81,893,914 998 GBE1 3 81,894,474 999 HTR1F 3 88,105,976 1000 STX19 3 95,301,818 1001 EPHA6 3 97,947,064 1002 EPHA6 3 97,998,729 1003 EPHA6 3 98,070,623 1004 EPHA6 3 98,108,626 1005 EPHA6 3 98,164,249 1006 EPHA6 3 98,267,154 1007 EPHA6 3 98,686,182 1008 EPHA6 3 98,787,645 1009 EPHA6 3 98,810,974 1010 PLCXD2 3 112,883,336 1011 PLCXD2 3 112,941,527 1012 PLCXD2 3 112,949,845 1013 PLCXD2 3 112,953,907 1014 PLCXD2 3 112,960,464 1015 PLCXD2 3 112,964,847 1016 PLCXD2 3 113,021,589 1017 PLCXD2 3 113,072,668 1018 CDGAP 3 120,517,200 1019 CDGAP 3 120,525,701 1020 CDGAP 3 120,527,813 1021 CDGAP 3 120,551,002 1022 CDGAP 3 120,606,504 1023 CDGAP 3 120,612,831 1024 CDGAP 3 120,615,873 1025 CDGAP 3 120,621,365 1026 STXBP5L 3 122,127,643 1027 STXBP5L 3 122,140,467 1028 STXBP5L 3 122,173,450 1029 STXBP5L 3 122,346,648 1030 STXBP5L 3 122,406,894 1031 STXBP5L 3 122,476,483 1032 STXBP5L 3 122,522,839 1033 STXBP5L 3 122,608,097 1034 STXBP5L 3 122,623,726 1035 STXBP5L 3 122,626,569 1036 STXBP5L 3 122,628,751 1037 KALRN 3 125,461,439 1038 KALRN 3 125,461,555 1039 KALRN 3 125,462,341 1040 KALRN 3 125,586,787 1041 KALRN 3 125,602,730 1042 KALRN 3 125,610,651 1043 KALRN 3 125,632,871 1044 KALRN 3 125,876,300 1045 KALRN 3 125,928,454 1046 KALRN 3 125,928,594 1047 ZXDC 3 127,665,610 1048 CPNE4 3 132,725,192 1049 CPNE4 3 132,741,385 1050 CPNE4 3 132,749,292 1051 CPNE4 3 132,772,981 1052 CPNE4 3 132,802,779 1053 CPNE4 3 132,865,495 1054 CPNE4 3 132,885,425 1055 CPNE4 3 132,886,287 1056 CPNE4 3 132,907,690 1057 CPNE4 3 132,918,068 1058 CPNE4 3 133,145,979 1059 CPNE4 3 133,235,987 1060 CPNE4 3 133,241,957 1061 RAB6B 3 135,041,388 1062 RAB6B 3 135,064,149 1063 EPHB1 3 136,138,136 1064 EPHB1 3 136,151,931 1065 EPHB1 3 136,154,975 1066 EPHB1 3 136,156,084 1067 EPHB1 3 136,165,323 1068 EPHB1 3 136,172,644 1069 EPHB1 3 136,306,915 1070 EPHB1 3 136,390,869 1071 EPHB1 3 136,505,913 1072 EPHB1 3 136,509,166 1073 CLSTN2 3 141,659,332 1074 CLSTN2 3 141,661,175 1075 CLSTN2 3 141,662,920 1076 CLSTN2 3 141,663,200 1077 CLSTN2 3 141,764,774 1078 CLSTN2 3 141,770,820 1079 CLSTN2 3 141,773,663 1080 CLSTN2 3 141,774,103 1081 CLSTN2 3 141,775,226 1082 SPSB4 3 142,241,400 1083 SPSB4 3 142,258,988 1084 SPSB4 3 142,286,988 1085 SPSB4 3 142,287,637 1086 SPSB4 3 142,328,274 1087 SERPINI2 3 168,658,115 1088 SERPINI2 3 168,667,572 1089 SERPINI2 3 168,672,301 1090 SERPINI2 3 168,681,607 1091 SERPINI1 3 168,954,239 1092 SERPINI1 3 168,985,871 1093 SLC7A14 3 171,682,206 1094 SLC7A14 3 171,736,501 1095 SLC7A14 3 171,743,763 1096 SLC7A14 3 171,815,650 1097 TNIK 3 172,281,618 1098 TNIK 3 172,294,982 1099 TNIK 3 172,313,766 1100 TNIK 3 172,381,296 1101 TNIK 3 172,402,113 1102 TNIK 3 172,428,696 1103 TNIK 3 172,715,462 1104 PLD1 3 172,791,538 1105 PLD1 3 172,935,130 1106 PLD1 3 172,970,915 1107 PLD1 3 172,984,008 1108 PLD1 3 172,990,075 1109 PLD1 3 172,991,671 1110 NLGN1 3 174,810,790 1111 NLGN1 3 174,819,343 1112 NLGN1 3 174,822,098 1113 NLGN1 3 174,845,437 1114 NLGN1 3 174,861,258 1115 NLGN1 3 174,879,091 1116 NLGN1 3 174,967,790 1117 NLGN1 3 174,995,392 1118 NLGN1 3 175,026,145 1119 NLGN1 3 175,384,416 1120 NLGN1 3 175,458,980 1121 NLGN1 3 175,478,622 1122 NLGN1 3 175,493,649 1123 NLGN1 3 175,497,804 1124 NLGN1 3 175,515,979 1125 NLGN1 3 175,516,080 1126 NLGN1 3 175,541,931 1127 NLGN1 3 175,543,000 1128 HTR3D 3 185,232,425 1129 HTR3D 3 185,236,739 1130 HTR3D 3 185,238,516 1131 HTR3C 3 185,276,148 1132 LEPREL1 3 191,189,805 1133 LEPREL1 3 191,218,155 1134 LEPREL1 3 191,237,107 1135 LEPREL1 3 191,244,878 1136 LEPREL1 3 191,331,953 1137 LEPREL1 3 191,356,159 1138 LEPREL1 3 191,356,831 1139 LEPREL1 3 191,356,896 1140 LEPREL1 3 191,358,612 1141 IL1RAP 3 191,716,532 1142 IL1RAP 3 191,719,452 1143 IL1RAP 3 191,825,136 1144 IL1RAP 3 191,859,482 1145 LRRC15 3 195,561,991 1146 LRRC15 3 195,562,211 1147 LRRC15 3 195,566,153 1148 LRRC15 3 195,567,372 1149 LRRC15 3 195,569,243 1150 LRRC15 3 195,586,726 1151 UBXD7 3 197,576,308 1152 UBXD7 3 197,632,452 1153 UBXD7 3 197,636,526 1154 UBXD7 3 197,642,729 1155 SLC2A9 4 9,423,554 1156 SLC2A9 4 9,476,600 1157 SLC2A9 4 9,480,639 1158 SLC2A9 4 9,500,096 1159 SLC2A9 4 9,531,228 1160 SLC2A9 4 9,606,210 1161 SLC2A9 4 9,606,401 1162 SLC2A9 4 9,606,822 1163 SLC2A9 4 9,606,899 1164 SLC2A9 4 9,613,930 1165 SLC2A9 4 9,616,184 1166 SLC2A9 4 9,616,373 1167 SLC2A9 4 9,633,401 1168 SLC2A9 4 9,636,640 1169 LDB2 4 16,106,226 1170 LDB2 4 16,119,229 1171 LDB2 4 16,128,817 1172 LDB2 4 16,197,827 1173 LDB2 4 16,200,696 1174 LDB2 4 16,362,961 1175 LDB2 4 16,379,333 1176 LDB2 4 16,386,273 1177 LDB2 4 16,387,385 1178 LDB2 4 16,390,278 1179 LDB2 4 16,410,139 1180 LDB2 4 16,417,600 1181 LDB2 4 16,498,396 1182 LDB2 4 16,513,031 1183 LDB2 4 16,515,486 1184 LDB2 4 16,525,999 1185 SLIT2 4 19,864,404 1186 SLIT2 4 19,872,156 1187 SLIT2 4 20,162,402 1188 SLIT2 4 20,172,206 1189 SLIT2 4 20,177,664 1190 SLIT2 4 20,194,981 1191 SLIT2 4 20,202,844 1192 PPARGC1A 4 23,422,850 1193 PPARGC1A 4 23,424,760 1194 PPARGC1A 4 23,439,336 1195 PPARGC1A 4 23,445,751 1196 SOD3 4 24,399,778 1197 CCKAR 4 26,098,368 1198 CCKAR 4 26,113,255 1199 PCDH7 4 30,383,181 1200 PCDH7 4 30,417,378 1201 PCDH7 4 30,420,872 1202 PCDH7 4 30,440,719 1203 PCDH7 4 30,441,417 1204 KIAA1239 4 36,941,226 1205 KIAA1239 4 36,945,500 1206 KIAA1239 4 37,005,415 1207 KIAA1239 4 37,007,192 1208 KIAA1239 4 37,133,996 1209 KIAA1239 4 37,134,494 1210 KIAA1239 4 37,140,169 1211 KIAA1239 4 37,157,082 1212 TBCID1 4 37,815,251 1213 UBE2K 4 39,386,342 1214 UBE2K 4 39,494,511 1215 N4BP2 4 39,864,889 1216 LIMCH1 4 41,179,983 1217 LIMCH1 4 41,257,923 1218 LIMCH1 4 41,260,644 1219 LIMCH1 4 41,285,436 1220 LIMCH1 4 41,294,746 1221 LIMCH1 4 41,308,688 1222 LIMCH1 4 41,314,999 1223 LIMCH1 4 41,354,243 1224 LIMCH1 4 41,368,361 1225 LIMCH1 4 41,394,864 1226 LIMCH1 4 41,421,570 1227 LIMCH1 4 41,429,386 1228 LIMCH1 4 41,433,490 1229 LOC389207 4 42,562,218 1230 LOC389207 4 42,597,411 1231 LPHN3 4 62,501,063 1232 LPHN3 4 62,708,418 1233 LPHN3 4 62,719,919 1234 NPFFR2 4 73,054,817 1235 NPFFR2 4 73,103,842 1236 NPFFR2 4 73,115,321 1237 NPFFR2 4 73,122,046 1238 NPFFR2 4 73,122,182 1239 NPFFR2 4 73,143,891 1240 NPFFR2 4 73,145,571 1241 NPFFR2 4 73,147,681 1242 NPFFR2 4 73,153,403 1243 NPFFR2 4 73,153,496 1244 NPFFR2 4 73,154,786 1245 NPFFR2 4 73,160,673 1246 NPFFR2 4 73,161,337 1247 NPFFR2 4 73,163,818 1248 NPFFR2 4 73,219,749 1249 NPFFR2 4 73,236,822 1250 NPFFR2 4 73,263,574 1251 NPFFR2 4 73,279,891 1252 NPFFR2 4 73,291,379 1253 CXCL9 4 77,140,838 1254 CXCL9 4 77,152,469 1255 SHROOM3 4 77,819,898 1256 SHROOM3 4 77,835,586 1257 SHROOM3 4 77,879,755 1258 SHROOM3 4 77,883,172 1259 SHROOM3 4 77,888,752 1260 SHROOM3 4 77,944,496 1261 SCD5 4 83,782,853 1262 SCD5 4 83,794,856 1263 SCD5 4 83,794,931 1264 SCD5 4 83,803,520 1265 SCD5 4 83,809,123 1266 SCD5 4 83,816,306 1267 SCD5 4 83,832,656 1268 SCD5 4 83,843,002 1269 SCD5 4 83,845,049 1270 SCD5 4 83,847,997 1271 SCD5 4 83,920,815 1272 SCD5 4 83,923,596 1273 SCD5 4 83,944,297 1274 HERC3 4 89,711,547 1275 HERC3 4 89,741,644 1276 HERC3 4 89,751,705 1277 HERC3 4 89,786,790 1278 HERC3 4 89,803,447 1279 HERC3 4 89,822,108 1280 FAM13A1 4 89,887,882 1281 FAM13A1 4 89,950,302 1282 FAM13A1 4 89,950,932 1283 FAM13A1 4 89,952,905 1284 FAM13A1 4 89,958,502 1285 FAM13A1 4 90,116,396 1286 FAM13A1 4 90,156,345 1287 FAM13A1 4 90,160,944 1288 FAM13A1 4 90,213,209 1289 FAM13A1 4 90,214,821 1290 PDLIM5 4 95,638,542 1291 PDLIM5 4 95,660,333 1292 PDLIM5 4 95,660,615 1293 PDLIM5 4 95,679,972 1294 PDLIM5 4 95,701,843 1295 PDLIM5 4 95,715,905 1296 PDLIM5 4 95,716,677 1297 PDLIM5 4 95,728,786 1298 PDLIM5 4 95,747,196 1299 PDLIM5 4 95,780,482 1300 PDLIM5 4 95,781,900 1301 PDLIM5 4 95,791,722 1302 PDLIM5 4 95,810,999 1303 TSPAN5 4 99,862,201 1304 DKK2 4 108,063,606 1305 DKK2 4 108,084,600 1306 DKK2 4 108,236,721 1307 PAPSS1 4 108,757,215 1308 PAPSS1 4 108,791,600 1309 PAPSS1 4 108,824,661 1310 PAPSS1 4 108,829,312 1311 PAPSS1 4 108,831,390 1312 PAPSS1 4 108,846,299 1313 PAPSS1 4 108,901,540 1314 PAPSS1 4 108,902,359 1315 COL25A1 4 109,933,621 1316 COL25A1 4 109,934,307 1317 COL25A1 4 109,954,162 1318 COL25A1 4 109,959,534 1319 COL25A1 4 109,967,676 1320 COL25A1 4 109,982,367 1321 COL25A1 4 109,987,393 1322 COL25A1 4 110,046,425 1323 COL25A1 4 110,050,277 1324 COL25A1 4 110,066,070 1325 COL25A1 4 110,067,552 1326 COL25A1 4 110,067,736 1327 COL25A1 4 110,166,630 1328 COL25A1 4 110,173,221 1329 COL25A1 4 110,179,691 1330 COL25A1 4 110,195,082 1331 COL25A1 4 110,198,580 1332 COL25A1 4 110,320,625 1333 COL25A1 4 110,322,934 1334 COL25A1 4 110,351,151 1335 COL25A1 4 110,397,623 1336 COL25A1 4 110,409,320 1337 COL25A1 4 110,469,277 1338 COL25A1 4 110,497,932 1339 ANK2 4 114,184,993 1340 ANK2 4 114,298,380 1341 ANK2 4 114,298,464 1342 ANK2 4 114,298,576 1343 ANK2 4 114,318,660 1344 ANK2 4 114,329,441 1345 ANK2 4 114,338,099 1346 ANK2 4 114,340,609 1347 ANK2 4 114,348,644 1348 ANK2 4 114,388,294 1349 ANK2 4 114,424,380 1350 ANK2 4 114,429,212 1351 ANK2 4 114,436,352 1352 ANK2 4 114,437,446 1353 ANK2 4 114,445,280 1354 ANK2 4 114,474,018 1355 ANK2 4 114,480,090 1356 ANK2 4 114,504,770 1357 CAMK2D 4 114,620,118 1358 CAMK2D 4 114,648,856 1359 CAMK2D 4 114,651,522 1360 CAMK2D 4 114,715,574 1361 CAMK2D 4 114,727,378 1362 CAMK2D 4 114,729,956 1363 CAMK2D 4 114,766,153 1364 CAMK2D 4 114,772,042 1365 CAMK2D 4 114,781,182 1366 CAMK2D 4 114,782,182 1367 CAMK2D 4 114,799,352 1368 CAMK2D 4 114,923,416 1369 NDST3 4 119,169,101 1370 NDST3 4 119,169,326 1371 NDST3 4 119,186,644 1372 NDST3 4 119,186,984 1373 NDST3 4 119,210,639 1374 NDST3 4 119,235,665 1375 NDST3 4 119,256,090 1376 NDST3 4 119,257,098 1377 PRSS12 4 119,462,492 1378 PRSS12 4 119,488,872 1379 PRSS12 4 119,498,546 1380 GPR103 4 122,484,922 1381 GPR103 4 122,487,863 1382 GPR103 4 122,510,972 1383 GPR103 4 122,517,665 1384 GPR103 4 122,518,528 1385 GPR103 4 122,521,072 1386 MAML3 4 140,868,325 1387 MAML3 4 140,870,180 1388 MAML3 4 140,878,048 1389 MAML3 4 140,895,835 1390 MAML3 4 140,896,430 1391 MAML3 4 140,902,213 1392 MAML3 4 140,983,797 1393 MAML3 4 141,004,965 1394 MAML3 4 141,007,145 1395 MAML3 4 141,030,150 1396 MAML3 4 141,043,992 1397 MAML3 4 141,044,880 1398 MAML3 4 141,051,231 1399 MAML3 4 141,130,298 1400 MAML3 4 141,138,533 1401 MAML3 4 141,142,480 1402 IL15 4 142,734,966 1403 IL15 4 142,737,011 1404 IL15 4 142,764,901 1405 IL15 4 142,873,534 1406 IL15 4 142,907,840 1407 IL15 4 142,911,413 1408 IL15 4 142,916,618 1409 IL15 4 142,924,868 1410 INPP4B 4 143,195,583 1411 INPP4B 4 143,201,848 1412 INPP4B 4 143,221,023 1413 INPP4B 4 143,222,465 1414 INPP4B 4 143,223,756 1415 INPP4B 4 143,242,213 1416 INPP4B 4 143,262,085 1417 INPP4B 4 143,269,904 1418 INPP4B 4 143,269,935 1419 INPP4B 4 143,275,746 1420 INPP4B 4 143,295,856 1421 INPP4B 4 143,380,957 1422 INPP4B 4 143,436,768 1423 INPP4B 4 143,476,047 1424 INPP4B 4 143,593,360 1425 POU4F2 4 147,727,101 1426 POU4F2 4 147,731,368 1427 POU4F2 4 147,739,219 1428 POU4F2 4 147,748,659 1429 POU4F2 4 147,758,283 1430 POU4F2 4 147,768,753 1431 POU4F2 4 147,799,157 1432 DCLK2 4 151,229,912 1433 DCLK2 4 151,230,058 1434 DCLK2 4 151,230,190 1435 DCLK2 4 151,236,783 1436 DCLK2 4 151,259,013 1437 DCLK2 4 151,291,338 1438 DCLK2 4 151,294,657 1439 DCLK2 4 151,355,610 1440 DCLK2 4 151,366,761 1441 DCLK2 4 151,372,390 1442 DCLK2 4 151,378,402 1443 DCLK2 4 151,401,865 1444 CTSO 4 157,072,641 1445 CTSO 4 157,090,787 1446 CTSO 4 157,091,152 1447 CTSO 4 157,119,171 1448 CTSO 4 157,124,684 1449 CTSO 4 157,125,805 1450 FSTL5 4 162,602,916 1451 FSTL5 4 162,608,107 1452 FSTL5 4 162,696,532 1453 FSTL5 4 162,784,518 1454 FSTL5 4 162,786,977 1455 FSTL5 4 162,828,621 1456 FSTL5 4 162,852,707 1457 FSTL5 4 162,863,519 1458 FSTL5 4 162,901,935 1459 FSTL5 4 162,923,589 1460 FSTL5 4 162,953,212 1461 FSTL5 4 163,113,553 1462 FSTL5 4 163,171,406 1463 FSTL5 4 163,172,602 1464 FSTL5 4 163,204,852 1465 FSTL5 4 163,224,500 1466 FSTL5 4 163,262,634 1467 FSTL5 4 163,274,178 1468 FSTL5 4 163,275,058 1469 FSTL5 4 163,282,207 1470 FSTL5 4 163,306,761 1471 FSTL5 4 163,316,581 1472 FSTL5 4 163,369,235 1473 FSTL5 4 163,379,495 1474 TLL1 4 166,984,039 1475 TLL1 4 167,012,651 1476 TLL1 4 167,017,110 1477 TLL1 4 167,022,978 1478 TLL1 4 167,186,954 1479 TLL1 4 167,200,417 1480 TLL1 4 167,215,864 1481 TLL1 4 167,247,157 1482 TLL1 4 167,250,203 1483 PALLD 4 169,678,354 1484 PALLD 4 169,678,426 1485 PALLD 4 169,680,592 1486 PALLD 4 169,685,203 1487 PALLD 4 169,690,892 1488 PALLD 4 169,693,362 1489 PALLD 4 169,693,682 1490 PALLD 4 169,701,141 1491 PALLD 4 169,702,565 1492 PALLD 4 169,713,776 1493 PALLD 4 169,721,943 1494 PALLD 4 169,766,914 1495 PALLD 4 169,828,987 1496 PALLD 4 169,831,329 1497 PALLD 4 169,831,979 1498 PALLD 4 169,854,703 1499 PALLD 4 169,866,028 1500 PALLD 4 169,894,890 1501 PALLD 4 169,910,252 1502 PALLD 4 169,910,404 1503 PALLD 4 169,938,153 1504 PALLD 4 169,938,977 1505 PALLD 4 169,939,539 1506 PALLD 4 170,077,542 1507 PALLD 4 170,085,964 1508 PALLD 4 170,111,195 1509 PALLD 4 170,118,492 1510 PALLD 4 170,135,598 1511 PALLD 4 170,136,535 1512 PALLD 4 170,137,800 1513 ODZ3 4 183,476,755 1514 ODZ3 4 183,478,510 1515 ODZ3 4 183,764,260 1516 ODZ3 4 183,790,373 1517 ODZ3 4 183,876,156 1518 ODZ3 4 183,917,862 1519 ODZ3 4 183,917,955 1520 ENPP6 4 185,234,241 1521 ENPP6 4 185,238,625 1522 ENPP6 4 185,251,384 1523 ENPP6 4 185,254,744 1524 ENPP6 4 185,258,135 1525 ENPP6 4 185,260,510 1526 ENPP6 4 185,263,371 1527 ENPP6 4 185,269,255 1528 ENPP6 4 185,314,773 1529 CASP3 4 185,792,230 1530 AHRR 5 399,636 1531 AHRR 5 401,598 1532 AHRR 5 431,413 1533 AHRR 5 465,694 1534 AHRR 5 510,955 1535 SEMA5A 5 9,066,544 1536 SEMA5A 5 9,066,608 1537 SEMA5A 5 9,071,565 1538 SEMA5A 5 9,093,141 1539 SEMA5A 5 9,103,410 1540 SEMA5A 5 9,119,802 1541 SEMA5A 5 9,474,794 1542 SEMA5A 5 9,477,130 1543 SEMA5A 5 9,488,305 1544 SEMA5A 5 9,489,697 1545 SEMA5A 5 9,613,249 1546 DNAH5 5 13,711,926 1547 DNAH5 5 13,776,956 1548 DNAH5 5 13,780,181 1549 DNAH5 5 13,780,350 1550 DNAH5 5 13,795,858 1551 DNAH5 5 13,802,952 1552 DNAH5 5 13,807,394 1553 DNAH5 5 13,822,974 1554 DNAH5 5 13,832,743 1555 DNAH5 5 13,841,886 1556 DNAH5 5 13,842,420 1557 DNAH5 5 13,896,485 1558 DNAH5 5 13,897,249 1559 DNAH5 5 13,897,274 1560 DNAH5 5 13,953,345 1561 DNAH5 5 13,955,220 1562 DNAH5 5 13,957,400 1563 DNAH5 5 13,988,491 1564 DNAH5 5 13,988,683 1565 DNAH5 5 13,988,747 1566 DNAH5 5 13,989,500 1567 DNAH5 5 14,007,463 1568 DNAH5 5 14,032,397 1569 MYO10 5 16,711,524 1570 MYO10 5 16,822,273 1571 MYO10 5 16,836,327 1572 MYO10 5 16,837,873 1573 MYO10 5 16,838,077 1574 CDH10 5 24,500,153 1575 CDH10 5 24,533,855 1576 CDH10 5 24,663,859 1577 CDH10 5 24,727,740 1578 SLC45A2 5 33,979,974 1579 SLC45A2 5 33,990,637 1580 C1QTNF3 5 34,083,721 1581 SLC1A3 5 36,644,918 1582 SLC1A3 5 36,670,315 1583 SLC1A3 5 36,675,215 1584 SLC1A3 5 36,712,840 1585 SLC1A3 5 36,755,577 1586 SLC1A3 5 36,755,736 1587 EGFLAM 5 38,246,651 1588 EGFLAM 5 38,307,878 1589 EGFLAM 5 38,337,535 1590 EGFLAM 5 38,357,270 1591 EGFLAM 5 38,357,424 1592 EGFLAM 5 38,382,422 1593 EGFLAM 5 38,386,400 1594 EGFLAM 5 38,402,419 1595 EGFLAM 5 38,450,087 1596 EGFLAM 5 38,485,966 1597 EGFLAM 5 38,492,523 1598 EGFLAM 5 38,502,504 1599 ITGA1 5 52,114,759 1600 ITGA1 5 52,130,669 1601 ITGA1 5 52,133,521 1602 ITGA1 5 52,134,676 1603 ITGA1 5 52,146,916 1604 ITGA1 5 52,149,807 1605 ITGA1 5 52,155,113 1606 ITGA1 5 52,185,286 1607 ITGA1 5 52,194,858 1608 ITGA1 5 52,223,785 1609 ITGA1 5 52,231,264 1610 ITGA1 5 52,250,338 1611 ITGA1 5 52,259,107 1612 ITGA1 5 52,265,502 1613 ITGA1 5 52,277,790 1614 ITGA1 5 52,278,143 1615 ITGA1 5 52,285,233 1616 ITGA1 5 52,289,413 1617 ITGA2 5 52,369,177 1618 ITGA2 5 52,376,821 1619 ITGA2 5 52,388,590 1620 ITGA2 5 52,402,662 1621 ITGA2 5 52,425,212 1622 PDE4D 5 58,313,749 1623 PDE4D 5 58,367,198 1624 PDE4D 5 58,406,595 1625 PDE4D 5 58,429,089 1626 PDE4D 5 58,431,868 1627 PDE4D 5 58,432,005 1628 PDE4D 5 58,681,562 1629 PDE4D 5 58,712,773 1630 PDE4D 5 58,715,241 1631 PDE4D 5 58,895,884 1632 PDE4D 5 58,917,427 1633 PDE4D 5 58,935,951 1634 PDE4D 5 58,936,088 1635 PDE4D 5 58,941,002 1636 ELOVL7 5 60,152,637 1637 ELOVL7 5 60,152,959 1638 ELOVL7 5 60,171,742 1639 TNPO1 5 72,120,843 1640 TNPO1 5 72,172,369 1641 TNPO1 5 72,182,236 1642 TNPO1 5 72,185,181 1643 TNPO1 5 72,217,160 1644 TNPO1 5 72,292,936 1645 FCHO2 5 72,374,865 1646 FCHO2 5 72,384,028 1647 FCHO2 5 72,426,767 1648 FCHO2 5 72,429,851 1649 FCHO2 5 72,430,491 1650 CMYA5 5 79,029,508 1651 CMYA5 5 79,058,467 1652 CMYA5 5 79,122,639 1653 CMYA5 5 79,136,873 1654 THBS4 5 79,356,433 1655 THBS4 5 79,356,634 1656 THBS4 5 79,375,707 1657 THBS4 5 79,376,918 1658 THBS4 5 79,387,300 1659 THBS4 5 79,397,021 1660 THBS4 5 79,411,480 1661 THBS4 5 79,415,294 1662 THBS4 5 79,425,956 1663 VCAN 5 82,795,773 1664 VCAN 5 82,798,333 1665 VCAN 5 82,806,912 1666 VCAN 5 82,818,286 1667 VCAN 5 82,822,305 1668 VCAN 5 82,851,164 1669 VCAN 5 82,869,125 1670 VCAN 5 82,873,387 1671 VCAN 5 82,875,330 1672 VCAN 5 82,900,222 1673 VCAN 5 82,914,275 1674 MEF2C 5 88,077,688 1675 MEF2C 5 88,091,517 1676 MEF2C 5 88,138,619 1677 MEF2C 5 88,161,609 1678 MEF2C 5 88,193,308 1679 MEF2C 5 88,216,865 1680 GPR98 5 89,882,699 1681 GPR98 5 89,899,035 1682 GPR98 5 89,923,439 1683 GPR98 5 89,976,245 1684 GPR98 5 89,988,287 1685 GPR98 5 89,992,773 1686 GPR98 5 90,015,345 1687 GPR98 5 90,020,637 1688 GPR98 5 90,024,260 1689 GPR98 5 90,026,080 1690 GPR98 5 90,071,845 1691 GPR98 5 90,078,258 1692 GPR98 5 90,203,767 1693 GPR98 5 90,444,837 1694 CAST 5 96,112,090 1695 CAST 5 96,112,771 1696 CAST 5 96,114,802 1697 FBXL17 5 107,223,636 1698 FBXL17 5 107,224,897 1699 FBXL17 5 107,256,661 1700 FBXL17 5 107,283,768 1701 FBXL17 5 107,381,014 1702 FBXL17 5 107,423,133 1703 FBXL17 5 107,433,375 1704 FBXL17 5 107,441,485 1705 FBXL17 5 107,513,060 1706 FBXL17 5 107,527,862 1707 FBXL17 5 107,540,044 1708 FBXL17 5 107,546,460 1709 FBXL17 5 107,584,601 1710 FBXL17 5 107,598,684 1711 FBXL17 5 107,614,682 1712 FBXL17 5 107,641,934 1713 FBXL17 5 107,681,849 1714 FBXL17 5 107,705,110 1715 FBXL17 5 107,715,515 1716 FBXL17 5 107,716,753 1717 FBXL17 5 107,773,275 1718 FBXL17 5 107,810,930 1719 FBXL17 5 107,833,753 1720 PJA2 5 108,713,575 1721 PJA2 5 108,727,060 1722 PJA2 5 108,742,197 1723 PJA2 5 108,787,364 1724 KCNN2 5 113,739,288 1725 KCNN2 5 113,759,422 1726 KCNN2 5 113,763,996 1727 KCNN2 5 113,766,613 1728 KCNN2 5 113,784,704 1729 KCNN2 5 113,836,263 1730 KCNN2 5 113,858,701 1731 KCNN2 5 113,879,949 1732 SEMA6A 5 115,803,210 1733 SEMA6A 5 115,816,311 1734 SEMA6A 5 115,823,087 1735 SEMA6A 5 115,914,844 1736 SEMA6A 5 115,919,012 1737 SEMA6A 5 115,967,240 1738 HSD17B4 5 118,865,967 1739 HSD17B4 5 118,872,179 1740 HSD17B4 5 118,872,385 1741 HSD17B4 5 118,915,055 1742 HSD17B4 5 118,918,814 1743 HSD17B4 5 118,927,674 1744 LOC340069 5 118,989,273 1745 LOC340069 5 118,992,036 1746 LOC340069 5 118,997,859 1747 FTMT 5 121,238,114 1748 SNCAIP 5 121,656,692 1749 SNCAIP 5 121,699,768 1750 SNCAIP 5 121,757,816 1751 SNCAIP 5 121,768,808 1752 SNCAIP 5 121,778,228 1753 SNCAIP 5 121,796,570 1754 SNCAIP 5 121,807,289 1755 SNCAIP 5 121,824,037 1756 SNCAIP 5 121,831,417 1757 SNCAIP 5 121,854,840 1758 SNX2 5 122,116,630 1759 SNX2 5 122,174,518 1760 SNX2 5 122,201,930 1761 SNX24 5 122,237,091 1762 SNX24 5 122,273,273 1763 SNX24 5 122,283,900 1764 SNX24 5 122,295,903 1765 SNX24 5 122,309,550 1766 ADAMTS19 5 128,850,315 1767 ADAMTS19 5 129,039,887 1768 ADAMTS19 5 129,043,351 1769 ADAMTS19 5 129,078,440 1770 VDAC1 5 133,352,457 1771 VDAC1 5 133,392,157 1772 VDAC1 5 133,405,061 1773 TRPC7 5 135,551,643 1774 TRPC7 5 135,641,325 1775 TRPC7 5 135,680,121 1776 TRPC7 5 135,683,035 1777 TRPC7 5 135,705,746 1778 TRPC7 5 135,708,380 1779 TRPC7 5 135,713,994 1780 CTNNA1 5 138,200,119 1781 CTNNA1 5 138,216,610 1782 CTNNA1 5 138,254,666 1783 CTNNA1 5 138,264,654 1784 CTNNA1 5 138,289,570 1785 CTNNA1 5 138,298,631 1786 CTNNA1 5 138,300,046 1787 ODZ2 5 167,085,900 1788 ODZ2 5 167,105,972 1789 ODZ2 5 167,191,250 1790 ODZ2 5 167,391,524 1791 ODZ2 5 167,400,913 1792 ODZ2 5 167,485,949 1793 ODZ2 5 167,486,071 1794 ODZ2 5 167,486,458 1795 ODZ2 5 167,491,001 1796 ODZ2 5 167,527,141 1797 ODZ2 5 167,576,871 1798 ODZ2 5 167,606,948 1799 ODZ2 5 167,634,311 1800 WWC1 5 167,705,652 1801 WWC1 5 167,720,663 1802 WWC1 5 167,819,115 1803 GABRP 5 170,134,117 1804 GABRP 5 170,143,829 1805 GABRP 5 170,147,972 1806 SERPINB6 6 2,926,223 1807 SLC22A23 6 3,215,063 1808 SLC22A23 6 3,222,297 1809 SLC22A23 6 3,281,912 1810 SLC22A23 6 3,282,785 1811 SLC22A23 6 3,284,105 1812 SLC22A23 6 3,395,265 1813 SLC22A23 6 3,398,658 1814 NEDD9 6 11,294,417 1815 NEDD9 6 11,302,962 1816 PHACTR1 6 12,845,008 1817 PHACTR1 6 12,858,919 1818 PHACTR1 6 12,989,841 1819 PHACTR1 6 13,002,890 1820 PHACTR1 6 13,006,278 1821 PHACTR1 6 13,035,530 1822 PHACTR1 6 13,035,831 1823 PHACTR1 6 13,286,048 1824 PHACTR1 6 13,297,254 1825 PHACTR1 6 13,373,352 1826 JARID2 6 15,388,186 1827 JARID2 6 15,449,354 1828 JARID2 6 15,499,187 1829 JARID2 6 15,512,229 1830 JARID2 6 15,516,507 1831 JARID2 6 15,537,710 1832 JARID2 6 15,567,913 1833 JARID2 6 15,593,357 1834 JARID2 6 15,624,264 1835 ATXN1 6 16,595,385 1836 ATXN1 6 16,755,970 1837 ATXN1 6 16,785,550 1838 ATXN1 6 16,808,077 1839 RNF144B 6 18,530,528 1840 RNF144B 6 18,546,855 1841 RNF144B 6 18,563,593 1842 RNF144B 6 18,566,740 1843 RNF144B 6 18,568,182 1844 RNF144B 6 18,574,729 1845 SLC17A4 6 25,848,481 1846 SLC17A4 6 25,861,619 1847 SLC17A4 6 25,872,171 1848 SLC17A4 6 25,876,893 1849 SLC17A4 6 25,880,026 1850 SLC17A4 6 25,887,371 1851 SLC17A4 6 25,890,293 1852 SLC17A4 6 25,900,229 1853 SLC17A1 6 25,909,950 1854 SLC17A1 6 25,921,129 1855 SLC17A1 6 25,937,612 1856 SLC17A1 6 25,937,638 1857 SLC17A1 6 25,950,182 1858 SLC17A3 6 25,971,584 1859 SLC17A3 6 25,972,341 1860 SLC17A3 6 25,972,877 1861 SLC17A3 6 25,973,245 1862 SLC17A3 6 25,978,521 1863 SLC17A3 6 25,993,793 1864 SLC17A2 6 26,009,112 1865 SLC17A2 6 26,020,795 1866 SLC17A2 6 26,022,056 1867 SLC17A2 6 26,032,492 1868 SLC17A2 6 26,042,503 1869 SLC17A2 6 26,065,387 1870 SLC17A2 6 26,067,106 1871 SLC17A2 6 26,068,488 1872 BTN3A1 6 26,506,534 1873 BTN3A1 6 26,525,105 1874 BTN3A3 6 26,559,532 1875 MSH5 6 31,838,993 1876 BTNL2 6 32,469,155 1877 BTNL2 6 32,471,430 1878 BTNL2 6 32,471,794 1879 BRD2 6 32,961,584 1880 LRFN2 6 40,462,772 1881 LRFN2 6 40,635,612 1882 PPP2R5D 6 43,066,878 1883 KLC4 6 43,173,891 1884 PARC 6 43,277,865 1885 ABCC10 6 43,504,834 1886 TJAP1 6 43,604,640 1887 TJAP1 6 43,636,419 1888 ELOVL5 6 53,221,300 1889 ELOVL5 6 53,238,244 1890 ELOVL5 6 53,267,506 1891 ELOVL5 6 53,280,718 1892 ELOVL5 6 53,296,096 1893 ELOVL5 6 53,298,093 1894 ELOVL5 6 53,298,209 1895 ELOVL5 6 53,350,763 1896 ELOVL5 6 53,372,444 1897 ELOVL5 6 53,386,201 1898 RIMS1 6 72,772,376 1899 RIMS1 6 72,784,876 1900 RIMS1 6 72,799,111 1901 RIMS1 6 72,806,741 1902 RIMS1 6 72,843,114 1903 RIMS1 6 72,860,627 1904 RIMS1 6 72,910,499 1905 RIMS1 6 72,939,135 1906 RIMS1 6 72,967,122 1907 RIMS1 6 72,982,413 1908 RIMS1 6 73,021,641 1909 RIMS1 6 73,031,069 1910 RIMS1 6 73,052,051 1911 RIMS1 6 73,063,804 1912 RIMS1 6 73,113,269 1913 RIMS1 6 73,114,364 1914 RIMS1 6 73,118,107 1915 RIMS1 6 73,148,099 1916 RIMS1 6 73,166,669 1917 RIMS1 6 73,170,109 1918 GABRR2 6 90,024,574 1919 GABRR2 6 90,034,625 1920 GABRR2 6 90,069,593 1921 KLHL32 6 97,549,988 1922 KLHL32 6 97,602,178 1923 KLHL32 6 97,632,117 1924 KLHL32 6 97,643,903 1925 KLHL32 6 97,673,659 1926 SLC22A16 6 110,850,843 1927 SLC22A16 6 110,853,761 1928 SLC22A16 6 110,857,245 1929 SLC22A16 6 110,870,568 1930 SLC22A16 6 110,897,601 1931 SLC22A16 6 110,900,785 1932 SLC22A16 6 110,903,098 1933 SLC22A16 6 110,914,475 1934 HS3ST5 6 114,502,447 1935 TRDN 6 123,553,000 1936 TRDN 6 123,728,987 1937 TRDN 6 123,738,465 1938 TRDN 6 123,743,637 1939 TRDN 6 123,749,431 1940 TRDN 6 123,753,816 1941 TRDN 6 123,766,181 1942 TRDN 6 123,774,707 1943 TRDN 6 123,862,152 1944 TRDN 6 123,865,649 1945 TRDN 6 123,871,263 1946 TRDN 6 123,875,156 1947 TRDN 6 123,877,575 1948 TRDN 6 123,878,251 1949 TRDN 6 123,931,045 1950 TRDN 6 123,991,308 1951 TRDN 6 124,006,657 1952 TRDN 6 124,017,012 1953 NKAIN2 6 124,086,439 1954 NKAIN2 6 124,145,158 1955 NKAIN2 6 124,173,325 1956 NKAIN2 6 124,174,594 1957 NKAIN2 6 124,462,813 1958 NKAIN2 6 124,473,210 1959 NKAIN2 6 124,481,807 1960 NKAIN2 6 124,488,366 1961 NKAIN2 6 124,492,154 1962 NKAIN2 6 124,658,216 1963 NKAIN2 6 124,742,885 1964 NKAIN2 6 124,850,664 1965 NKAIN2 6 124,859,016 1966 NKAIN2 6 124,953,233 1967 NKAIN2 6 124,962,839 1968 NKAIN2 6 124,977,809 1969 NKAIN2 6 124,987,301 1970 NKAIN2 6 125,020,491 1971 NKAIN2 6 125,198,148 1972 EYA4 6 133,617,346 1973 EYA4 6 133,625,496 1974 EYA4 6 133,672,254 1975 EYA4 6 133,674,026 1976 EYA4 6 133,678,316 1977 EYA4 6 133,790,074 1978 EYA4 6 133,876,222 1979 PDE7B 6 136,206,400 1980 PDE7B 6 136,244,527 1981 PDE7B 6 136,251,409 1982 PDE7B 6 136,262,109 1983 PDE7B 6 136,263,312 1984 PDE7B 6 136,308,009 1985 PDE7B 6 136,313,220 1986 PDE7B 6 136,326,169 1987 PDE7B 6 136,346,863 1988 PDE7B 6 136,357,577 1989 PDE7B 6 136,408,668 1990 PLAGL1 6 144,319,261 1991 PLAGL1 6 144,326,195 1992 PLAGL1 6 144,345,108 1993 PLAGL1 6 144,355,380 1994 STX11 6 144,498,222 1995 STX11 6 144,554,694 1996 STX11 6 144,584,781 1997 UTRN 6 144,651,202 1998 UTRN 6 144,665,805 1999 UTRN 6 144,698,346 2000 UTRN 6 144,723,376 2001 UTRN 6 144,728,467 2002 UTRN 6 144,943,208 2003 SYNE1 6 152,485,437 2004 SYNE1 6 152,511,829 2005 SYNE1 6 152,549,890 2006 SYNE1 6 152,683,133 2007 SYNE1 6 152,683,299 2008 SYNE1 6 152,685,563 2009 TFB1M 6 155,621,092 2010 TFB1M 6 155,621,249 2011 TFB1M 6 155,663,514 2012 TFB1M 6 155,686,995 2013 SLC22A3 6 160,754,505 2014 SLC22A3 6 160,762,527 2015 SLC22A3 6 160,783,522 2016 PARK2 6 161,894,294 2017 PARK2 6 161,894,696 2018 PARK2 6 161,910,473 2019 PARK2 6 161,921,426 2020 PARK2 6 161,941,630 2021 PARK2 6 161,952,077 2022 PARK2 6 161,960,395 2023 PARK2 6 162,001,625 2024 PARK2 6 162,001,753 2025 PARK2 6 162,026,087 2026 PARK2 6 162,194,371 2027 PARK2 6 162,199,188 2028 PARK2 6 162,199,563 2029 PARK2 6 162,201,523 2030 PARK2 6 162,204,134 2031 PARK2 6 162,651,333 2032 PARK2 6 162,656,326 2033 PARK2 6 162,666,256 2034 PARK2 6 162,666,349 2035 PARK2 6 162,709,903 2036 PARK2 6 162,719,593 2037 PARK2 6 162,724,935 2038 PARK2 6 162,725,125 2039 PARK2 6 162,728,999 2040 PARK2 6 162,770,133 2041 PARK2 6 162,782,182 2042 PARK2 6 162,795,324 2043 PARK2 6 162,871,284 2044 PARK2 6 162,891,538 2045 PARK2 6 162,902,279 2046 PARK2 6 162,916,186 2047 PARK2 6 162,947,100 2048 PARK2 6 162,960,031 2049 PARK2 6 163,103,553 2050 PACRG 6 163,515,155 2051 PACRG 6 163,520,215 2052 PACRG 6 163,520,791 2053 PACRG 6 163,523,252 2054 PACRG 6 163,571,731 2055 PDE10A 6 165,679,905 2056 PDE10A 6 165,711,808 2057 PDE10A 6 165,714,078 2058 PDE10A 6 165,741,392 2059 PDE10A 6 165,787,781 2060 PDE10A 6 165,834,350 2061 PDE10A 6 165,835,911 2062 PDE10A 6 165,840,748 2063 PDE10A 6 165,868,541 2064 PDE10A 6 165,883,564 2065 PDE10A 6 166,023,863 2066 CARD11 7 2,917,872 2067 CARD11 7 2,923,531 2068 CARD11 7 2,928,819 2069 CARD11 7 2,985,379 2070 SDK1 7 4,118,110 2071 SDK1 7 4,118,615 2072 SDK1 7 4,140,139 2073 SDK1 7 4,152,211 2074 SDK1 7 4,152,228 2075 SDK1 7 4,153,102 2076 SDK1 7 4,158,337 2077 SDK1 7 4,162,572 2078 SDK1 7 4,174,523 2079 SDK1 7 4,174,875 2080 SDK1 7 4,214,383 2081 SDK1 7 4,230,185 2082 SDK1 7 4,272,360 2083 NXPH1 7 8,578,640 2084 NXPH1 7 8,589,612 2085 NXPH1 7 8,600,283 2086 NXPH1 7 8,608,391 2087 NXPH1 7 8,647,759 2088 NXPH1 7 8,662,332 2089 NXPH1 7 8,700,069 2090 NXPH1 7 8,780,133 2091 SCIN 7 12,576,204 2092 SCIN 7 12,576,513 2093 SCIN 7 12,579,777 2094 SCIN 7 12,634,312 2095 ETV1 7 13,906,357 2096 ETV1 7 13,945,334 2097 ETV1 7 13,982,894 2098 ETV1 7 13,987,646 2099 ETV1 7 13,996,042 2100 SNX13 7 17,861,458 2101 SNX13 7 17,937,235 2102 SNX13 7 17,974,835 2103 FERD3L 7 19,153,324 2104 FERD3L 7 19,164,657 2105 FERD3L 7 19,167,340 2106 FERD3L 7 19,346,900 2107 FERD3L 7 19,353,440 2108 FERD3L 7 19,353,457 2109 FERD3L 7 19,354,351 2110 STK31 7 23,742,002 2111 STK31 7 23,760,407 2112 STK31 7 23,859,818 2113 STK31 7 23,906,389 2114 NPY 7 24,297,290 2115 NPY 7 24,298,324 2116 SKAP2 7 26,917,430 2117 SKAP2 7 26,969,979 2118 SKAP2 7 26,982,204 2119 CREB5 7 28,798,822 2120 CREB5 7 28,804,778 2121 CREB5 7 28,811,671 2122 CREB5 7 28,812,569 2123 CREB5 7 28,815,049 2124 CREB5 7 28,818,987 2125 CREB5 7 28,870,041 2126 CREB5 7 28,906,935 2127 CHN2 7 29,215,509 2128 CHN2 7 29,483,175 2129 SCRN1 7 29,926,736 2130 SCRN1 7 29,929,111 2131 SCRN1 7 29,929,459 2132 SCRN1 7 30,010,342 2133 SCRN1 7 30,011,939 2134 PLEKHA8 7 30,034,151 2135 PLEKHA8 7 30,037,069 2136 SCRN1 7 30,052,432 2137 PLEKHA8 7 30,083,942 2138 PLEKHA8 7 30,097,689 2139 PLEKHA8 7 30,099,727 2140 CRHR2 7 30,663,882 2141 CRHR2 7 30,665,429 2142 CRHR2 7 30,676,000 2143 CRHR2 7 30,775,386 2144 FLJ22374 7 30,787,631 2145 FLJ22374 7 30,803,801 2146 FLJ22374 7 30,832,290 2147 FLJ22374 7 30,842,957 2148 FLJ22374 7 30,843,167 2149 FLJ22374 7 30,860,754 2150 FLJ22374 7 30,865,222 2151 FLJ22374 7 30,880,636 2152 PDE1C 7 31,794,059 2153 PDE1C 7 31,815,231 2154 PDE1C 7 31,931,223 2155 PDE1C 7 31,968,183 2156 PDE1C 7 31,979,118 2157 PDE1C 7 32,001,981 2158 PDE1C 7 32,037,670 2159 PDE1C 7 32,064,508 2160 PDE1C 7 32,094,250 2161 PDE1C 7 32,095,407 2162 PDE1C 7 32,167,820 2163 BMPER 7 33,934,543 2164 BMPER 7 33,942,093 2165 BMPER 7 34,056,348 2166 BMPER 7 34,067,083 2167 BMPER 7 34,077,080 2168 BMPER 7 34,077,746 2169 BMPER 7 34,107,862 2170 BMPER 7 34,184,882 2171 EEPD1 7 36,280,985 2172 EEPD1 7 36,306,659 2173 VPS41 7 38,745,317 2174 VPS41 7 38,758,751 2175 VPS41 7 38,759,185 2176 VPS41 7 38,768,570 2177 VPS41 7 38,768,817 2178 VPS41 7 38,812,386 2179 VPS41 7 38,855,826 2180 VPS41 7 38,866,716 2181 VPS41 7 38,936,691 2182 CDC2L5 7 39,994,009 2183 CDC2L5 7 40,051,522 2184 CDC2L5 7 40,056,457 2185 CDC2L5 7 40,063,896 2186 CDC2L5 7 40,067,860 2187 CDC2L5 7 40,083,623 2188 CDC2L5 7 40,124,213 2189 IGFBP3 7 45,916,971 2190 ABCA13 7 48,253,360 2191 ABCA13 7 48,256,966 2192 ABCA13 7 48,351,224 2193 ABCA13 7 48,388,584 2194 ABCA13 7 48,399,261 2195 ABCA13 7 48,415,696 2196 ABCA13 7 48,420,703 2197 ABCA13 7 48,424,446 2198 ABCA13 7 48,425,312 2199 ABCA13 7 48,427,057 2200 ABCA13 7 48,471,003 2201 ABCA13 7 48,472,098 2202 ABCA13 7 48,477,112 2203 ABCA13 7 48,516,335 2204 ABCA13 7 48,521,048 2205 ABCA13 7 48,537,470 2206 ABCA13 7 48,537,723 2207 ABCA13 7 48,538,115 2208 ABCA13 7 48,549,904 2209 ABCA13 7 48,553,490 2210 ABCA13 7 48,557,231 2211 ABCA13 7 48,622,770 2212 ABCA13 7 48,656,578 2213 ABCA13 7 48,707,129 2214 ABCA13 7 48,714,222 2215 GRB10 7 50,707,082 2216 GRB10 7 50,738,123 2217 GRB10 7 50,745,597 2218 GRB10 7 50,751,377 2219 GRB10 7 50,752,942 2220 GRB10 7 50,767,383 2221 GRB10 7 50,790,805 2222 GRB10 7 50,791,895 2223 GRB10 7 50,797,467 2224 GRB10 7 50,814,098 2225 GRB10 7 50,839,403 2226 GRB10 7 50,878,465 2227 WBSCR17 7 69,708,664 2228 WBSCR17 7 69,982,663 2229 WBSCR17 7 70,003,525 2230 WBSCR17 7 70,008,405 2231 WBSCR17 7 70,009,819 2232 WBSCR17 7 70,020,032 2233 WBSCR17 7 70,196,421 2234 WBSCR17 7 70,318,305 2235 WBSCR17 7 70,327,601 2236 WBSCR17 7 70,328,803 2237 WBSCR17 7 70,438,836 2238 WBSCR17 7 70,486,737 2239 WBSCR17 7 70,508,901 2240 WBSCR17 7 70,527,975 2241 WBSCR17 7 70,537,333 2242 WBSCR17 7 70,542,497 2243 WBSCR17 7 70,553,758 2244 WBSCR17 7 70,605,584 2245 WBSCR17 7 70,610,898 2246 WBSCR17 7 70,622,039 2247 WBSCR17 7 70,661,813 2248 WBSCR17 7 70,677,555 2249 LIMK1 7 73,143,124 2250 LIMK1 7 73,155,050 2251 GTF2IRD1 7 73,536,522 2252 GTF2IRD1 7 73,552,324 2253 GTF2IRD1 7 73,739,845 2254 HIP1 7 74,641,558 2255 HIP1 7 75,014,321 2256 HIP1 7 75,071,583 2257 HIP1 7 75,093,684 2258 HIP1 7 75,125,346 2259 HIP1 7 75,132,211 2260 HIP1 7 75,134,148 2261 HIP1 7 75,137,795 2262 HIP1 7 75,146,409 2263 HIP1 7 75,149,973 2264 HIP1 7 75,186,242 2265 HIP1 7 75,198,775 2266 MAGI2 7 77,062,170 2267 MAGI2 7 77,491,345 2268 MAGI2 7 77,497,177 2269 MAGI2 7 77,562,324 2270 MAGI2 7 77,596,871 2271 MAGI2 7 77,707,944 2272 MAGI2 7 77,807,229 2273 MAGI2 7 77,811,392 2274 MAGI2 7 77,818,446 2275 MAGI2 7 78,085,231 2276 MAGI2 7 78,087,129 2277 MAGI2 7 78,091,049 2278 MAGI2 7 78,305,682 2279 MAGI2 7 78,331,358 2280 MAGI2 7 78,350,745 2281 MAGI2 7 78,378,995 2282 MAGI2 7 78,393,425 2283 MAGI2 7 78,548,747 2284 MAGI2 7 78,554,879 2285 MAGI2 7 78,581,862 2286 MAGI2 7 78,589,166 2287 MAGI2 7 78,621,037 2288 MAGI2 7 78,634,193 2289 MAGI2 7 78,639,527 2290 MAGI2 7 78,753,565 2291 MAGI2 7 78,760,470 2292 MAGI2 7 78,779,395 2293 MAGI2 7 78,817,132 2294 MAGI2 7 78,829,240 2295 MAGI2 7 78,847,570 2296 MAGI2 7 78,865,894 2297 MAGI2 7 78,867,313 2298 MAGI2 7 78,872,510 2299 MAGI2 7 78,884,537 2300 MAGI2 7 78,894,096 2301 MAGI2 7 78,902,124 2302 GNAI1 7 79,129,442 2303 CACNA2D1 7 81,000,419 2304 CACNA2D1 7 81,262,844 2305 CACNA2D1 7 81,397,331 2306 CACNA2D1 7 81,409,867 2307 CACNA2D1 7 81,410,981 2308 CACNA2D1 7 81,501,211 2309 CACNA2D1 7 81,551,628 2310 PCLO 7 81,734,489 2311 PCLO 7 81,754,524 2312 CACNA2D1 7 81,819,131 2313 CACNA2D1 7 81,829,947 2314 CACNA2D1 7 81,842,488 2315 CACNA2D1 7 81,846,503 2316 PCLO 7 81,895,238 2317 CACNA2D1 7 81,925,395 2318 PCLO 7 81,935,063 2319 PCLO 7 81,953,190 2320 PCLO 7 82,252,869 2321 PCLO 7 82,287,971 2322 PCLO 7 82,291,644 2323 PCLO 7 82,292,608 2324 PCLO 7 82,317,658 2325 PCLO 7 82,341,345 2326 PCLO 7 82,341,378 2327 PCLO 7 82,358,102 2328 PCLO 7 82,391,885 2329 PCLO 7 82,401,452 2330 PCLO 7 82,419,795 2331 PCLO 7 82,454,771 2332 PCLO 7 82,581,867 2333 PCLO 7 82,636,908 2334 PCLO 7 82,659,120 2335 SEMA3E 7 82,881,204 2336 SEMA3E 7 82,882,893 2337 SEMA3E 7 82,883,620 2338 SEMA3E 7 82,895,964 2339 SEMA3E 7 82,913,893 2340 SEMA3E 7 82,935,623 2341 SEMA3E 7 82,946,973 2342 SEMA3E 7 82,970,533 2343 SEMA3E 7 83,029,806 2344 SEMA3E 7 83,047,248 2345 SEMA3E 7 83,061,152 2346 SEMA3E 7 83,125,543 2347 SEMA3A 7 83,697,056 2348 ABCB4 7 86,372,139 2349 ABCB4 7 86,868,839 2350 ABCB4 7 86,877,077 2351 ABCB4 7 86,883,520 2352 ABCB4 7 86,892,183 2353 ABCB4 7 86,897,339 2354 ABCB4 7 86,941,606 2355 ADAM22 7 87,441,679 2356 ADAM22 7 87,471,187 2357 ADAM22 7 87,471,440 2358 ADAM22 7 87,554,236 2359 ADAM22 7 87,557,024 2360 ADAM22 7 87,579,450 2361 ADAM22 7 87,606,110 2362 GTPBP10 7 89,357,529 2363 GTPBP10 7 89,852,344 2364 GTPBP10 7 89,857,773 2365 PPP1R9A 7 94,064,776 2366 PON1 7 94,266,443 2367 PPP1R9A 7 94,453,195 2368 PPP1R9A 7 94,534,075 2369 PPP1R9A 7 94,569,490 2370 PPP1R9A 7 94,607,167 2371 PPP1R9A 7 94,632,721 2372 PPP1R9A 7 94,632,764 2373 PPP1R9A 7 94,681,040 2374 PPP1R9A 7 94,681,285 2375 PPP1R9A 7 94,717,161 2376 PPP1R9A 7 94,733,892 2377 PPP1R9A 7 94,746,827 2378 PPP1R9A 7 94,747,598 2379 DYNC1I1 7 94,748,308 2380 PPP1R9A 7 94,759,427 2381 PON1 7 94,775,829 2382 PON1 7 94,776,193 2383 PON1 7 94,780,701 2384 DYNC1I1 7 94,786,218 2385 PON1 7 94,804,103 2386 DYNC1I1 7 95,242,508 2387 DYNC1I1 7 95,242,854 2388 DYNC1I1 7 95,242,972 2389 DYNC1I1 7 95,325,994 2390 DYNC1I1 7 95,369,751 2391 DYNC1I1 7 95,384,186 2392 DYNC1I1 7 95,451,958 2393 DYNC1I1 7 95,452,403 2394 DYNC1I1 7 95,503,995 2395 DYNC1I1 7 95,548,598 2396 DYNC1I1 7 95,556,260 2397 DYNC1I1 7 95,581,854 2398 ZNF3 7 99,024,937 2399 ZNF3 7 99,480,681 2400 CUX1 7 100,785,884 2401 EMID2 7 100,787,736 2402 EMID2 7 100,828,478 2403 CUX1 7 100,962,370 2404 CUX1 7 101,306,594 2405 CUX1 7 101,391,246 2406 CUX1 7 101,533,073 2407 CUX1 7 101,612,087 2408 CUX1 7 101,694,544 2409 CUX1 7 101,704,241 2410 CUX1 7 101,704,367 2411 KCND2 7 119,301,300 2412 KCND2 7 119,564,389 2413 KCND2 7 120,060,200 2414 KCND2 7 120,110,963 2415 KCND2 7 120,117,902 2416 KCND2 7 120,130,284 2417 KCND2 7 120,197,437 2418 KCND2 7 120,197,820 2419 CADPS2 7 121,805,395 2420 CADPS2 7 121,865,650 2421 CADPS2 7 122,066,038 2422 CADPS2 7 122,074,175 2423 CADPS2 7 122,146,928 2424 CADPS2 7 122,329,673 2425 CADPS2 7 122,329,881 2426 SLC13A1 7 122,523,202 2427 SLC13A1 7 122,572,907 2428 SLC13A1 7 122,585,872 2429 SLC13A1 7 122,587,919 2430 SLC13A1 7 122,596,470 2431 SLC13A1 7 122,613,192 2432 SLC13A1 7 122,631,110 2433 GRM8 7 125,769,933 2434 GRM8 7 125,816,605 2435 GRM8 7 125,837,771 2436 GRM8 7 125,855,816 2437 GRM8 7 125,871,585 2438 GRM8 7 125,879,584 2439 GRM8 7 125,888,362 2440 GRM8 7 126,095,504 2441 GRM8 7 126,114,635 2442 GRM8 7 126,156,034 2443 GRM8 7 126,159,625 2444 GRM8 7 126,163,369 2445 GRM8 7 126,167,389 2446 GRM8 7 126,170,542 2447 GRM8 7 126,216,753 2448 GRM8 7 126,295,139 2449 GRM8 7 126,299,256 2450 GRM8 7 126,521,407 2451 GRM8 7 126,552,824 2452 GRM8 7 126,623,193 2453 EXOC4 7 132,456,559 2454 EXOC4 7 132,476,956 2455 EXOC4 7 132,754,129 2456 EXOC4 7 132,754,657 2457 EXOC4 7 132,781,480 2458 EXOC4 7 132,788,184 2459 EXOC4 7 132,789,020 2460 EXOC4 7 132,797,614 2461 EXOC4 7 132,917,865 2462 EXOC4 7 132,953,563 2463 EXOC4 7 132,991,170 2464 EXOC4 7 132,996,175 2465 EXOC4 7 133,002,858 2466 EXOC4 7 133,045,046 2467 EXOC4 7 133,081,578 2468 EXOC4 7 133,240,386 2469 EXOC4 7 133,241,477 2470 EXOC4 7 133,246,042 2471 EXOC4 7 133,352,637 2472 EXOC4 7 133,378,037 2473 DGKI 7 136,578,863 2474 DGKI 7 136,726,387 2475 DGKI 7 136,730,489 2476 DGKI 7 136,757,487 2477 DGKI 7 136,769,909 2478 DGKI 7 136,770,651 2479 DGKI 7 136,772,491 2480 DGKI 7 136,782,783 2481 CREB3L2 7 137,343,428 2482 TBXAS1 7 138,950,079 2483 TBXAS1 7 139,135,304 2484 TBXAS1 7 139,225,646 2485 TBXAS1 7 139,311,144 2486 CNTNAP2 7 145,425,744 2487 CNTNAP2 7 145,431,076 2488 CNTNAP2 7 145,485,790 2489 CNTNAP2 7 145,686,573 2490 CNTNAP2 7 145,710,838 2491 CNTNAP2 7 145,724,542 2492 CNTNAP2 7 145,743,361 2493 CNTNAP2 7 145,865,999 2494 CNTNAP2 7 145,906,353 2495 CNTNAP2 7 146,204,639 2496 CNTNAP2 7 146,414,565 2497 CNTNAP2 7 146,671,711 2498 CNTNAP2 7 146,671,930 2499 CNTNAP2 7 146,689,924 2500 CNTNAP2 7 146,724,262 2501 CNTNAP2 7 146,762,507 2502 CNTNAP2 7 146,788,354 2503 CNTNAP2 7 146,795,593 2504 CNTNAP2 7 146,800,067 2505 CNTNAP2 7 146,816,270 2506 CNTNAP2 7 146,816,456 2507 CNTNAP2 7 147,669,284 2508 CNTNAP2 7 147,695,819 2509 CNTNAP2 7 147,712,266 2510 CNTNAP2 7 147,748,438 2511 CNTNAP2 7 147,749,182 2512 PTPRN2 7 156,566,641 2513 PTPRN2 7 156,598,397 2514 PTPRN2 7 157,007,427 2515 PTPRN2 7 157,007,523 2516 PTPRN2 7 157,017,352 2517 PTPRN2 7 157,044,149 2518 PTPRN2 7 157,149,210 2519 PTPRN2 7 157,175,770 2520 PTPRN2 7 157,421,786 2521 PTPRN2 7 157,499,807 2522 PTPRN2 7 157,511,759 2523 PTPRN2 7 157,609,674 2524 PTPRN2 7 157,619,954 2525 PTPRN2 7 157,621,221 2526 PTPRN2 7 157,662,662 2527 PTPRN2 7 157,875,149 2528 PTPRN2 7 157,904,553 2529 PTPRN2 7 157,908,408 2530 PTPRN2 7 157,919,551 2531 PTPRN2 7 157,920,856 2532 PTPRN2 7 157,973,350 2533 PTPRN2 7 158,015,477 2534 PTPRN2 7 158,029,235 2535 PTPRN2 7 158,077,879 2536 CSMD1 8 2,819,792 2537 CSMD1 8 2,849,233 2538 CSMD1 8 2,958,438 2539 CSMD1 8 3,207,377 2540 CSMD1 8 3,209,023 2541 CSMD1 8 3,209,202 2542 CSMD1 8 3,211,642 2543 CSMD1 8 3,213,631 2544 CSMD1 8 3,216,613 2545 CSMD1 8 3,230,805 2546 CSMD1 8 3,232,022 2547 CSMD1 8 3,232,222 2548 CSMD1 8 3,250,935 2549 CSMD1 8 3,275,090 2550 CSMD1 8 3,340,467 2551 MCPH1 8 6,266,787 2552 MCPH1 8 6,282,480 2553 MCPH1 8 6,288,880 2554 MCPH1 8 6,289,562 2555 MCPH1 8 6,290,919 2556 MCPH1 8 6,298,146 2557 MCPH1 8 6,306,930 2558 MCPH1 8 6,307,055 2559 MCPH1 8 6,307,171 2560 MCPH1 8 6,314,156 2561 MCPH1 8 6,314,682 2562 MCPH1 8 6,316,969 2563 MCPH1 8 6,357,338 2564 MCPH1 8 6,362,452 2565 MCPH1 8 6,373,849 2566 MCPH1 8 6,379,955 2567 MCPH1 8 6,407,942 2568 MCPH1 8 6,461,123 2569 MCPH1 8 6,461,154 2570 MCPH1 8 6,461,166 2571 MCPH1 8 6,466,450 2572 MCPH1 8 6,475,913 2573 MCPH1 8 6,475,985 2574 MCPH1 8 6,509,698 2575 DLC1 8 13,006,870 2576 DLC1 8 13,013,028 2577 DLC1 8 13,014,125 2578 DLC1 8 13,016,678 2579 SGCZ 8 13,962,387 2580 SGCZ 8 14,242,631 2581 SGCZ 8 14,247,697 2582 SGCZ 8 14,292,030 2583 SGCZ 8 14,303,019 2584 SGCZ 8 14,313,399 2585 SGCZ 8 14,316,760 2586 SGCZ 8 14,330,923 2587 SGCZ 8 14,351,624 2588 SGCZ 8 14,357,736 2589 SGCZ 8 14,362,495 2590 SGCZ 8 14,390,316 2591 SGCZ 8 14,390,686 2592 SGCZ 8 14,420,466 2593 SGCZ 8 14,594,583 2594 SGCZ 8 14,623,703 2595 SGCZ 8 14,915,797 2596 SGCZ 8 15,179,623 2597 SLC7A2 8 17,436,984 2598 SLC7A2 8 17,454,671 2599 SLC7A2 8 17,460,770 2600 SLC7A2 8 17,471,816 2601 SLC7A2 8 17,472,551 2602 PSD3 8 18,428,754 2603 PSD3 8 18,431,654 2604 PSD3 8 18,529,675 2605 PSD3 8 18,559,152 2606 PSD3 8 18,560,182 2607 PSD3 8 18,709,420 2608 PSD3 8 18,734,189 2609 PSD3 8 18,737,733 2610 PSD3 8 18,737,939 2611 PSD3 8 18,757,428 2612 PSD3 8 18,765,584 2613 PSD3 8 18,772,229 2614 PSD3 8 18,819,182 2615 PSD3 8 18,953,685 2616 ATP6V1B2 8 20,124,602 2617 ATP6V1B2 8 20,137,423 2618 GFRA2 8 21,554,368 2619 GFRA2 8 21,642,357 2620 XPO7 8 21,886,104 2621 XPO7 8 21,892,330 2622 XPO7 8 21,901,374 2623 XPO7 8 21,916,371 2624 XPO7 8 21,924,970 2625 PPP3CC 8 22,380,522 2626 PEBP4 8 22,632,507 2627 PEBP4 8 22,634,532 2628 PEBP4 8 22,648,953 2629 PEBP4 8 22,828,329 2630 PEBP4 8 22,842,095 2631 ENTPD4 8 23,415,906 2632 SLC25A37 8 23,453,211 2633 SLC25A37 8 23,454,180 2634 SLC25A37 8 23,471,600 2635 SLC25A37 8 23,490,677 2636 UNC5D 8 35,516,694 2637 UNC5D 8 35,526,631 2638 UNC5D 8 35,529,087 2639 UNC5D 8 35,531,300 2640 UNC5D 8 35,544,036 2641 UNC5D 8 35,574,119 2642 UNC5D 8 35,586,829 2643 UNC5D 8 35,752,828 2644 UNC5D 8 36,047,709 2645 SFRP1 8 41,244,318 2646 SFRP1 8 41,254,926 2647 SFRP1 8 41,256,599 2648 SFRP1 8 41,262,183 2649 SFRP1 8 41,276,396 2650 PRKDC 8 49,008,811 2651 SNTG1 8 50,996,988 2652 SNTG1 8 51,028,383 2653 SNTG1 8 51,082,766 2654 SNTG1 8 51,106,589 2655 SNTG1 8 51,127,991 2656 SNTG1 8 51,142,873 2657 SNTG1 8 51,234,566 2658 SNTG1 8 51,276,836 2659 SNTG1 8 51,289,749 2660 SNTG1 8 51,320,466 2661 SNTG1 8 51,329,479 2662 SNTG1 8 51,333,190 2663 SNTG1 8 51,557,371 2664 SNTG1 8 51,603,877 2665 SNTG1 8 51,605,982 2666 SNTG1 8 51,616,502 2667 SNTG1 8 51,620,897 2668 SNTG1 8 51,624,716 2669 SNTG1 8 51,624,769 2670 SNTG1 8 51,859,715 2671 SNTG1 8 51,888,421 2672 SNTG1 8 51,900,540 2673 LYN 8 56,987,448 2674 LYN 8 57,034,636 2675 LYN 8 57,039,314 2676 LYN 8 57,053,118 2677 LYN 8 57,054,784 2678 LYN 8 57,107,537 2679 LYN 8 57,108,529 2680 LYN 8 57,108,914 2681 LYN 8 57,110,114 2682 PLAG1 8 57,263,345 2683 TOX 8 59,972,394 2684 TOX 8 59,980,027 2685 TOX 8 60,043,593 2686 NKAIN3 8 63,450,713 2687 NKAIN3 8 63,461,008 2688 NKAIN3 8 63,496,176 2689 NKAIN3 8 63,498,893 2690 NKAIN3 8 63,502,193 2691 NKAIN3 8 63,552,090 2692 NKAIN3 8 63,555,581 2693 NKAIN3 8 63,557,252 2694 NKAIN3 8 63,608,657 2695 NKAIN3 8 63,649,765 2696 NKAIN3 8 63,651,711 2697 NKAIN3 8 63,659,439 2698 NKAIN3 8 63,662,642 2699 NKAIN3 8 63,670,367 2700 NKAIN3 8 63,692,734 2701 NKAIN3 8 63,693,165 2702 NKAIN3 8 63,711,876 2703 NKAIN3 8 63,750,511 2704 NKAIN3 8 63,781,261 2705 NKAIN3 8 63,821,921 2706 NKAIN3 8 63,822,189 2707 NKAIN3 8 63,825,859 2708 NKAIN3 8 63,862,125 2709 NKAIN3 8 63,868,884 2710 NKAIN3 8 63,897,057 2711 NKAIN3 8 63,900,353 2712 NKAIN3 8 63,930,295 2713 NKAIN3 8 63,935,531 2714 NKAIN3 8 63,936,341 2715 NKAIN3 8 63,989,029 2716 NKAIN3 8 63,994,228 2717 NKAIN3 8 64,008,938 2718 NKAIN3 8 64,011,110 2719 NKAIN3 8 64,020,373 2720 NKAIN3 8 64,030,047 2721 NKAIN3 8 64,033,505 2722 NKAIN3 8 64,056,708 2723 NKAIN3 8 64,068,304 2724 NKAIN3 8 64,084,956 2725 DEPDC2 8 69,043,977 2726 DEPDC2 8 69,121,712 2727 DEPDC2 8 69,176,372 2728 DEPDC2 8 69,176,632 2729 DEPDC2 8 69,207,400 2730 DEPDC2 8 69,208,963 2731 DEPDC2 8 69,209,296 2732 DEPDC2 8 69,269,021 2733 DEPDC2 8 69,308,908 2734 DEPDC2 8 69,314,054 2735 KCNB2 8 73,601,624 2736 KCNB2 8 73,614,029 2737 KCNB2 8 73,618,324 2738 KCNB2 8 73,628,966 2739 KCNB2 8 73,638,413 2740 KCNB2 8 73,651,827 2741 KCNB2 8 73,740,108 2742 KCNB2 8 73,742,670 2743 KCNB2 8 73,754,776 2744 KCNB2 8 73,762,984 2745 KCNB2 8 73,776,211 2746 KCNB2 8 73,780,051 2747 KCNB2 8 73,780,154 2748 KCNB2 8 73,798,241 2749 KCNB2 8 73,818,016 2750 KCNB2 8 73,821,159 2751 KCNB2 8 73,901,806 2752 KCNB2 8 73,975,854 2753 KCNB2 8 74,014,801 2754 KCNB2 8 74,026,549 2755 CRISPLD1 8 76,072,659 2756 CRISPLD1 8 76,086,655 2757 CRISPLD1 8 76,103,499 2758 CRISPLD1 8 76,109,250 2759 CRISPLD1 8 76,158,048 2760 CRISPLD1 8 76,167,652 2761 MMP16 8 89,112,004 2762 MMP16 8 89,163,898 2763 MMP16 8 89,276,696 2764 MMP16 8 89,337,659 2765 MMP16 8 89,358,861 2766 MMP16 8 89,399,547 2767 MMP16 8 89,413,738 2768 MMP16 8 89,414,303 2769 MMP16 8 89,421,430 2770 GRHL2 8 102,613,455 2771 GRHL2 8 102,617,910 2772 GRHL2 8 102,618,040 2773 GRHL2 8 102,690,095 2774 GRHL2 8 102,697,131 2775 GRHL2 8 102,718,857 2776 GRHL2 8 102,740,588 2777 GRHL2 8 102,746,981 2778 GRHL2 8 102,759,164 2779 GRHL2 8 102,769,504 2780 NCALD 8 102,777,547 2781 NCALD 8 102,812,988 2782 NCALD 8 102,868,670 2783 NCALD 8 102,903,699 2784 NCALD 8 102,907,196 2785 BAALC 8 104,238,041 2786 BAALC 8 104,265,315 2787 BAALC 8 104,271,601 2788 BAALC 8 104,319,015 2789 BAALC 8 104,325,901 2790 ZFPM2 8 106,413,317 2791 ZFPM2 8 106,488,930 2792 ZFPM2 8 106,504,399 2793 ZFPM2 8 106,505,157 2794 ZFPM2 8 106,507,154 2795 ZFPM2 8 106,507,756 2796 ZFPM2 8 106,530,047 2797 ZFPM2 8 106,794,362 2798 ZFPM2 8 106,800,179 2799 ZFPM2 8 106,801,553 2800 ZFPM2 8 106,824,935 2801 ZFPM2 8 106,828,892 2802 ZFPM2 8 106,847,240 2803 ZFPM2 8 106,864,559 2804 ZFPM2 8 106,880,858 2805 ZFPM2 8 106,880,874 2806 ZFPM2 8 106,888,057 2807 ZFPM2 8 106,910,116 2808 ZFPM2 8 106,922,815 2809 CSMD3 8 113,479,682 2810 CSMD3 8 113,505,578 2811 CSMD3 8 114,209,523 2812 CSMD3 8 114,259,566 2813 CSMD3 8 114,319,937 2814 CSMD3 8 114,458,866 2815 CSMD3 8 114,475,512 2816 CSMD3 8 114,519,694 2817 CSMD3 8 114,552,699 2818 SAMD12 8 119,448,826 2819 SAMD12 8 119,531,636 2820 SAMD12 8 119,532,372 2821 SAMD12 8 119,532,971 2822 SAMD12 8 119,536,976 2823 SAMD12 8 119,622,273 2824 SAMD12 8 119,669,482 2825 SAMD12 8 119,671,788 2826 SAMD12 8 119,676,462 2827 SAMD12 8 119,719,731 2828 SAMD12 8 119,740,378 2829 SAMD12 8 119,741,315 2830 FBXO32 8 124,583,159 2831 FBXO32 8 124,595,944 2832 FER1L6 8 125,020,334 2833 FER1L6 8 125,032,627 2834 FER1L6 8 125,053,616 2835 FER1L6 8 125,102,788 2836 FER1L6 8 125,108,933 2837 FER1L6 8 125,122,813 2838 FER1L6 8 125,123,546 2839 FER1L6 8 125,142,993 2840 FER1L6 8 125,144,097 2841 FER1L6 8 125,145,770 2842 FER1L6 8 125,147,531 2843 FER1L6 8 125,157,817 2844 FER1L6 8 125,158,437 2845 FER1L6 8 125,171,480 2846 FER1L6 8 125,186,054 2847 FER1L6 8 125,223,811 2848 MTSS1 8 125,643,333 2849 MTSS1 8 125,648,174 2850 MTSS1 8 125,649,171 2851 MTSS1 8 125,651,280 2852 MTSS1 8 125,669,999 2853 MTSS1 8 125,690,229 2854 MTSS1 8 125,700,462 2855 MTSS1 8 125,802,301 2856 MTSS1 8 125,954,015 2857 FAM84B 8 127,836,839 2858 DDEF1 8 131,125,920 2859 DDEF1 8 131,179,288 2860 DDEF1 8 131,199,776 2861 DDEF1 8 131,225,253 2862 DDEF1 8 131,236,230 2863 DDEF1 8 131,247,872 2864 DDEF1 8 131,254,886 2865 DDEF1 8 131,286,874 2866 DDEF1 8 131,296,201 2867 DDEF1 8 131,325,860 2868 DDEF1 8 131,350,781 2869 DDEF1 8 131,365,205 2870 DDEF1 8 131,373,060 2871 DDEF1 8 131,379,036 2872 DDEF1 8 131,394,209 2873 DDEF1 8 131,406,218 2874 DDEF1 8 131,407,018 2875 DDEF1 8 131,415,088 2876 DDEF1 8 131,415,248 2877 DDEF1 8 131,418,292 2878 DDEF1 8 131,423,273 2879 DDEF1 8 131,436,663 2880 DDEF1 8 131,465,743 2881 DDEF1 8 131,469,150 2882 DDEF1 8 131,480,431 2883 DDEF1 8 131,490,170 2884 ADCY8 8 131,862,883 2885 ADCY8 8 131,872,404 2886 ADCY8 8 131,876,740 2887 ADCY8 8 131,930,184 2888 ADCY8 8 131,958,850 2889 ADCY8 8 131,961,234 2890 ADCY8 8 131,972,316 2891 ADCY8 8 131,983,404 2892 ADCY8 8 131,985,500 2893 ADCY8 8 131,997,583 2894 ADCY8 8 132,016,683 2895 ADCY8 8 132,056,557 2896 ADCY8 8 132,057,791 2897 ADCY8 8 132,070,010 2898 ADCY8 8 132,071,996 2899 ADCY8 8 132,151,934 2900 KCNQ3 8 133,208,937 2901 KCNQ3 8 133,575,550 2902 ST3GAL1 8 134,608,818 2903 ST3GAL1 8 134,609,061 2904 ST3GAL1 8 134,610,724 2905 ST3GAL1 8 134,664,388 2906 ST3GAL1 8 134,664,414 2907 COL22A1 8 139,668,834 2908 COL22A1 8 139,744,740 2909 COL22A1 8 139,763,602 2910 COL22A1 8 139,770,391 2911 COL22A1 8 139,777,590 2912 COL22A1 8 139,834,014 2913 COL22A1 8 139,871,695 2914 COL22A1 8 139,901,545 2915 COL22A1 8 139,976,026 2916 COL22A1 8 139,980,721 2917 COL22A1 8 139,992,260 2918 COL22A1 8 139,992,787 2919 COL22A1 8 139,994,229 2920 ZC3H3 8 144,670,321 2921 ZC3H3 8 144,684,823 2922 SMARCA2 9 2,053,356 2923 SMARCA2 9 2,083,551 2924 SMARCA2 9 2,115,231 2925 SMARCA2 9 2,120,828 2926 SMARCA2 9 2,120,917 2927 SMARCA2 9 2,123,189 2928 SMARCA2 9 2,147,097 2929 SMARCA2 9 2,163,296 2930 SMARCA2 9 2,175,324 2931 SMARCA2 9 2,177,750 2932 SMARCA2 9 2,178,335 2933 SMARCA2 9 2,178,383 2934 SMARCA2 9 2,181,309 2935 SLC1A1 9 4,550,348 2936 SLC1A1 9 4,552,472 2937 SLC1A1 9 4,567,130 2938 SLC1A1 9 4,576,808 2939 PTPRD 9 8,283,622 2940 PTPRD 9 8,299,450 2941 PTPRD 9 8,365,585 2942 PTPRD 9 8,372,966 2943 PTPRD 9 8,389,766 2944 PTPRD 9 8,390,681 2945 PTPRD 9 8,393,640 2946 PTPRD 9 8,417,170 2947 PTPRD 9 8,418,856 2948 PTPRD 9 8,420,033 2949 PTPRD 9 8,420,742 2950 PTPRD 9 8,422,445 2951 PTPRD 9 8,423,160 2952 PTPRD 9 8,727,316 2953 PTPRD 9 8,728,267 2954 PTPRD 9 8,752,705 2955 PTPRD 9 8,764,062 2956 PTPRD 9 8,765,087 2957 ADAMTSL1 9 18,714,225 2958 ADAMTSL1 9 18,718,689 2959 KIAA1797 9 20,678,117 2960 KIAA1797 9 20,686,043 2961 KIAA1797 9 20,732,210 2962 KIAA1797 9 20,752,645 2963 KIAA1797 9 20,754,870 2964 KIAA1797 9 20,791,991 2965 KIAA1797 9 20,794,446 2966 KIAA1797 9 20,833,841 2967 KIAA1797 9 20,872,525 2968 KIAA1797 9 20,882,952 2969 KIAA1797 9 20,886,938 2970 KIAA1797 9 20,898,513 2971 KIAA1797 9 20,914,474 2972 KIAA1797 9 20,921,349 2973 KIAA1797 9 20,935,207 2974 KIAA1797 9 20,935,372 2975 KIAA1797 9 20,943,335 2976 KIAA1797 9 20,943,750 2977 KIAA1797 9 20,951,906 2978 KIAA1797 9 20,977,703 2979 KIAA1797 9 20,978,426 2980 KIAA1797 9 20,986,709 2981 KIAA1797 9 20,989,770 2982 IFT74 9 26,999,100 2983 IFT74 9 27,052,721 2984 IFT74 9 27,056,070 2985 IFT74 9 27,063,650 2986 TEK 9 27,129,817 2987 TEK 9 27,142,292 2988 TEK 9 27,142,308 2989 TEK 9 27,144,617 2990 TEK 9 27,175,101 2991 PIP5K1B 9 70,499,527 2992 PIP5K1B 9 70,515,001 2993 PIP5K1B 9 70,515,728 2994 PIP5K1B 9 70,520,963 2995 PIP5K1B 9 70,545,037 2996 PIP5K1B 9 70,670,116 2997 PIP5K1B 9 70,703,782 2998 PIP5K1B 9 70,811,920 2999 PIP5K1B 9 70,814,515 3000 APBA1 9 71,276,235 3001 APBA1 9 71,280,626 3002 APBA1 9 71,298,607 3003 APBA1 9 71,324,247 3004 APBA1 9 71,327,356 3005 APBA1 9 71,332,520 3006 APBA1 9 71,343,317 3007 APBA1 9 71,415,835 3008 MAMDC2 9 71,887,859 3009 MAMDC2 9 71,892,836 3010 MAMDC2 9 71,896,167 3011 MAMDC2 9 71,913,927 3012 MAMDC2 9 71,930,214 3013 MAMDC2 9 71,979,450 3014 MAMDC2 9 71,991,846 3015 MAMDC2 9 71,998,663 3016 MAMDC2 9 72,025,025 3017 MAMDC2 9 72,051,438 3018 MAMDC2 9 72,051,513 3019 MAMDC2 9 72,053,813 3020 TRPM3 9 72,346,211 3021 TRPM3 9 72,383,248 3022 TRPM3 9 72,384,667 3023 TRPM3 9 72,616,673 3024 TRPM3 9 72,617,325 3025 TRPM3 9 72,673,741 3026 TRPM3 9 72,946,351 3027 TMC1 9 74,339,851 3028 TMC1 9 74,345,877 3029 TMC1 9 74,363,736 3030 TMC1 9 74,379,155 3031 TMC1 9 74,383,637 3032 TMC1 9 74,415,525 3033 TMC1 9 74,434,104 3034 TMC1 9 74,470,431 3035 TMC1 9 74,485,413 3036 TMC1 9 74,507,002 3037 TMC1 9 74,507,694 3038 TMC1 9 74,537,387 3039 TMC1 9 74,555,746 3040 TMC1 9 74,558,826 3041 TMC1 9 74,574,594 3042 TMC1 9 74,579,921 3043 TMC1 9 74,701,976 3044 TRPM6 9 76,580,880 3045 TRPM6 9 76,604,375 3046 TRPM6 9 76,605,104 3047 TRPM6 9 76,616,041 3048 TRPM6 9 76,616,993 3049 TRPM6 9 76,617,856 3050 PCSK5 9 77,687,086 3051 PCSK5 9 77,798,692 3052 PCSK5 9 77,810,526 3053 PCSK5 9 77,824,856 3054 PCSK5 9 77,896,771 3055 PCSK5 9 77,897,682 3056 PCSK5 9 77,915,932 3057 PCSK5 9 77,932,517 3058 PCSK5 9 77,974,918 3059 GNAQ 9 79,595,252 3060 GNAQ 9 79,600,333 3061 GNAQ 9 79,659,567 3062 GNAQ 9 79,734,072 3063 GNAQ 9 79,809,631 3064 GNAQ 9 79,812,915 3065 GNAQ 9 79,845,641 3066 GNAQ 9 79,856,574 3067 GNAQ 9 79,868,777 3068 GNAQ 9 79,874,660 3069 GNAQ 9 79,908,815 3070 GNAQ 9 79,946,188 3071 NTRK2 9 86,464,568 3072 NTRK2 9 86,472,347 3073 NTRK2 9 86,479,100 3074 NTRK2 9 86,571,296 3075 NTRK2 9 86,577,727 3076 NTRK2 9 86,590,037 3077 NTRK2 9 86,598,770 3078 NTRK2 9 86,598,798 3079 NTRK2 9 86,599,187 3080 NTRK2 9 86,627,979 3081 DAPK1 9 89,356,618 3082 DAPK1 9 89,446,457 3083 DAPK1 9 89,510,774 3084 DAPK1 9 89,516,915 3085 SHC3 9 90,829,608 3086 DIRAS2 9 92,422,258 3087 DIRAS2 9 92,426,243 3088 DIRAS2 9 92,432,978 3089 NFIL3 9 93,218,808 3090 NFIL3 9 93,220,448 3091 NFIL3 9 93,276,485 3092 NFIL3 9 93,283,388 3093 NFIL3 9 93,286,276 3094 NFIL3 9 93,286,497 3095 NFIL3 9 93,286,593 3096 NFIL3 9 93,286,700 3097 ZNF169 9 96,102,802 3098 ZNF169 9 96,255,984 3099 HIATL1 9 96,261,255 3100 HIATL1 9 96,268,739 3101 GABBR2 9 100,095,943 3102 GABBR2 9 100,110,308 3103 GABBR2 9 100,111,343 3104 GABBR2 9 100,114,693 3105 GABBR2 9 100,116,448 3106 GABBR2 9 100,118,041 3107 GABBR2 9 100,429,660 3108 RP11-35N6.1 9 102,447,217 3109 RP11-35N6.1 9 102,472,272 3110 GRIN3A 9 103,636,342 3111 FKTN 9 107,402,666 3112 FKTN 9 107,449,221 3113 FKTN 9 107,449,435 3114 FKTN 9 107,449,527 3115 FKTN 9 107,455,377 3116 PALM2 9 111,500,859 3117 PALM2 9 111,531,505 3118 PALM2 9 111,545,842 3119 PALM2 9 111,552,566 3120 PALM2 9 111,555,049 3121 PALM2 9 111,985,226 3122 PALM2 9 111,985,595 3123 SVEP1 9 112,145,525 3124 SVEP1 9 112,152,393 3125 SVEP1 9 112,154,879 3126 SVEP1 9 112,166,117 3127 SVEP1 9 112,167,878 3128 SVEP1 9 112,395,423 3129 ZNF618 9 115,804,104 3130 ZNF618 9 115,820,286 3131 ZNF618 9 115,839,747 3132 ZNF618 9 115,840,427 3133 ZNF618 9 115,848,968 3134 ZNF618 9 115,862,471 3135 CDK5RAP2 9 122,190,274 3136 CDK5RAP2 9 122,245,733 3137 CDK5RAP2 9 122,247,523 3138 CDK5RAP2 9 122,341,167 3139 CDK5RAP2 9 122,362,134 3140 CDK5RAP2 9 122,370,634 3141 RAB14 9 123,011,433 3142 STOM 9 123,210,311 3143 DAB2IP 9 123,691,611 3144 TTLL11 9 123,780,890 3145 TTLL11 9 123,816,925 3146 TTLL11 9 123,894,371 3147 TTLL11 9 123,904,206 3148 TTLL11 9 123,908,883 3149 LHX6 9 124,033,326 3150 PTGS1 9 124,226,030 3151 RALGPS1 9 128,740,226 3152 RALGPS1 9 128,789,924 3153 RALGPS1 9 128,809,594 3154 RALGPS1 9 128,851,222 3155 RALGPS1 9 128,902,817 3156 RALGPS1 9 128,946,477 3157 RALGPS1 9 128,955,452 3158 RALGPS1 9 128,972,837 3159 RALGPS1 9 128,973,145 3160 RALGPS1 9 129,028,297 3161 SLC25A25 9 129,895,358 3162 SLC25A25 9 129,899,153 3163 FREQ 9 131,997,035 3164 EXOSC2 9 132,557,580 3165 ABL1 9 132,607,062 3166 EXOSC2 9 132,620,443 3167 ABL1 9 132,698,182 3168 ABL1 9 132,722,573 3169 ABL1 9 132,723,896 3170 ABL1 9 132,729,556 3171 ABL1 9 132,743,853 3172 ABL1 9 132,757,571 3173 NTNG2 9 134,032,706 3174 NTNG2 9 134,048,486 3175 NTNG2 9 134,061,758 3176 NTNG2 9 134,063,788 3177 NTNG2 9 134,063,884 3178 NTNG2 9 134,072,800 3179 TSC1 9 134,776,725 3180 TSC1 9 134,786,003 3181 TSC1 9 134,811,193 3182 TSC1 9 134,812,111 3183 VAV2 9 135,652,749 3184 VAV2 9 135,708,866 3185 VAV2 9 135,712,953 3186 VAV2 9 135,714,835 3187 VAV2 9 135,725,041 3188 VAV2 9 135,735,578 3189 VAV2 9 135,750,672 3190 VAV2 9 135,797,591 3191 VAV2 9 135,800,678 3192 VAV2 9 135,816,278 3193 OLFM1 9 137,163,836 3194 OLFM1 9 137,166,820 3195 KCNT1 9 137,739,699 3196 KCNT1 9 137,760,712 3197 KCNT1 9 137,761,268 3198 KCNT1 9 137,771,812 3199 KCNT1 9 137,780,294 3200 NOTCH1 9 138,588,006 3201 ABCA2 9 139,049,256 3202 NPDC1 9 139,079,674 3203 GRIN1 9 139,123,742 3204 PNPLA7 9 139,552,139 3205 CACNA1B 9 139,875,052 3206 CACNA1B 9 140,019,421 3207 CACNA1B 9 140,019,503 3208 CACNA1B 9 140,029,466 3209 CACNA1B 9 140,075,368 3210 CACNA1B 9 140,078,171 3211 CACNA1B 9 140,089,212 3212 CACNA1B 9 140,094,586 3213 CACNA1B 9 140,121,687 3214 PITRM1 10 3,173,747 3215 PITRM1 10 3,179,380 3216 PITRM1 10 3,181,527 3217 PITRM1 10 3,192,065 3218 PITRM1 10 3,196,365 3219 PITRM1 10 3,197,632 3220 PITRM1 10 3,198,140 3221 PITRM1 10 3,198,512 3222 PITRM1 10 3,209,794 3223 PITRM1 10 3,213,179 3224 PITRM1 10 3,782,844 3225 PITRM1 10 3,786,569 3226 PRKCQ 10 6,508,611 3227 PRKCQ 10 6,509,161 3228 PRKCQ 10 6,509,823 3229 PRKCQ 10 6,512,253 3230 PRKCQ 10 7,151,877 3231 CUGBP2 10 11,261,372 3232 CUGBP2 10 11,397,516 3233 CACNB2 10 18,499,288 3234 CACNB2 10 18,693,867 3235 CACNB2 10 18,737,688 3236 CACNB2 10 18,751,294 3237 CACNB2 10 18,756,352 3238 CACNB2 10 18,767,907 3239 CACNB2 10 18,781,800 3240 CACNB2 10 18,784,954 3241 CACNB2 10 18,850,680 3242 CACNB2 10 18,875,360 3243 ARMC3 10 23,192,732 3244 ARMC3 10 23,204,056 3245 ARMC3 10 23,243,088 3246 ARMC3 10 23,249,050 3247 ARMC3 10 23,264,868 3248 ARMC3 10 23,277,574 3249 ARMC3 10 23,289,115 3250 ARMC3 10 23,318,053 3251 ARMC3 10 23,337,258 3252 ARMC3 10 23,343,422 3253 ARHGAP21 10 24,973,706 3254 ARHGAP21 10 25,007,098 3255 ARHGAP21 10 25,017,790 3256 ARHGAP21 10 25,037,439 3257 ARHGAP21 10 25,046,553 3258 ARHGAP21 10 25,121,861 3259 MYO3A 10 26,224,703 3260 MYO3A 10 26,227,755 3261 MYO3A 10 26,246,862 3262 MYO3A 10 26,247,055 3263 MYO3A 10 26,247,564 3264 MYO3A 10 26,252,100 3265 MYO3A 10 26,265,542 3266 MYO3A 10 26,266,216 3267 MYO3A 10 26,326,995 3268 MYO3A 10 26,344,078 3269 MYO3A 10 26,350,685 3270 MYO3A 10 26,352,830 3271 MYO3A 10 26,355,103 3272 MYO3A 10 26,385,171 3273 MYO3A 10 26,389,693 3274 MYO3A 10 26,396,941 3275 MYO3A 10 26,398,640 3276 MYO3A 10 26,443,297 3277 MYO3A 10 26,473,372 3278 MYO3A 10 26,486,318 3279 MYO3A 10 26,499,719 3280 MYO3A 10 26,503,136 3281 MYO3A 10 26,503,593 3282 MYO3A 10 26,511,966 3283 MYO3A 10 26,523,271 3284 MYO3A 10 26,523,510 3285 MYO3A 10 26,524,160 3286 MYO3A 10 26,526,934 3287 MYO3A 10 26,552,050 3288 MYO3A 10 26,677,147 3289 MYO3A 10 26,679,306 3290 SLC16A9 10 61,084,017 3291 SLC16A9 10 61,120,938 3292 SLC16A9 10 61,122,758 3293 SLC16A9 10 61,177,020 3294 SLC16A9 10 61,178,790 3295 SLC16A9 10 61,187,929 3296 JMJD1C 10 64,732,014 3297 JMJD1C 10 64,761,165 3298 JMJD1C 10 64,771,213 3299 JMJD1C 10 64,778,162 3300 JMJD1C 10 64,791,571 3301 JMJD1C 10 64,792,793 3302 JMJD1C 10 64,873,814 3303 JMJD1C 10 64,917,025 3304 CDH23 10 72,828,713 3305 CDH23 10 72,997,429 3306 CDH23 10 73,084,016 3307 CDH23 10 73,104,912 3308 CDH23 10 73,171,562 3309 CDH23 10 73,192,700 3310 CDH23 10 73,209,936 3311 CDH23 10 73,211,015 3312 CDH23 10 73,214,092 3313 CDH23 10 73,228,958 3314 CDH23 10 73,236,209 3315 CDH23 10 73,251,566 3316 KCNMA1 10 78,240,799 3317 KCNMA1 10 78,297,136 3318 KCNMA1 10 78,300,503 3319 KCNMA1 10 78,319,405 3320 KCNMA1 10 78,324,802 3321 KCNMA1 10 78,337,197 3322 KCNMA1 10 78,348,173 3323 KCNMA1 10 78,426,444 3324 KCNMA1 10 78,426,609 3325 KCNMA1 10 78,446,565 3326 KCNMA1 10 78,616,033 3327 KCNMA1 10 78,626,486 3328 KCNMA1 10 78,738,696 3329 KCNMA1 10 78,738,970 3330 KCNMA1 10 78,756,964 3331 KCNMA1 10 78,757,037 3332 KCNMA1 10 78,794,600 3333 KCNMA1 10 79,033,394 3334 KCNMA1 10 79,073,940 3335 KCNMA1 10 79,094,637 3336 KCNMA1 10 79,162,833 3337 KCNMA1 10 79,168,796 3338 KCNMA1 10 79,176,445 3339 NRG3 10 84,078,553 3340 NRG3 10 84,136,852 3341 NRG3 10 84,197,554 3342 NRG3 10 84,479,001 3343 NRG3 10 84,479,024 3344 NRG3 10 84,487,647 3345 NRG3 10 84,604,364 3346 NRG3 10 84,613,706 3347 NRG3 10 84,616,939 3348 NRG3 10 84,679,040 3349 NRG3 10 84,680,434 3350 NRG3 10 84,681,866 3351 NRG3 10 84,683,470 3352 NRG3 10 84,688,185 3353 NRG3 10 84,820,632 3354 SORBS1 10 97,064,414 3355 SORBS1 10 97,075,121 3356 SORBS1 10 97,076,023 3357 SORBS1 10 97,095,565 3358 SORBS1 10 97,097,088 3359 SORBS1 10 97,109,583 3360 SORBS1 10 97,112,231 3361 SORBS1 10 97,112,420 3362 SORBS1 10 97,122,546 3363 SORBS1 10 97,122,783 3364 SORBS1 10 97,150,503 3365 SORBS1 10 97,200,805 3366 SORBS1 10 97,204,408 3367 SORBS1 10 97,216,419 3368 SORBS1 10 97,216,500 3369 SORBS1 10 97,329,428 3370 SORCS3 10 106,367,232 3371 SORCS3 10 106,371,034 3372 SORCS3 10 106,374,605 3373 SORCS3 10 106,590,333 3374 SORCS3 10 106,614,338 3375 SORCS3 10 106,636,964 3376 SORCS3 10 106,646,127 3377 SORCS3 10 106,664,021 3378 SORCS3 10 106,684,869 3379 SORCS3 10 106,684,970 3380 SORCS3 10 106,689,202 3381 SORCS3 10 106,701,972 3382 SORCS3 10 106,703,623 3383 SORCS3 10 106,784,111 3384 SORCS3 10 106,897,228 3385 SORCS3 10 106,906,037 3386 SORCS3 10 106,906,641 3387 SORCS3 10 106,935,226 3388 SORCS3 10 107,025,958 3389 VTI1A 10 114,212,444 3390 VTI1A 10 114,214,053 3391 VTI1A 10 114,214,492 3392 VTI1A 10 114,218,153 3393 VTI1A 10 114,226,855 3394 VTI1A 10 114,228,361 3395 VTI1A 10 114,404,784 3396 VTI1A 10 114,424,611 3397 VTI1A 10 114,426,056 3398 VTI1A 10 114,454,027 3399 VTI1A 10 114,465,945 3400 VTI1A 10 114,469,252 3401 VTI1A 10 114,471,012 3402 VTI1A 10 114,473,068 3403 VTI1A 10 114,489,994 3404 VTI1A 10 114,506,363 3405 VTI1A 10 114,508,308 3406 ATRNL1 10 116,818,582 3407 ATRNL1 10 116,818,761 3408 ATRNL1 10 116,826,992 3409 ATRNL1 10 117,051,783 3410 ATRNL1 10 117,186,878 3411 ATRNL1 10 117,208,818 3412 ATRNL1 10 117,226,168 3413 ATRNL1 10 117,257,300 3414 ATRNL1 10 117,342,514 3415 ATRNL1 10 117,348,932 3416 ATRNL1 10 117,350,294 3417 ATRNL1 10 117,404,353 3418 ATRNL1 10 117,429,854 3419 ATRNL1 10 117,485,967 3420 ATRNL1 10 117,697,723 3421 ATRNL1 10 117,743,056 3422 ATRNL1 10 117,761,145 3423 HSPA12A 10 118,432,901 3424 HSPA12A 10 118,434,753 3425 HSPA12A 10 118,438,068 3426 HSPA12A 10 118,446,140 3427 HSPA12A 10 118,463,943 3428 HSPA12A 10 118,527,758 3429 GRK5 10 120,961,454 3430 GRK5 10 121,055,451 3431 ATE1 10 123,426,686 3432 ATE1 10 123,427,443 3433 ATE1 10 123,432,831 3434 ATE1 10 123,440,223 3435 ATE1 10 123,450,896 3436 ATE1 10 123,491,722 3437 ATE1 10 123,491,947 3438 ATE1 10 123,521,812 3439 ATE1 10 123,529,351 3440 ATE1 10 123,529,439 3441 ATE1 10 123,531,179 3442 ATE1 10 123,531,856 3443 ATE1 10 123,539,198 3444 ATE1 10 123,546,416 3445 ATE1 10 123,604,845 3446 ATE1 10 123,644,015 3447 ATE1 10 123,648,608 3448 ATE1 10 123,651,712 3449 ATE1 10 123,663,196 3450 ATE1 10 123,666,737 3451 ATE1 10 123,669,674 3452 ATE1 10 123,697,603 3453 CTBP2 10 126,677,518 3454 CTBP2 10 127,123,254 3455 CTBP2 10 127,125,130 3456 CTBP2 10 127,127,898 3457 STIM1 11 3,847,536 3458 STIM1 11 3,867,621 3459 STIM1 11 3,915,404 3460 STIM1 11 3,927,655 3461 STIM1 11 3,931,164 3462 STIM1 11 3,949,530 3463 STIM1 11 3,949,807 3464 STIM1 11 3,960,254 3465 STIM1 11 4,033,624 3466 STIM1 11 4,042,105 3467 STIM1 11 4,085,062 3468 GALNTL4 11 11,222,747 3469 GALNTL4 11 11,228,193 3470 GALNTL4 11 11,246,167 3471 GALNTL4 11 11,497,136 3472 MICAL2 11 12,084,055 3473 MICAL2 11 12,092,180 3474 MICAL2 11 12,139,036 3475 MICAL2 11 12,142,872 3476 MICAL2 11 12,150,320 3477 MICAL2 11 12,156,032 3478 MICAL2 11 12,175,779 3479 MICAL2 11 12,191,280 3480 MICAL2 11 12,212,874 3481 MICAL2 11 12,222,118 3482 ARNTL 11 13,212,114 3483 ARNTL 11 13,212,547 3484 ARNTL 11 13,222,791 3485 ARNTL 11 13,231,816 3486 ARNTL 11 13,234,603 3487 ARNTL 11 13,249,824 3488 ARNTL 11 13,250,844 3489 ARNTL 11 13,262,887 3490 ARNTL 11 13,267,430 3491 ARNTL 11 13,274,540 3492 ARNTL 11 13,277,919 3493 ARNTL 11 13,302,169 3494 ARNTL 11 13,366,374 3495 ARNTL 11 13,366,419 3496 SPON1 11 13,877,677 3497 SPON1 11 13,922,920 3498 SPON1 11 13,990,100 3499 SPON1 11 13,994,054 3500 SPON1 11 14,004,879 3501 SPON1 11 14,005,230 3502 SPON1 11 14,005,260 3503 SPON1 11 14,008,775 3504 SPON1 11 14,014,762 3505 SPON1 11 14,014,854 3506 SPON1 11 14,023,125 3507 SPON1 11 14,034,087 3508 SPON1 11 14,058,326 3509 SPON1 11 14,070,335 3510 SPON1 11 14,075,677 3511 SPON1 11 14,115,440 3512 SPON1 11 14,169,786 3513 SPON1 11 14,215,231 3514 SPON1 11 14,248,953 3515 IGSF22 11 18,646,965 3516 NELL1 11 20,753,829 3517 KCNA4 11 30,011,330 3518 KCNA4 11 30,174,079 3519 C11ORF49 11 47,114,253 3520 C11ORF49 11 47,130,872 3521 C11ORF49 11 47,132,581 3522 C11ORF49 11 47,144,987 3523 81.99 mb 11 81,921,684 3524 81.99 mb 11 81,928,698 3525 81.99 mb 11 81,935,230 3526 DLG2 11 82,720,706 3527 DLG2 11 82,925,435 3528 DLG2 11 83,018,964 3529 DLG2 11 83,021,566 3530 DLG2 11 83,036,277 3531 DLG2 11 83,055,612 3532 DLG2 11 83,083,527 3533 DLG2 11 83,086,000 3534 DLG2 11 83,099,929 3535 DLG2 11 83,189,802 3536 DLG2 11 83,212,271 3537 DLG2 11 83,418,483 3538 DLG2 11 83,452,078 3539 DLG2 11 83,517,920 3540 DLG2 11 83,609,529 3541 DLG2 11 84,136,207 3542 DLG2 11 84,140,727 3543 DLG2 11 84,147,518 3544 DLG2 11 84,170,883 3545 DLG2 11 84,171,952 3546 DLG2 11 84,214,566 3547 DLG2 11 84,251,688 3548 DLG2 11 84,251,805 3549 DLG2 11 84,273,766 3550 DLG2 11 84,283,321 3551 DLG2 11 84,283,477 3552 DLG2 11 84,340,897 3553 DLG2 11 84,399,900 3554 DLG2 11 84,425,370 3555 DLG2 11 84,428,334 3556 ELMOD1 11 106,964,269 3557 ELMOD1 11 107,036,969 3558 ELMOD1 11 107,051,899 3559 ELMOD1 11 107,077,060 3560 OPCML 11 131,718,194 3561 OPCML 11 131,734,280 3562 OPCML 11 131,771,635 3563 OPCML 11 131,776,950 3564 OPCML 11 131,778,201 3565 OPCML 11 131,792,538 3566 OPCML 11 131,819,986 3567 OPCML 11 132,037,815 3568 OPCML 11 132,058,790 3569 OPCML 11 132,071,379 3570 OPCML 11 132,086,652 3571 OPCML 11 132,087,137 3572 OPCML 11 132,639,204 3573 OPCML 11 132,649,186 3574 OPCML 11 132,665,988 3575 OPCML 11 132,803,817 3576 OPCML 11 132,813,942 3577 OPCML 11 132,820,428 3578 OPCML 11 132,820,536 3579 OPCML 11 132,820,701 3580 OPCML 11 132,821,079 3581 OPCML 11 132,856,014 3582 OPCML 11 132,868,027 3583 OPCML 11 132,873,386 3584 OPCML 11 132,874,542 3585 OPCML 11 132,884,694 3586 OPCML 11 132,895,402 3587 OPCML 11 132,895,679 3588 OPCML 11 132,895,944 3589 OPCML 11 132,897,912 3590 WNT5B 12 1,617,734 3591 TSPAN9 12 3,065,463 3592 TSPAN9 12 3,216,860 3593 TSPAN9 12 3,258,265 3594 TSPAN9 12 3,310,366 3595 TSPAN9 12 3,331,863 3596 TMEM16B 12 5,505,585 3597 TMEM16B 12 5,507,133 3598 TMEM16B 12 5,694,683 3599 TMEM16B 12 5,697,894 3600 TMEM16B 12 5,704,425 3601 TMEM16B 12 5,711,994 3602 TMEM16B 12 5,717,063 3603 TMEM16B 12 5,793,894 3604 TMEM16B 12 5,870,387 3605 TMEM16B 12 5,892,756 3606 TMEM16B 12 5,894,743 3607 TMEM16B 12 5,900,666 3608 STYK1 12 10,665,965 3609 STYK1 12 10,666,462 3610 STYK1 12 10,667,780 3611 STYK1 12 10,673,382 3612 STYK1 12 10,676,279 3613 STYK1 12 10,696,179 3614 STYK1 12 10,697,767 3615 STYK1 12 10,708,924 3616 STYK1 12 10,711,189 3617 LOC729025 12 16,235,442 3618 LOC729025 12 16,236,368 3619 LOC729025 12 16,250,464 3620 LOC729025 12 16,264,150 3621 LOC729025 12 16,288,678 3622 LOC729025 12 16,297,957 3623 LOC729025 12 16,298,403 3624 LOC729025 12 16,302,981 3625 LOC729025 12 16,310,672 3626 LOC729025 12 16,319,824 3627 LOC729025 12 16,328,662 3628 LOC729025 12 16,328,782 3629 LOC729025 12 16,334,812 3630 LOC729025 12 16,384,311 3631 PIK3C2G 12 18,237,964 3632 PIK3C2G 12 18,274,187 3633 PIK3C2G 12 18,291,303 3634 PIK3C2G 12 18,301,821 3635 ITPR2 12 26,382,742 3636 ITPR2 12 26,383,105 3637 ITPR2 12 26,475,978 3638 ITPR2 12 26,476,845 3639 ITPR2 12 26,477,096 3640 ITPR2 12 26,624,329 3641 CNOT2 12 68,794,819 3642 CNOT2 12 68,819,144 3643 CNOT2 12 68,831,198 3644 CNOT2 12 68,841,926 3645 CNOT2 12 68,893,334 3646 CNOT2 12 68,960,922 3647 CNOT2 12 68,977,572 3648 CNOT2 12 69,001,757 3649 CNOT2 12 69,005,612 3650 CNOT2 12 69,015,087 3651 CNOT2 12 69,023,213 3652 CNOT2 12 69,026,461 3653 CNOT2 12 69,027,002 3654 CNOT2 12 69,063,143 3655 KCNC2 12 73,596,702 3656 KCNC2 12 73,597,602 3657 KCNC2 12 73,620,979 3658 KCNC2 12 73,625,557 3659 KCNC2 12 73,723,470 3660 KCNC2 12 73,877,027 3661 KCNC2 12 73,886,479 3662 KCNC2 12 73,898,155 3663 NAV3 12 76,718,256 3664 NAV3 12 76,748,290 3665 NAV3 12 76,793,282 3666 NAV3 12 76,798,556 3667 NAV3 12 76,817,706 3668 NAV3 12 76,824,819 3669 NAV3 12 76,839,838 3670 NAV3 12 76,845,308 3671 NAV3 12 76,847,522 3672 NAV3 12 76,854,382 3673 NAV3 12 76,862,517 3674 NAV3 12 76,872,382 3675 NAV3 12 76,891,682 3676 NAV3 12 77,014,895 3677 NAV3 12 77,064,747 3678 NAV3 12 77,070,387 3679 NAV3 12 77,126,330 3680 GAS2L3 12 99,495,794 3681 GAS2L3 12 99,498,724 3682 GAS2L3 12 99,519,980 3683 CHST11 12 103,426,320 3684 CHST11 12 103,448,913 3685 ATXN2 12 110,487,733 3686 ATXN2 12 110,547,258 3687 PLA2G1B 12 119,247,148 3688 MTIF3 13 26,895,999 3689 MTIF3 13 26,938,502 3690 MTIF3 13 26,939,055 3691 MTIF3 13 26,945,908 3692 MTIF3 13 26,979,535 3693 SLC46A3 13 28,207,069 3694 SLC46A3 13 28,267,317 3695 SLC46A3 13 28,270,443 3696 UBL3 13 29,334,889 3697 UBL3 13 29,360,712 3698 UBL3 13 29,362,035 3699 N4BP2L2 13 31,898,581 3700 N4BP2L2 13 31,915,043 3701 N4BP2L2 13 31,934,759 3702 N4BP2L2 13 32,021,516 3703 NBEA 13 33,950,130 3704 NBEA 13 34,391,285 3705 NBEA 13 34,694,247 3706 NBEA 13 34,706,182 3707 NBEA 13 34,784,368 3708 NBEA 13 34,784,675 3709 NBEA 13 34,835,455 3710 NBEA 13 34,844,029 3711 NBEA 13 34,878,006 3712 NBEA 13 34,964,578 3713 NBEA 13 34,969,786 3714 NBEA 13 34,979,260 3715 NBEA 13 34,980,142 3716 NBEA 13 34,988,680 3717 NBEA 13 35,037,473 3718 NBEA 13 35,070,282 3719 NBEA 13 35,086,809 3720 NBEA 13 35,087,894 3721 NBEA 13 35,112,563 3722 NBEA 13 35,118,281 3723 NBEA 13 35,130,015 3724 NBEA 13 35,142,667 3725 TRPC4 13 37,134,885 3726 TRPC4 13 37,148,211 3727 TRPC4 13 37,178,430 3728 TRPC4 13 37,187,961 3729 TRPC4 13 37,203,414 3730 TRPC4 13 37,247,236 3731 TRPC4 13 37,259,744 3732 TRPC4 13 37,343,288 3733 FNDC3A 13 48,210,811 3734 FNDC3A 13 48,211,076 3735 PCDH17 13 57,157,493 3736 PCDH17 13 57,209,470 3737 PCDH20 13 60,876,811 3738 PCDH20 13 60,884,919 3739 PCDH20 13 60,887,176 3740 LMO7 13 75,185,966 3741 LMO7 13 75,218,115 3742 LMO7 13 75,241,934 3743 LMO7 13 75,245,817 3744 LMO7 13 75,260,740 3745 LMO7 13 75,261,656 3746 LMO7 13 75,261,722 3747 LMO7 13 75,293,621 3748 LMO7 13 75,308,726 3749 LMO7 13 75,311,839 3750 LMO7 13 75,315,102 3751 LMO7 13 75,319,632 3752 LMO7 13 75,321,249 3753 LMO7 13 75,334,096 3754 SLAIN1 13 77,130,842 3755 SLAIN1 13 77,151,328 3756 SLAIN1 13 77,192,452 3757 SLAIN1 13 77,192,550 3758 SLAIN1 13 77,211,551 3759 SLAIN1 13 77,232,218 3760 SLAIN1 13 77,290,759 3761 GPC5 13 90,547,957 3762 GPC5 13 90,811,945 3763 GPC5 13 90,818,043 3764 GPC5 13 90,832,063 3765 GPC5 13 90,924,773 3766 GPC5 13 90,925,132 3767 GPC5 13 90,931,610 3768 GPC5 13 90,931,942 3769 GPC5 13 90,932,220 3770 GPC5 13 91,109,203 3771 GPC5 13 91,143,580 3772 GPC5 13 91,145,267 3773 GPC5 13 91,149,048 3774 GPC5 13 91,159,705 3775 GPC5 13 91,160,283 3776 GPC5 13 91,222,210 3777 GPC5 13 91,293,729 3778 GPC5 13 91,346,842 3779 GPC5 13 91,356,566 3780 GPC5 13 91,382,163 3781 GPC5 13 91,389,873 3782 GPC5 13 91,399,197 3783 GPC5 13 92,117,688 3784 GPC5 13 92,117,738 3785 GPC5 13 92,121,270 3786 GPC5 13 92,164,430 3787 GPC5 13 92,275,844 3788 GPC5 13 92,310,485 3789 GPC5 13 92,332,949 3790 GPC5 13 92,347,342 3791 GPC5 13 92,354,245 3792 GPC5 13 92,362,008 3793 GPC6 13 92,673,304 3794 GPC6 13 92,693,343 3795 GPC6 13 92,712,064 3796 GPC6 13 92,775,697 3797 GPC6 13 92,805,108 3798 GPC6 13 92,807,207 3799 GPC6 13 92,807,479 3800 GPC6 13 92,807,544 3801 GPC6 13 92,809,170 3802 GPC6 13 92,916,576 3803 GPC6 13 93,081,095 3804 GPC6 13 93,088,009 3805 GPC6 13 93,091,677 3806 GPC6 13 93,115,588 3807 GPC6 13 93,183,430 3808 GPC6 13 93,185,878 3809 GPC6 13 93,196,895 3810 GPC6 13 93,196,981 3811 GPC6 13 93,235,896 3812 GPC6 13 93,340,807 3813 GPC6 13 93,341,695 3814 GPC6 13 93,416,682 3815 GPC6 13 93,417,250 3816 GPC6 13 93,430,821 3817 GPC6 13 93,434,569 3818 GPC6 13 93,497,436 3819 GPC6 13 93,540,169 3820 GPC6 13 93,667,409 3821 GPC6 13 93,668,359 3822 GPC6 13 93,851,561 3823 NALCN 13 100,517,778 3824 NALCN 13 100,522,814 3825 NALCN 13 100,523,120 3826 NALCN 13 100,535,252 3827 NALCN 13 100,611,732 3828 NALCN 13 100,681,085 3829 NALCN 13 100,688,436 3830 NALCN 13 100,690,246 3831 NALCN 13 100,700,656 3832 NALCN 13 100,766,311 3833 NALCN 13 100,774,404 3834 NALCN 13 100,777,500 3835 NALCN 13 100,849,091 3836 NALCN 13 100,853,208 3837 NALCN 13 100,906,309 3838 ITGBL1 13 100,939,679 3839 ITGBL1 13 100,956,004 3840 ITGBL1 13 100,973,899 3841 ITGBL1 13 101,003,300 3842 ITGBL1 13 101,022,894 3843 ITGBL1 13 101,028,277 3844 ITGBL1 13 101,066,640 3845 ITGBL1 13 101,070,551 3846 ITGBL1 13 101,075,206 3847 ITGBL1 13 101,088,453 3848 ITGBL1 13 101,144,060 3849 ITGBL1 13 101,163,997 3850 ITGBL1 13 101,164,826 3851 ITGBL1 13 101,165,404 3852 ITGBL1 13 101,165,489 3853 WDR23 14 23,656,673 3854 WDR23 14 23,664,573 3855 WDR23 14 23,671,158 3856 NOVA1 14 26,027,844 3857 NOVA1 14 26,060,196 3858 NOVA1 14 26,107,933 3859 NOVA1 14 26,129,186 3860 NOVA1 14 26,159,322 3861 NOVA1 14 26,193,254 3862 NOVA1 14 26,201,964 3863 NOVA1 14 26,210,860 3864 NPAS3 14 32,658,581 3865 NPAS3 14 32,661,665 3866 NPAS3 14 32,777,738 3867 NPAS3 14 32,782,805 3868 NPAS3 14 32,887,201 3869 NPAS3 14 32,887,304 3870 NPAS3 14 32,894,144 3871 NPAS3 14 32,983,731 3872 NPAS3 14 33,099,951 3873 NPAS3 14 33,099,995 3874 NPAS3 14 33,192,243 3875 NPAS3 14 33,192,848 3876 NPAS3 14 33,200,625 3877 NPAS3 14 33,206,451 3878 SLC25A21 14 36,227,370 3879 SLC25A21 14 36,242,267 3880 SLC25A21 14 36,246,679 3881 SLC25A21 14 36,406,723 3882 SLC25A21 14 36,411,454 3883 SLC25A21 14 36,411,583 3884 SLC25A21 14 36,419,219 3885 SLC25A21 14 36,419,536 3886 SLC25A21 14 36,557,939 3887 SLC25A21 14 36,558,759 3888 SLC25A21 14 36,657,448 3889 SLC25A21 14 36,664,123 3890 SLC25A21 14 36,727,597 3891 LRFN5 14 41,011,370 3892 LRFN5 14 41,019,623 3893 LRFN5 14 41,023,512 3894 LRFN5 14 41,066,681 3895 LRFN5 14 41,246,521 3896 LRFN5 14 41,252,963 3897 LRFN5 14 41,299,858 3898 LRFN5 14 41,357,595 3899 LRFN5 14 41,372,302 3900 LRFN5 14 41,379,353 3901 LRFN5 14 41,384,489 3902 LRFN5 14 41,388,962 3903 LRFN5 14 41,389,331 3904 LRFN5 14 41,484,830 3905 GNG2 14 51,340,131 3906 GNG2 14 51,340,221 3907 GNG2 14 51,402,742 3908 GNG2 14 51,409,101 3909 GNG2 14 51,428,644 3910 SAMD4A 14 54,111,220 3911 SAMD4A 14 54,112,365 3912 SAMD4A 14 54,113,270 3913 SAMD4A 14 54,319,095 3914 SAMD4A 14 54,327,340 3915 SAMD4A 14 54,335,279 3916 SAMD4A 14 54,335,321 3917 SAMD4A 14 54,373,811 3918 SAMD4A 14 54,375,990 3919 SAMD4A 14 54,376,207 3920 PPP2R5E 14 62,856,493 3921 PPP2R5E 14 62,858,991 3922 PPP2R5E 14 62,949,791 3923 PPP2R5E 14 62,985,912 3924 PPP2R5E 14 62,986,716 3925 PPP2R5E 14 63,014,544 3926 PPP2R5E 14 63,044,719 3927 PPP2R5E 14 63,091,961 3928 PPP2R5E 14 63,099,534 3929 PPP2R5E 14 63,213,578 3930 RGS6 14 71,459,842 3931 RGS6 14 71,461,797 3932 RGS6 14 71,524,688 3933 RGS6 14 71,527,435 3934 RGS6 14 71,532,362 3935 RGS6 14 71,532,447 3936 RGS6 14 71,730,259 3937 RGS6 14 71,789,160 3938 RGS6 14 71,802,071 3939 RGS6 14 71,806,722 3940 RGS6 14 71,850,274 3941 RGS6 14 71,868,756 3942 RGS6 14 71,872,419 3943 RGS6 14 71,886,146 3944 RGS6 14 71,886,379 3945 RGS6 14 71,889,437 3946 RGS6 14 71,896,348 3947 RGS6 14 71,903,671 3948 RGS6 14 71,904,219 3949 RGS6 14 71,907,687 3950 RGS6 14 71,921,862 3951 RGS6 14 71,922,573 3952 RGS6 14 71,925,692 3953 RGS6 14 72,020,234 3954 RGS6 14 72,129,058 3955 NRXN3 14 77,481,947 3956 NRXN3 14 79,336,370 3957 NRXN3 14 79,340,786 3958 NRXN3 14 79,343,602 3959 NRXN3 14 79,403,317 3960 KCNK10 14 87,720,759 3961 KCNK10 14 87,768,396 3962 KCNK10 14 87,843,799 3963 KCNK10 14 87,846,012 3964 KCNK10 14 87,874,519 3965 KCNK10 14 87,881,781 3966 KCNK10 14 87,887,777 3967 KCNK13 14 89,669,023 3968 KCNK13 14 89,728,563 3969 KCNK13 14 89,740,891 3970 PSMC1 14 89,806,078 3971 PSMC1 14 89,810,027 3972 RPS6KA5 14 90,431,677 3973 RPS6KA5 14 90,501,524 3974 RPS6KA5 14 90,502,182 3975 RPS6KA5 14 90,527,909 3976 RPS6KA5 14 90,536,260 3977 RPS6KA5 14 90,572,871 3978 RPS6KA5 14 90,600,783 3979 RPS6KA5 14 90,600,927 3980 RPS6KA5 14 90,616,889 3981 CCDC88C 14 90,843,247 3982 CCDC88C 14 90,864,783 3983 CCDC88C 14 90,916,433 3984 CCDC88C 14 90,918,598 3985 CCDC88C 14 90,919,949 3986 CCDC88C 14 90,920,049 3987 CCDC88C 14 90,960,430 3988 CCDC88C 14 90,966,287 3989 ATXN3 14 91,603,867 3990 ATXN3 14 91,606,712 3991 ATXN3 14 91,610,714 3992 ATXN3 14 91,610,975 3993 ATXN3 14 91,611,093 3994 ATXN3 14 91,618,538 3995 ATXN3 14 91,621,082 3996 ATXN3 14 91,621,815 3997 ATXN3 14 91,621,825 3998 BCL11B 14 98,713,688 3999 BCL11B 14 98,742,719 4000 BCL11B 14 98,746,376 4001 BCL11B 14 98,757,526 4002 BCL11B 14 98,765,857 4003 BCL11B 14 98,816,027 4004 MAGEL2 15 21,460,719 4005 ATP10A 15 23,469,206 4006 ATP10A 15 23,471,534 4007 ATP10A 15 23,474,886 4008 ATP10A 15 23,476,768 4009 ATP10A 15 23,478,440 4010 ATP10A 15 23,486,252 4011 ATP10A 15 23,486,388 4012 ATP10A 15 23,493,398 4013 ATP10A 15 23,496,935 4014 ATP10A 15 23,497,677 4015 ATP10A 15 23,498,058 4016 ATP10A 15 23,504,535 4017 ATP10A 15 23,825,206 4018 RYR3 15 31,385,694 4019 RYR3 15 31,386,142 4020 RYR3 15 31,397,903 4021 RYR3 15 31,406,234 4022 RYR3 15 31,410,065 4023 RYR3 15 31,424,553 4024 RYR3 15 31,507,982 4025 RYR3 15 31,661,043 4026 RYR3 15 31,701,532 4027 RYR3 15 31,707,341 4028 RYR3 15 31,716,682 4029 RYR3 15 31,741,944 4030 RYR3 15 31,744,674 4031 RYR3 15 31,750,983 4032 RYR3 15 31,815,285 4033 RYR3 15 31,899,901 4034 RYR3 15 31,900,545 4035 RYR3 15 31,922,164 4036 RYR3 15 31,926,584 4037 C15ORF41 15 34,692,069 4038 C15ORF41 15 34,733,595 4039 C15ORF41 15 34,791,082 4040 C15ORF41 15 34,796,937 4041 C15ORF41 15 34,833,829 4042 C15ORF41 15 34,863,762 4043 C15ORF41 15 34,863,820 4044 C15ORF41 15 34,890,144 4045 C15ORF41 15 34,901,333 4046 C15ORF41 15 34,901,385 4047 C15ORF41 15 34,902,489 4048 MEIS2 15 34,979,253 4049 MEIS2 15 35,010,253 4050 MEIS2 15 35,073,394 4051 RASGRP1 15 36,581,858 4052 RASGRP1 15 36,689,768 4053 RASGRP1 15 36,707,739 4054 RASGRP1 15 37,051,959 4055 GLDN 15 49,444,605 4056 GLDN 15 49,450,678 4057 GLDN 15 49,457,033 4058 GLDN 15 49,457,768 4059 GLDN 15 49,459,928 4060 GLDN 15 49,460,922 4061 GLDN 15 49,461,033 4062 GLDN 15 49,477,064 4063 GLDN 15 49,481,784 4064 KIAA1370 15 50,717,008 4065 KIAA1370 15 50,742,531 4066 KIAA1370 15 50,746,979 4067 CGNL1 15 55,403,598 4068 CGNL1 15 55,423,011 4069 CGNL1 15 55,516,581 4070 CGNL1 15 55,518,865 4071 CGNL1 15 55,520,686 4072 CGNL1 15 55,521,306 4073 CGNL1 15 55,527,416 4074 CGNL1 15 55,627,080 4075 CGNL1 15 55,627,123 4076 CGNL1 15 55,632,176 4077 CGNL1 15 55,633,731 4078 RORA 15 58,605,378 4079 RORA 15 58,680,723 4080 RORA 15 58,710,721 4081 RORA 15 58,718,548 4082 RORA 15 58,721,610 4083 RORA 15 59,614,183 4084 CLK3 15 72,697,052 4085 CLK3 15 72,702,941 4086 CLK3 15 72,707,585 4087 CLK3 15 72,727,323 4088 TBC1D2B 15 75,981,714 4089 TBC1D2B 15 76,076,030 4090 TBC1D2B 15 76,083,890 4091 TBC1D2B 15 76,096,608 4092 TBC1D2B 15 76,098,398 4093 TBC1D2B 15 76,121,710 4094 TBC1D2B 15 76,124,994 4095 TBC1D2B 15 76,150,830 4096 TBC1D2B 15 76,157,798 4097 TBC1D2B 15 76,168,715 4098 TBC1D2B 15 76,170,084 4099 ARNT2 15 78,539,124 4100 ARNT2 15 78,542,039 4101 ARNT2 15 78,566,813 4102 ARNT2 15 78,700,178 4103 ARNT2 15 78,704,322 4104 ARNT2 15 78,713,205 4105 ARNT2 15 78,718,605 4106 SH3GL3 15 81,924,484 4107 SH3GL3 15 82,039,470 4108 SH3GL3 15 82,089,602 4109 PCSK6 15 99,687,851 4110 PCSK6 15 99,842,741 4111 PCSK6 15 99,970,111 4112 A2BP1 16 6,521,767 4113 A2BP1 16 6,523,126 4114 A2BP1 16 6,526,273 4115 A2BP1 16 6,528,853 4116 A2BP1 16 6,531,472 4117 A2BP1 16 6,676,476 4118 A2BP1 16 6,691,358 4119 A2BP1 16 6,963,875 4120 A2BP1 16 6,970,310 4121 A2BP1 16 6,974,269 4122 A2BP1 16 6,980,934 4123 A2BP1 16 7,223,623 4124 A2BP1 16 7,223,826 4125 A2BP1 16 7,224,553 4126 A2BP1 16 7,226,822 4127 A2BP1 16 7,234,640 4128 A2BP1 16 7,247,111 4129 A2BP1 16 7,253,357 4130 A2BP1 16 7,435,187 4131 A2BP1 16 7,551,379 4132 A2BP1 16 7,556,763 4133 A2BP1 16 7,560,608 4134 A2BP1 16 7,629,108 4135 A2BP1 16 7,630,072 4136 A2BP1 16 7,632,187 4137 A2BP1 16 7,633,275 4138 A2BP1 16 7,700,000 4139 TMC5 16 19,254,444 4140 TMC5 16 19,311,395 4141 TMC5 16 19,321,487 4142 TMC5 16 19,413,314 4143 GDE1 16 19,455,004 4144 EEF2K 16 22,107,225 4145 EEF2K 16 22,114,775 4146 EEF2K 16 22,169,198 4147 EEF2K 16 22,170,015 4148 EEF2K 16 22,249,604 4149 KIFC3 16 56,410,585 4150 HYDIN 16 69,818,152 4151 WWOX 16 76,643,771 4152 WWOX 16 76,655,506 4153 WWOX 16 76,672,696 4154 WWOX 16 76,673,124 4155 WWOX 16 76,674,781 4156 WWOX 16 76,691,956 4157 WWOX 16 77,016,847 4158 WWOX 16 77,024,259 4159 WWOX 16 77,041,675 4160 WWOX 16 77,045,378 4161 PLCG2 16 80,379,032 4162 MPHOSPH6 16 80,705,905 4163 MPHOSPH6 16 80,722,907 4164 MPHOSPH6 16 80,723,078 4165 MPHOSPH6 16 80,728,226 4166 MPHOSPH6 16 80,728,868 4167 MPHOSPH6 16 80,737,839 4168 MPHOSPH6 16 80,744,073 4169 MPHOSPH6 16 80,750,997 4170 MPHOSPH6 16 80,757,604 4171 MPHOSPH6 16 80,759,877 4172 MPHOSPH6 16 80,765,783 4173 MPHOSPH6 16 80,787,893 4174 MPHOSPH6 16 80,815,052 4175 MPHOSPH6 16 80,815,095 4176 MPHOSPH6 16 80,817,367 4177 MPHOSPH6 16 80,820,057 4178 MPHOSPH6 16 80,831,050 4179 MPHOSPH6 16 80,831,708 4180 MPHOSPH6 16 80,833,378 4181 MPHOSPH6 16 80,833,755 4182 CDH13 16 81,340,088 4183 CDH13 16 81,348,352 4184 CDH13 16 81,374,752 4185 CDH13 16 81,380,017 4186 CDH13 16 81,390,450 4187 CDH13 16 81,443,634 4188 CDH13 16 81,464,521 4189 CDH13 16 81,470,072 4190 CDH13 16 81,813,878 4191 CDH13 16 81,884,064 4192 CDH13 16 81,887,115 4193 CDH13 16 81,888,111 4194 CDH13 16 81,898,337 4195 CDH13 16 81,899,890 4196 CDH13 16 81,917,154 4197 CDH13 16 81,919,816 4198 CDH13 16 81,925,901 4199 CDH13 16 81,931,464 4200 CDH13 16 81,933,244 4201 CDH13 16 82,194,302 4202 CDH13 16 82,357,323 4203 CDH13 16 82,394,233 4204 CDH13 16 82,410,620 4205 CDH13 16 82,420,137 4206 USP10 16 83,305,397 4207 USP10 16 83,311,158 4208 USP10 16 83,325,736 4209 USP10 16 83,328,544 4210 USP10 16 83,331,937 4211 USP10 16 83,371,654 4212 CRISPLD2 16 83,443,531 4213 CRISPLD2 16 83,475,493 4214 CRISPLD2 16 83,480,748 4215 CRISPLD2 16 83,495,998 4216 CRISPLD2 16 83,497,517 4217 CRISPLD2 16 83,540,736 4218 ALOX12B 17 7,981,019 4219 GAS7 17 9,808,904 4220 DNAH9 17 11,444,122 4221 DNAH9 17 11,650,220 4222 DNAH9 17 11,662,069 4223 DNAH9 17 11,715,142 4224 RAB11FIP4 17 26,746,745 4225 RAB11FIP4 17 27,005,299 4226 CA10 17 47,089,473 4227 CA10 17 47,092,582 4228 CA10 17 47,092,738 4229 CA10 17 47,098,311 4230 CA10 17 47,099,992 4231 CA10 17 47,382,993 4232 CA10 17 47,412,115 4233 CA10 17 47,427,244 4234 CA10 17 47,434,848 4235 CA10 17 47,435,142 4236 CA10 17 47,453,436 4237 CA10 17 47,528,183 4238 CA10 17 47,531,938 4239 CA10 17 47,547,164 4240 CA10 17 47,566,855 4241 CA10 17 47,599,744 4242 CA10 17 47,674,724 4243 CA10 17 47,675,666 4244 CA10 17 48,115,311 4245 CA10 17 48,122,155 4246 CA10 17 48,191,994 4247 CA10 17 48,209,418 4248 CA10 17 48,233,607 4249 CA10 17 48,242,213 4250 CA10 17 48,243,428 4251 CA10 17 48,264,257 4252 CA10 17 48,275,354 4253 CA10 17 48,292,028 4254 CA10 17 48,292,853 4255 MSI2 17 52,558,314 4256 MSI2 17 52,773,732 4257 MSI2 17 52,817,244 4258 MSI2 17 53,002,826 4259 MSI2 17 53,007,065 4260 MSI2 17 53,093,648 4261 CACNG4 17 62,462,327 4262 SDK2 17 68,829,410 4263 SDK2 17 68,954,425 4264 DNAH17 17 73,942,963 4265 DNAH17 17 73,950,638 4266 DNAH17 17 73,950,704 4267 DNAH17 17 73,954,236 4268 DNAH17 17 73,990,984 4269 DNAH17 17 74,017,503 4270 DNAH17 17 74,071,124 4271 HRNBP3 17 74,776,568 4272 HRNBP3 17 74,845,144 4273 HRNBP3 17 74,857,410 4274 HRNBP3 17 75,313,214 4275 TGIF1 18 3,319,448 4276 DLGAP1 18 3,829,680 4277 DLGAP1 18 3,838,826 4278 DLGAP1 18 3,840,002 4279 DLGAP1 18 3,927,944 4280 ZFP161 18 5,251,246 4281 ZFP161 18 5,269,052 4282 ZFP161 18 5,280,198 4283 ZFP161 18 5,283,943 4284 ZFP161 18 5,284,323 4285 ZFP161 18 5,398,997 4286 ZFP161 18 5,399,208 4287 PTPRM 18 7,523,566 4288 PTPRM 18 7,563,510 4289 PTPRM 18 7,571,167 4290 PTPRM 18 7,585,927 4291 PTPRM 18 7,598,911 4292 PTPRM 18 7,599,137 4293 PTPRM 18 7,892,147 4294 PTPRM 18 8,000,444 4295 PTPRM 18 8,040,886 4296 PTPRM 18 8,042,261 4297 PTPRM 18 8,059,868 4298 PTPRM 18 8,068,553 4299 PTPRM 18 8,086,608 4300 PTPRM 18 8,087,133 4301 PTPRM 18 8,288,088 4302 PTPRM 18 8,288,633 4303 PTPRM 18 8,377,680 4304 KIAA0802 18 8,839,087 4305 KIAA0802 18 8,840,062 4306 KIAA0802 18 8,844,132 4307 KIAA0802 18 8,884,977 4308 OSBPL1A 18 20,006,364 4309 OSBPL1A 18 20,042,294 4310 OSBPL1A 18 20,093,929 4311 CHST9 18 22,804,050 4312 CHST9 18 22,854,839 4313 CHST9 18 22,874,628 4314 CHST9 18 22,886,548 4315 CHST9 18 22,965,754 4316 CHST9 18 23,010,213 4317 CHST9 18 23,012,354 4318 LOXHD1 18 42,342,838 4319 LOXHD1 18 42,382,501 4320 NEDD4L 18 54,010,852 4321 NEDD4L 18 54,013,845 4322 NEDD4L 18 54,039,159 4323 NEDD4L 18 54,047,200 4324 NEDD4L 18 54,095,115 4325 NEDD4L 18 54,100,941 4326 NEDD4L 18 54,155,894 4327 NEDD4L 18 54,165,956 4328 NEDD4L 18 54,173,333 4329 NEDD4L 18 54,179,311 4330 NEDD4L 18 54,188,829 4331 NEDD4L 18 54,202,520 4332 NEDD4L 18 54,202,587 4333 NEDD4L 18 54,238,628 4334 NEDD4L 18 54,250,387 4335 NEDD4L 18 54,259,246 4336 CCBE1 18 55,220,303 4337 CCBE1 18 55,241,702 4338 CCBE1 18 55,332,724 4339 CCBE1 18 55,333,626 4340 CCBE1 18 55,372,586 4341 CCBE1 18 55,372,710 4342 CCBE1 18 55,372,725 4343 CCBE1 18 55,375,168 4344 CCBE1 18 55,377,089 4345 CCBE1 18 55,494,237 4346 CCBE1 18 55,507,128 4347 CCBE1 18 55,510,412 4348 CDH20 18 57,031,422 4349 CDH7 18 61,289,294 4350 CDH7 18 61,305,341 4351 CDH7 18 61,305,944 4352 CDH7 18 61,316,783 4353 CDH7 18 61,469,322 4354 CDH7 18 61,566,553 4355 CDH7 18 61,586,240 4356 CDH7 18 61,590,121 4357 CDH7 18 61,595,280 4358 CDH7 18 61,595,696 4359 CDH7 18 61,626,782 4360 CDH7 18 61,668,497 4361 CDH7 18 61,690,373 4362 CDH7 18 61,691,931 4363 CDH7 18 61,693,003 4364 CDH7 18 61,697,352 4365 CDH7 18 61,697,973 4366 CDH7 18 61,716,015 4367 CDH7 18 61,716,853 4368 CDH7 18 61,736,852 4369 CDH7 18 61,739,825 4370 TXNDC10 18 64,477,750 4371 TXNDC10 18 64,483,360 4372 TXNDC10 18 64,483,488 4373 TXNDC10 18 64,536,945 4374 DOK6 18 65,224,346 4375 DOK6 18 65,312,795 4376 DOK6 18 65,312,915 4377 DOK6 18 65,324,331 4378 DOK6 18 65,437,835 4379 DOK6 18 65,452,233 4380 DOK6 18 65,453,592 4381 DOK6 18 65,637,817 4382 DOK6 18 65,649,653 4383 MBP 18 72,823,708 4384 LDLR 19 11,102,877 4385 LDLR 19 11,163,807 4386 ZNF667 19 61,678,984 4387 ZNF667 19 61,723,565 4388 ZNF544 19 63,458,980 4389 ZNF544 19 63,476,544 4390 ATRN 20 3,443,074 4391 ATRN 20 3,560,688 4392 ATRN 20 3,587,019 4393 RNF24 20 3,882,766 4394 RNF24 20 3,941,491 4395 RNF24 20 4,034,314 4396 PRNT 20 4,659,767 4397 PRNT 20 4,665,262 4398 PRNT 20 4,667,344 4399 PRNT 20 4,667,407 4400 PRNT 20 4,676,075 4401 PRNT 20 4,678,559 4402 PRNT 20 4,678,670 4403 PRNT 20 4,679,022 4404 PRNT 20 4,679,142 4405 PRNT 20 4,690,080 4406 PRNT 20 4,690,705 4407 PRNT 20 4,690,937 4408 FERMT1 20 6,003,038 4409 FERMT1 20 6,037,797 4410 FERMT1 20 6,048,088 4411 FERMT1 20 6,162,234 4412 PLCB1 20 8,000,158 4413 PLCB1 20 8,001,312 4414 PLCB1 20 8,082,140 4415 PLCB1 20 8,092,135 4416 PLCB1 20 8,159,200 4417 PLCB1 20 8,166,965 4418 PLCB1 20 8,185,056 4419 PLCB1 20 8,186,289 4420 PLCB1 20 8,195,326 4421 PLCB1 20 8,322,803 4422 PLCB1 20 8,677,119 4423 PLCB1 20 8,691,637 4424 PLCB1 20 8,710,195 4425 PLCB1 20 8,713,736 4426 PLCB1 20 8,714,952 4427 PLCB1 20 8,756,294 4428 PLCB1 20 8,759,482 4429 PLCB1 20 8,761,509 4430 PLCB1 20 8,761,544 4431 PLCB1 20 8,794,006 4432 PLCB1 20 8,824,090 4433 PLCB1 20 8,837,613 4434 PLCB4 20 8,837,897 4435 PLCB1 20 8,842,975 4436 PLCB4 20 8,846,570 4437 PLCB4 20 9,313,241 4438 PLCB4 20 9,433,807 4439 JAG1 20 10,589,470 4440 JAG1 20 10,589,575 4441 MACROD2 20 14,218,096 4442 MACROD2 20 14,242,180 4443 MACROD2 20 14,265,679 4444 MACROD2 20 14,275,899 4445 MACROD2 20 15,066,513 4446 MACROD2 20 15,068,323 4447 MACROD2 20 15,073,972 4448 MACROD2 20 15,085,117 4449 MACROD2 20 15,087,547 4450 MACROD2 20 15,094,357 4451 MACROD2 20 15,557,292 4452 MACROD2 20 15,559,316 4453 MACROD2 20 15,780,282 4454 MACROD2 20 15,839,419 4455 MACROD2 20 15,846,812 4456 MACROD2 20 15,890,876 4457 MACROD2 20 15,908,144 4458 MACROD2 20 15,943,358 4459 MACROD2 20 15,981,022 4460 MACROD2 20 15,993,679 4461 KIF16B 20 16,199,083 4462 KIF16B 20 16,221,665 4463 KIF16B 20 16,270,199 4464 KIF16B 20 16,273,140 4465 KIF16B 20 16,275,825 4466 KIF16B 20 16,288,458 4467 KIF16B 20 16,288,836 4468 KIF16B 20 16,293,233 4469 KIF16B 20 16,294,439 4470 KIF16B 20 16,294,523 4471 KIF16B 20 16,301,934 4472 KIF16B 20 16,307,567 4473 KIF16B 20 16,314,615 4474 KIF16B 20 16,371,330 4475 KIF16B 20 16,395,367 4476 KIF16B 20 16,435,785 4477 KIF16B 20 16,436,083 4478 KIF16B 20 16,442,919 4479 KIF16B 20 16,445,469 4480 KIF16B 20 16,454,298 4481 KIF16B 20 16,454,369 4482 KIF16B 20 16,459,991 4483 KIF16B 20 16,476,914 4484 KIF16B 20 16,591,934 4485 SEC23B 20 18,435,014 4486 SEC23B 20 18,454,825 4487 SEC23B 20 18,470,933 4488 SEC23B 20 18,471,002 4489 SEC23B 20 18,517,599 4490 MAPRE1 20 30,888,730 4491 MAPRE1 20 30,891,296 4492 PTPRT 20 40,069,405 4493 PTPRT 20 40,087,340 4494 PTPRT 20 40,104,368 4495 PTPRT 20 40,111,844 4496 PTPRT 20 40,141,351 4497 PTPRT 20 40,141,648 4498 PTPRT 20 40,143,404 4499 PTPRT 20 40,151,573 4500 PTPRT 20 40,153,367 4501 PTPRT 20 40,176,580 4502 PTPRT 20 40,353,349 4503 PTPRT 20 40,525,385 4504 PTPRT 20 40,541,070 4505 PTPRT 20 40,715,840 4506 PTPRT 20 40,724,350 4507 PTPRT 20 40,745,754 4508 PTPRT 20 40,759,541 4509 PTPRT 20 40,759,651 4510 PTPRT 20 40,766,955 4511 PTPRT 20 40,781,649 4512 PTPRT 20 40,832,585 4513 PTPRT 20 41,380,590 4514 PTPRT 20 41,380,842 4515 PTPRT 20 41,381,326 4516 ZSWIM3 20 43,929,395 4517 KCNB1 20 47,457,043 4518 KCNB1 20 47,468,865 4519 KCNB1 20 47,543,084 4520 KCNB1 20 47,550,362 4521 KCNB1 20 47,554,184 4522 PTGIS 20 47,563,735 4523 PTGIS 20 47,596,551 4524 SNAI1 20 48,025,165 4525 SNAI1 20 48,034,331 4526 SNAI1 20 48,036,030 4527 SNAI1 20 48,038,206 4528 SNAI1 20 48,051,852 4529 CDH4 20 59,287,591 4530 CDH4 20 59,359,672 4531 CDH4 20 59,410,397 4532 CDH4 20 59,411,482 4533 CDH4 20 59,456,145 4534 CDH4 20 59,516,281 4535 CDH4 20 59,708,754 4536 CDH4 20 59,854,564 4537 CDH4 20 59,923,377 4538 CDH4 20 59,936,745 4539 CDH4 20 59,972,047 4540 C21ORF37 21 17,711,037 4541 C21ORF37 21 17,738,145 4542 NCAM2 21 20,822,764 4543 NCAM2 21 20,823,179 4544 NCAM2 21 21,399,247 4545 NCAM2 21 21,668,058 4546 NCAM2 21 21,717,043 4547 NCAM2 21 21,722,038 4548 NCAM2 21 21,734,222 4549 NCAM2 21 21,757,884 4550 NCAM2 21 21,763,517 4551 NCAM2 21 21,791,467 4552 NCAM2 21 21,849,510 4553 MIRN155 21 24,246,806 4554 MIRN155 21 24,492,909 4555 MIRN155 21 24,857,632 4556 PCP4 21 40,147,412 4557 PCP4 21 40,194,909 4558 PCP4 21 40,196,193 4559 PCP4 21 40,196,614 4560 SLC37A1 21 42,871,651 4561 PDE9A 21 42,977,018 4562 PDE9A 21 42,997,501 4563 PDE9A 21 42,998,397 4564 PDE9A 21 43,012,117 4565 PDE9A 21 43,061,181 4566 PDE9A 21 43,101,819 4567 ARVCF 22 18,342,380 4568 ARVCF 22 18,343,666 4569 ARVCF 22 18,358,558 4570 ARVCF 22 18,376,255 4571 SGSM1 22 23,675,537 4572 ASPHD2 22 25,130,199 4573 ASPHD2 22 25,171,643 4574 HPS4 22 25,200,502 4575 HPS4 22 25,207,539 4576 HPS4 22 25,207,981 4577 HPS4 22 25,208,024 4578 ARFGAP3 22 41,526,978 4579 ARFGAP3 22 41,542,725 4580 ARFGAP3 22 41,556,543 4581 ARFGAP3 22 41,562,917 4582 ARFGAP3 22 41,590,371 4583 ARFGAP3 22 41,591,167 4584 PACSIN2 22 41,617,234 4585 PACSIN2 22 41,619,417 4586 PACSIN2 22 41,635,805 4587 PACSIN2 22 41,679,576 4588 PACSIN2 22 41,722,800 4589 PACSIN2 22 41,727,507 4590 PACSIN2 22 41,765,612 4591 TTLL1 22 41,776,832 4592 TTLL1 22 41,789,790 4593 TTLL1 22 41,800,470 4594 TTLL1 22 41,822,583 4595 TTLL1 22 41,822,906 4596 EFCAB6 22 42,262,997 4597 EFCAB6 22 42,278,436 4598 EFCAB6 22 42,307,729 4599 EFCAB6 22 42,320,777 4600 EFCAB6 22 42,341,477 4601 EFCAB6 22 42,354,506 4602 EFCAB6 22 42,358,549 4603 EFCAB6 22 42,364,511 4604 EFCAB6 22 42,387,277 4605 EFCAB6 22 42,411,013 4606 EFCAB6 22 42,414,775 4607 EFCAB6 22 42,426,302 4608 EFCAB6 22 42,433,349 4609 EFCAB6 22 42,451,208 4610 EFCAB6 22 42,494,726 4611 EFCAB6 22 42,496,931 4612 EFCAB6 22 42,500,759 4613 EFCAB6 22 42,521,911 4614 EFCAB6 22 42,527,300 4615 EFCAB6 22 42,584,422 4616 RIBC2 22 44,257,735 4617 RIBC2 22 44,258,667 

1. A method of predicting a human patient's likely response to a treatment for schizophrenia (SZ), the method comprising determining the identity of an allele of at least one polymorphism listed in Tables 1-20, wherein the presence of an allele associated with a known response indicates the patient's likely response to the treatment.
 2. A method of selecting a treatment for schizophrenia (SZ) for administration to a human patient, the method comprising: determining the identity in the subject of an allele of at least one polymorphism listed in Tables 1-20; comparing the identity of the allele in the subject to a reference allele of the same polymorphism, wherein the reference allele is associated with a known response to a treatment; and selecting a treatment if the allele in the patient is the same as a reference allele that is associated with a positive response to that treatment.
 3. The method of claim 1 or 2, wherein the treatment is administration of an antipsychotic medication, and the at least one polymorphism is selected from the markers listed in Tables 1-20.
 4. The method of claim 3, wherein the antipsychotic medication is olanzapine, and the at least one polymorphism is selected from the markers listed in Tables 1, 6, 11, and
 16. 5. The method of claim 4, wherein the at least one polymorphism is nucleotide 31 of a sequence selected from the group consisting of SEQ ID NO:2971, 2019, 684, 1109, 1336, 2256, 4414, 3296, 3298, 1853, 2390, 2813, 4603, 3746, 1309, 1588, 1197, 1717, and
 248. 6. The method of claim 3, wherein the antipsychotic medication is risperidone, and the at least one polymorphism is selected from the markers listed in Tables 2, 7, 12, and
 17. 7. The method of claim 6, wherein the at least one polymorphism is nucleotide 31 of a sequence selected from the group consisting of SEQ ID NO:27, 3878, 882, 882, 1439, 4213, 457, 2394, 1571, 4598, 559, 914, 4340, 1895, 22, 3078, 23, or
 4573. 8. The method of claim 3, wherein the antipsychotic medication is quetiapine, and the at least one polymorphism is selected from the markers listed in Tables 3, 8, 13, and
 18. 9. The method of claim 8, wherein the at least one polymorphism is nucleotide 31 of a sequence selected from the group consisting of SEQ ID NO:4571, 2383, 3737, 694, 795, 695, 2162, 574, 4414, 56, 1416, 1835, 3201, 2445, 1292, 1291, 745, 746, and
 3528. 10. The method of claim 3, wherein the antipsychotic medication is perphenazine, and the at least one polymorphism is selected from the markers listed in Tables 4, 9, 14, and
 19. 11. The method of claim 10, wherein the at least one polymorphism is nucleotide 31 of a sequence selected from the group consisting of SEQ ID NO:48, 3715, 2829, 3869, 2240, 4282 2409, 2634, 3312, 2797, 1665, 4250, 507, 3077, 3303, 1508,
 307. 12. The method of claim 3, wherein the antipsychotic medication is ziprasidone, and the at least one polymorphism is selected from the markers listed in Tables 5, 10, 15, and
 20. 13. The method of claim 12, wherein the at least one polymorphism is nucleotide 31 of a sequence selected from the group consisting of SEQ ID NO:3092, 3424, 62, 297, 2618, 1787 788, 1711, 4425, 2159, 3475, 1738, 2429, 2538, and
 3589. 14. The method of claim 1 or 2, wherein determining the identity of an allele comprises obtaining a sample comprising DNA from the subject, and determining identity of the nucleotide at the polymorphic site.
 15. The method of claim 14, wherein determining the identity of the nucleotide comprises contacting the sample with a probe specific for a selected allele of the polymorphism, and detecting the formation of complexes between the probe and the selected allele of the polymorphism, wherein the formation of complexes between the probe and the test marker indicates the presence of the selected allele in the sample.
 16. The method of claim 14, wherein determining the identity of an allele comprises determining the identity of a nucleotide at position 31 of one of SEQ ID NOs: 1-4617.
 17. The method of claim 1 or 2, further comprising selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele.
 18. The method of claim 1 or 2, further comprising stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects.
 19. The method of claim 2, further comprising administering the selected treatment to the subject.
 20. The method of claim 1 or 2, wherein the response is selected from the group consisting of a change in a PANNS score; length of time until a discontinuation of therapy; likelihood of discontinuing therapy due to lack of efficacy; and likelihood of discontinuing therapy due to a serious adverse event.
 21. The method of claim 2, wherein a positive response is a decrease in a PANNS score relative to baseline; a long time until discontinuation of therapy; a low likelihood of discontinuing therapy due to lack of efficacy; and a low likelihood of discontinuing therapy due to a serious adverse event.
 22. The method of claim 1 or 2, further comprising recording the identity of the allele in a tangible medium.
 23. The method of claim 1 or 2, wherein the tangible medium comprises a computer-readable disk, a solid state memory device, or an optical storage device. 